ZRdb KZFP & Repeats
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Human_ZNF419

  • Protein
    Zinc finger protein 419
  • Length
    510
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q96HQ0
  • NCBI_ID
    79744
Sequence:
MAAAALRDPAQVPVAADLLTDHEEGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLGLASSKTHEITQLESWEEPFMPAWEVVTSAIPRGCWHGAEAEEAPEQIASVGLLSSNIQQHQKQHCGEKPLKRQEGRVPVLRSCKVHLSEKSLQSREVGKALLISSGVLKHQVTHTGEKSHRSSKSREAFHAGKRHYKCSECGKAFGQKYLLVQHQRLHAGKKTYECSECGKLFRDMSNLFIHQIVHTGERPYGCSNCGKSFSRNAHLIEHQRVHTGEKPFTCSECGKAFRHNSTLVQHHKIHTGVRPYECSECGKLFSFNSSLMKHQRIHTGERPYKCSECGKFYSHKSNLIKHWRVHTGERPYKCSDCGKFFTQCSSLMQHQKVHTGEKPFKCNECGRFFRENSTLVRHQRVHTGAKPYECRECGKFFSQSSTLMQHRKVHIGEKPFKCNECGRLFRENSSLVKHQRVHTGAKPYECRECGKFFRHNSSLFKHRRIHTGEMQ
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 27..98
2 C2h2 203..225
3 C2h2 231..253
4 C2h2 259..281
5 C2h2 287..309
6 C2h2 315..337
7 C2h2 343..365
8 C2h2 371..393
9 C2h2 399..421
10 C2h2 427..449
11 C2h2 455..477
12 C2h2 483..505
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HERVK22-int 95 **** 43.0 Moderately correlated
2 L1PA5 8 n.s 19.6 Weakly correlated
3 LTR10A 7 **** 28.9 Highly correlated
4 L1P3 7 **** 74.0 Weakly correlated
5 L1P1 7 **** 19.6 Weakly correlated
6 AluJb 6 n.s 74.0 Weakly correlated
7 AluY 6 n.s 74.0 Weakly correlated
8 LTR76 5 **** 74.0 Weakly correlated
9 MER50 4 *** 43.0 Moderately correlated
10 MER50-int 4 **** 43.0 Moderately correlated
11 MLT1L 3 * 99.0 Weakly correlated
12 LTR16 3 *** 99.0 Weakly correlated
13 LTR8 3 ** 43.0 Moderately correlated
14 AluYm1 3 ** 19.6 Weakly correlated
15 L2a 3 n.s 99.0 Weakly correlated
16 AluSc8 3 n.s 74.0 Weakly correlated
17 MER39B 3 **** 74.0 Weakly correlated
18 AluSg 2 n.s 74.0 Weakly correlated
19 AluSz6 2 n.s 74.0 Weakly correlated
20 L1P4 2 * 74.0 Weakly correlated
21 L1PA16 2 n.s 74.0 Weakly correlated
22 L1PA2 2 n.s 15.2 Weakly correlated
23 L2c 2 n.s 99.0 Weakly correlated
24 AluJr 2 n.s 74.0 Weakly correlated
25 LTR13 2 *** 19.6 Weakly correlated
26 LTR18A 2 **** 43.0 Moderately correlated
27 MIRb 2 n.s 99.0 Weakly correlated
28 MamSINE1 2 ** 99.0 Weakly correlated
29 MLT1F1 2 ** 99.0 Weakly correlated
30 FRAM 2 * 74.0 Weakly correlated
31 AluYj4 2 ** 0.0 Weakly correlated
32 AluYh9 2 **** 15.2 Weakly correlated
33 MLT1K 2 n.s 99.0 Weakly correlated
34 AluYa5 2 * 15.2 Weakly correlated
35 AluSx1 2 n.s 74.0 Weakly correlated
36 Plat_L3 1 * 99.0 Weakly correlated
37 MIR 1 n.s 99.0 Weakly correlated
38 MIR3 1 n.s 99.0 Weakly correlated
39 MIRc 1 n.s 99.0 Weakly correlated
40 MER21A 1 * 74.0 Weakly correlated
41 SVA_C 1 * 15.2 Weakly correlated
42 L1MA9 1 n.s 99.0 Weakly correlated
43 AluJo 1 n.s 74.0 Weakly correlated
44 AluSq10 1 * 74.0 Weakly correlated
45 AluSq2 1 n.s 74.0 Weakly correlated
46 AluSx 1 n.s 74.0 Weakly correlated
47 AluYa8 1 *** 15.2 Weakly correlated
48 HAL1 1 n.s 99.0 Weakly correlated
49 HERV3-int 1 * 28.9 Highly correlated
50 L1MA8 1 n.s 87.0 Weakly correlated
51 LTR67B 1 * 99.0 Weakly correlated
52 L1MB8 1 n.s 99.0 Weakly correlated
53 L1MC4 1 n.s 99.0 Weakly correlated
54 L1ME4b 1 n.s 99.0 Weakly correlated
55 L1PA14 1 n.s 74.0 Weakly correlated
56 L2b 1 n.s 99.0 Weakly correlated
57 LTR12C 1 n.s 19.6 Weakly correlated
58 LTR4 1 *** 28.9 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HERVK22-int 28 **** 43.0 Moderately correlated
2 AluYh9 1 **** 15.2 Weakly correlated
3 L1P1 1 n.s 19.6 Weakly correlated
4 AluSz6 1 n.s 74.0 Weakly correlated
5 AluYa8 1 *** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP