ZRdb KZFP & Repeats
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Human_ZNF433

  • Protein
    Zinc finger protein 433
  • Length
    673
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q8N7K0
  • NCBI_ID
    163059
Sequence:
MMFQDSVAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASIGKKWKPQNIYVEYENLRRNLRIVGERLFESKEGHQHGEILTQVPDDMLKKTTTGVKSCESSVYGEVGSAHSSLNRHIRDDTGHKAYEYQEYGQKPYKCKYCKKPFNCLSSVQTHERAHSGRKLYVCEECGKTFISHSNLQRHRIMHRGDGPYKCKFCGKALMFLSLYLIHKRTHTGEKPYQCKQCGKAFSHSSSLRIHERTHTGEKPYKCNECGKAFHSSTCLHAHKRTHTGEKPYECKQCGKAFSSSHSFQIHERTHTGEKPYECKECGKAFKCPSSVRRHERTHSRKKPYECKHCGKVLSYLTSFQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEKTHTGEKPYKCNQCGKAFNSSSSFRYHERTHTGEKPYECKQCGKAFRSASLLQTHGRTHTGEKPYACKECGKPFSNFSFFQIHERMHREEKPYECKGYGKTFSLPSLFHRHERTHTGGKTYECKQCGRSFNCSSSFRYHGRTHTGEKPYECKQCGKAFRSASQLQIHGRTHTGEKPYECKQCGKAFGSASHLQMHGRTHTGEKPYECKQCGKSFGCASRLQMHGRTHTGEKPYKCKQCGKAFGCPSNLRRHGRTHTGEKPYKCNQCGKVFRCSSQLQVHGRAHCIDTP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 7..85
2 C2h2 142..164
3 C2h2 170..192
4 C2h2 198..220
5 C2h2 226..248
6 C2h2 254..276
7 C2h2 282..304
8 C2h2 310..332
9 C2h2 338..360
10 C2h2 366..388
11 C2h2 394..416
12 C2h2 422..444
13 C2h2 450..472
14 dec2h2 478..500
15 C2h2 506..528
16 C2h2 534..556
17 C2h2 562..584
18 C2h2 590..612
19 C2h2 618..640
20 C2h2 646..668
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11A 172 **** 28.9 Weakly correlated
2 L1PREC2 96 **** 43.0 Highly correlated
3 L1PA15 67 **** 74.0 Weakly correlated
4 L1PA13 41 **** 74.0 Weakly correlated
5 L1PA14 25 **** 74.0 Weakly correlated
6 L2a 21 n.s 99.0 Weakly correlated
7 MIRb 16 n.s 99.0 Weakly correlated
8 MIR 14 n.s 99.0 Weakly correlated
9 L1PA12 11 **** 74.0 Weakly correlated
10 AluJr 10 n.s 74.0 Weakly correlated
11 AluY 10 n.s 74.0 Weakly correlated
12 L2 10 n.s 99.0 Weakly correlated
13 L2b 10 n.s 99.0 Weakly correlated
14 MIR3 10 ** 99.0 Weakly correlated
15 L2c 9 n.s 99.0 Weakly correlated
16 L1MB8 8 ** 99.0 Weakly correlated
17 AluSp 7 n.s 74.0 Weakly correlated
18 AluSz 7 n.s 74.0 Weakly correlated
19 MIRc 7 n.s 99.0 Weakly correlated
20 AluSx1 6 n.s 74.0 Weakly correlated
21 L1MC4 6 n.s 99.0 Weakly correlated
22 MLT1C 6 * 94.0 Weakly correlated
23 AluJo 5 n.s 74.0 Weakly correlated
24 L1MB7 5 n.s 99.0 Weakly correlated
25 LTR10A 5 **** 28.9 Weakly correlated
26 AluJb 4 n.s 74.0 Weakly correlated
27 L1MA9 4 n.s 99.0 Weakly correlated
28 L1P4e 4 **** 74.0 Weakly correlated
29 AluSg 3 n.s 74.0 Weakly correlated
30 AluSz6 3 n.s 74.0 Weakly correlated
31 L1MB3 3 n.s 99.0 Weakly correlated
32 L1MC4a 3 n.s 99.0 Weakly correlated
33 L1MC5a 3 n.s 99.0 Weakly correlated
34 L1MEd 3 n.s 99.0 Weakly correlated
35 L1P3 3 * 74.0 Weakly correlated
36 L1PA16 3 n.s 74.0 Weakly correlated
37 L1PA2 3 n.s 15.2 Weakly correlated
38 L1PA8A 3 n.s 74.0 Weakly correlated
39 L1PB1 3 n.s 74.0 Weakly correlated
40 L1PBa 3 * 74.0 Weakly correlated
41 L3 3 n.s 99.0 Weakly correlated
42 LTR33 3 * 99.0 Weakly correlated
43 AluSc 2 n.s 74.0 Weakly correlated
44 AluSc8 2 n.s 74.0 Weakly correlated
45 AluSq2 2 n.s 74.0 Weakly correlated
46 AluSx 2 n.s 74.0 Weakly correlated
47 AluSx3 2 n.s 74.0 Weakly correlated
48 FRAM 2 * 74.0 Weakly correlated
49 HUERS-P3-int 2 ** 43.0 Highly correlated
50 L1MC2 2 n.s 99.0 Weakly correlated
51 L1MDa 2 n.s 99.0 Weakly correlated
52 L1ME3 2 n.s 99.0 Weakly correlated
53 L1PA5 2 n.s 19.6 Weakly correlated
54 L1PA7 2 n.s 74.0 Weakly correlated
55 LTR16 2 ** 99.0 Weakly correlated
56 MER4-int 2 * 74.0 Weakly correlated
57 MLT1D 2 n.s 99.0 Weakly correlated
58 MLT1H2 2 * 99.0 Weakly correlated
59 MLT1I 2 n.s 99.0 Weakly correlated
60 MSTA 2 n.s 43.0 Highly correlated
61 Plat_L3 2 ** 99.0 Weakly correlated
62 THE1B 2 n.s 43.0 Highly correlated
63 Alu 1 ** 74.0 Weakly correlated
64 AluJr4 1 n.s 74.0 Weakly correlated
65 AluSg4 1 n.s 74.0 Weakly correlated
66 AluSg7 1 n.s 74.0 Weakly correlated
67 AluSx4 1 n.s 74.0 Weakly correlated
68 AluYa5 1 n.s 15.2 Weakly correlated
69 AluYc 1 n.s 74.0 Weakly correlated
70 AluYk4 1 ** 15.2 Weakly correlated
71 AluYm1 1 n.s 19.6 Weakly correlated
72 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
73 ERVL-B4-int 1 n.s 99.0 Weakly correlated
74 ERVL-E-int 1 n.s 99.0 Weakly correlated
75 ERVL-int 1 * 99.0 Weakly correlated
76 HAL1 1 n.s 99.0 Weakly correlated
77 HUERS-P3b-int 1 * 43.0 Highly correlated
78 L1M2 1 n.s 99.0 Weakly correlated
79 L1M3 1 n.s 99.0 Weakly correlated
80 L1M3a 1 ** 99.0 Weakly correlated
81 L1M4 1 n.s 99.0 Weakly correlated
82 L1M4c 1 n.s 99.0 Weakly correlated
83 L1M6 1 n.s 99.0 Weakly correlated
84 L1MA4 1 n.s 87.0 Weakly correlated
85 L1MA5 1 n.s 87.0 Weakly correlated
86 L1MA8 1 n.s 87.0 Weakly correlated
87 L1MB1 1 n.s 99.0 Weakly correlated
88 L1MB4 1 n.s 99.0 Weakly correlated
89 L1MC1 1 n.s 99.0 Weakly correlated
90 L1MC5 1 n.s 99.0 Weakly correlated
91 L1MCa 1 n.s 99.0 Weakly correlated
92 L1MD 1 n.s 99.0 Weakly correlated
93 L1MD3 1 n.s 99.0 Weakly correlated
94 L1ME1 1 n.s 99.0 Weakly correlated
95 L1ME2 1 n.s 99.0 Weakly correlated
96 L1ME3F 1 n.s 99.0 Weakly correlated
97 L1ME4a 1 n.s 99.0 Weakly correlated
98 L1ME4b 1 n.s 99.0 Weakly correlated
99 L1ME4c 1 n.s 99.0 Weakly correlated
100 L1ME5 1 n.s 99.0 Weakly correlated
101 L1P1 1 n.s 19.6 Weakly correlated
102 L1P4 1 n.s 74.0 Weakly correlated
103 L1P4a 1 * 74.0 Weakly correlated
104 L1PA3 1 n.s 19.6 Weakly correlated
105 L1PB4 1 n.s 99.0 Weakly correlated
106 L2-1_AMi 1 ** 319.0 Weakly correlated
107 L3b 1 n.s 99.0 Weakly correlated
108 L5 1 ** 99.0 Weakly correlated
109 LTR104_Mam 1 * 99.0 Weakly correlated
110 LTR12C 1 n.s 19.6 Weakly correlated
111 LTR13 1 * 19.6 Weakly correlated
112 LTR16B2 1 * 99.0 Weakly correlated
113 LTR16C 1 n.s 99.0 Weakly correlated
114 LTR16E1 1 * 99.0 Weakly correlated
115 LTR18A 1 *** 43.0 Highly correlated
116 LTR26 1 ** 74.0 Weakly correlated
117 LTR27D 1 ** 43.0 Highly correlated
118 LTR38-int 1 *** 74.0 Weakly correlated
119 LTR38B 1 *** 74.0 Weakly correlated
120 LTR78 1 n.s 99.0 Weakly correlated
121 LTR78B 1 * 99.0 Weakly correlated
122 LTR79 1 * 99.0 Weakly correlated
123 LTR88a 1 ** 99.0 Weakly correlated
124 LTR8A 1 * 43.0 Highly correlated
125 LTR8B 1 * 43.0 Highly correlated
126 LTR9 1 * 43.0 Highly correlated
127 MER21C 1 n.s 99.0 Weakly correlated
128 MER31B 1 * 99.0 Weakly correlated
129 MER4B-int 1 * 99.0 Weakly correlated
130 MER54B 1 ** 87.0 Weakly correlated
131 MIR1_Amn 1 n.s 319.0 Weakly correlated
132 MLT1A1 1 n.s 87.0 Weakly correlated
133 MLT1B 1 n.s 99.0 Weakly correlated
134 MLT1F 1 n.s 99.0 Weakly correlated
135 MLT1F1 1 n.s 99.0 Weakly correlated
136 MLT1G1 1 n.s 99.0 Weakly correlated
137 MLT1G3 1 n.s 99.0 Weakly correlated
138 MLT1H 1 n.s 99.0 Weakly correlated
139 MLT1J 1 n.s 99.0 Weakly correlated
140 MLT1K 1 n.s 99.0 Weakly correlated
141 MLT2D 1 n.s 99.0 Weakly correlated
142 MSTA-int 1 n.s 43.0 Highly correlated
143 MSTB 1 n.s 43.0 Highly correlated
144 MamRTE1 1 n.s 99.0 Weakly correlated
145 PABL_A-int 1 ** 74.0 Weakly correlated
146 THE1B-int 1 n.s 43.0 Highly correlated
147 THE1D 1 n.s 43.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11A 158 **** 28.9 Weakly correlated
2 L1PREC2 75 **** 43.0 Highly correlated
3 L1PA15 61 **** 74.0 Weakly correlated
4 L1PA13 36 **** 74.0 Weakly correlated
5 L1PA14 20 **** 74.0 Weakly correlated
6 L2a 15 n.s 99.0 Weakly correlated
7 MIR3 9 * 99.0 Weakly correlated
8 L1PA12 9 **** 74.0 Weakly correlated
9 L2 8 n.s 99.0 Weakly correlated
10 MIRb 8 n.s 99.0 Weakly correlated
11 L2b 7 n.s 99.0 Weakly correlated
12 L1MB8 7 * 99.0 Weakly correlated
13 MIR 6 n.s 99.0 Weakly correlated
14 L1MB7 4 n.s 99.0 Weakly correlated
15 AluJr 3 n.s 74.0 Weakly correlated
16 L1MC4a 3 n.s 99.0 Weakly correlated
17 L2c 3 n.s 99.0 Weakly correlated
18 L1PA16 3 n.s 74.0 Weakly correlated
19 L1MB3 3 n.s 99.0 Weakly correlated
20 MIRc 3 n.s 99.0 Weakly correlated
21 L3 3 n.s 99.0 Weakly correlated
22 L1PA8A 2 n.s 74.0 Weakly correlated
23 L1PBa 2 n.s 74.0 Weakly correlated
24 L1MA9 2 n.s 99.0 Weakly correlated
25 LTR16 2 ** 99.0 Weakly correlated
26 L1P4e 2 **** 74.0 Weakly correlated
27 L1PB1 2 n.s 74.0 Weakly correlated
28 MLT1H2 2 * 99.0 Weakly correlated
29 HUERS-P3-int 2 ** 43.0 Highly correlated
30 LTR33 2 n.s 99.0 Weakly correlated
31 AluY 2 n.s 74.0 Weakly correlated
32 L1MC4 2 n.s 99.0 Weakly correlated
33 L1ME4b 1 n.s 99.0 Weakly correlated
34 FRAM 1 n.s 74.0 Weakly correlated
35 MLT1F 1 n.s 99.0 Weakly correlated
36 MER4B-int 1 * 99.0 Weakly correlated
37 MLT1D 1 n.s 99.0 Weakly correlated
38 MLT2D 1 n.s 99.0 Weakly correlated
39 MLT1B 1 n.s 99.0 Weakly correlated
40 L1MA5 1 n.s 87.0 Weakly correlated
41 L1MC5 1 n.s 99.0 Weakly correlated
42 L1MD3 1 n.s 99.0 Weakly correlated
43 L1ME3F 1 n.s 99.0 Weakly correlated
44 L1MEd 1 n.s 99.0 Weakly correlated
45 LTR78B 1 * 99.0 Weakly correlated
46 LTR79 1 * 99.0 Weakly correlated
47 L1MC2 1 n.s 99.0 Weakly correlated
48 HUERS-P3b-int 1 * 43.0 Highly correlated
49 L1M4c 1 n.s 99.0 Weakly correlated
50 L1MB1 1 n.s 99.0 Weakly correlated
51 L1MCa 1 n.s 99.0 Weakly correlated
52 L1PA3 1 n.s 19.6 Weakly correlated
53 L1ME2 1 n.s 99.0 Weakly correlated
54 L1MDa 1 n.s 99.0 Weakly correlated
55 L3b 1 n.s 99.0 Weakly correlated
56 LTR16E1 1 * 99.0 Weakly correlated
57 LTR8B 1 * 43.0 Highly correlated
58 MLT1F1 1 n.s 99.0 Weakly correlated
59 MLT1I 1 n.s 99.0 Weakly correlated
60 L1ME3 1 n.s 99.0 Weakly correlated
61 L1M6 1 n.s 99.0 Weakly correlated
62 LTR12C 1 n.s 19.6 Weakly correlated
63 AluJb 1 n.s 74.0 Weakly correlated
64 ERVL-B4-int 1 n.s 99.0 Weakly correlated
65 L1MA4 1 n.s 87.0 Weakly correlated
66 HAL1 1 n.s 99.0 Weakly correlated
67 MLT1G3 1 n.s 99.0 Weakly correlated
68 MLT1K 1 n.s 99.0 Weakly correlated
69 Plat_L3 1 * 99.0 Weakly correlated
70 ERVL-E-int 1 n.s 99.0 Weakly correlated
71 L1M2 1 n.s 99.0 Weakly correlated
72 L1M3 1 n.s 99.0 Weakly correlated
73 L1M4 1 n.s 99.0 Weakly correlated
74 AluJo 1 n.s 74.0 Weakly correlated
75 L1PA2 1 n.s 15.2 Weakly correlated
76 MamRTE1 1 n.s 99.0 Weakly correlated
77 L1PB4 1 n.s 99.0 Weakly correlated
78 MLT1H 1 n.s 99.0 Weakly correlated
79 MLT1G1 1 n.s 99.0 Weakly correlated
80 MLT1C 1 n.s 94.0 Weakly correlated
81 LTR26 1 ** 74.0 Weakly correlated
82 LTR38-int 1 *** 74.0 Weakly correlated
83 LTR8A 1 * 43.0 Highly correlated
84 LTR27D 1 ** 43.0 Highly correlated
85 L1M3a 1 ** 99.0 Weakly correlated
86 LTR16C 1 n.s 99.0 Weakly correlated
87 L1MB4 1 n.s 99.0 Weakly correlated
88 LTR16B2 1 * 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1MB8 99.0 Weakly correlated
2 L2 99.0 Weakly correlated