Human_ZNF43
-
ProteinZinc finger protein 43
-
Length809
-
OrganismHomo sapiens (Human)
-
Time of emergence43.0 Mya
-
Time of Changing in binding specificity43.0 Mya
-
Uniprot_ID
-
NCBI_ID
Sequence:
MGPLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPWEPMRRHEMVAKPPVMCSHFTQDFWPEQHIKDPFQKATLRRYKNCEHKNVHLKKDHKSVDECKVHRGGYNGFNQCLPATQSKIFLFDKCVKAFHKFSNSNRHKISHTEKKLFKCKECGKSFCMLPHLAQHKIIHTRVNFCKCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFNWSSRLTTHKKNYTRYKLYKCEECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWSSKLTEHKITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECGKAFTQSSNLTTHKKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWSSTLTKHKIIHTGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKAFNYSSHLNTHKRIHTKEQPYKCKECGKAFNQYSNLTTHNKIHTGEKLYKPEDVTVILTTPQTFSNIK
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 7..75 | |
| 2 | C2h2 | 174..196 | |
| 3 | dec2h2 | 202..224 | |
| 4 | dec2h2 | 230..252 | |
| 5 | dec2h2 | 258..280 | |
| 6 | C2h2 | 286..308 | |
| 7 | C2h2 | 314..336 | |
| 8 | C2h2 | 342..364 | |
| 9 | C2h2 | 370..392 | |
| 10 | C2h2 | 398..420 | |
| 11 | C2h2 | 426..448 | |
| 12 | C2h2 | 454..476 | |
| 13 | C2h2 | 482..504 | |
| 14 | C2h2 | 510..532 | |
| 15 | C2h2 | 538..560 | |
| 16 | C2h2 | 566..588 | |
| 17 | C2h2 | 594..616 | |
| 18 | C2h2 | 622..644 | |
| 19 | C2h2 | 650..672 | |
| 20 | C2h2 | 678..700 | |
| 21 | C2h2 | 706..728 | |
| 22 | C2h2 | 734..756 | |
| 23 | C2h2 | 762..784 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleus | |
| 2 | Molecular Function | DNA binding | |
| 3 | Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
| 4 | Molecular Function | metal ion binding | |
| 5 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| 6 | Biological Process | regulation of transcription by RNA polymerase II |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MER4-int | 134 | **** | 74.0 | Weakly correlated | |
| 2 | MER41-int | 126 | **** | 74.0 | Weakly correlated | |
| 3 | MER61-int | 42 | **** | 43.0 | Highly correlated | |
| 4 | PABL_A-int | 33 | **** | 74.0 | Weakly correlated | |
| 5 | HUERS-P1-int | 30 | **** | 43.0 | Highly correlated | |
| 6 | LTR49-int | 25 | **** | 74.0 | Weakly correlated | |
| 7 | LOR1-int | 21 | **** | 74.0 | Weakly correlated | |
| 8 | MER51-int | 21 | **** | 43.0 | Highly correlated | |
| 9 | HERV35I-int | 19 | **** | 43.0 | Highly correlated | |
| 10 | AluY | 16 | n.s | 74.0 | Weakly correlated | |
| 11 | HUERS-P3b-int | 14 | **** | 43.0 | Highly correlated | |
| 12 | MER50-int | 11 | **** | 43.0 | Highly correlated | |
| 13 | AluSq2 | 9 | n.s | 74.0 | Weakly correlated | |
| 14 | AluSx1 | 9 | n.s | 74.0 | Weakly correlated | |
| 15 | LTR25-int | 9 | **** | 43.0 | Highly correlated | |
| 16 | MLT1D | 9 | ** | 99.0 | Weakly correlated | |
| 17 | AluSp | 8 | n.s | 74.0 | Weakly correlated | |
| 18 | L2c | 7 | n.s | 99.0 | Weakly correlated | |
| 19 | AluSx | 6 | n.s | 74.0 | Weakly correlated | |
| 20 | L2 | 6 | n.s | 99.0 | Weakly correlated | |
| 21 | L2a | 6 | n.s | 99.0 | Weakly correlated | |
| 22 | MER101-int | 6 | **** | 74.0 | Weakly correlated | |
| 23 | AluSz6 | 5 | n.s | 74.0 | Weakly correlated | |
| 24 | L1MB7 | 5 | n.s | 99.0 | Weakly correlated | |
| 25 | MER4B-int | 5 | **** | 99.0 | Weakly correlated | |
| 26 | AluJb | 4 | n.s | 74.0 | Weakly correlated | |
| 27 | AluJr | 4 | n.s | 74.0 | Weakly correlated | |
| 28 | AluSz | 4 | n.s | 74.0 | Weakly correlated | |
| 29 | L1M2 | 4 | n.s | 99.0 | Weakly correlated | |
| 30 | L1MA6 | 4 | * | 87.0 | Weakly correlated | |
| 31 | L1MC5a | 4 | n.s | 99.0 | Weakly correlated | |
| 32 | L1PB3 | 4 | * | 74.0 | Weakly correlated | |
| 33 | LTR10A | 4 | **** | 28.9 | Weakly correlated | |
| 34 | LTR19-int | 4 | **** | 43.0 | Highly correlated | |
| 35 | MIRb | 4 | n.s | 99.0 | Weakly correlated | |
| 36 | AluSc8 | 3 | n.s | 74.0 | Weakly correlated | |
| 37 | AluSg | 3 | n.s | 74.0 | Weakly correlated | |
| 38 | HAL1ME | 3 | * | 99.0 | Weakly correlated | |
| 39 | L1M1 | 3 | n.s | 74.0 | Weakly correlated | |
| 40 | L1M4 | 3 | n.s | 99.0 | Weakly correlated | |
| 41 | L1M5 | 3 | n.s | 99.0 | Weakly correlated | |
| 42 | L1MA4A | 3 | n.s | 87.0 | Weakly correlated | |
| 43 | L1MB4 | 3 | n.s | 99.0 | Weakly correlated | |
| 44 | L1MCa | 3 | n.s | 99.0 | Weakly correlated | |
| 45 | L1MD1 | 3 | n.s | 99.0 | Weakly correlated | |
| 46 | L1MDa | 3 | n.s | 99.0 | Weakly correlated | |
| 47 | L1ME1 | 3 | n.s | 99.0 | Weakly correlated | |
| 48 | L1ME3Cz | 3 | n.s | 99.0 | Weakly correlated | |
| 49 | L1ME3G | 3 | n.s | 99.0 | Weakly correlated | |
| 50 | L1MEc | 3 | n.s | 99.0 | Weakly correlated | |
| 51 | L1PA16 | 3 | n.s | 74.0 | Weakly correlated | |
| 52 | L1PA17 | 3 | n.s | 74.0 | Weakly correlated | |
| 53 | MER21B | 3 | ** | 99.0 | Weakly correlated | |
| 54 | MER4A1 | 3 | ** | 74.0 | Weakly correlated | |
| 55 | MER4E | 3 | **** | 74.0 | Weakly correlated | |
| 56 | MLT1L | 3 | * | 99.0 | Weakly correlated | |
| 57 | AluJo | 2 | n.s | 74.0 | Weakly correlated | |
| 58 | AluJr4 | 2 | n.s | 74.0 | Weakly correlated | |
| 59 | AluSc | 2 | n.s | 74.0 | Weakly correlated | |
| 60 | AluSc5 | 2 | n.s | 74.0 | Weakly correlated | |
| 61 | AluYh3 | 2 | ** | 15.2 | Weakly correlated | |
| 62 | AluYj4 | 2 | ** | 0.0 | Weakly correlated | |
| 63 | FLAM_C | 2 | n.s | 74.0 | Weakly correlated | |
| 64 | HAL1 | 2 | n.s | 99.0 | Weakly correlated | |
| 65 | HERV17-int | 2 | * | 28.9 | Weakly correlated | |
| 66 | L1M3c | 2 | ** | 99.0 | Weakly correlated | |
| 67 | L1M4a1 | 2 | * | 99.0 | Weakly correlated | |
| 68 | L1M4b | 2 | n.s | 99.0 | Weakly correlated | |
| 69 | L1MB3 | 2 | n.s | 99.0 | Weakly correlated | |
| 70 | L1MB8 | 2 | n.s | 99.0 | Weakly correlated | |
| 71 | L1MC4 | 2 | n.s | 99.0 | Weakly correlated | |
| 72 | L1MD3 | 2 | n.s | 99.0 | Weakly correlated | |
| 73 | L1ME2 | 2 | n.s | 99.0 | Weakly correlated | |
| 74 | L1ME3A | 2 | n.s | 99.0 | Weakly correlated | |
| 75 | L1ME4b | 2 | n.s | 99.0 | Weakly correlated | |
| 76 | L1MEd | 2 | n.s | 99.0 | Weakly correlated | |
| 77 | L1MEf | 2 | n.s | 99.0 | Weakly correlated | |
| 78 | L1PA10 | 2 | n.s | 74.0 | Weakly correlated | |
| 79 | L1PA4 | 2 | n.s | 19.6 | Weakly correlated | |
| 80 | L1PA7 | 2 | n.s | 74.0 | Weakly correlated | |
| 81 | L3 | 2 | n.s | 99.0 | Weakly correlated | |
| 82 | LTR8 | 2 | n.s | 43.0 | Highly correlated | |
| 83 | MER41B | 2 | * | 74.0 | Weakly correlated | |
| 84 | MER57-int | 2 | * | 87.0 | Weakly correlated | |
| 85 | MER65-int | 2 | ** | 87.0 | Weakly correlated | |
| 86 | MLT1E2 | 2 | * | 99.0 | Weakly correlated | |
| 87 | THE1A-int | 2 | n.s | 43.0 | Highly correlated | |
| 88 | AluSg4 | 1 | n.s | 74.0 | Weakly correlated | |
| 89 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 90 | AluSq4 | 1 | * | 74.0 | Weakly correlated | |
| 91 | AluSx3 | 1 | n.s | 74.0 | Weakly correlated | |
| 92 | AluSx4 | 1 | n.s | 74.0 | Weakly correlated | |
| 93 | FLAM_A | 1 | n.s | 74.0 | Weakly correlated | |
| 94 | HAL1M8 | 1 | n.s | 99.0 | Weakly correlated | |
| 95 | HAL1b | 1 | n.s | 99.0 | Weakly correlated | |
| 96 | L1HS | 1 | n.s | 8.6 | Weakly correlated | |
| 97 | L1M2a | 1 | * | 87.0 | Weakly correlated | |
| 98 | L1MA2 | 1 | n.s | 74.0 | Weakly correlated | |
| 99 | L1MA3 | 1 | n.s | 74.0 | Weakly correlated | |
| 100 | L1MA5 | 1 | n.s | 87.0 | Weakly correlated | |
| 101 | L1MA8 | 1 | n.s | 87.0 | Weakly correlated | |
| 102 | L1MA9 | 1 | n.s | 99.0 | Weakly correlated | |
| 103 | L1MB2 | 1 | n.s | 99.0 | Weakly correlated | |
| 104 | L1MC | 1 | n.s | 99.0 | Weakly correlated | |
| 105 | L1MC3 | 1 | n.s | 99.0 | Weakly correlated | |
| 106 | L1MC5 | 1 | n.s | 99.0 | Weakly correlated | |
| 107 | L1MD | 1 | n.s | 99.0 | Weakly correlated | |
| 108 | L1MD2 | 1 | n.s | 99.0 | Weakly correlated | |
| 109 | L1ME3B | 1 | n.s | 99.0 | Weakly correlated | |
| 110 | L1ME3C | 1 | n.s | 99.0 | Weakly correlated | |
| 111 | L1ME4a | 1 | n.s | 99.0 | Weakly correlated | |
| 112 | L1ME5 | 1 | n.s | 99.0 | Weakly correlated | |
| 113 | L1MEb | 1 | * | 99.0 | Weakly correlated | |
| 114 | L1MEg | 1 | n.s | 99.0 | Weakly correlated | |
| 115 | L1MEh | 1 | n.s | 99.0 | Weakly correlated | |
| 116 | L1PA15-16 | 1 | n.s | 74.0 | Weakly correlated | |
| 117 | L1PA2 | 1 | n.s | 15.2 | Weakly correlated | |
| 118 | L1PA5 | 1 | n.s | 19.6 | Weakly correlated | |
| 119 | L1PB2 | 1 | n.s | 74.0 | Weakly correlated | |
| 120 | L2-1_AMi | 1 | ** | 319.0 | Weakly correlated | |
| 121 | L2b | 1 | n.s | 99.0 | Weakly correlated | |
| 122 | LTR10B1 | 1 | *** | 28.9 | Weakly correlated | |
| 123 | LTR40a | 1 | n.s | 99.0 | Weakly correlated | |
| 124 | LTR41 | 1 | * | 99.0 | Weakly correlated | |
| 125 | LTR49 | 1 | * | 74.0 | Weakly correlated | |
| 126 | LTR5_Hs | 1 | * | 0.0 | Weakly correlated | |
| 127 | LTR78 | 1 | n.s | 99.0 | Weakly correlated | |
| 128 | LTR80A | 1 | ** | 99.0 | Weakly correlated | |
| 129 | LTR88b | 1 | ** | 99.0 | Weakly correlated | |
| 130 | MER21A | 1 | n.s | 74.0 | Weakly correlated | |
| 131 | MER41A | 1 | n.s | 74.0 | Weakly correlated | |
| 132 | MER4D | 1 | * | 74.0 | Weakly correlated | |
| 133 | MER50 | 1 | n.s | 43.0 | Highly correlated | |
| 134 | MER57A-int | 1 | n.s | 43.0 | Highly correlated | |
| 135 | MER57B1 | 1 | * | 43.0 | Highly correlated | |
| 136 | MIR | 1 | n.s | 99.0 | Weakly correlated | |
| 137 | MIRc | 1 | n.s | 99.0 | Weakly correlated | |
| 138 | MLT1A | 1 | n.s | 99.0 | Weakly correlated | |
| 139 | MLT1A0 | 1 | n.s | 99.0 | Weakly correlated | |
| 140 | MLT1A1 | 1 | n.s | 87.0 | Weakly correlated | |
| 141 | MLT1B | 1 | n.s | 99.0 | Weakly correlated | |
| 142 | MLT1E | 1 | ** | 99.0 | Weakly correlated | |
| 143 | MLT1H1 | 1 | n.s | 99.0 | Weakly correlated | |
| 144 | MLT1H1-int | 1 | ** | 99.0 | Weakly correlated | |
| 145 | MLT1I | 1 | n.s | 99.0 | Weakly correlated | |
| 146 | MLT1J1 | 1 | n.s | 99.0 | Weakly correlated | |
| 147 | MLT1K | 1 | n.s | 99.0 | Weakly correlated | |
| 148 | MLT2D | 1 | n.s | 99.0 | Weakly correlated | |
| 149 | MSTD | 1 | n.s | 74.0 | Weakly correlated | |
| 150 | PRIMA41-int | 1 | * | 74.0 | Weakly correlated | |
| 151 | THE1B | 1 | n.s | 43.0 | Highly correlated | |
| 152 | THE1C | 1 | n.s | 43.0 | Highly correlated | |
| 153 | X7C_LINE | 1 | *** | 319.0 | Weakly correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MER4-int | 126 | **** | 74.0 | Weakly correlated | |
| 2 | MER41-int | 116 | **** | 74.0 | Weakly correlated | |
| 3 | MER61-int | 41 | **** | 43.0 | Highly correlated | |
| 4 | HUERS-P1-int | 31 | **** | 43.0 | Highly correlated | |
| 5 | PABL_A-int | 30 | **** | 74.0 | Weakly correlated | |
| 6 | LTR49-int | 25 | **** | 74.0 | Weakly correlated | |
| 7 | LOR1-int | 20 | **** | 74.0 | Weakly correlated | |
| 8 | MER51-int | 19 | **** | 43.0 | Highly correlated | |
| 9 | HERV35I-int | 18 | **** | 43.0 | Highly correlated | |
| 10 | HUERS-P3b-int | 15 | **** | 43.0 | Highly correlated | |
| 11 | MER50-int | 11 | **** | 43.0 | Highly correlated | |
| 12 | LTR25-int | 9 | **** | 43.0 | Highly correlated | |
| 13 | MER101-int | 5 | **** | 74.0 | Weakly correlated | |
| 14 | LTR19-int | 4 | **** | 43.0 | Highly correlated | |
| 15 | MER4B-int | 2 | ** | 99.0 | Weakly correlated | |
| 16 | MER57-int | 2 | * | 87.0 | Weakly correlated | |
| 17 | L1ME1 | 2 | n.s | 99.0 | Weakly correlated | |
| 18 | MER65-int | 2 | ** | 87.0 | Weakly correlated | |
| 19 | L1MEd | 1 | n.s | 99.0 | Weakly correlated | |
| 20 | MLT1D | 1 | n.s | 99.0 | Weakly correlated | |
| 21 | L1ME3Cz | 1 | n.s | 99.0 | Weakly correlated | |
| 22 | L1MA8 | 1 | n.s | 87.0 | Weakly correlated | |
| 23 | L1ME2 | 1 | n.s | 99.0 | Weakly correlated | |
| 24 | L1MD1 | 1 | n.s | 99.0 | Weakly correlated | |
| 25 | L1MB7 | 1 | n.s | 99.0 | Weakly correlated | |
| 26 | AluY | 1 | n.s | 74.0 | Weakly correlated | |
| 27 | L1PA16 | 1 | n.s | 74.0 | Weakly correlated | |
| 28 | MER4D | 1 | * | 74.0 | Weakly correlated | |
| 29 | L1PB3 | 1 | n.s | 74.0 | Weakly correlated | |
| 30 | L1ME3G | 1 | n.s | 99.0 | Weakly correlated | |
| 31 | L1M2 | 1 | n.s | 99.0 | Weakly correlated | |
| 32 | L1ME4b | 1 | n.s | 99.0 | Weakly correlated | |
| 33 | HERV17-int | 1 | n.s | 28.9 | Weakly correlated | |
| 34 | L1MEb | 1 | * | 99.0 | Weakly correlated | |
| 35 | L1PA10 | 1 | n.s | 74.0 | Weakly correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|
| 1 | HUERS-P1-INT | 43.0 | Highly correlated | |
| 2 | MER4-INT | 74.0 | Weakly correlated | |
| 3 | MER41-INT | 74.0 | Weakly correlated | |
| 4 | MER51-INT | 43.0 | Highly correlated | |
| 5 | PABL_A-INT | 74.0 | Weakly correlated |