Human_ZNF460
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ProteinZinc finger protein 460
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Length562
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OrganismHomo sapiens (Human)
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Time of emergence94.0 Mya
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Time of Changing in binding specificity74.0 Mya
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Uniprot_ID
-
NCBI_ID
Sequence:
MAAAWMAPAQESVTFEDVAVTFTQEEWGQLDVTQRALYVEVMLETCGLLVALGDSTKPETVEPIPSHLALPEEVSLQEQLAQGVPRYSYLGQAMDQDGPSEMQEYFLRPGTDPQSEKLHGKMSLEHEGLATADGICSMMIQNQVSPEDALYGFDSYGPVTDSLIHEGENSYKFEEMFNENCFLVQHEQILPRVKPYDCPECGKAFGKSKHLLQHHIIHTGEKPYKCLECGKDFNRRSHLTRHQRTHNGDKPFVCSECGRTFNRGSHLTRHQRVHSGEKPFVCNECGKAFTYRSNFVLHNKSHNEKKPFACSECGKGFYESTALIQHFIIHTGERPFKCLECGKAFNCRSHLKQHERIHTGEKPFVCSQCGKAFTHYSTYVLHERAHTGEKPFECKECGKAFSIRKDLIRHFNIHTGEKPYECLQCGKAFTRMSGLTRHQWIHTGEKPYVCIQCGKAFCRTTNLIRHFSIHTGEKPYECVECGKAFNRRSPLTRHQRIHTAEKSHEPIQSGNVSCESTDLIQHSIIHTESSPVSAVNMETPSIAAHSSSLDINGFIVEETLPL
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 13..99 | |
| 2 | C2h2 | 196..218 | |
| 3 | C2h2 | 224..246 | |
| 4 | C2h2 | 252..274 | |
| 5 | C2h2 | 280..302 | |
| 6 | C2h2 | 308..330 | |
| 7 | C2h2 | 336..358 | |
| 8 | C2h2 | 364..386 | |
| 9 | C2h2 | 392..414 | |
| 10 | C2h2 | 420..442 | |
| 11 | C2h2 | 448..470 | |
| 12 | C2h2 | 476..498 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleus | |
| 2 | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| 3 | Molecular Function | metal ion binding | |
| 4 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| 5 | Molecular Function | sequence-specific double-stranded DNA binding | |
| 6 | Biological Process | regulation of DNA-templated transcription |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | AluY | 346 | **** | 74.0 | Highly correlated | |
| 2 | AluSx | 180 | **** | 74.0 | Highly correlated | |
| 3 | AluSx1 | 171 | **** | 74.0 | Highly correlated | |
| 4 | AluSz | 138 | **** | 74.0 | Highly correlated | |
| 5 | AluJb | 103 | **** | 74.0 | Highly correlated | |
| 6 | AluSg | 91 | **** | 74.0 | Highly correlated | |
| 7 | AluSc | 85 | **** | 74.0 | Highly correlated | |
| 8 | AluSq2 | 81 | **** | 74.0 | Highly correlated | |
| 9 | AluSp | 69 | **** | 74.0 | Highly correlated | |
| 10 | AluSx3 | 63 | **** | 74.0 | Highly correlated | |
| 11 | AluSc8 | 47 | **** | 74.0 | Highly correlated | |
| 12 | AluJo | 44 | **** | 74.0 | Highly correlated | |
| 13 | AluJr | 39 | **** | 74.0 | Highly correlated | |
| 14 | AluSz6 | 35 | **** | 74.0 | Highly correlated | |
| 15 | AluSq | 33 | **** | 74.0 | Highly correlated | |
| 16 | AluSx4 | 30 | **** | 74.0 | Highly correlated | |
| 17 | AluSg7 | 28 | **** | 74.0 | Highly correlated | |
| 18 | AluYm1 | 16 | **** | 19.6 | Weakly correlated | |
| 19 | AluYf1 | 14 | **** | 19.6 | Weakly correlated | |
| 20 | AluSg4 | 11 | **** | 74.0 | Highly correlated | |
| 21 | AluYc | 9 | **** | 74.0 | Highly correlated | |
| 22 | AluSc5 | 9 | **** | 74.0 | Highly correlated | |
| 23 | AluYj4 | 9 | **** | 0.0 | Weakly correlated | |
| 24 | MIRb | 8 | n.s | 99.0 | Weakly correlated | |
| 25 | FLAM_C | 7 | ** | 74.0 | Highly correlated | |
| 26 | AluYe5 | 7 | **** | 74.0 | Highly correlated | |
| 27 | FRAM | 5 | *** | 74.0 | Highly correlated | |
| 28 | AluSq4 | 5 | **** | 74.0 | Highly correlated | |
| 29 | L2a | 5 | n.s | 99.0 | Weakly correlated | |
| 30 | LTR10A | 4 | **** | 28.9 | Weakly correlated | |
| 31 | FLAM_A | 4 | ** | 74.0 | Highly correlated | |
| 32 | L2b | 4 | n.s | 99.0 | Weakly correlated | |
| 33 | AluYk2 | 4 | **** | 19.6 | Weakly correlated | |
| 34 | AluSq10 | 4 | **** | 74.0 | Highly correlated | |
| 35 | L2c | 3 | n.s | 99.0 | Weakly correlated | |
| 36 | AluYh3 | 3 | *** | 15.2 | Weakly correlated | |
| 37 | MIR | 3 | n.s | 99.0 | Weakly correlated | |
| 38 | L1ME4a | 3 | n.s | 99.0 | Weakly correlated | |
| 39 | AluYa5 | 3 | ** | 15.2 | Weakly correlated | |
| 40 | MLT1D | 2 | n.s | 99.0 | Weakly correlated | |
| 41 | SVA_E | 2 | ** | 0.0 | Weakly correlated | |
| 42 | L1MC4 | 2 | n.s | 99.0 | Weakly correlated | |
| 43 | AluYh3a3 | 2 | **** | 15.2 | Weakly correlated | |
| 44 | MER52D | 1 | n.s | 74.0 | Highly correlated | |
| 45 | AluYi6 | 1 | ** | 15.2 | Weakly correlated | |
| 46 | LTR23 | 1 | ** | 74.0 | Highly correlated | |
| 47 | LTR24B | 1 | ** | 74.0 | Highly correlated | |
| 48 | LTR40c | 1 | ** | 99.0 | Weakly correlated | |
| 49 | LTR71B | 1 | ** | 43.0 | Weakly correlated | |
| 50 | MER31B | 1 | * | 99.0 | Weakly correlated | |
| 51 | MER50 | 1 | n.s | 43.0 | Weakly correlated | |
| 52 | MER50-int | 1 | * | 43.0 | Weakly correlated | |
| 53 | AluYk3 | 1 | * | 19.6 | Weakly correlated | |
| 54 | AluYg6 | 1 | ** | 15.2 | Weakly correlated | |
| 55 | MIR1_Amn | 1 | n.s | 319.0 | Weakly correlated | |
| 56 | MIR3 | 1 | n.s | 99.0 | Weakly correlated | |
| 57 | AluYc3 | 1 | ** | 74.0 | Highly correlated | |
| 58 | MIRc | 1 | n.s | 99.0 | Weakly correlated | |
| 59 | AluYb9 | 1 | ** | 15.2 | Weakly correlated | |
| 60 | MamRep1151 | 1 | * | 99.0 | Weakly correlated | |
| 61 | SVA_C | 1 | * | 15.2 | Weakly correlated | |
| 62 | AluJr4 | 1 | n.s | 74.0 | Highly correlated | |
| 63 | L1MD2 | 1 | n.s | 99.0 | Weakly correlated | |
| 64 | L1M4 | 1 | n.s | 99.0 | Weakly correlated | |
| 65 | L1M5 | 1 | n.s | 99.0 | Weakly correlated | |
| 66 | L1MA9 | 1 | n.s | 99.0 | Weakly correlated | |
| 67 | L1MB1 | 1 | n.s | 99.0 | Weakly correlated | |
| 68 | L1MB4 | 1 | n.s | 99.0 | Weakly correlated | |
| 69 | L1MB7 | 1 | n.s | 99.0 | Weakly correlated | |
| 70 | L1MB8 | 1 | n.s | 99.0 | Weakly correlated | |
| 71 | HERVK3-int | 1 | * | 28.9 | Weakly correlated | |
| 72 | L1MC5 | 1 | n.s | 99.0 | Weakly correlated | |
| 73 | HUERS-P3-int | 1 | n.s | 43.0 | Weakly correlated | |
| 74 | L1ME3 | 1 | n.s | 99.0 | Weakly correlated | |
| 75 | L1ME3Cz | 1 | n.s | 99.0 | Weakly correlated | |
| 76 | FAM | 1 | n.s | 87.0 | Moderately correlated | |
| 77 | L1MEc | 1 | n.s | 99.0 | Weakly correlated | |
| 78 | L1PA14 | 1 | n.s | 74.0 | Highly correlated | |
| 79 | L1PA2 | 1 | n.s | 15.2 | Weakly correlated | |
| 80 | L1PA5 | 1 | n.s | 19.6 | Weakly correlated | |
| 81 | L2 | 1 | n.s | 99.0 | Weakly correlated | |
| 82 | AluYk4 | 1 | * | 15.2 | Weakly correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | AluY | 309 | **** | 74.0 | Highly correlated | |
| 2 | AluSx | 159 | **** | 74.0 | Highly correlated | |
| 3 | AluSx1 | 157 | **** | 74.0 | Highly correlated | |
| 4 | AluSz | 124 | **** | 74.0 | Highly correlated | |
| 5 | AluSg | 84 | **** | 74.0 | Highly correlated | |
| 6 | AluJb | 82 | **** | 74.0 | Highly correlated | |
| 7 | AluSc | 79 | **** | 74.0 | Highly correlated | |
| 8 | AluSq2 | 73 | **** | 74.0 | Highly correlated | |
| 9 | AluSp | 63 | **** | 74.0 | Highly correlated | |
| 10 | AluSx3 | 60 | **** | 74.0 | Highly correlated | |
| 11 | AluSc8 | 42 | **** | 74.0 | Highly correlated | |
| 12 | AluJo | 39 | **** | 74.0 | Highly correlated | |
| 13 | AluSz6 | 34 | **** | 74.0 | Highly correlated | |
| 14 | AluJr | 33 | **** | 74.0 | Highly correlated | |
| 15 | AluSq | 31 | **** | 74.0 | Highly correlated | |
| 16 | AluSx4 | 26 | **** | 74.0 | Highly correlated | |
| 17 | AluSg7 | 21 | **** | 74.0 | Highly correlated | |
| 18 | AluYm1 | 15 | **** | 19.6 | Weakly correlated | |
| 19 | AluYf1 | 13 | **** | 19.6 | Weakly correlated | |
| 20 | AluSg4 | 9 | **** | 74.0 | Highly correlated | |
| 21 | AluSc5 | 8 | **** | 74.0 | Highly correlated | |
| 22 | AluYj4 | 8 | **** | 0.0 | Weakly correlated | |
| 23 | AluYc | 7 | **** | 74.0 | Highly correlated | |
| 24 | FLAM_C | 5 | * | 74.0 | Highly correlated | |
| 25 | AluYe5 | 5 | **** | 74.0 | Highly correlated | |
| 26 | AluSq4 | 5 | **** | 74.0 | Highly correlated | |
| 27 | AluYk2 | 4 | **** | 19.6 | Weakly correlated | |
| 28 | FLAM_A | 4 | ** | 74.0 | Highly correlated | |
| 29 | AluSq10 | 4 | **** | 74.0 | Highly correlated | |
| 30 | AluYh3 | 3 | *** | 15.2 | Weakly correlated | |
| 31 | FRAM | 2 | * | 74.0 | Highly correlated | |
| 32 | AluYh3a3 | 2 | **** | 15.2 | Weakly correlated | |
| 33 | AluYa5 | 2 | * | 15.2 | Weakly correlated | |
| 34 | AluYc3 | 1 | ** | 74.0 | Highly correlated | |
| 35 | L2a | 1 | n.s | 99.0 | Weakly correlated | |
| 36 | AluYi6 | 1 | ** | 15.2 | Weakly correlated | |
| 37 | AluYk3 | 1 | * | 19.6 | Weakly correlated | |
| 38 | AluYk4 | 1 | * | 15.2 | Weakly correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP |
|---|