ZRdb KZFP & Repeats
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Human_ZNF470

  • Protein
    Zinc finger protein 470
  • Length
    717
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q6ECI4
  • NCBI_ID
    388566
Sequence:
MKSQEEVEVAGIKLCKAMSLGSVTFTDVAIDFSQDEWEWLNLAQRSLYKKVMLENYRNLVSVGLCISKPDVISLLEQEKDPWVIKGGMNRGLCPDLECVWVTKSLSLNQDIYEEKLPPAIIMERLKSYDLECSTLGKNWKCEDLFERELVNQKTHFRQETITHIDTLIEKRDHSNKSGTVFHLNTLSYIKQIFPMEERIFNFHTDKKSLKTHSVVKKHKQDRGEKKLLKCNDCEKIFSKISTLTLHQRIHTGEKPYECIECGKAFSQSAHLAQHQRIHTGEKPFECTECGKAFSQNAHLVQHQRVHTGEKPYQCKQCNKAFSQLAHLAQHQRVHTGEKPYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPFDCIDCGKAFTDHIGLIQHKRTHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICEKAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQSTHLAHHQRIHTGEKPYECKECSKTFSQNAHLAQHQKIHTGEKPYECKECGKAFSQIAHLVQHQRVHTGEKPYECIECGKAFSDGSYLVQHQRLHSGKRPYECLECGKAFRQRASLICHQRCHTGEKPYECNVCGKAFSHRKSLTLHQRIHTGEKPYECKECSKAFSQVAHLTLHKRIHTGERPYECKECGKAFRQSVHLAHHQRIHTGESSVILSSALPYHQVL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 23..94
2 C2h2 228..250
3 C2h2 256..278
4 C2h2 284..306
5 C2h2 312..334
6 C2h2 340..362
7 C2h2 368..391
8 C2h2 397..419
9 C2h2 425..447
10 C2h2 453..475
11 C2h2 481..503
12 C2h2 509..531
13 C2h2 537..559
14 C2h2 565..587
15 C2h2 593..615
16 C2h2 621..643
17 C2h2 649..671
18 C2h2 677..699
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nuclear body
2 Cellular Component nucleoplasm
3 Cellular Component nucleus
4 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MIR 4 n.s 99.0 Highly correlated
2 MER21B 4 **** 99.0 Highly correlated
3 LTR10A 4 **** 28.9 Weakly correlated
4 AluY 3 n.s 74.0 Weakly correlated
5 L2a 3 n.s 99.0 Highly correlated
6 L2 2 n.s 99.0 Highly correlated
7 HAL1b 2 ** 99.0 Highly correlated
8 L2b 2 n.s 99.0 Highly correlated
9 L1PA15-16 1 * 74.0 Weakly correlated
10 L1PA10 1 n.s 74.0 Weakly correlated
11 L1PA4 1 n.s 19.6 Weakly correlated
12 L2c 1 n.s 99.0 Highly correlated
13 LTR16A2 1 ** 99.0 Highly correlated
14 LTR33B 1 ** 99.0 Highly correlated
15 LTR78 1 * 99.0 Highly correlated
16 MLT1C 1 n.s 94.0 Weakly correlated
17 MLT1L 1 n.s 99.0 Highly correlated
18 L1PA15 1 n.s 74.0 Weakly correlated
19 AluJr4 1 n.s 74.0 Weakly correlated
20 L1MEj 1 ** 99.0 Highly correlated
21 L1MC 1 n.s 99.0 Highly correlated
22 L1MB4 1 n.s 99.0 Highly correlated
23 L1MA1 1 n.s 74.0 Weakly correlated
24 L1M5 1 n.s 99.0 Highly correlated
25 L1HS 1 n.s 8.6 Weakly correlated
26 HAL1ME 1 * 99.0 Highly correlated
27 HAL1 1 n.s 99.0 Highly correlated
28 FRAM 1 * 74.0 Weakly correlated
29 FLAM_C 1 n.s 74.0 Weakly correlated
30 AluSz6 1 n.s 74.0 Weakly correlated
31 AluSx1 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 1 n.s 74.0 Weakly correlated
2 L2b 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP