ZRdb KZFP & Repeats
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Human_ZNF445

  • Protein
    Zinc finger protein 445
  • Length
    1031
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
  • NCBI_ID
Sequence:
MPPGRWHAAYPAQAQSSRERGRLQTVKKEEEDESYTPVQAARPQTLNRPGQELFRQLFRQLRYHESSGPLETLSRLRELCRWWLRPDVLSKAQILELLVLEQFLSILPGELRVWVQLHNPESGEEAVALLEELQRDLDGTSWRDPGPAQSPDVHWMGTGALRSAQIWSLASPLRSSSALGDHLEPPYEIEARDFLAGQSDTPAAQMPALFPREGCPGDQVTPTRSLTAQLQETMTFKDVEVTFSQDEWGWLDSAQRNLYRDVMLENYRNMASLVGPFTKPALISWLEAREPWGLNMQAAQPKGNPVAAPTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSRQKDQCENPIQVRVKKEETNFSHRTGKDSEVSGSNSLDLKHVTYLRVSGRKESLKHGCGKHFRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQSLHTVGVSFKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHTGVKPYKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCSQCRKSFHCKSYVLEHQRIHTQEKPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECREGFRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKPEGGPSFSQDTVFQVPQSSHSKEEPYKCSQCGKAFRNHSFLLIHQRVHTGEKPYKCRECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEKRFWCQECGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSHQRKHTRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQDISIGKKCHKCSICGKTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSNLARHMKNHIRD
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 scan 55..137
2 KRAB 234..304
3 C2h2 485..507
4 C2h2 513..535
5 C2h2 541..563
6 C2h2 597..619
7 C2h2 625..647
8 C2h2 681..703
9 C2h2 709..731
10 C2h2 762..784
11 C2h2 790..812
12 C2h2 840..862
13 C2h2 868..890
14 C2h2 896..918
15 C2h2 978..1000
16 C2h2 1006..1028
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function chromatin binding
3 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
4 Molecular Function double-stranded methylated DNA binding
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
7 Biological Process maintenance of DNA methylation
8 Biological Process regulation of genetic imprinting
9 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 90 **** 74.0 Weakly correlated
2 AluSx 53 **** 74.0 Weakly correlated
3 AluSx1 38 * 74.0 Weakly correlated
4 AluSc 32 **** 74.0 Weakly correlated
5 AluSz 32 n.s 74.0 Weakly correlated
6 AluSp 31 **** 74.0 Weakly correlated
7 AluSq2 25 ** 74.0 Weakly correlated
8 AluJb 24 n.s 74.0 Weakly correlated
9 AluSc8 18 **** 74.0 Weakly correlated
10 AluSg 17 ** 74.0 Weakly correlated
11 AluSx3 16 ** 74.0 Weakly correlated
12 L2c 16 n.s 99.0 Highly correlated
13 L1PA5 14 n.s 19.6 Weakly correlated
14 L1PA7 13 n.s 74.0 Weakly correlated
15 AluJo 11 n.s 74.0 Weakly correlated
16 L1PA4 10 n.s 19.6 Weakly correlated
17 LTR12C 10 *** 19.6 Weakly correlated
18 MIRb 10 n.s 99.0 Highly correlated
19 AluYa5 9 **** 15.2 Weakly correlated
20 AluYc 9 **** 74.0 Weakly correlated
21 HERVIP10B3-int 9 **** 28.9 Weakly correlated
22 MIR 9 n.s 99.0 Highly correlated
23 MIRc 9 n.s 99.0 Highly correlated
24 AluSq 8 * 74.0 Weakly correlated
25 AluSz6 8 n.s 74.0 Weakly correlated
26 L1M3 8 *** 99.0 Highly correlated
27 L2b 8 n.s 99.0 Highly correlated
28 LTR8 8 **** 43.0 Weakly correlated
29 MER11A 8 **** 28.9 Weakly correlated
30 AluYm1 7 **** 19.6 Weakly correlated
31 L1PA6 7 n.s 28.9 Weakly correlated
32 MLT1D 7 n.s 99.0 Highly correlated
33 AluSc5 6 ** 74.0 Weakly correlated
34 L1M5 6 n.s 99.0 Highly correlated
35 L1MB7 6 n.s 99.0 Highly correlated
36 L1PA3 6 n.s 19.6 Weakly correlated
37 L2a 6 n.s 99.0 Highly correlated
38 MIR3 6 n.s 99.0 Highly correlated
39 L1MC3 5 n.s 99.0 Highly correlated
40 L2 5 n.s 99.0 Highly correlated
41 LTR7B 5 **** 28.9 Weakly correlated
42 MSTB 5 * 43.0 Weakly correlated
43 AluJr 4 n.s 74.0 Weakly correlated
44 ERV3-16A3_I-int 4 n.s 99.0 Highly correlated
45 L1MB3 4 n.s 99.0 Highly correlated
46 L1P1 4 n.s 19.6 Weakly correlated
47 LTR10A 4 **** 28.9 Weakly correlated
48 MER21C 4 n.s 99.0 Highly correlated
49 MER41-int 4 ** 74.0 Weakly correlated
50 AluSg4 3 n.s 74.0 Weakly correlated
51 AluYj4 3 ** 0.0 Weakly correlated
52 HERV17-int 3 ** 28.9 Weakly correlated
53 HERVE-int 3 ** 19.6 Weakly correlated
54 HERVH48-int 3 **** 28.9 Weakly correlated
55 L1MB5 3 n.s 99.0 Highly correlated
56 L1MB8 3 n.s 99.0 Highly correlated
57 L1MC4a 3 n.s 99.0 Highly correlated
58 L1MC5a 3 n.s 99.0 Highly correlated
59 L1MD2 3 n.s 99.0 Highly correlated
60 L1ME3A 3 n.s 99.0 Highly correlated
61 L1P3 3 n.s 74.0 Weakly correlated
62 L1P4 3 n.s 74.0 Weakly correlated
63 L1PA12 3 * 74.0 Weakly correlated
64 L1PB1 3 n.s 74.0 Weakly correlated
65 MER21A 3 ** 74.0 Weakly correlated
66 MER50 3 * 43.0 Weakly correlated
67 MLT1A0 3 n.s 99.0 Highly correlated
68 MLT1C 3 n.s 94.0 Weakly correlated
69 MLT2A2 3 * 74.0 Weakly correlated
70 AluSg7 2 n.s 74.0 Weakly correlated
71 AluSq10 2 ** 74.0 Weakly correlated
72 AluSx4 2 n.s 74.0 Weakly correlated
73 AluYa8 2 **** 15.2 Weakly correlated
74 ERVL-E-int 2 n.s 99.0 Highly correlated
75 HAL1 2 n.s 99.0 Highly correlated
76 HERV9NC-int 2 * 19.6 Weakly correlated
77 L1M1 2 n.s 74.0 Weakly correlated
78 L1M4 2 n.s 99.0 Highly correlated
79 L1M4c 2 n.s 99.0 Highly correlated
80 L1MC1 2 n.s 99.0 Highly correlated
81 L1MC4 2 n.s 99.0 Highly correlated
82 L1MC5 2 n.s 99.0 Highly correlated
83 L1MD1 2 n.s 99.0 Highly correlated
84 L1ME1 2 n.s 99.0 Highly correlated
85 L1ME3D 2 n.s 99.0 Highly correlated
86 L1ME3G 2 n.s 99.0 Highly correlated
87 L1ME4b 2 n.s 99.0 Highly correlated
88 L1MEd 2 n.s 99.0 Highly correlated
89 L1MEh 2 * 99.0 Highly correlated
90 L1P2 2 n.s 28.9 Weakly correlated
91 L1PA10 2 n.s 74.0 Weakly correlated
92 L1PA2 2 n.s 15.2 Weakly correlated
93 L1PA8 2 n.s 74.0 Weakly correlated
94 L1PB2 2 n.s 74.0 Weakly correlated
95 L1PBa 2 n.s 74.0 Weakly correlated
96 LTR1B1 2 *** 43.0 Weakly correlated
97 LTR2C 2 **** 19.6 Weakly correlated
98 LTR46 2 **** 43.0 Weakly correlated
99 MER41B 2 n.s 74.0 Weakly correlated
100 MLT1B 2 n.s 99.0 Highly correlated
101 MSTD 2 n.s 74.0 Weakly correlated
102 MamRTE1 2 n.s 99.0 Highly correlated
103 PRIMA41-int 2 ** 74.0 Weakly correlated
104 SVA_F 2 * 0.0 Weakly correlated
105 Alu 1 * 74.0 Weakly correlated
106 AluJr4 1 n.s 74.0 Weakly correlated
107 AluYc3 1 ** 74.0 Weakly correlated
108 AluYf1 1 n.s 19.6 Weakly correlated
109 AluYg6 1 ** 15.2 Weakly correlated
110 AluYk2 1 * 19.6 Weakly correlated
111 AluYk4 1 * 15.2 Weakly correlated
112 FRAM 1 n.s 74.0 Weakly correlated
113 HAL1ME 1 n.s 99.0 Highly correlated
114 HAL1b 1 n.s 99.0 Highly correlated
115 HERV4_I-int 1 * 43.0 Weakly correlated
116 HERV9-int 1 n.s 28.9 Weakly correlated
117 HERVI-int 1 ** 28.9 Weakly correlated
118 HUERS-P3-int 1 n.s 43.0 Weakly correlated
119 L1M7 1 n.s 99.0 Highly correlated
120 L1MA10 1 n.s 99.0 Highly correlated
121 L1MA3 1 n.s 74.0 Weakly correlated
122 L1MA4 1 n.s 87.0 Weakly correlated
123 L1MA4A 1 n.s 87.0 Weakly correlated
124 L1MA5A 1 n.s 87.0 Weakly correlated
125 L1MA8 1 n.s 87.0 Weakly correlated
126 L1MA9 1 n.s 99.0 Highly correlated
127 L1MB4 1 n.s 99.0 Highly correlated
128 L1MC 1 n.s 99.0 Highly correlated
129 L1MC2 1 n.s 99.0 Highly correlated
130 L1ME2 1 n.s 99.0 Highly correlated
131 L1ME2z 1 n.s 99.0 Highly correlated
132 L1ME3B 1 n.s 99.0 Highly correlated
133 L1ME3C 1 n.s 99.0 Highly correlated
134 L1ME3Cz 1 n.s 99.0 Highly correlated
135 L1MEc 1 n.s 99.0 Highly correlated
136 L1MEg 1 n.s 99.0 Highly correlated
137 L4_A_Mam 1 n.s 99.0 Highly correlated
138 L4_B_Mam 1 n.s 99.0 Highly correlated
139 LTR1 1 ** 43.0 Weakly correlated
140 LTR12 1 n.s 28.9 Weakly correlated
141 LTR12D 1 * 19.6 Weakly correlated
142 LTR13 1 n.s 19.6 Weakly correlated
143 LTR16A 1 n.s 99.0 Highly correlated
144 LTR16A2 1 n.s 99.0 Highly correlated
145 LTR16D2 1 ** 99.0 Highly correlated
146 LTR19C 1 ** 43.0 Weakly correlated
147 LTR1A1 1 * 43.0 Weakly correlated
148 LTR27 1 ** 43.0 Weakly correlated
149 LTR27B 1 ** 43.0 Weakly correlated
150 LTR38B 1 ** 74.0 Weakly correlated
151 LTR3A 1 ** 28.9 Weakly correlated
152 LTR55 1 ** 99.0 Highly correlated
153 LTR5B 1 * 28.9 Weakly correlated
154 LTR5_Hs 1 n.s 0.0 Weakly correlated
155 LTR8A 1 n.s 43.0 Weakly correlated
156 MER11C 1 n.s 19.6 Weakly correlated
157 MER39 1 n.s 74.0 Weakly correlated
158 MER39B 1 n.s 74.0 Weakly correlated
159 MER41A 1 n.s 74.0 Weakly correlated
160 MER4A1 1 n.s 74.0 Weakly correlated
161 MER4B 1 n.s 74.0 Weakly correlated
162 MER50-int 1 * 43.0 Weakly correlated
163 MER51A 1 * 43.0 Weakly correlated
164 MER52C 1 * 74.0 Weakly correlated
165 MER54A 1 * 87.0 Weakly correlated
166 MER66B 1 n.s 43.0 Weakly correlated
167 MER9a2 1 ** 19.6 Weakly correlated
168 MIR1_Amn 1 n.s 319.0 Weakly correlated
169 MLT1A 1 n.s 99.0 Highly correlated
170 MLT1E 1 * 99.0 Highly correlated
171 MLT1E1A 1 n.s 99.0 Highly correlated
172 MLT1E2 1 n.s 99.0 Highly correlated
173 MLT1E2-int 1 ** 99.0 Highly correlated
174 MLT1E3 1 n.s 99.0 Highly correlated
175 MLT1F2 1 n.s 99.0 Highly correlated
176 MLT1G 1 n.s 99.0 Highly correlated
177 MLT1G1 1 n.s 99.0 Highly correlated
178 MLT1J 1 n.s 99.0 Highly correlated
179 MLT1K 1 n.s 99.0 Highly correlated
180 MLT2B1 1 n.s 99.0 Highly correlated
181 MLT2B4 1 n.s 99.0 Highly correlated
182 MLT2F 1 n.s 99.0 Highly correlated
183 MamGypLTR3 1 ** 99.0 Highly correlated
184 MamGypsy2-I 1 n.s 99.0 Highly correlated
185 SVA_A 1 n.s 19.6 Weakly correlated
186 SVA_C 1 n.s 15.2 Weakly correlated
187 SVA_D 1 n.s 15.2 Weakly correlated
188 THE1A 1 n.s 43.0 Weakly correlated
189 THE1B 1 n.s 43.0 Weakly correlated
190 THE1D 1 n.s 43.0 Weakly correlated
191 THE1D-int 1 n.s 28.9 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 70 **** 74.0 Weakly correlated
2 AluSx 38 * 74.0 Weakly correlated
3 AluSx1 30 n.s 74.0 Weakly correlated
4 AluSp 25 *** 74.0 Weakly correlated
5 AluSz 24 n.s 74.0 Weakly correlated
6 AluSc 24 **** 74.0 Weakly correlated
7 AluSq2 20 n.s 74.0 Weakly correlated
8 AluJb 14 n.s 74.0 Weakly correlated
9 AluSc8 13 ** 74.0 Weakly correlated
10 AluSx3 13 * 74.0 Weakly correlated
11 AluSg 12 n.s 74.0 Weakly correlated
12 AluYc 8 **** 74.0 Weakly correlated
13 AluYa5 8 **** 15.2 Weakly correlated
14 AluSq 6 n.s 74.0 Weakly correlated
15 AluJo 4 n.s 74.0 Weakly correlated
16 AluYm1 4 ** 19.6 Weakly correlated
17 AluSz6 4 n.s 74.0 Weakly correlated
18 AluSc5 3 n.s 74.0 Weakly correlated
19 AluYj4 3 ** 0.0 Weakly correlated
20 AluSq10 2 ** 74.0 Weakly correlated
21 AluJr 2 n.s 74.0 Weakly correlated
22 AluSx4 2 n.s 74.0 Weakly correlated
23 AluSg7 2 n.s 74.0 Weakly correlated
24 ERVL-E-int 2 n.s 99.0 Highly correlated
25 MER11A 2 * 28.9 Weakly correlated
26 AluYc3 1 ** 74.0 Weakly correlated
27 AluYf1 1 n.s 19.6 Weakly correlated
28 SVA_F 1 n.s 0.0 Weakly correlated
29 LTR16D2 1 ** 99.0 Highly correlated
30 SVA_D 1 n.s 15.2 Weakly correlated
31 MIR3 1 n.s 99.0 Highly correlated
32 AluJr4 1 n.s 74.0 Weakly correlated
33 SVA_A 1 n.s 19.6 Weakly correlated
34 LTR38B 1 ** 74.0 Weakly correlated
35 L1PA12 1 n.s 74.0 Weakly correlated
36 FRAM 1 n.s 74.0 Weakly correlated
37 AluYk4 1 * 15.2 Weakly correlated
38 AluSg4 1 n.s 74.0 Weakly correlated
39 LTR12D 1 * 19.6 Weakly correlated
40 L2b 1 n.s 99.0 Highly correlated
41 MIRc 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 ALUJB 74.0 Weakly correlated
2 ALUSC 74.0 Weakly correlated
3 ALUSC8 74.0 Weakly correlated
4 ALUSG 74.0 Weakly correlated
5 ALUSP 74.0 Weakly correlated
6 ALUSQ 74.0 Weakly correlated
7 ALUSQ2 74.0 Weakly correlated
8 ALUSX 74.0 Weakly correlated
9 ALUSX1 74.0 Weakly correlated
10 ALUSX3 74.0 Weakly correlated
11 ALUSZ 74.0 Weakly correlated
12 ALUY 74.0 Weakly correlated
13 ALUYA5 15.2 Weakly correlated
14 ALUYC 74.0 Weakly correlated