ZRdb KZFP & Repeats
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Human_ZNF45

  • Protein
    Zinc finger protein 45
  • Length
    682
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q02386
  • NCBI_ID
    7596
Sequence:
MTKSKEAVTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVSVGHQSTPDGLPQLEREEKLWMMKMATQRDNSSGAKNLKEMETLQEVGLRYLPHEELFCSQIWQQITRELIKYQDSVVNIQRTGCQLEKRDDLHYKDEGFSNQSSHLQVHRVHTGEKPYKGEHCVKSFSWSSHLQINQRAHAGEKPYKCEKCDNAFRRFSSLQAHQRVHSRAKSYTNDASYRSFSQRSHLPHHQRVPTGENPYKYEECGRNVGKSSHCQAPLIVHTGEKPYKCEECGVGFSQRSYLQVHLKVHTGKKPYKCEECGKSFSWRSRLQAHERIHTGEKPYKCNACGKSFSYSSHLNIHCRIHTGEKPYKCEECGKGFSVGSHLQAHQISHTGEKPYKCEECGKGFCRASNLLDHQRGHTGEKPYQCDACGKGFSRSSDFNIHFRVHTGEKPYKCEECGKGFSQASNLLAHQRGHTGEKPYKCGTCGKGFSRSSDLNVHCRIHTGEKPYKCERCGKAFSQFSSLQVHQRVHTGEKPYQCAECGKGFSVGSQLQAHQRCHTGEKPYQCEECGKGFCRASNFLAHRGVHTGEKPYRCDVCGKRFRQRSYLQAHQRVHTGERPYKCEECGKVFSWSSYLQAHQRVHTGEKPYKCEECGKGFSWSSSLIIHQRVHADDEGDKDFPSSEDSHRKTR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..78
2 dec2h2 164..186
3 C2h2 192..214
4 C2h2 220..247
5 C2h2 248..275
6 C2h2 276..298
7 C2h2 304..326
8 C2h2 332..354
9 C2h2 360..382
10 C2h2 388..410
11 C2h2 416..438
12 C2h2 444..466
13 C2h2 472..494
14 C2h2 500..522
15 C2h2 528..550
16 C2h2 556..578
17 C2h2 584..606
18 C2h2 612..634
19 C2h2 640..662
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleoplasm
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEb 16 **** 99.0 Highly correlated
2 L1MEf 10 **** 99.0 Highly correlated
3 L1M4a1 9 **** 99.0 Highly correlated
4 L1P3 7 **** 74.0 Weakly correlated
5 L1MEc 6 *** 99.0 Highly correlated
6 AluJb 5 n.s 74.0 Weakly correlated
7 LTR8 5 **** 43.0 Weakly correlated
8 LTR10A 4 **** 28.9 Weakly correlated
9 AluY 4 n.s 74.0 Weakly correlated
10 L1PA5 3 n.s 19.6 Weakly correlated
11 AluSz 3 n.s 74.0 Weakly correlated
12 MIRb 3 n.s 99.0 Highly correlated
13 AluSx 2 n.s 74.0 Weakly correlated
14 AluYm1 2 ** 19.6 Weakly correlated
15 LTR12C 2 * 19.6 Weakly correlated
16 MER50 2 *** 43.0 Weakly correlated
17 L2c 2 n.s 99.0 Highly correlated
18 L1P1 2 ** 19.6 Weakly correlated
19 L1MA5 2 ** 87.0 Weakly correlated
20 L1ME1 2 n.s 99.0 Highly correlated
21 L1PA16 1 n.s 74.0 Weakly correlated
22 L1PA2 1 n.s 15.2 Weakly correlated
23 L1MEa 1 *** 99.0 Highly correlated
24 L1PA4 1 n.s 19.6 Weakly correlated
25 L1PB1 1 n.s 74.0 Weakly correlated
26 L2b 1 n.s 99.0 Highly correlated
27 LTR13 1 ** 19.6 Weakly correlated
28 MER39B 1 ** 74.0 Weakly correlated
29 MER50-int 1 ** 43.0 Weakly correlated
30 MIR 1 n.s 99.0 Highly correlated
31 MLT1F1 1 ** 99.0 Highly correlated
32 CR1-3_Croc 1 *** 319.0 Weakly correlated
33 AluJr 1 n.s 74.0 Weakly correlated
34 AluSc5 1 * 74.0 Weakly correlated
35 AluSc8 1 n.s 74.0 Weakly correlated
36 AluSg 1 n.s 74.0 Weakly correlated
37 AluSq 1 n.s 74.0 Weakly correlated
38 AluSx1 1 n.s 74.0 Weakly correlated
39 AluSx3 1 n.s 74.0 Weakly correlated
40 AluYh9 1 **** 15.2 Weakly correlated
41 L1P4 1 * 74.0 Weakly correlated
42 FRAM 1 * 74.0 Weakly correlated
43 L1M4 1 n.s 99.0 Highly correlated
44 L1MB7 1 n.s 99.0 Highly correlated
45 L1ME2 1 n.s 99.0 Highly correlated
46 L1ME2z 1 * 99.0 Highly correlated
47 L1ME3Cz 1 n.s 99.0 Highly correlated
48 L1ME4b 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEb 4 **** 99.0 Highly correlated
2 L1MEf 4 ** 99.0 Highly correlated
3 L1MEc 3 * 99.0 Highly correlated
4 L1M4a1 2 *** 99.0 Highly correlated
5 L1MEa 1 *** 99.0 Highly correlated
6 L1MA5 1 n.s 87.0 Weakly correlated
7 L1ME1 1 n.s 99.0 Highly correlated
8 L1ME2 1 n.s 99.0 Highly correlated
9 L1ME3Cz 1 n.s 99.0 Highly correlated
10 L1PA5 1 n.s 19.6 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP