ZRdb KZFP & Repeats
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Human_ZNF443

  • Protein
    Zinc finger protein 443
  • Length
    671
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    19.6 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    Q9Y2A4
  • NCBI_ID
    10224
Sequence:
MASVALEDVAVNFTREEWALLGPCQKNLYKDVMQETIRNLDCVVMKWKDQNIEDQYRYPRKNLRCRMLERFVESKDGTQCGETSSQIQDSIVTKNTLPGVGPCESSMRGEKVMGHSSLNCYIRVGAGHKPHEYHECGEKPDTHKQRGKAFSYHNSFQTHERLHTGKKPYDCKECGKSFSSLGNLQRHMAVQRGDGPYKCKLCGKAFFWPSLLHMHERTHTGEKPYECKQCSKAFSFYSSYLRHERTHTGEKPYECKQCSKAFPFYSSYLRHERTHTGEKPYKCKQCSKAFPDSSSCLIHERTHTGEKPYTCKQCGKAFSVSGSLQRHETTHSAEKPYACQQCGKAFHHLGSFQRHMIRHTGNGPHKCKICGKGFDCPSSLQSHERTHTGEKPYECKQCGKALSHRSSFRSHMIMHTGDGPHKCKVCGKAFVYPSVFQRHERTHTAEKPYKCKQCGKAYRISSSLRRHETTHTGEKPYKCKLGKACIDFCSFQNHKTTHTGEKPYECKECGKAFSRFRYLSRHKRTHTGEKPYECKTCRKAFGHYDNLKVHERIHSGEKPYECKECGKAFSWLTCFLRHERIHMREKSYECPQCGKAFTHSRFLQGHEKTHTGENPYECKECGKAFASLSSLHRHKKTHWKKTHTGENPYECKECGKAFASLSSLHRHKKTH
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..86
2 dec2h2 134..159
3 dec2h2 169..191
4 C2h2 197..219
5 C2h2 225..247
6 C2h2 253..275
7 C2h2 281..303
8 C2h2 309..331
9 C2h2 337..359
10 C2h2 365..387
11 C2h2 393..415
12 C2h2 421..443
13 C2h2 449..471
14 dec2h2 477..498
15 C2h2 504..526
16 C2h2 532..554
17 C2h2 560..582
18 C2h2 588..610
19 C2h2 616..638
20 C2h2 649..671
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process apoptotic process
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR13 117 **** 19.6 Highly correlated
2 AluJb 9 n.s 74.0 Weakly correlated
3 L1P3 8 **** 74.0 Weakly correlated
4 AluSc8 6 ** 74.0 Weakly correlated
5 AluYj4 4 **** 0.0 Weakly correlated
6 LTR10A 4 **** 28.9 Moderately correlated
7 MER65-int 3 **** 87.0 Weakly correlated
8 LTR10F 3 **** 28.9 Moderately correlated
9 AluSx 2 n.s 74.0 Weakly correlated
10 AluSz 2 n.s 74.0 Weakly correlated
11 L3 1 n.s 99.0 Weakly correlated
12 MLT1L 1 n.s 99.0 Weakly correlated
13 LTR1 1 *** 43.0 Weakly correlated
14 LTR10B1 1 *** 28.9 Moderately correlated
15 LTR1A2 1 ** 43.0 Weakly correlated
16 LTR2C 1 *** 19.6 Highly correlated
17 MER11A 1 * 28.9 Moderately correlated
18 MIRc 1 n.s 99.0 Weakly correlated
19 L2a 1 n.s 99.0 Weakly correlated
20 L1PB1 1 n.s 74.0 Weakly correlated
21 L1P4 1 n.s 74.0 Weakly correlated
22 L1MB8 1 n.s 99.0 Weakly correlated
23 L1M3 1 n.s 99.0 Weakly correlated
24 HERV17-int 1 * 28.9 Moderately correlated
25 FRAM 1 * 74.0 Weakly correlated
26 AluYm1 1 n.s 19.6 Highly correlated
27 AluYi6 1 *** 15.2 Weakly correlated
28 AluYa8 1 **** 15.2 Weakly correlated
29 AluY 1 n.s 74.0 Weakly correlated
30 AluSp 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR13 114 **** 19.6 Highly correlated
2 AluYj4 2 ** 0.0 Weakly correlated
3 AluY 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP