ZRdb KZFP & Repeats
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Human_ZNF416

  • Protein
    Zinc finger protein 416
  • Length
    594
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q9BWM5
  • NCBI_ID
    55659
Sequence:
MAAAVLRDSTSVPVTAEAKLMGFTQGCVTFEDVAIYFSQEEWGLLDEAQRLLYRDVMLENFALITALVCWHGMEDEETPEQSVSVEGVPQVRTPEASPSTQKIQSCDMCVPFLTDILHLTDLPGQELYLTGACAVFHQDQKHHSAEKPLESDMDKASFVQCCLFHESGMPFTSSEVGKDFLAPLGILQPQAIANYEKPNKISKCEEAFHVGISHYKWSQCRRESSHKHTFFHPRVCTGKRLYESSKCGKACCCECSLVQLQRVHPGERPYECSECGKSFSQTSHLNDHRRIHTGERPYVCGQCGKSFSQRATLIKHHRVHTGERPYECGECGKSFSQSSNLIEHCRIHTGERPYECDECGKAFGSKSTLVRHQRTHTGEKPYECGECGKLFRQSFSLVVHQRIHTTARPYECGQCGKSFSLKCGLIQHQLIHSGARPFECDECGKSFSQRTTLNKHHKVHTAERPYVCGECGKAFMFKSKLVRHQRTHTGERPFECSECGKFFRQSYTLVEHQKIHTGLRPYDCGQCGKSFIQKSSLIQHQVVHTGERPYECGKCGKSFTQHSGLILHRKSHTVERPRDSSKCGKPYSPRSNIV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 28..111
2 dec2h2 242..264
3 C2h2 270..292
4 C2h2 298..320
5 C2h2 326..348
6 C2h2 354..376
7 C2h2 382..404
8 C2h2 410..432
9 C2h2 438..460
10 C2h2 466..488
11 C2h2 494..516
12 C2h2 522..544
13 C2h2 550..572
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 10 **** 0.0 Weakly correlated
2 AluJb 9 n.s 74.0 Weakly correlated
3 AluSc8 9 *** 74.0 Weakly correlated
4 L1P3 9 **** 74.0 Weakly correlated
5 LTR8 6 **** 43.0 Highly correlated
6 MER21B 4 *** 99.0 Weakly correlated
7 AluY 4 n.s 74.0 Weakly correlated
8 AluYm1 4 *** 19.6 Weakly correlated
9 LTR10A 4 **** 28.9 Weakly correlated
10 AluYa8 3 **** 15.2 Weakly correlated
11 FRAM 3 *** 74.0 Weakly correlated
12 LTR10F 3 **** 28.9 Weakly correlated
13 L1PA5 2 n.s 19.6 Weakly correlated
14 L1PA2 2 n.s 15.2 Weakly correlated
15 L2a 2 n.s 99.0 Weakly correlated
16 AluSp 2 n.s 74.0 Weakly correlated
17 AluJo 2 n.s 74.0 Weakly correlated
18 LTR10B1 1 *** 28.9 Weakly correlated
19 LTR13 1 * 19.6 Weakly correlated
20 MLT1L 1 n.s 99.0 Weakly correlated
21 L2c 1 n.s 99.0 Weakly correlated
22 SVA_C 1 * 15.2 Weakly correlated
23 L1PA4 1 n.s 19.6 Weakly correlated
24 L1PA10 1 n.s 74.0 Weakly correlated
25 L1P4 1 n.s 74.0 Weakly correlated
26 L1MB8 1 n.s 99.0 Weakly correlated
27 L1M3 1 n.s 99.0 Weakly correlated
28 HERVH-int 1 n.s 28.9 Weakly correlated
29 HERV17-int 1 * 28.9 Weakly correlated
30 AluYi6 1 *** 15.2 Weakly correlated
31 AluSz 1 n.s 74.0 Weakly correlated
32 AluSq 1 n.s 74.0 Weakly correlated
33 AluJr 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 4 **** 0.0 Weakly correlated
2 FRAM 2 ** 74.0 Weakly correlated
3 AluYa8 1 *** 15.2 Weakly correlated
4 L2c 1 n.s 99.0 Weakly correlated
5 AluJo 1 n.s 74.0 Weakly correlated
6 AluY 1 n.s 74.0 Weakly correlated
7 AluSc8 1 n.s 74.0 Weakly correlated
8 SVA_C 1 * 15.2 Weakly correlated
9 AluSq 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP