ZRdb KZFP & Repeats
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Human_ZNF420

  • Protein
    Zinc finger protein 420
  • Length
    688
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q8TAQ5
  • NCBI_ID
    147923
Sequence:
MARKLVMFRDVAIDFSQEEWECLDSAQRDLYRDVMLENYSNLVSLDLPSRCASKDLSPEKNTYETELSQWEMSDRLENCDLEESNSRDYLEAKGKMEKQQENQKEYFRQGMIIYDKMSIFNQHTYLSQHSRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECKECGRAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKMFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYECKECGKAFSHGSQLTLHQRIHTGEKPYECRECRKAFTQSSHLSRHQRIHTGEKPYQCKECGKAFTRGSQLTQHQRIHISEKSFEYKECGIDFSHGSQVYM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..86
2 C2h2 139..161
3 C2h2 167..189
4 C2h2 195..217
5 C2h2 223..245
6 C2h2 251..273
7 C2h2 279..301
8 C2h2 307..329
9 C2h2 335..357
10 C2h2 363..385
11 C2h2 391..413
12 C2h2 419..441
13 C2h2 447..469
14 C2h2 475..497
15 C2h2 503..525
16 C2h2 531..553
17 C2h2 559..581
18 C2h2 587..609
19 C2h2 615..637
20 C2h2 643..665
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleoplasm
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1J 240 **** 99.0 Moderately correlated
2 MLT1L 135 **** 99.0 Moderately correlated
3 AluJb 24 n.s 74.0 Weakly correlated
4 L2c 15 n.s 99.0 Moderately correlated
5 AluSx 13 n.s 74.0 Weakly correlated
6 MLT1K 13 *** 99.0 Moderately correlated
7 MIR3 12 n.s 99.0 Moderately correlated
8 MIRb 12 n.s 99.0 Moderately correlated
9 AluSx1 11 n.s 74.0 Weakly correlated
10 AluSc8 10 n.s 74.0 Weakly correlated
11 L2a 10 n.s 99.0 Moderately correlated
12 AluY 9 n.s 74.0 Weakly correlated
13 L1P3 9 ** 74.0 Weakly correlated
14 AluSp 8 n.s 74.0 Weakly correlated
15 AluSz 8 n.s 74.0 Weakly correlated
16 AluYj4 8 **** 0.0 Weakly correlated
17 LTR8 8 *** 43.0 Weakly correlated
18 MIRc 8 n.s 99.0 Moderately correlated
19 AluSg 6 n.s 74.0 Weakly correlated
20 L2 6 n.s 99.0 Moderately correlated
21 AluJo 5 n.s 74.0 Weakly correlated
22 AluSz6 5 n.s 74.0 Weakly correlated
23 L1PA2 5 n.s 15.2 Weakly correlated
24 MIR 5 n.s 99.0 Moderately correlated
25 MLT1O 5 *** 99.0 Moderately correlated
26 MamRTE1 5 ** 99.0 Moderately correlated
27 AluJr 4 n.s 74.0 Weakly correlated
28 LTR10A 4 **** 28.9 Weakly correlated
29 MER21B 4 * 99.0 Moderately correlated
30 SVA_F 4 ** 0.0 Weakly correlated
31 AluSx4 3 n.s 74.0 Weakly correlated
32 AluYc 3 * 74.0 Weakly correlated
33 FRAM 3 * 74.0 Weakly correlated
34 L1M4 3 n.s 99.0 Moderately correlated
35 L1MB8 3 n.s 99.0 Moderately correlated
36 L1MC4 3 n.s 99.0 Moderately correlated
37 L1PA3 3 n.s 19.6 Weakly correlated
38 L2b 3 n.s 99.0 Moderately correlated
39 LTR12E 3 **** 19.6 Weakly correlated
40 MLT1D 3 n.s 99.0 Moderately correlated
41 AluSc 2 n.s 74.0 Weakly correlated
42 AluSq 2 n.s 74.0 Weakly correlated
43 AluSq2 2 n.s 74.0 Weakly correlated
44 AluYa5 2 n.s 15.2 Weakly correlated
45 ERV3-16A3_I-int 2 n.s 99.0 Moderately correlated
46 L1HS 2 n.s 8.6 Weakly correlated
47 L1M4b 2 n.s 99.0 Moderately correlated
48 L1MB3 2 n.s 99.0 Moderately correlated
49 L1MC5a 2 n.s 99.0 Moderately correlated
50 L1P4 2 n.s 74.0 Weakly correlated
51 L1PA5 2 n.s 19.6 Weakly correlated
52 L3 2 n.s 99.0 Moderately correlated
53 MER52A 2 n.s 74.0 Weakly correlated
54 MIR1_Amn 2 n.s 319.0 Weakly correlated
55 MLT1A 2 n.s 99.0 Moderately correlated
56 MLT1B 2 n.s 99.0 Moderately correlated
57 MLT1E3 2 * 99.0 Moderately correlated
58 AluSx3 1 n.s 74.0 Weakly correlated
59 AluYh9 1 *** 15.2 Weakly correlated
60 AluYi6 1 ** 15.2 Weakly correlated
61 AluYk3 1 n.s 19.6 Weakly correlated
62 AluYm1 1 n.s 19.6 Weakly correlated
63 AmnSINE1 1 * 319.0 Weakly correlated
64 FLAM_A 1 n.s 74.0 Weakly correlated
65 HERV17-int 1 n.s 28.9 Weakly correlated
66 HUERS-P3-int 1 n.s 43.0 Weakly correlated
67 L1M2 1 n.s 99.0 Moderately correlated
68 L1M3 1 n.s 99.0 Moderately correlated
69 L1MA4 1 n.s 87.0 Weakly correlated
70 L1MA5 1 n.s 87.0 Weakly correlated
71 L1MA6 1 n.s 87.0 Weakly correlated
72 L1MA8 1 n.s 87.0 Weakly correlated
73 L1MB5 1 n.s 99.0 Moderately correlated
74 L1MC3 1 n.s 99.0 Moderately correlated
75 L1MC5 1 n.s 99.0 Moderately correlated
76 L1MD1 1 n.s 99.0 Moderately correlated
77 L1ME2 1 n.s 99.0 Moderately correlated
78 L1P1 1 n.s 19.6 Weakly correlated
79 L1PA10 1 n.s 74.0 Weakly correlated
80 L1PA4 1 n.s 19.6 Weakly correlated
81 L1PA7 1 n.s 74.0 Weakly correlated
82 LTR10B1 1 ** 28.9 Weakly correlated
83 LTR12C 1 n.s 19.6 Weakly correlated
84 LTR13 1 n.s 19.6 Weakly correlated
85 LTR16A 1 n.s 99.0 Moderately correlated
86 LTR33 1 n.s 99.0 Moderately correlated
87 LTR41B 1 * 99.0 Moderately correlated
88 LTR41C 1 * 99.0 Moderately correlated
89 LTR5_Hs 1 n.s 0.0 Weakly correlated
90 LTR65 1 ** 99.0 Moderately correlated
91 MER21C 1 n.s 99.0 Moderately correlated
92 MER4D1 1 n.s 74.0 Weakly correlated
93 MER52C 1 n.s 74.0 Weakly correlated
94 MER65A 1 n.s 74.0 Weakly correlated
95 MER66A 1 ** 43.0 Weakly correlated
96 MLT1A0 1 n.s 99.0 Moderately correlated
97 MLT1F 1 n.s 99.0 Moderately correlated
98 MLT1H 1 n.s 99.0 Moderately correlated
99 MLT1I 1 n.s 99.0 Moderately correlated
100 MLT1J2 1 n.s 99.0 Moderately correlated
101 MLT1M 1 n.s 99.0 Moderately correlated
102 MLT1N2 1 n.s 99.0 Moderately correlated
103 MLT2B2 1 n.s 99.0 Moderately correlated
104 MSTD 1 n.s 74.0 Weakly correlated
105 MamGypLTR3a 1 * 99.0 Moderately correlated
106 SVA_D 1 n.s 15.2 Weakly correlated
107 SVA_E 1 * 0.0 Weakly correlated
108 THE1C 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1J 20 **** 99.0 Moderately correlated
2 MLT1L 13 **** 99.0 Moderately correlated
3 AluSc8 6 n.s 74.0 Weakly correlated
4 LTR41C 1 * 99.0 Moderately correlated
5 MIR3 1 n.s 99.0 Moderately correlated
6 MamRTE1 1 n.s 99.0 Moderately correlated
7 LTR5_Hs 1 n.s 0.0 Weakly correlated
8 L2a 1 n.s 99.0 Moderately correlated
9 AluSp 1 n.s 74.0 Weakly correlated
10 AluSg 1 n.s 74.0 Weakly correlated
11 L2b 1 n.s 99.0 Moderately correlated
12 LTR41B 1 * 99.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 ALUSC8 74.0 Weakly correlated