ZRdb KZFP & Repeats
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Human_ZNF418

  • Protein
    Zinc finger protein 418
  • Length
    676
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q8TF45
  • NCBI_ID
    147686
Sequence:
MQGTVAFEDVAVNFSQEEWSLLSEVQRCLYHDVMLENWVLISSLGCWCGSEDEEAPSKKSISIQRVSQVSTPGAGVSPKKAHSCEMCGAILGDILHLADHQGTHHKQKLHRCEAWGNKLYDSSNRPHQNQYLGEKPYRSSVEEALFVKRCKFHVSEESSIFIQSGKDFLPSSGLLLQEATHTGEKSNSKPECESPFQWGDTHYSCGECMKHSSTKHVFVQQQRLPSREECYCWECGKSFSKYDSVSNHQRVHTGKRPYECGECGKSFSHKGSLVQHQRVHTGKRPYECGECGKSFSHKGSLVQHQRVHTGERPYECGECGKSFSQNGTLIKHQRVHTGERPYECEECGKCFTQKGNLIQHQRGHTSERPYECEECGKCFSQKGTLTEHHRVHTRERPYECGECGKSFSRKGHLRNHQRGHTGERPYECGECGKSFSRKGNLIQHQRSHTGERPYECRECRKLFRGKSHLIEHQRVHTGERPYECNECGKSFQDSSGFRVHQRVHTGEKPFECSECGKSFPQSCSLLRHRRVHTGERPYECGECGKSFHQSSSLLRHQKTHTAERPYECRECGKFFSSLLEHRRVHTGERPYECRECGKTFTRRSAHFKHQRLHTRGKPYECSECGKSFAETFSLTEHRRVHTGERPYECSECGKSFHRSSSLLRHQRVHTERSPYK
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 5..91
2 C2h2 82..105
3 C2h2 230..252
4 C2h2 258..280
5 C2h2 286..308
6 C2h2 314..336
7 C2h2 342..364
8 C2h2 370..392
9 C2h2 398..420
10 C2h2 426..448
11 C2h2 454..476
12 C2h2 482..504
13 C2h2 510..532
14 C2h2 538..560
15 C2h2 591..613
16 C2h2 619..641
17 C2h2 647..669
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER72 246 **** 43.0 Highly correlated
2 MER49 53 **** 43.0 Highly correlated
3 MER72B 30 **** 43.0 Highly correlated
4 MLT1C 17 **** 94.0 Weakly correlated
5 HERV17-int 15 **** 28.9 Weakly correlated
6 MIR 15 n.s 99.0 Weakly correlated
7 L2a 14 n.s 99.0 Weakly correlated
8 THE1A 13 **** 43.0 Highly correlated
9 AluJb 12 n.s 74.0 Weakly correlated
10 AluSx 11 n.s 74.0 Weakly correlated
11 L1PB1 10 n.s 74.0 Weakly correlated
12 AluJr 9 n.s 74.0 Weakly correlated
13 AluY 8 n.s 74.0 Weakly correlated
14 MIRc 8 n.s 99.0 Weakly correlated
15 MLT1D 8 * 99.0 Weakly correlated
16 L2c 7 n.s 99.0 Weakly correlated
17 HERVH-int 6 * 28.9 Weakly correlated
18 L1P3 6 *** 74.0 Weakly correlated
19 L1PA5 6 n.s 19.6 Weakly correlated
20 LTR8 6 **** 43.0 Highly correlated
21 AluSz 5 n.s 74.0 Weakly correlated
22 L1PA2 5 n.s 15.2 Weakly correlated
23 L2 5 n.s 99.0 Weakly correlated
24 MER50 5 **** 43.0 Highly correlated
25 MIRb 5 n.s 99.0 Weakly correlated
26 MLT1J 5 * 99.0 Weakly correlated
27 FRAM 4 *** 74.0 Weakly correlated
28 L1ME4b 4 n.s 99.0 Weakly correlated
29 L1PA15 4 n.s 74.0 Weakly correlated
30 L1PA3 4 n.s 19.6 Weakly correlated
31 L2b 4 n.s 99.0 Weakly correlated
32 LTR10A 4 **** 28.9 Weakly correlated
33 MER21C 4 ** 99.0 Weakly correlated
34 MLT1F1 4 *** 99.0 Weakly correlated
35 AluSp 3 n.s 74.0 Weakly correlated
36 L1M5 3 n.s 99.0 Weakly correlated
37 L1MC4 3 n.s 99.0 Weakly correlated
38 L1ME3Cz 3 n.s 99.0 Weakly correlated
39 L1MEd 3 n.s 99.0 Weakly correlated
40 L1PA4 3 n.s 19.6 Weakly correlated
41 LTR8A 3 *** 43.0 Highly correlated
42 MER50-int 3 **** 43.0 Highly correlated
43 MLT1A 3 * 99.0 Weakly correlated
44 AluJo 2 n.s 74.0 Weakly correlated
45 AluSc 2 n.s 74.0 Weakly correlated
46 AluSc8 2 n.s 74.0 Weakly correlated
47 AluSg7 2 n.s 74.0 Weakly correlated
48 AluSq2 2 n.s 74.0 Weakly correlated
49 AluSx3 2 n.s 74.0 Weakly correlated
50 AluSz6 2 n.s 74.0 Weakly correlated
51 AluYj4 2 ** 0.0 Weakly correlated
52 HAL1 2 n.s 99.0 Weakly correlated
53 HERVH48-int 2 *** 28.9 Weakly correlated
54 L1M4 2 n.s 99.0 Weakly correlated
55 L1MA9 2 n.s 99.0 Weakly correlated
56 L1MC5a 2 n.s 99.0 Weakly correlated
57 L1ME4a 2 n.s 99.0 Weakly correlated
58 L1MEc 2 n.s 99.0 Weakly correlated
59 L1MEi 2 n.s 99.0 Weakly correlated
60 L1P1 2 n.s 19.6 Weakly correlated
61 L1PA11 2 n.s 74.0 Weakly correlated
62 L1PB4 2 n.s 99.0 Weakly correlated
63 L1PREC2 2 n.s 43.0 Highly correlated
64 L4_A_Mam 2 n.s 99.0 Weakly correlated
65 LTR10F 2 *** 28.9 Weakly correlated
66 LTR12C 2 n.s 19.6 Weakly correlated
67 LTR1A2 2 ** 43.0 Highly correlated
68 LTR37-int 2 ** 99.0 Weakly correlated
69 LTR41B 2 *** 99.0 Weakly correlated
70 LTR47B4 2 **** 74.0 Weakly correlated
71 LTR50 2 ** 99.0 Weakly correlated
72 LTR76 2 **** 74.0 Weakly correlated
73 LTR8B 2 ** 43.0 Highly correlated
74 MER39B 2 ** 74.0 Weakly correlated
75 MER4B-int 2 ** 99.0 Weakly correlated
76 MER88 2 **** 99.0 Weakly correlated
77 MIR3 2 n.s 99.0 Weakly correlated
78 MLT1A1 2 n.s 87.0 Weakly correlated
79 MLT1B 2 n.s 99.0 Weakly correlated
80 MLT1E2 2 * 99.0 Weakly correlated
81 MLT1E3 2 ** 99.0 Weakly correlated
82 MLT1F 2 * 99.0 Weakly correlated
83 MLT1J1 2 * 99.0 Weakly correlated
84 MLT1J2 2 * 99.0 Weakly correlated
85 Alu 1 ** 74.0 Weakly correlated
86 AluJr4 1 n.s 74.0 Weakly correlated
87 AluSx1 1 n.s 74.0 Weakly correlated
88 AluYa5 1 n.s 15.2 Weakly correlated
89 AluYh9 1 **** 15.2 Weakly correlated
90 AluYm1 1 n.s 19.6 Weakly correlated
91 ERVL-E-int 1 n.s 99.0 Weakly correlated
92 FLAM_C 1 n.s 74.0 Weakly correlated
93 HERVK9-int 1 n.s 28.9 Weakly correlated
94 HUERS-P1-int 1 * 43.0 Highly correlated
95 L1M4b 1 n.s 99.0 Weakly correlated
96 L1MA2 1 n.s 74.0 Weakly correlated
97 L1MA4 1 n.s 87.0 Weakly correlated
98 L1MA8 1 n.s 87.0 Weakly correlated
99 L1MB3 1 n.s 99.0 Weakly correlated
100 L1MB5 1 n.s 99.0 Weakly correlated
101 L1MB7 1 n.s 99.0 Weakly correlated
102 L1MB8 1 n.s 99.0 Weakly correlated
103 L1MC3 1 n.s 99.0 Weakly correlated
104 L1MCa 1 n.s 99.0 Weakly correlated
105 L1MDa 1 n.s 99.0 Weakly correlated
106 L1ME2z 1 n.s 99.0 Weakly correlated
107 L1ME3 1 n.s 99.0 Weakly correlated
108 L1MEf 1 n.s 99.0 Weakly correlated
109 L1MEh 1 n.s 99.0 Weakly correlated
110 L1P4 1 n.s 74.0 Weakly correlated
111 L1PA10 1 n.s 74.0 Weakly correlated
112 L1PB3 1 n.s 74.0 Weakly correlated
113 L3 1 n.s 99.0 Weakly correlated
114 LTR12F 1 ** 28.9 Weakly correlated
115 LTR13 1 * 19.6 Weakly correlated
116 LTR16A 1 n.s 99.0 Weakly correlated
117 LTR16B1 1 * 99.0 Weakly correlated
118 LTR18A 1 *** 43.0 Highly correlated
119 LTR19B 1 ** 43.0 Highly correlated
120 LTR25-int 1 * 43.0 Highly correlated
121 LTR33A_ 1 * 99.0 Weakly correlated
122 LTR33B 1 * 99.0 Weakly correlated
123 LTR4 1 *** 28.9 Weakly correlated
124 LTR49-int 1 n.s 74.0 Weakly correlated
125 LTR52 1 * 99.0 Weakly correlated
126 LTR7C 1 ** 28.9 Weakly correlated
127 MER21A 1 n.s 74.0 Weakly correlated
128 MER31B 1 * 99.0 Weakly correlated
129 MER4-int 1 n.s 74.0 Weakly correlated
130 MER41-int 1 n.s 74.0 Weakly correlated
131 MER41G 1 *** 74.0 Weakly correlated
132 MER52D 1 * 74.0 Weakly correlated
133 MER61-int 1 n.s 43.0 Highly correlated
134 MER73 1 ** 87.0 Weakly correlated
135 MER9a3 1 ** 28.9 Weakly correlated
136 MIR1_Amn 1 n.s 319.0 Weakly correlated
137 MLT-int 1 ** 99.0 Weakly correlated
138 MLT1E1A 1 n.s 99.0 Weakly correlated
139 MLT1F1-int 1 *** 99.0 Weakly correlated
140 MLT1G3 1 n.s 99.0 Weakly correlated
141 MLT1H 1 n.s 99.0 Weakly correlated
142 MLT1H2 1 n.s 99.0 Weakly correlated
143 MLT1I 1 n.s 99.0 Weakly correlated
144 MLT1K 1 n.s 99.0 Weakly correlated
145 MLT1L 1 n.s 99.0 Weakly correlated
146 MLT1L-int 1 **** 99.0 Weakly correlated
147 MLT1M 1 * 99.0 Weakly correlated
148 MSTB 1 n.s 43.0 Highly correlated
149 Mam_R4 1 ** 99.0 Weakly correlated
150 PRIMA4-int 1 ** 74.0 Weakly correlated
151 THE1A-int 1 n.s 43.0 Highly correlated
152 THE1B 1 n.s 43.0 Highly correlated
153 THE1B-int 1 n.s 43.0 Highly correlated
154 THE1D-int 1 n.s 28.9 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER72 148 **** 43.0 Highly correlated
2 MER49 29 **** 43.0 Highly correlated
3 MER72B 16 **** 43.0 Highly correlated
4 MLT1J 2 n.s 99.0 Weakly correlated
5 MER50 1 n.s 43.0 Highly correlated
6 MLT1J2 1 n.s 99.0 Weakly correlated
7 MLT1J1 1 n.s 99.0 Weakly correlated
8 LTR12F 1 ** 28.9 Weakly correlated
9 L1PA2 1 n.s 15.2 Weakly correlated
10 L1MA2 1 n.s 74.0 Weakly correlated
11 LTR7C 1 ** 28.9 Weakly correlated
12 MLT1E2 1 n.s 99.0 Weakly correlated
13 AluJr 1 n.s 74.0 Weakly correlated
14 AluY 1 n.s 74.0 Weakly correlated
15 L1PA5 1 n.s 19.6 Weakly correlated
16 MLT1M 1 * 99.0 Weakly correlated
17 MER21A 1 n.s 74.0 Weakly correlated
18 LTR1A2 1 * 43.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 MER49 43.0 Highly correlated
2 MER72 43.0 Highly correlated
3 MER72B 43.0 Highly correlated