ZRdb KZFP & Repeats
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Human_ZNF417

  • Protein
    Zinc finger protein 417
  • Length
    575
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q8TAU3
  • NCBI_ID
    147687
Sequence:
MAAAAPRRPTQQGTVTFEDVAVNFSQEEWCLLSEAQRCLYRDVMLENLALISSLGCWCGSKDEEAPCKQRISVQRESQSRTPRAGVSPKKAHPCEMCGLILEDVFHFADHQETHHKQKLNRSGACGKNLDDTAYLHQHQKQHIGEKFYRKSVREASFVKKRKLRVSQEPFVFREFGKDVLPSSGLCQEAAAVEKTDSETMHGPPFQEGKTNYSCGKRTKAFSTKHSVIPHQKLFTRDGCYVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKSYSRKSSLIQHQRVHTGKTAYPCEECGKSFSQKGSLISHQRVHTGERPYECREYGKSFGQKGNLIQHQQGHTGERAYHCGECGKSFRQKFCFINHQRVHTGERPYKCGECGKSFGQKGNLVQHQRGHTGERPYECKECGKSFRYRSHLTEHQRLHTGERPYNCRECGKLFNRKYHLLVHERVHTGERPYACEVCGKLFGNKNCVTIHQRIHTGERPYECNECGKSFLSSSALHVHKRVHSGQKPYKCSECGKSFAECSSLIKHRRIHTGERPYECTKCGKTFQRSSTLLHHQSSHRRKAL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 15..88
2 C2h2 92..114
3 C2h2 240..262
4 C2h2 268..290
5 C2h2 296..318
6 dec2h2 324..346
7 C2h2 352..374
8 C2h2 380..402
9 C2h2 408..430
10 C2h2 436..458
11 C2h2 464..486
12 C2h2 492..514
13 C2h2 520..542
14 C2h2 548..570
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER61-int 37 **** 43.0 Moderately correlated
2 MER61A 30 **** 43.0 Moderately correlated
3 HERVK9-int 23 **** 28.9 Highly correlated
4 HERVK-int 19 **** 28.9 Highly correlated
5 MER9a3 15 **** 28.9 Highly correlated
6 L2c 11 n.s 99.0 Weakly correlated
7 LTR5B 11 **** 28.9 Highly correlated
8 AluSx1 10 n.s 74.0 Weakly correlated
9 HERVK3-int 9 **** 28.9 Highly correlated
10 LTR12C 9 **** 19.6 Weakly correlated
11 LTR5_Hs 9 **** 0.0 Weakly correlated
12 AluY 8 n.s 74.0 Weakly correlated
13 L2a 8 n.s 99.0 Weakly correlated
14 LTR3B_ 8 **** 28.9 Highly correlated
15 AluSx 6 n.s 74.0 Weakly correlated
16 HERVK14-int 6 **** 28.9 Highly correlated
17 L2b 6 n.s 99.0 Weakly correlated
18 LTR3A 6 **** 28.9 Highly correlated
19 MER4B-int 6 **** 99.0 Weakly correlated
20 MER9a1 6 **** 19.6 Weakly correlated
21 HERVK11-int 5 **** 28.9 Highly correlated
22 LTR14C 5 **** 28.9 Highly correlated
23 MER4E 5 **** 74.0 Weakly correlated
24 MER61B 5 **** 43.0 Moderately correlated
25 MIR 5 n.s 99.0 Weakly correlated
26 AluJb 4 n.s 74.0 Weakly correlated
27 AluJo 4 n.s 74.0 Weakly correlated
28 AluSp 4 n.s 74.0 Weakly correlated
29 AluSq2 4 n.s 74.0 Weakly correlated
30 AluSz 4 n.s 74.0 Weakly correlated
31 HERVK14C-int 4 **** 28.9 Highly correlated
32 LTR10A 4 **** 28.9 Highly correlated
33 LTR14B 4 **** 28.9 Highly correlated
34 LTR5A 4 **** 19.6 Weakly correlated
35 MIRb 4 n.s 99.0 Weakly correlated
36 AluSg 3 n.s 74.0 Weakly correlated
37 HERV9N-int 3 **** 19.6 Weakly correlated
38 L1M5 3 n.s 99.0 Weakly correlated
39 L1P3 3 ** 74.0 Weakly correlated
40 L1PA2 3 n.s 15.2 Weakly correlated
41 L1PA5 3 n.s 19.6 Weakly correlated
42 L3 3 n.s 99.0 Weakly correlated
43 LTR12 3 **** 28.9 Highly correlated
44 LTR12_ 3 **** 28.9 Highly correlated
45 MLT1B 3 * 99.0 Weakly correlated
46 THE1B-int 3 * 43.0 Moderately correlated
47 AluJr 2 n.s 74.0 Weakly correlated
48 AluJr4 2 n.s 74.0 Weakly correlated
49 AluSc8 2 n.s 74.0 Weakly correlated
50 HERVK11D-int 2 **** 19.6 Weakly correlated
51 HERVK13-int 2 **** 19.6 Weakly correlated
52 L1P1 2 * 19.6 Weakly correlated
53 L1PA4 2 n.s 19.6 Weakly correlated
54 L1PA7 2 n.s 74.0 Weakly correlated
55 L2 2 n.s 99.0 Weakly correlated
56 L3b 2 ** 99.0 Weakly correlated
57 LTR12D 2 *** 19.6 Weakly correlated
58 LTR13 2 *** 19.6 Weakly correlated
59 LTR14A 2 **** 28.9 Highly correlated
60 MER11B 2 *** 19.6 Weakly correlated
61 MER11D 2 **** 19.6 Weakly correlated
62 MER61C 2 **** 43.0 Moderately correlated
63 MER9B 2 **** 28.9 Highly correlated
64 MER9a2 2 **** 19.6 Weakly correlated
65 MIRc 2 n.s 99.0 Weakly correlated
66 MSTB1 2 * 74.0 Weakly correlated
67 THE1B 2 n.s 43.0 Moderately correlated
68 AluSg4 1 n.s 74.0 Weakly correlated
69 AluSq 1 n.s 74.0 Weakly correlated
70 AluSq4 1 ** 74.0 Weakly correlated
71 AluSz6 1 n.s 74.0 Weakly correlated
72 AluYe5 1 ** 74.0 Weakly correlated
73 AluYm1 1 n.s 19.6 Weakly correlated
74 CR1-3_Croc 1 ** 319.0 Weakly correlated
75 ERVL-B4-int 1 n.s 99.0 Weakly correlated
76 ERVL-E-int 1 n.s 99.0 Weakly correlated
77 FLAM_A 1 n.s 74.0 Weakly correlated
78 HERV3-int 1 ** 28.9 Highly correlated
79 HERV9-int 1 * 28.9 Highly correlated
80 HERV9NC-int 1 * 19.6 Weakly correlated
81 HERVH-int 1 n.s 28.9 Highly correlated
82 HERVH48-int 1 ** 28.9 Highly correlated
83 HERVI-int 1 ** 28.9 Highly correlated
84 HERVK22-int 1 * 43.0 Moderately correlated
85 HERVKC4-int 1 *** 28.9 Highly correlated
86 L1M4a1 1 * 99.0 Weakly correlated
87 L1MA2 1 n.s 74.0 Weakly correlated
88 L1MA3 1 n.s 74.0 Weakly correlated
89 L1MB1 1 n.s 99.0 Weakly correlated
90 L1MB3 1 n.s 99.0 Weakly correlated
91 L1MB8 1 n.s 99.0 Weakly correlated
92 L1MC4 1 n.s 99.0 Weakly correlated
93 L1MC5a 1 n.s 99.0 Weakly correlated
94 L1MDa 1 n.s 99.0 Weakly correlated
95 L1ME4a 1 n.s 99.0 Weakly correlated
96 L1ME4c 1 n.s 99.0 Weakly correlated
97 L1P4 1 n.s 74.0 Weakly correlated
98 L1PA10 1 n.s 74.0 Weakly correlated
99 L1PA13 1 n.s 74.0 Weakly correlated
100 L1PA3 1 n.s 19.6 Weakly correlated
101 L1PREC2 1 n.s 43.0 Moderately correlated
102 LTR10B1 1 *** 28.9 Highly correlated
103 LTR10C 1 ** 28.9 Highly correlated
104 LTR10D 1 *** 28.9 Highly correlated
105 LTR13_ 1 **** 28.9 Highly correlated
106 LTR14 1 **** 28.9 Highly correlated
107 LTR16C 1 n.s 99.0 Weakly correlated
108 LTR17 1 ** 28.9 Highly correlated
109 LTR22B2 1 **** 28.9 Highly correlated
110 LTR26 1 ** 74.0 Weakly correlated
111 LTR2752 1 ** 43.0 Moderately correlated
112 LTR3 1 **** 28.9 Highly correlated
113 LTR31 1 *** 74.0 Weakly correlated
114 LTR32 1 ** 43.0 Moderately correlated
115 LTR3B 1 **** 28.9 Highly correlated
116 LTR88b 1 ** 99.0 Weakly correlated
117 MER11A 1 * 28.9 Highly correlated
118 MER11C 1 * 19.6 Weakly correlated
119 MER21B 1 * 99.0 Weakly correlated
120 MER34-int 1 *** 99.0 Weakly correlated
121 MER34A1 1 ** 99.0 Weakly correlated
122 MER34B-int 1 ** 99.0 Weakly correlated
123 MER34D 1 *** 74.0 Weakly correlated
124 MER48 1 *** 28.9 Highly correlated
125 MER4A1 1 * 74.0 Weakly correlated
126 MER4D 1 * 74.0 Weakly correlated
127 MER50 1 * 43.0 Moderately correlated
128 MER50-int 1 ** 43.0 Moderately correlated
129 MER51-int 1 ** 43.0 Moderately correlated
130 MER52D 1 * 74.0 Weakly correlated
131 MER66-int 1 ** 43.0 Moderately correlated
132 MER66A 1 *** 43.0 Moderately correlated
133 MER66B 1 ** 43.0 Moderately correlated
134 MER66C 1 *** 43.0 Moderately correlated
135 MER72 1 ** 43.0 Moderately correlated
136 MER74A 1 * 99.0 Weakly correlated
137 MER77B 1 ** 99.0 Weakly correlated
138 MIR3 1 n.s 99.0 Weakly correlated
139 MLT1A 1 n.s 99.0 Weakly correlated
140 MLT1A0 1 n.s 99.0 Weakly correlated
141 MLT1A0-int 1 ** 99.0 Weakly correlated
142 MLT1C 1 n.s 94.0 Weakly correlated
143 MLT1F2 1 n.s 99.0 Weakly correlated
144 MLT1G 1 * 99.0 Weakly correlated
145 MLT1G3 1 * 99.0 Weakly correlated
146 MLT1J 1 n.s 99.0 Weakly correlated
147 MLT1K 1 n.s 99.0 Weakly correlated
148 MLT1N2 1 * 99.0 Weakly correlated
149 MSTA1-int 1 **** 74.0 Weakly correlated
150 MSTB-int 1 * 43.0 Moderately correlated
151 MSTD 1 n.s 74.0 Weakly correlated
152 MamGypLTR3a 1 ** 99.0 Weakly correlated
153 PABL_A-int 1 ** 74.0 Weakly correlated
154 THE1A-int 1 n.s 43.0 Moderately correlated
155 THE1C-int 1 n.s 43.0 Moderately correlated
156 THE1D 1 n.s 43.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER61-int 32 **** 43.0 Moderately correlated
2 HERVK9-int 23 **** 28.9 Highly correlated
3 HERVK-int 17 **** 28.9 Highly correlated
4 MER61A 16 **** 43.0 Moderately correlated
5 MER9a3 15 **** 28.9 Highly correlated
6 LTR5B 9 **** 28.9 Highly correlated
7 LTR12C 8 **** 19.6 Weakly correlated
8 LTR5_Hs 7 **** 0.0 Weakly correlated
9 L2c 7 n.s 99.0 Weakly correlated
10 HERVK14-int 6 **** 28.9 Highly correlated
11 L2a 6 n.s 99.0 Weakly correlated
12 LTR3A 6 **** 28.9 Highly correlated
13 LTR3B_ 6 **** 28.9 Highly correlated
14 AluSx1 5 n.s 74.0 Weakly correlated
15 AluY 5 n.s 74.0 Weakly correlated
16 MER9a1 5 **** 19.6 Weakly correlated
17 L2b 5 n.s 99.0 Weakly correlated
18 AluSx 5 n.s 74.0 Weakly correlated
19 HERVK14C-int 4 **** 28.9 Highly correlated
20 HERVK3-int 4 **** 28.9 Highly correlated
21 AluSq2 4 n.s 74.0 Weakly correlated
22 MER4B-int 4 **** 99.0 Weakly correlated
23 LTR5A 4 **** 19.6 Weakly correlated
24 LTR14C 4 **** 28.9 Highly correlated
25 AluSp 3 n.s 74.0 Weakly correlated
26 THE1B-int 3 * 43.0 Moderately correlated
27 AluJo 3 n.s 74.0 Weakly correlated
28 LTR12 3 **** 28.9 Highly correlated
29 LTR12_ 3 **** 28.9 Highly correlated
30 AluJb 3 n.s 74.0 Weakly correlated
31 MLT1B 3 * 99.0 Weakly correlated
32 HERVK11-int 2 *** 28.9 Highly correlated
33 LTR14B 2 **** 28.9 Highly correlated
34 MER61C 2 **** 43.0 Moderately correlated
35 L1M5 2 n.s 99.0 Weakly correlated
36 LTR14A 2 **** 28.9 Highly correlated
37 MER9a2 2 **** 19.6 Weakly correlated
38 MIR 2 n.s 99.0 Weakly correlated
39 THE1B 2 n.s 43.0 Moderately correlated
40 LTR12D 2 *** 19.6 Weakly correlated
41 HERVK13-int 2 **** 19.6 Weakly correlated
42 L2 2 n.s 99.0 Weakly correlated
43 MER11D 2 **** 19.6 Weakly correlated
44 AluJr4 2 n.s 74.0 Weakly correlated
45 HERVK11D-int 2 **** 19.6 Weakly correlated
46 MER11B 2 *** 19.6 Weakly correlated
47 MER61B 2 **** 43.0 Moderately correlated
48 AluJr 1 n.s 74.0 Weakly correlated
49 AluSq4 1 ** 74.0 Weakly correlated
50 L1M4a1 1 * 99.0 Weakly correlated
51 LTR26 1 ** 74.0 Weakly correlated
52 MER34A1 1 ** 99.0 Weakly correlated
53 MLT1N2 1 * 99.0 Weakly correlated
54 MSTB-int 1 * 43.0 Moderately correlated
55 HERV9N-int 1 ** 19.6 Weakly correlated
56 L3 1 n.s 99.0 Weakly correlated
57 LTR10A 1 *** 28.9 Highly correlated
58 LTR2752 1 ** 43.0 Moderately correlated
59 MER11C 1 * 19.6 Weakly correlated
60 MSTB1 1 n.s 74.0 Weakly correlated
61 THE1D 1 n.s 43.0 Moderately correlated
62 AluSz 1 n.s 74.0 Weakly correlated
63 AluSz6 1 n.s 74.0 Weakly correlated
64 CR1-3_Croc 1 ** 319.0 Weakly correlated
65 ERVL-B4-int 1 n.s 99.0 Weakly correlated
66 MER4E 1 ** 74.0 Weakly correlated
67 MER52D 1 * 74.0 Weakly correlated
68 MLT1C 1 n.s 94.0 Weakly correlated
69 MLT1J 1 n.s 99.0 Weakly correlated
70 HERVH48-int 1 ** 28.9 Highly correlated
71 L1P1 1 n.s 19.6 Weakly correlated
72 L1PA10 1 n.s 74.0 Weakly correlated
73 MER48 1 *** 28.9 Highly correlated
74 MER66-int 1 ** 43.0 Moderately correlated
75 MER66B 1 ** 43.0 Moderately correlated
76 MER77B 1 ** 99.0 Weakly correlated
77 MIR3 1 n.s 99.0 Weakly correlated
78 MLT1K 1 n.s 99.0 Weakly correlated
79 THE1C-int 1 n.s 43.0 Moderately correlated
80 AluSg 1 n.s 74.0 Weakly correlated
81 L1MDa 1 n.s 99.0 Weakly correlated
82 L1ME4a 1 n.s 99.0 Weakly correlated
83 L1PA3 1 n.s 19.6 Weakly correlated
84 L1PA4 1 n.s 19.6 Weakly correlated
85 L1PREC2 1 n.s 43.0 Moderately correlated
86 LTR10C 1 ** 28.9 Highly correlated
87 LTR17 1 ** 28.9 Highly correlated
88 MER11A 1 * 28.9 Highly correlated
89 MER34D 1 *** 74.0 Weakly correlated
90 PABL_A-int 1 ** 74.0 Weakly correlated
91 L1MB3 1 n.s 99.0 Weakly correlated
92 MER74A 1 * 99.0 Weakly correlated
93 MER9B 1 **** 28.9 Highly correlated
94 MLT1A0 1 n.s 99.0 Weakly correlated
95 AluYe5 1 ** 74.0 Weakly correlated
96 ERVL-E-int 1 n.s 99.0 Weakly correlated
97 HERVKC4-int 1 *** 28.9 Highly correlated
98 L1MA3 1 n.s 74.0 Weakly correlated
99 L1MC4 1 n.s 99.0 Weakly correlated
100 L1PA5 1 n.s 19.6 Weakly correlated
101 LTR88b 1 ** 99.0 Weakly correlated
102 MER50 1 * 43.0 Moderately correlated
103 MER51-int 1 ** 43.0 Moderately correlated
104 MSTA1-int 1 **** 74.0 Weakly correlated
105 AluSq 1 n.s 74.0 Weakly correlated
106 HERVI-int 1 ** 28.9 Highly correlated
107 L1MB1 1 n.s 99.0 Weakly correlated
108 L1PA13 1 n.s 74.0 Weakly correlated
109 LTR10D 1 *** 28.9 Highly correlated
110 LTR13 1 ** 19.6 Weakly correlated
111 LTR13_ 1 **** 28.9 Highly correlated
112 LTR14 1 **** 28.9 Highly correlated
113 LTR32 1 ** 43.0 Moderately correlated
114 MER66A 1 *** 43.0 Moderately correlated
115 MLT1A 1 n.s 99.0 Weakly correlated
116 THE1A-int 1 n.s 43.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 HERVK-INT 28.9 Highly correlated