ZRdb KZFP & Repeats
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Human_ZNF432

  • Protein
    Zinc finger protein 432
  • Length
    652
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    O94892
  • NCBI_ID
    9668
Sequence:
MINAQELLTLEDVTVEFTWEEWQLLGPFQKDLYRDVMLEIYSNLLSMGYQVSKPDALSKLERGEEPWTMEDERHSRICPENNEVDDHLQDHLENQRMLKSVEQYHEHNAFGNTASQTKSLCLFRENHDTFELYIKTLKSNLSLVNQNKSCEINNSTKFSGDGKSFLHGNYEELYSAAKFSVSTKANSTKSQVSKHQRTHEIEKNHVCSECGKAFVKKSQLTDHERVHTGEKPYGCTLCAKVFSRKSRLNEHQRIHKREKSFICSECGKVFTMKSRLIEHQRTHTGEKPYICNECGKGFPGKRNLIVHQRNHTGEKSYICSECGKGFTGKSMLIIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFTMKSRMIEHQRTHTGEKPYICSECGKGFPRKSNLIVHQRNHTVEKSYLCSECGKGFTVKSMLIIHQRTHTGEKPYTCSECGKGFPLKSRLIVHQRTHTGEKPYRCSECGKGFIVNSGLMLHQRTHTGEKPYICNECGKGFAFKSNLVVHQRTHTGEKPFMCSECGKGFTMKRYLIVHQQIHTEEKSCICSECGRGFAKETELALHKQVHTGEKPYGCNECGKGFTMKSRLIVHQRTHTGEKPFVCSECRKAFSSKRNLIVHQRTHNGNKP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 205..227
3 C2h2 233..255
4 C2h2 261..283
5 C2h2 289..311
6 C2h2 317..339
7 C2h2 345..367
8 C2h2 373..395
9 C2h2 401..423
10 C2h2 429..451
11 C2h2 457..479
12 C2h2 485..507
13 C2h2 513..535
14 C2h2 541..563
15 C2h2 567..591
16 C2h2 597..619
17 C2h2 625..647
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleoplasm
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M4 87 **** 99.0 Highly correlated
2 L1MB7 29 **** 99.0 Highly correlated
3 LTR8 7 **** 43.0 Weakly correlated
4 L1ME1 7 * 99.0 Highly correlated
5 AluJb 6 n.s 74.0 Weakly correlated
6 AluY 5 n.s 74.0 Weakly correlated
7 L1MB5 5 *** 99.0 Highly correlated
8 L1MB8 5 * 99.0 Highly correlated
9 L1P3 4 *** 74.0 Weakly correlated
10 L1PA2 4 n.s 15.2 Weakly correlated
11 LTR10A 4 **** 28.9 Weakly correlated
12 MER50 3 *** 43.0 Weakly correlated
13 AluYj4 3 **** 0.0 Weakly correlated
14 L1PA5 3 n.s 19.6 Weakly correlated
15 L1MB3 3 n.s 99.0 Highly correlated
16 L1ME3 2 n.s 99.0 Highly correlated
17 L2c 2 n.s 99.0 Highly correlated
18 L1PA3 2 n.s 19.6 Weakly correlated
19 LTR10F 2 **** 28.9 Weakly correlated
20 L1MA9 2 n.s 99.0 Highly correlated
21 MER65C 2 **** 74.0 Weakly correlated
22 AluSc8 2 n.s 74.0 Weakly correlated
23 MIR 2 n.s 99.0 Highly correlated
24 AluSg 2 n.s 74.0 Weakly correlated
25 AluSp 2 n.s 74.0 Weakly correlated
26 AluSx1 2 n.s 74.0 Weakly correlated
27 AluYa5 2 ** 15.2 Weakly correlated
28 L1M5 2 n.s 99.0 Highly correlated
29 MER39B 1 ** 74.0 Weakly correlated
30 L1P1 1 n.s 19.6 Weakly correlated
31 THE1B 1 n.s 43.0 Weakly correlated
32 LTR13 1 ** 19.6 Weakly correlated
33 LTR61 1 *** 43.0 Weakly correlated
34 MamRTE1 1 * 99.0 Highly correlated
35 MLT2B5 1 *** 87.0 Weakly correlated
36 LTR8B 1 * 43.0 Weakly correlated
37 MLT1E3 1 * 99.0 Highly correlated
38 MER21A 1 * 74.0 Weakly correlated
39 MLT1C 1 n.s 94.0 Weakly correlated
40 MLT1B 1 n.s 99.0 Highly correlated
41 MER50-int 1 ** 43.0 Weakly correlated
42 MER57A-int 1 * 43.0 Weakly correlated
43 MER57C1 1 **** 74.0 Weakly correlated
44 MIRc 1 n.s 99.0 Highly correlated
45 MIRb 1 n.s 99.0 Highly correlated
46 MIR3 1 n.s 99.0 Highly correlated
47 MER61C 1 *** 43.0 Weakly correlated
48 MER77 1 ** 99.0 Highly correlated
49 MER68 1 ** 99.0 Highly correlated
50 MER66B 1 ** 43.0 Weakly correlated
51 L1MA5 1 n.s 87.0 Weakly correlated
52 AluJr 1 n.s 74.0 Weakly correlated
53 AluSq 1 n.s 74.0 Weakly correlated
54 AluSq2 1 n.s 74.0 Weakly correlated
55 AluSz 1 n.s 74.0 Weakly correlated
56 AluSz6 1 n.s 74.0 Weakly correlated
57 AluYh9 1 **** 15.2 Weakly correlated
58 AluYm1 1 n.s 19.6 Weakly correlated
59 FAM 1 * 87.0 Weakly correlated
60 FRAM 1 * 74.0 Weakly correlated
61 HAL1 1 n.s 99.0 Highly correlated
62 L1M1 1 n.s 74.0 Weakly correlated
63 L1M3e 1 ** 99.0 Highly correlated
64 L1MA2 1 n.s 74.0 Weakly correlated
65 L2b 1 n.s 99.0 Highly correlated
66 L1MB4 1 n.s 99.0 Highly correlated
67 L1MC3 1 n.s 99.0 Highly correlated
68 L1MC4 1 n.s 99.0 Highly correlated
69 L1MDb 1 ** 99.0 Highly correlated
70 L1ME2 1 n.s 99.0 Highly correlated
71 L1ME2z 1 n.s 99.0 Highly correlated
72 L1ME4a 1 n.s 99.0 Highly correlated
73 L1P4 1 n.s 74.0 Weakly correlated
74 L1PA4 1 n.s 19.6 Weakly correlated
75 L1PA6 1 n.s 28.9 Weakly correlated
76 L2 1 n.s 99.0 Highly correlated
77 L2a 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M4 73 **** 99.0 Highly correlated
2 L1MB7 19 **** 99.0 Highly correlated
3 L1ME1 6 n.s 99.0 Highly correlated
4 L1MB5 4 ** 99.0 Highly correlated
5 L1MB8 4 * 99.0 Highly correlated
6 LTR8B 1 * 43.0 Weakly correlated
7 L1MB3 1 n.s 99.0 Highly correlated
8 L1PA3 1 n.s 19.6 Weakly correlated
9 L1ME4a 1 n.s 99.0 Highly correlated
10 L1MC3 1 n.s 99.0 Highly correlated
11 L1MA2 1 n.s 74.0 Weakly correlated
12 L1PA5 1 n.s 19.6 Weakly correlated
13 L1ME2 1 n.s 99.0 Highly correlated
14 L1MA5 1 n.s 87.0 Weakly correlated
15 AluYh9 1 **** 15.2 Weakly correlated
16 L1ME2z 1 n.s 99.0 Highly correlated
17 L1MB4 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP