ZRdb KZFP & Repeats
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Human_ZNF454

  • Protein
    Zinc finger protein 454
  • Length
    522
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q8N9F8
  • NCBI_ID
    285676
Sequence:
MAVSHLPTMVQESVTFKDVAILFTQEEWGQLSPAQRALYRDVMLENYSNLVSLGLLGPKPDTFSQLEKREVWMPEDTPGGFCLDWMTMPASKKSTVKAEIPEEELDQWTIKERFSSSSHWKCASLLEWQCGGQEISLQRVVLTHPNTPSQECDESGSTMSSSLHSDQSQGFQPSKNAFECSECGKVFSKSSTLNKHQKIHNEKNANQKIHIKEKRYECRECGKAFHQSTHLIHHQRIHTGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNLCGKAFIRNIHLAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFNQSTSFLQHQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFRDQSALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKICEKAFIRSTHLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQHQRHHIGEK
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..84
2 C2h2 178..200
3 C2h2 216..238
4 C2h2 244..266
5 C2h2 272..294
6 C2h2 300..322
7 C2h2 328..350
8 C2h2 356..378
9 C2h2 384..406
10 C2h2 412..434
11 C2h2 440..462
12 C2h2 468..490
13 C2h2 496..518
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Molecular Function sequence-specific double-stranded DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M5 22 **** 99.0 Highly correlated
2 L1MC 18 **** 99.0 Highly correlated
3 AluJb 11 n.s 74.0 Weakly correlated
4 L1M4 10 *** 99.0 Highly correlated
5 L1MD 10 **** 99.0 Highly correlated
6 AluSx 10 n.s 74.0 Weakly correlated
7 L2b 9 n.s 99.0 Highly correlated
8 L1MC1 9 *** 99.0 Highly correlated
9 AluY 9 n.s 74.0 Weakly correlated
10 MIRb 8 n.s 99.0 Highly correlated
11 L1MC2 8 **** 99.0 Highly correlated
12 AluSx1 7 n.s 74.0 Weakly correlated
13 L1MB3 7 ** 99.0 Highly correlated
14 L1MCa 7 **** 99.0 Highly correlated
15 L1MEc 6 * 99.0 Highly correlated
16 LTR8 6 **** 43.0 Weakly correlated
17 L1MA9 5 * 99.0 Highly correlated
18 LTR10A 5 **** 28.9 Weakly correlated
19 L1M3 5 *** 99.0 Highly correlated
20 AluJr 5 n.s 74.0 Weakly correlated
21 L2c 5 n.s 99.0 Highly correlated
22 AluSc8 5 * 74.0 Weakly correlated
23 AluSp 5 n.s 74.0 Weakly correlated
24 L1MC3 4 n.s 99.0 Highly correlated
25 L1PA5 4 n.s 19.6 Weakly correlated
26 L1PB1 4 n.s 74.0 Weakly correlated
27 L1MEf 4 * 99.0 Highly correlated
28 L1MEd 4 n.s 99.0 Highly correlated
29 AluSq2 4 n.s 74.0 Weakly correlated
30 AluSz 4 n.s 74.0 Weakly correlated
31 L1MB8 4 n.s 99.0 Highly correlated
32 L1PA10 3 n.s 74.0 Weakly correlated
33 L1ME3A 3 n.s 99.0 Highly correlated
34 MIR 3 n.s 99.0 Highly correlated
35 AluSz6 3 n.s 74.0 Weakly correlated
36 MIR3 3 n.s 99.0 Highly correlated
37 L1MA8 3 n.s 87.0 Weakly correlated
38 L1MA4 3 n.s 87.0 Weakly correlated
39 L1P4 3 ** 74.0 Weakly correlated
40 L2a 2 n.s 99.0 Highly correlated
41 L1ME4a 2 n.s 99.0 Highly correlated
42 L1PBa 2 n.s 74.0 Weakly correlated
43 L1PA4 2 n.s 19.6 Weakly correlated
44 L1PA2 2 n.s 15.2 Weakly correlated
45 L1MEg 2 n.s 99.0 Highly correlated
46 L1ME3G 2 n.s 99.0 Highly correlated
47 L1P1 2 n.s 19.6 Weakly correlated
48 L1P3 2 n.s 74.0 Weakly correlated
49 L1ME3C 2 ** 99.0 Highly correlated
50 LTR10F 2 **** 28.9 Weakly correlated
51 L1PA16 2 n.s 74.0 Weakly correlated
52 L1M6 2 * 99.0 Highly correlated
53 AluSg 2 n.s 74.0 Weakly correlated
54 FRAM 2 ** 74.0 Weakly correlated
55 MLT1F2 2 * 99.0 Highly correlated
56 MLT1D 2 n.s 99.0 Highly correlated
57 HAL1ME 2 * 99.0 Highly correlated
58 MIRc 2 n.s 99.0 Highly correlated
59 L1M1 2 n.s 74.0 Weakly correlated
60 AluYj4 2 ** 0.0 Weakly correlated
61 L1M2 2 n.s 99.0 Highly correlated
62 L1MA3 2 n.s 74.0 Weakly correlated
63 L1MB2 2 n.s 99.0 Highly correlated
64 L1MB7 2 n.s 99.0 Highly correlated
65 L1MC5a 2 n.s 99.0 Highly correlated
66 MER50-int 2 *** 43.0 Weakly correlated
67 MER50 2 ** 43.0 Weakly correlated
68 L1ME1 2 n.s 99.0 Highly correlated
69 MamRep605 2 ** 99.0 Highly correlated
70 THE1A 1 n.s 43.0 Weakly correlated
71 SVA_F 1 * 0.0 Weakly correlated
72 L1MDb 1 * 99.0 Highly correlated
73 MER39B 1 ** 74.0 Weakly correlated
74 MLT1N2 1 * 99.0 Highly correlated
75 MLT1L 1 n.s 99.0 Highly correlated
76 MLT1F1 1 * 99.0 Highly correlated
77 LTR41 1 ** 99.0 Highly correlated
78 LTR76 1 *** 74.0 Weakly correlated
79 LTR88b 1 ** 99.0 Highly correlated
80 L1M4c 1 n.s 99.0 Highly correlated
81 AluJo 1 n.s 74.0 Weakly correlated
82 AluSc 1 n.s 74.0 Weakly correlated
83 AluYc 1 * 74.0 Weakly correlated
84 AluYh3 1 * 15.2 Weakly correlated
85 AluYh9 1 **** 15.2 Weakly correlated
86 AluYm1 1 n.s 19.6 Weakly correlated
87 AmnSINE1 1 ** 319.0 Weakly correlated
88 HAL1 1 n.s 99.0 Highly correlated
89 HERVL74-int 1 ** 99.0 Highly correlated
90 LTR13 1 ** 19.6 Weakly correlated
91 L1MB1 1 n.s 99.0 Highly correlated
92 L1MC4 1 n.s 99.0 Highly correlated
93 L1MD1 1 n.s 99.0 Highly correlated
94 L1MDa 1 n.s 99.0 Highly correlated
95 L1ME2 1 n.s 99.0 Highly correlated
96 L1ME2z 1 n.s 99.0 Highly correlated
97 L1ME3E 1 n.s 99.0 Highly correlated
98 L1MEi 1 n.s 99.0 Highly correlated
99 L1PA15 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MC 3 ** 99.0 Highly correlated
2 L1MCa 2 n.s 99.0 Highly correlated
3 L1MC1 2 n.s 99.0 Highly correlated
4 AluYj4 2 ** 0.0 Weakly correlated
5 L1MC2 2 n.s 99.0 Highly correlated
6 L2c 1 n.s 99.0 Highly correlated
7 AluSx 1 n.s 74.0 Weakly correlated
8 AluYh9 1 **** 15.2 Weakly correlated
9 L1MA9 1 n.s 99.0 Highly correlated
10 L2b 1 n.s 99.0 Highly correlated
11 L1M1 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP