ZRdb KZFP & Repeats
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Human_ZNF436

  • Protein
    Zinc finger protein 436
  • Length
    470
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    180.0 Mya
  • Time of Changing in binding specificity
    180.0 Mya
  • Uniprot_ID
    Q9C0F3
  • NCBI_ID
    80818
Sequence:
MAATLLMAGSQAPVTFEDMAMYLTREEWRPLDAAQRDLYRDVMQENYGNVVSLDFEIRSENEVNPKQEISEDVQFGTTSERPAENAEENPESEEGFESGDRSERQWGDLTAEEWVSYPLQPVTDLLVHKEVHTGIRYHICSHCGKAFSQISDLNRHQKTHTGDRPYKCYECGKGFSRSSHLIQHQRTHTGERPYDCNECGKSFGRSSHLIQHQTIHTGEKPHKCNECGKSFCRLSHLIQHQRTHSGEKPYECEECGKSFSRSSHLAQHQRTHTGEKPYECNECGRGFSERSDLIKHYRVHTGERPYKCDECGKNFSQNSDLVRHRRAHTGEKPYHCNECGENFSRISHLVQHQRTHTGEKPYECNACGKSFSRSSHLITHQKIHTGEKPYECNECWRSFGERSDLIKHQRTHTGEKPYECVQCGKGFTQSSNLITHQRVHTGEKPYECTECEKSFSRSSALIKHKRVHTD
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..86
2 C2h2 138..160
3 C2h2 166..188
4 C2h2 194..216
5 C2h2 222..244
6 C2h2 250..272
7 C2h2 278..300
8 C2h2 306..328
9 C2h2 334..356
10 C2h2 362..384
11 C2h2 390..412
12 C2h2 418..440
13 C2h2 446..468
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component cytosol
2 Cellular Component nucleoplasm
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
7 Biological Process negative regulation of transcription by RNA polymerase II
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2c 1357 **** 99.0 Weakly correlated
2 L2b 1253 **** 99.0 Weakly correlated
3 L2a 335 **** 99.0 Weakly correlated
4 MIRb 163 **** 99.0 Weakly correlated
5 MIR 123 **** 99.0 Weakly correlated
6 MIRc 57 **** 99.0 Weakly correlated
7 MIR3 51 **** 99.0 Weakly correlated
8 AluSx1 48 n.s 74.0 Weakly correlated
9 AluSx 29 n.s 74.0 Weakly correlated
10 AluJb 28 n.s 74.0 Weakly correlated
11 AluJo 28 n.s 74.0 Weakly correlated
12 AluJr 26 n.s 74.0 Weakly correlated
13 AluSz 25 n.s 74.0 Weakly correlated
14 AluY 22 n.s 74.0 Weakly correlated
15 AluSq2 19 n.s 74.0 Weakly correlated
16 MIR1_Amn 19 **** 319.0 Weakly correlated
17 L3 16 n.s 99.0 Weakly correlated
18 AluSz6 15 n.s 74.0 Weakly correlated
19 L2 15 n.s 99.0 Weakly correlated
20 AluSp 13 n.s 74.0 Weakly correlated
21 FLAM_C 13 *** 74.0 Weakly correlated
22 MLT1K 11 * 99.0 Weakly correlated
23 AluSx3 9 n.s 74.0 Weakly correlated
24 LTR16C 7 ** 99.0 Weakly correlated
25 AluSc 6 n.s 74.0 Weakly correlated
26 AluSq 6 n.s 74.0 Weakly correlated
27 AluSg 5 n.s 74.0 Weakly correlated
28 L1M5 5 n.s 99.0 Weakly correlated
29 MLT1A0 5 n.s 99.0 Weakly correlated
30 MLT1B 5 n.s 99.0 Weakly correlated
31 MLT1C 5 n.s 94.0 Weakly correlated
32 MLT1J 5 n.s 99.0 Weakly correlated
33 MSTA 5 n.s 43.0 Weakly correlated
34 L1MC4 4 n.s 99.0 Weakly correlated
35 L1ME4a 4 n.s 99.0 Weakly correlated
36 LTR33 4 n.s 99.0 Weakly correlated
37 MLT1D 4 n.s 99.0 Weakly correlated
38 MamRTE1 4 * 99.0 Weakly correlated
39 AluJr4 3 n.s 74.0 Weakly correlated
40 AluSc8 3 n.s 74.0 Weakly correlated
41 L1MC3 3 n.s 99.0 Weakly correlated
42 L3b 3 n.s 99.0 Weakly correlated
43 LTR47A 3 *** 74.0 Weakly correlated
44 LTR79 3 * 99.0 Weakly correlated
45 AluYa5 2 n.s 15.2 Weakly correlated
46 FRAM 2 n.s 74.0 Weakly correlated
47 HAL1 2 n.s 99.0 Weakly correlated
48 L1MB3 2 n.s 99.0 Weakly correlated
49 L1ME1 2 n.s 99.0 Weakly correlated
50 L1ME3 2 n.s 99.0 Weakly correlated
51 L1ME3A 2 n.s 99.0 Weakly correlated
52 L1ME3G 2 n.s 99.0 Weakly correlated
53 L1ME4b 2 n.s 99.0 Weakly correlated
54 LTR10A 2 ** 28.9 Weakly correlated
55 LTR16 2 n.s 99.0 Weakly correlated
56 LTR78 2 n.s 99.0 Weakly correlated
57 MLT1E2 2 n.s 99.0 Weakly correlated
58 MLT1G3 2 n.s 99.0 Weakly correlated
59 MLT1I 2 n.s 99.0 Weakly correlated
60 MLT1J2 2 n.s 99.0 Weakly correlated
61 MLT1L 2 n.s 99.0 Weakly correlated
62 THE1B 2 n.s 43.0 Weakly correlated
63 Alu 1 n.s 74.0 Weakly correlated
64 AluSg7 1 n.s 74.0 Weakly correlated
65 AluSq10 1 n.s 74.0 Weakly correlated
66 AluSx4 1 n.s 74.0 Weakly correlated
67 AluYj4 1 n.s 0.0 Weakly correlated
68 FLAM_A 1 n.s 74.0 Weakly correlated
69 L1MA10 1 n.s 99.0 Weakly correlated
70 L1MA8 1 n.s 87.0 Weakly correlated
71 L1MB2 1 n.s 99.0 Weakly correlated
72 L1MB4 1 n.s 99.0 Weakly correlated
73 L1MB5 1 n.s 99.0 Weakly correlated
74 L1MB8 1 n.s 99.0 Weakly correlated
75 L1MC1 1 n.s 99.0 Weakly correlated
76 L1MC5 1 n.s 99.0 Weakly correlated
77 L1MD 1 n.s 99.0 Weakly correlated
78 L1MD1 1 n.s 99.0 Weakly correlated
79 L1MD2 1 n.s 99.0 Weakly correlated
80 L1MD3 1 n.s 99.0 Weakly correlated
81 L1ME3B 1 n.s 99.0 Weakly correlated
82 L1ME3C 1 n.s 99.0 Weakly correlated
83 L1ME3F 1 n.s 99.0 Weakly correlated
84 L1ME5 1 n.s 99.0 Weakly correlated
85 L1PB4 1 n.s 99.0 Weakly correlated
86 L2-3_Crp 1 n.s 431.0 Weakly correlated
87 L4_B_Mam 1 n.s 99.0 Weakly correlated
88 LOR1a 1 n.s 74.0 Weakly correlated
89 LTR101_Mam 1 n.s 99.0 Weakly correlated
90 LTR104_Mam 1 n.s 99.0 Weakly correlated
91 LTR13A 1 * 28.9 Weakly correlated
92 LTR16A 1 n.s 99.0 Weakly correlated
93 LTR16A1 1 n.s 99.0 Weakly correlated
94 LTR16A2 1 n.s 99.0 Weakly correlated
95 LTR16E1 1 n.s 99.0 Weakly correlated
96 LTR16E2 1 n.s 99.0 Weakly correlated
97 LTR2C 1 ** 19.6 Weakly correlated
98 LTR31 1 ** 74.0 Weakly correlated
99 LTR37A 1 n.s 99.0 Weakly correlated
100 LTR47B2 1 ** 74.0 Weakly correlated
101 LTR48B 1 n.s 74.0 Weakly correlated
102 LTR53 1 * 99.0 Weakly correlated
103 LTR67B 1 n.s 99.0 Weakly correlated
104 MER21C 1 n.s 99.0 Weakly correlated
105 MER34C_ 1 * 87.0 Weakly correlated
106 MER39 1 n.s 74.0 Weakly correlated
107 MER39B 1 n.s 74.0 Weakly correlated
108 MER41E 1 * 74.0 Weakly correlated
109 MER49 1 n.s 43.0 Weakly correlated
110 MER4A 1 n.s 74.0 Weakly correlated
111 MER4C 1 * 74.0 Weakly correlated
112 MER4CL34 1 n.s 43.0 Weakly correlated
113 MER4E 1 n.s 74.0 Weakly correlated
114 MER50-int 1 n.s 43.0 Weakly correlated
115 MER57F 1 * 74.0 Weakly correlated
116 MER66B 1 n.s 43.0 Weakly correlated
117 MER66D 1 ** 43.0 Weakly correlated
118 MER74A 1 n.s 99.0 Weakly correlated
119 MLT1E1A 1 n.s 99.0 Weakly correlated
120 MLT1F 1 n.s 99.0 Weakly correlated
121 MLT1G 1 n.s 99.0 Weakly correlated
122 MLT1G1 1 n.s 99.0 Weakly correlated
123 MLT1H 1 n.s 99.0 Weakly correlated
124 MLT1H1 1 n.s 99.0 Weakly correlated
125 MLT1J1 1 n.s 99.0 Weakly correlated
126 MLT1M 1 n.s 99.0 Weakly correlated
127 MLT1N2 1 n.s 99.0 Weakly correlated
128 MLT2B3 1 n.s 99.0 Weakly correlated
129 MLT2B4 1 n.s 99.0 Weakly correlated
130 MLT2D 1 n.s 99.0 Weakly correlated
131 MLT2F 1 n.s 99.0 Weakly correlated
132 MSTD 1 n.s 74.0 Weakly correlated
133 MamGypLTR1a 1 * 99.0 Weakly correlated
134 MamGypLTR1c 1 * 99.0 Weakly correlated
135 MamGypsy2-I 1 n.s 99.0 Weakly correlated
136 Plat_L3 1 n.s 99.0 Weakly correlated
137 SVA_E 1 n.s 0.0 Weakly correlated
138 SVA_F 1 n.s 0.0 Weakly correlated
139 THE1D 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2c 1270 **** 99.0 Weakly correlated
2 L2b 1139 **** 99.0 Weakly correlated
3 L2a 253 **** 99.0 Weakly correlated
4 MIRb 14 n.s 99.0 Weakly correlated
5 MIR 9 n.s 99.0 Weakly correlated
6 MIR1_Amn 3 n.s 319.0 Weakly correlated
7 MIRc 3 n.s 99.0 Weakly correlated
8 L2 3 n.s 99.0 Weakly correlated
9 LTR47A 3 *** 74.0 Weakly correlated
10 L3 3 n.s 99.0 Weakly correlated
11 LTR16C 1 n.s 99.0 Weakly correlated
12 LTR78 1 n.s 99.0 Weakly correlated
13 AluJo 1 n.s 74.0 Weakly correlated
14 L1M5 1 n.s 99.0 Weakly correlated
15 MLT2F 1 n.s 99.0 Weakly correlated
16 LTR104_Mam 1 n.s 99.0 Weakly correlated
17 L1MC4 1 n.s 99.0 Weakly correlated
18 MER34C_ 1 * 87.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L2B 99.0 Weakly correlated
2 L2C 99.0 Weakly correlated