ZRdb KZFP & Repeats
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Human_ZNF430

  • Protein
    Zinc finger protein 430
  • Length
    570
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    19.6 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    Q9H8G1
  • NCBI_ID
    80264
Sequence:
MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQGKEPWNMKRHAMVDQPPVTYSHFAQDLWPEQGIKDSFQEVILRRYGKCGHEDLQLRTGCKSVDECNLHKECYDELNQCLTTTQSEIFQYDKYVNVFYKFSNPNIQKIRHTGKKPFKCKKCDKSFCMLLHLTQHKRIHIRENSYQCEECGKVFNWFSTLTRHRRIHTGEKPYKCEQCGKAFKQSSTLTTHKIIHTGEKPYRCEECGKTFNRSSHLTTHKRIHTGEKPYRCEECGRAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLTTHKIIHAGEKPYKCEECGKAFYRFSYLTKHKIIHTGEKFYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEQCGKAFNESSNLTAHKIIHTGEKPYKCEECGKAFNRSPKLTAHKVIHSGEKPYKCEECGKAFNQFSNLTKHKITHIGDTSYKYLECDKAFSQSSTLTKHKVIHTGEKPYNCEEYGKAFNQSSNLIEQSNSYWRETLQM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 35..107
2 C2h2 205..227
3 C2h2 233..255
4 C2h2 261..283
5 C2h2 289..311
6 C2h2 317..339
7 C2h2 345..367
8 C2h2 373..395
9 C2h2 401..423
10 C2h2 429..451
11 C2h2 457..479
12 C2h2 485..507
13 dec2h2 513..535
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of DNA-templated transcription
6 Biological Process substantia nigra development
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 THE1B 1134 **** 43.0 Weakly correlated
2 THE1D 117 **** 43.0 Weakly correlated
3 THE1C 43 **** 43.0 Weakly correlated
4 THE1A 39 **** 43.0 Weakly correlated
5 AluJb 9 n.s 74.0 Weakly correlated
6 L2c 7 n.s 99.0 Weakly correlated
7 AluSx 5 n.s 74.0 Weakly correlated
8 AluSx1 5 n.s 74.0 Weakly correlated
9 L2a 5 n.s 99.0 Weakly correlated
10 L1P3 4 * 74.0 Weakly correlated
11 L1PA5 4 n.s 19.6 Highly correlated
12 AluY 4 n.s 74.0 Weakly correlated
13 LTR10A 4 **** 28.9 Moderately correlated
14 L1ME4b 3 n.s 99.0 Weakly correlated
15 L1PA2 3 n.s 15.2 Weakly correlated
16 AluSx4 3 n.s 74.0 Weakly correlated
17 MSTA 3 n.s 43.0 Weakly correlated
18 AluSp 3 n.s 74.0 Weakly correlated
19 LTR10F 2 *** 28.9 Moderately correlated
20 MER50 2 * 43.0 Weakly correlated
21 MIR3 2 n.s 99.0 Weakly correlated
22 MIRb 2 n.s 99.0 Weakly correlated
23 L2 2 n.s 99.0 Weakly correlated
24 L1PA4 2 n.s 19.6 Highly correlated
25 L1P1 2 n.s 19.6 Highly correlated
26 AluSc 2 n.s 74.0 Weakly correlated
27 AluSc5 2 n.s 74.0 Weakly correlated
28 AluSq2 2 n.s 74.0 Weakly correlated
29 AluSz 2 n.s 74.0 Weakly correlated
30 LTR7B 1 * 28.9 Moderately correlated
31 LTR67B 1 n.s 99.0 Weakly correlated
32 MER39B 1 * 74.0 Weakly correlated
33 MER49 1 n.s 43.0 Weakly correlated
34 AluYj4 1 n.s 0.0 Weakly correlated
35 MER50-int 1 * 43.0 Weakly correlated
36 MER66B 1 * 43.0 Weakly correlated
37 AluYh9 1 **** 15.2 Weakly correlated
38 MIRc 1 n.s 99.0 Weakly correlated
39 MLT1E2 1 n.s 99.0 Weakly correlated
40 MLT1F 1 n.s 99.0 Weakly correlated
41 MLT1F1 1 n.s 99.0 Weakly correlated
42 MLT1F2 1 n.s 99.0 Weakly correlated
43 MLT1J 1 n.s 99.0 Weakly correlated
44 MLT2F 1 n.s 99.0 Weakly correlated
45 MSTD 1 n.s 74.0 Weakly correlated
46 AluSq 1 n.s 74.0 Weakly correlated
47 AluSg 1 n.s 74.0 Weakly correlated
48 THE1B-int 1 n.s 43.0 Weakly correlated
49 AluSc8 1 n.s 74.0 Weakly correlated
50 THE1C-int 1 n.s 43.0 Weakly correlated
51 L1PB1 1 n.s 74.0 Weakly correlated
52 L1MC1 1 n.s 99.0 Weakly correlated
53 L1MB7 1 n.s 99.0 Weakly correlated
54 L1MB5 1 n.s 99.0 Weakly correlated
55 L1P4 1 n.s 74.0 Weakly correlated
56 L1PA10 1 n.s 74.0 Weakly correlated
57 L1PA11 1 n.s 74.0 Weakly correlated
58 L1MB3 1 n.s 99.0 Weakly correlated
59 L1MA3 1 n.s 74.0 Weakly correlated
60 L1M4c 1 n.s 99.0 Weakly correlated
61 L1PA8 1 n.s 74.0 Weakly correlated
62 L1PA8A 1 n.s 74.0 Weakly correlated
63 L1MD 1 n.s 99.0 Weakly correlated
64 L1PBa 1 n.s 74.0 Weakly correlated
65 L1M4 1 n.s 99.0 Weakly correlated
66 L1M1 1 n.s 74.0 Weakly correlated
67 L2b 1 n.s 99.0 Weakly correlated
68 HERVL-int 1 n.s 74.0 Weakly correlated
69 HAL1 1 n.s 99.0 Weakly correlated
70 AluYm1 1 n.s 19.6 Highly correlated
71 LTR13 1 * 19.6 Highly correlated
72 LTR24B 1 ** 74.0 Weakly correlated
73 LTR33 1 n.s 99.0 Weakly correlated
74 LTR41C 1 ** 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 THE1B 1129 **** 43.0 Weakly correlated
2 THE1D 114 **** 43.0 Weakly correlated
3 THE1C 42 **** 43.0 Weakly correlated
4 THE1A 38 **** 43.0 Weakly correlated
5 MSTA 3 n.s 43.0 Weakly correlated
6 AluYm1 1 n.s 19.6 Highly correlated
7 L1M4c 1 n.s 99.0 Weakly correlated
8 L1PA11 1 n.s 74.0 Weakly correlated
9 L2b 1 n.s 99.0 Weakly correlated
10 MLT1F2 1 n.s 99.0 Weakly correlated
11 AluJb 1 n.s 74.0 Weakly correlated
12 AluSc8 1 n.s 74.0 Weakly correlated
13 L2c 1 n.s 99.0 Weakly correlated
14 MLT1E2 1 n.s 99.0 Weakly correlated
15 MER50 1 n.s 43.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP