ZRdb KZFP & Repeats
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Human_ZNF439

  • Protein
    Zinc finger protein 439
  • Length
    499
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    8.6 Mya
  • Uniprot_ID
    Q8NDP4
  • NCBI_ID
    90594
Sequence:
MLSLSPILLYTCEMFQDPVAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSIGKKWKDQNIEYEYQNPRRNFRSVTEEKVNEIKEDSHCGETFTPVPDDRLNFQKKKASPEVKSCDSFVCEVGLGNSSSNMNIRGDTGHKACECQEYGPKPWKSQQPKKAFRYHPSLRTQERDHTGKKPYACKECGKNIIYHSSIQRHMVVHSGDGPYKCKFCGKAFHCLSLYLIHERTHTGEKPYECKQCGKSFSYSATHRIHERTHIGEKPYECQECGKAFHSPRSCHRHERSHMGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQCGKALSSLTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYHERTHTGEKPYECKQCGKAFRSAPNLQLHGRTHTGEKPYQCKECGKAFRSASQLRIHRRIHTGEKPYECKKCGKAFRYVQNFRFHERTQTHKNALWRKTL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 19..101
2 C2h2 186..208
3 C2h2 214..236
4 C2h2 242..264
5 C2h2 270..292
6 C2h2 298..320
7 C2h2 326..348
8 C2h2 354..376
9 C2h2 382..404
10 C2h2 410..432
11 C2h2 438..460
12 C2h2 466..490
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 4 **** 74.0 Weakly correlated
2 LTR10A 4 **** 28.9 Weakly correlated
3 L1PA2 3 n.s 15.2 Moderately correlated
4 L1PA5 3 n.s 19.6 Moderately correlated
5 LTR10F 2 **** 28.9 Weakly correlated
6 MER50 2 *** 43.0 Weakly correlated
7 AluYm1 2 ** 19.6 Moderately correlated
8 AluY 2 n.s 74.0 Weakly correlated
9 AluSz 2 n.s 74.0 Weakly correlated
10 L2b 2 n.s 99.0 Weakly correlated
11 AluSc8 2 n.s 74.0 Weakly correlated
12 AluJr 2 n.s 74.0 Weakly correlated
13 LTR13 1 ** 19.6 Moderately correlated
14 LTR16 1 ** 99.0 Weakly correlated
15 LTR3 1 **** 28.9 Weakly correlated
16 MIR 1 n.s 99.0 Weakly correlated
17 LTR3A 1 **** 28.9 Weakly correlated
18 MER39B 1 ** 74.0 Weakly correlated
19 MER50-int 1 ** 43.0 Weakly correlated
20 MamGypLTR1a 1 *** 99.0 Weakly correlated
21 MIR3 1 n.s 99.0 Weakly correlated
22 MIRb 1 n.s 99.0 Weakly correlated
23 MLT1A 1 n.s 99.0 Weakly correlated
24 MLT1J1 1 * 99.0 Weakly correlated
25 MLT2B4 1 * 99.0 Weakly correlated
26 MSTB1-int 1 *** 74.0 Weakly correlated
27 AluJb 1 n.s 74.0 Weakly correlated
28 L2c 1 n.s 99.0 Weakly correlated
29 L1PA10 1 n.s 74.0 Weakly correlated
30 L1P4 1 * 74.0 Weakly correlated
31 L1P1 1 n.s 19.6 Moderately correlated
32 L1MEg 1 n.s 99.0 Weakly correlated
33 L1MB2 1 n.s 99.0 Weakly correlated
34 L1MA9 1 n.s 99.0 Weakly correlated
35 HAL1 1 n.s 99.0 Weakly correlated
36 AluYc 1 ** 74.0 Weakly correlated
37 AluSz6 1 n.s 74.0 Weakly correlated
38 AluSx1 1 n.s 74.0 Weakly correlated
39 AluSx 1 n.s 74.0 Weakly correlated
40 AluSp 1 n.s 74.0 Weakly correlated
41 AluSg4 1 * 74.0 Weakly correlated
42 AluJo 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2c 1 n.s 99.0 Weakly correlated
2 L1MA9 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP