ZRdb KZFP & Repeats
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Human_ZNF446

  • Protein
    Zinc finger protein 446
  • Length
    450
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q9NWS9
  • NCBI_ID
    55663
Sequence:
MPSPLGPPCLPVMDPETTLEEPETARLRFRGFCYQEVAGPREALARLRELCCQWLQPEAHSKEQMLEMLVLEQFLGTLPPEIQAWVRGQRPGSPEEAAALVEGLQHDPGQLLGWITAHVLKQEVLPAAQKTEEPLGSPHPSGTVESPGEGPQDTRIEGSVQLSCSVKEEPNVDGQEVAPSSPPLAAQSPEGNHGHQEPASTSFHPPRIQEEWGLLDRSQKELYWDAMLEKYGTVVSLGLPPHQPEAQAQSELGMLLTGTGVCRSLRSGNESEGPPGCPEAQPPQGPGPAAWEGLSGAATPAPTVRPGTPPVPTQPTPAETRLEPAATPRKPYTCEQCGRGFDWKSVFVIHHRTHTSGPGVQSPGLATGESTEKPPQGEVAFPHHPRRSLTGPRSYPCEECGCSFSWKSQLVIHRKSHTGQRRHFCSDCGRAFDWKSQLVIHRKGHRPEVP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 scan 26..108
2 KRAB 208..254
3 C2h2 332..359
4 C2h2 395..422
5 C2h2 423..450
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component chromatin
2 Cellular Component extracellular space
3 Cellular Component nucleus
4 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
5 Molecular Function identical protein binding
6 Molecular Function metal ion binding
7 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYa5 10 **** 15.2 Weakly correlated
2 AluSc8 8 *** 74.0 Weakly correlated
3 L1P3 5 *** 74.0 Weakly correlated
4 AluJb 4 n.s 74.0 Weakly correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 AluYj4 4 **** 0.0 Weakly correlated
7 LTR10F 3 **** 28.9 Weakly correlated
8 AluY 2 n.s 74.0 Weakly correlated
9 AluYb8 2 ** 15.2 Weakly correlated
10 FRAM 2 ** 74.0 Weakly correlated
11 L1PA2 2 n.s 15.2 Weakly correlated
12 L1M4 2 n.s 99.0 Moderately correlated
13 LTR10B1 1 *** 28.9 Weakly correlated
14 L1PA5 1 n.s 19.6 Weakly correlated
15 L1PA4 1 n.s 19.6 Weakly correlated
16 L1P4 1 n.s 74.0 Weakly correlated
17 MLT1L 1 n.s 99.0 Moderately correlated
18 L1MD 1 n.s 99.0 Moderately correlated
19 L1MA8 1 n.s 87.0 Weakly correlated
20 L1HS 1 n.s 8.6 Weakly correlated
21 HERV17-int 1 * 28.9 Weakly correlated
22 ERV3-16A3_I-int 1 n.s 99.0 Moderately correlated
23 AluYm1 1 n.s 19.6 Weakly correlated
24 AluYi6 1 *** 15.2 Weakly correlated
25 AluYe5 1 ** 74.0 Weakly correlated
26 AluYa8 1 **** 15.2 Weakly correlated
27 AluSp 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 1 * 0.0 Weakly correlated
2 AluY 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP