ZRdb KZFP & Repeats
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Human_ZNF442

  • Protein
    Zinc finger protein 442
  • Length
    627
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    69.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q9H7R0
  • NCBI_ID
    79973
Sequence:
MIVFGGEDRSDLFLPDSQTNEERKQYDSVAFEDVAVNFTQEEWALLGPSQKSLYRDVMWETIRNLDCIGMKWEDTNIEDQHRNPRRSLRCHIIERFSESRQPDSTVNEKPPGVDPCKSSVCGEIMGCSFLNCYITFDAGHKPDECQEYGEKPHTHKQCGTAFNYHHSFQTQERPHTGKKRYDCKECGKTFSSSGNLRRHIIVQRGGGPYICKLCGKAFFWPSLFRMHERTHTGEKPYECKQCCKAFPIYSSYLRHERTHTGEKPYECKHCSKAFPDYSSYVRHERTHTGEKPYKCKRCGRAFSVSSSLRIHERTHTGEKPYECKQCGKAFHHLGSFQRHMIRHTGDGPHKCKICGKGFDCPSSLQSHERTHTGEKPYECKQCGKALSHHSSFRSHMIMHTGDGPHKCKVCGKAFIYPSVFQGHERTHTGEKPYECKECGKAFRISSSLRRHETTHTGEKPYKCKCGKAFIDFYSFQNHETTHTGEKPYECKECGKAFSCFTYLSQHRRTHMAEKPYECKTCKKAFSHFGNLKVHERIHTGEKPYECKECRKAFSWLTCLLRHERIHTGKKSYECQQCGKAFTRSRFLRGHEKTHTGEKMHECKECGKALSSLSSLHRHKRTHWRDTL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 29..115
2 dec2h2 181..203
3 C2h2 209..231
4 C2h2 237..259
5 C2h2 265..287
6 C2h2 293..315
7 C2h2 321..343
8 C2h2 349..371
9 C2h2 377..399
10 C2h2 405..427
11 C2h2 433..455
12 C2h2 461..482
13 C2h2 488..510
14 C2h2 516..538
15 C2h2 544..566
16 C2h2 572..594
17 C2h2 600..622
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR8B 41 **** 43.0 Highly correlated
2 AluJb 6 n.s 74.0 Weakly correlated
3 LTR8 5 **** 43.0 Highly correlated
4 L1PA5 4 n.s 19.6 Weakly correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 AluSx 2 n.s 74.0 Weakly correlated
7 L2a 2 n.s 99.0 Weakly correlated
8 L2b 2 n.s 99.0 Weakly correlated
9 L2c 2 n.s 99.0 Weakly correlated
10 L1PA2 2 n.s 15.2 Weakly correlated
11 L1P3 2 ** 74.0 Weakly correlated
12 L1P1 2 ** 19.6 Weakly correlated
13 LTR26 2 **** 74.0 Weakly correlated
14 MIR 2 n.s 99.0 Weakly correlated
15 AluY 2 n.s 74.0 Weakly correlated
16 MER50 1 * 43.0 Highly correlated
17 MLT1N2 1 * 99.0 Weakly correlated
18 MLT1F1 1 ** 99.0 Weakly correlated
19 MLT1E3 1 ** 99.0 Weakly correlated
20 LOR1a 1 ** 74.0 Weakly correlated
21 LOR1b 1 ** 74.0 Weakly correlated
22 MER50-int 1 ** 43.0 Highly correlated
23 MER21C 1 * 99.0 Weakly correlated
24 MER39B 1 ** 74.0 Weakly correlated
25 LTR10F 1 *** 28.9 Weakly correlated
26 LTR13 1 ** 19.6 Weakly correlated
27 MER34C2 1 *** 74.0 Weakly correlated
28 LTR26E 1 **** 74.0 Weakly correlated
29 LTR78 1 * 99.0 Weakly correlated
30 PRIMA4-int 1 *** 74.0 Weakly correlated
31 PABL_B 1 *** 43.0 Highly correlated
32 L1MA9 1 n.s 99.0 Weakly correlated
33 AluSg 1 n.s 74.0 Weakly correlated
34 AluSp 1 n.s 74.0 Weakly correlated
35 AluSq2 1 n.s 74.0 Weakly correlated
36 AluSx1 1 n.s 74.0 Weakly correlated
37 AluSz 1 n.s 74.0 Weakly correlated
38 AluSz6 1 n.s 74.0 Weakly correlated
39 AluYh9 1 **** 15.2 Weakly correlated
40 AluYj4 1 ** 0.0 Weakly correlated
41 AluYm1 1 * 19.6 Weakly correlated
42 AmnSINE1 1 *** 319.0 Weakly correlated
43 L1M4 1 n.s 99.0 Weakly correlated
44 L1PB3 1 n.s 74.0 Weakly correlated
45 L1MB4 1 n.s 99.0 Weakly correlated
46 L1MC3 1 n.s 99.0 Weakly correlated
47 L1MDa 1 n.s 99.0 Weakly correlated
48 L1ME1 1 n.s 99.0 Weakly correlated
49 L1ME2 1 n.s 99.0 Weakly correlated
50 L1ME4b 1 n.s 99.0 Weakly correlated
51 L1P4 1 * 74.0 Weakly correlated
52 L1PA15 1 n.s 74.0 Weakly correlated
53 L1PA4 1 n.s 19.6 Weakly correlated
54 L1PB1 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR8B 25 **** 43.0 Highly correlated
2 LTR8 3 **** 43.0 Highly correlated
3 L1PA5 1 n.s 19.6 Weakly correlated
4 AluSx 1 n.s 74.0 Weakly correlated
5 AluYh9 1 **** 15.2 Weakly correlated
6 L2c 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LTR8B 43.0 Highly correlated