ZRdb KZFP & Repeats
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Human_ZNF41

  • Protein
    Zinc finger protein 41
  • Length
    821
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P51814
  • NCBI_ID
    7592
Sequence:
MAANGDSPPWSPALAAEGRGSSCEVRRERTPEARIHSVKRYPDLSPGPKGRSSADHAALNSIVSLQASVSFEDVTVDFSKEEWQHLDPAQRRLYWDVTLENYSHLLSVGYQIPKSEAAFKLEQGEGPWMLEGEAPHQSCSGEAIGKMQQQGIPGGIFFHCERFDQPIGEDSLCSILEELWQDNDQLEQRQENQNNLLSHVKVLIKERGYEHKNIEKIIHVTTKLVPSIKRLHNCDTILKHTLNSHNHNRNSATKNLGKIFGNGNNFPHSPSSTKNENAKTGANSCEHDHYEKHLSHKQAPTHHQKIHPEEKLYVCTECVMGFTQKSHLFEHQRIHAGEKSRECDKSNKVFPQKPQVDVHPSVYTGEKPYLCTQCGKVFTLKSNLITHQKIHTGQKPYKCSECGKAFFQRSDLFRHLRIHTGEKPYECSECGKGFSQNSDLSIHQKTHTGEKHYECNECGKAFTRKSALRMHQRIHTGEKPYVCADCGKAFIQKSHFNTHQRIHTGEKPYECSDCGKSFTKKSQLHVHQRIHTGEKPYICTECGKVFTHRTNLTTHQKTHTGEKPYMCAECGKAFTDQSNLIKHQKTHTGEKPYKCNGCGKAFIWKSRLKIHQKSHIGERHYECKDCGKAFIQKSTLSVHQRIHTGEKPYVCPECGKAFIQKSHFIAHHRIHTGEKPYECSDCGKCFTKKSQLRVHQKIHTGEKPNICAECGKAFTDRSNLITHQKIHTREKPYECGDCGKTFTWKSRLNIHQKSHTGERHYECSKCGKAFIQKATLSMHQIIHTGKKPYACTECQKAFTDRSNLIKHQKMHSGEKRYKASD
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 69..140
2 C2h2 313..335
3 dec2h2 341..364
4 C2h2 369..391
5 C2h2 397..419
6 C2h2 425..447
7 C2h2 453..475
8 C2h2 481..503
9 C2h2 509..531
10 C2h2 537..559
11 C2h2 565..587
12 C2h2 593..615
13 C2h2 621..643
14 C2h2 649..671
15 C2h2 677..699
16 C2h2 705..727
17 C2h2 733..755
18 C2h2 761..783
19 C2h2 789..811
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEd 372 **** 99.0 Highly correlated
2 MER89 82 **** 99.0 Highly correlated
3 MER11A 47 **** 28.9 Weakly correlated
4 L2c 35 ** 99.0 Highly correlated
5 MIRb 35 * 99.0 Highly correlated
6 L2a 31 n.s 99.0 Highly correlated
7 L1MEg 25 **** 99.0 Highly correlated
8 L2b 24 ** 99.0 Highly correlated
9 AluJr 20 n.s 74.0 Weakly correlated
10 L1M1 20 **** 74.0 Weakly correlated
11 MIR3 20 **** 99.0 Highly correlated
12 MIRc 20 ** 99.0 Highly correlated
13 MIR 18 n.s 99.0 Highly correlated
14 L2 17 n.s 99.0 Highly correlated
15 AluSx 15 n.s 74.0 Weakly correlated
16 AluSz 15 n.s 74.0 Weakly correlated
17 AluJo 14 n.s 74.0 Weakly correlated
18 L1MB7 12 n.s 99.0 Highly correlated
19 HAL1 11 * 99.0 Highly correlated
20 L1MA2 11 * 74.0 Weakly correlated
21 AluSp 10 n.s 74.0 Weakly correlated
22 L1MC4 10 n.s 99.0 Highly correlated
23 L1MC5a 10 ** 99.0 Highly correlated
24 MLT1K 10 *** 99.0 Highly correlated
25 MLT1L 10 **** 99.0 Highly correlated
26 MSTA 10 * 43.0 Weakly correlated
27 THE1D 10 *** 43.0 Weakly correlated
28 AluJb 9 n.s 74.0 Weakly correlated
29 L1MA1 9 ** 74.0 Weakly correlated
30 L1MB5 9 ** 99.0 Highly correlated
31 L1ME1 9 n.s 99.0 Highly correlated
32 L1ME3A 9 * 99.0 Highly correlated
33 MLT1A0 9 * 99.0 Highly correlated
34 MLT1J 9 *** 99.0 Highly correlated
35 AluSq2 8 n.s 74.0 Weakly correlated
36 L1M5 8 n.s 99.0 Highly correlated
37 L1ME3B 8 *** 99.0 Highly correlated
38 AluY 7 n.s 74.0 Weakly correlated
39 L1MA3 7 n.s 74.0 Weakly correlated
40 L1ME4b 7 n.s 99.0 Highly correlated
41 L1PA4 7 n.s 19.6 Weakly correlated
42 L1PB3 7 ** 74.0 Weakly correlated
43 L1PREC2 7 n.s 43.0 Weakly correlated
44 MLT1C 7 n.s 94.0 Weakly correlated
45 L1MA9 6 n.s 99.0 Highly correlated
46 L1MB1 6 * 99.0 Highly correlated
47 L1MC5 6 n.s 99.0 Highly correlated
48 L1ME3Cz 6 * 99.0 Highly correlated
49 L1ME3D 6 *** 99.0 Highly correlated
50 MLT1B 6 n.s 99.0 Highly correlated
51 MLT1N2 6 **** 99.0 Highly correlated
52 L1M3 5 * 99.0 Highly correlated
53 L1MA6 5 * 87.0 Weakly correlated
54 L1MB3 5 n.s 99.0 Highly correlated
55 L1ME4a 5 n.s 99.0 Highly correlated
56 L1MEc 5 n.s 99.0 Highly correlated
57 L1MEf 5 n.s 99.0 Highly correlated
58 MamRTE1 5 *** 99.0 Highly correlated
59 AluSc 4 n.s 74.0 Weakly correlated
60 AluSc8 4 n.s 74.0 Weakly correlated
61 AluSx1 4 n.s 74.0 Weakly correlated
62 HAL1ME 4 * 99.0 Highly correlated
63 L1M2 4 n.s 99.0 Highly correlated
64 L1MA4 4 n.s 87.0 Weakly correlated
65 L1MA4A 4 n.s 87.0 Weakly correlated
66 L1MB2 4 n.s 99.0 Highly correlated
67 L1MB8 4 n.s 99.0 Highly correlated
68 L1MD2 4 n.s 99.0 Highly correlated
69 L1ME3C 4 ** 99.0 Highly correlated
70 L1ME3F 4 ** 99.0 Highly correlated
71 L1ME5 4 ** 99.0 Highly correlated
72 L1PA10 4 n.s 74.0 Weakly correlated
73 L1PB1 4 n.s 74.0 Weakly correlated
74 LTR10B1 4 **** 28.9 Weakly correlated
75 LTR81A 4 **** 99.0 Highly correlated
76 MLT1G 4 *** 99.0 Highly correlated
77 THE1B-int 4 n.s 43.0 Weakly correlated
78 THE1C 4 n.s 43.0 Weakly correlated
79 AluJr4 3 n.s 74.0 Weakly correlated
80 AluSg 3 n.s 74.0 Weakly correlated
81 AluSx3 3 n.s 74.0 Weakly correlated
82 AluSz6 3 n.s 74.0 Weakly correlated
83 ERV3-16A3_I-int 3 n.s 99.0 Highly correlated
84 FLAM_A 3 * 74.0 Weakly correlated
85 FLAM_C 3 n.s 74.0 Weakly correlated
86 HAL1M8 3 ** 99.0 Highly correlated
87 HERVI-int 3 **** 28.9 Weakly correlated
88 L1M4 3 n.s 99.0 Highly correlated
89 L1M4c 3 n.s 99.0 Highly correlated
90 L1M8 3 ** 99.0 Highly correlated
91 L1MA10 3 n.s 99.0 Highly correlated
92 L1MB4 3 n.s 99.0 Highly correlated
93 L1MC3 3 n.s 99.0 Highly correlated
94 L1ME3 3 n.s 99.0 Highly correlated
95 L1ME3E 3 * 99.0 Highly correlated
96 L1MEi 3 * 99.0 Highly correlated
97 L1PA16 3 n.s 74.0 Weakly correlated
98 L1PA7 3 n.s 74.0 Weakly correlated
99 LTR12C 3 n.s 19.6 Weakly correlated
100 LTR72 3 **** 74.0 Weakly correlated
101 MER39 3 * 74.0 Weakly correlated
102 MER90a 3 *** 99.0 Highly correlated
103 MLT1F1 3 ** 99.0 Highly correlated
104 MLT1F2 3 n.s 99.0 Highly correlated
105 MLT1G1 3 * 99.0 Highly correlated
106 MLT1I 3 n.s 99.0 Highly correlated
107 MLT1J1 3 ** 99.0 Highly correlated
108 MSTD 3 n.s 74.0 Weakly correlated
109 AluSc5 2 n.s 74.0 Weakly correlated
110 AluSg4 2 n.s 74.0 Weakly correlated
111 HERVIP10FH-int 2 ** 28.9 Weakly correlated
112 HERVK22-int 2 * 43.0 Weakly correlated
113 L1M4b 2 n.s 99.0 Highly correlated
114 L1M7 2 n.s 99.0 Highly correlated
115 L1MA5 2 n.s 87.0 Weakly correlated
116 L1MA7 2 n.s 87.0 Weakly correlated
117 L1MA8 2 n.s 87.0 Weakly correlated
118 L1MC1 2 n.s 99.0 Highly correlated
119 L1MC2 2 n.s 99.0 Highly correlated
120 L1MC4a 2 n.s 99.0 Highly correlated
121 L1MCc 2 n.s 99.0 Highly correlated
122 L1MD1 2 n.s 99.0 Highly correlated
123 L1MDa 2 n.s 99.0 Highly correlated
124 L1PA14 2 n.s 74.0 Weakly correlated
125 L1PA17 2 n.s 74.0 Weakly correlated
126 L1PA6 2 n.s 28.9 Weakly correlated
127 L1PBa 2 n.s 74.0 Weakly correlated
128 L3 2 n.s 99.0 Highly correlated
129 LOR1b 2 ** 74.0 Weakly correlated
130 LTR13 2 ** 19.6 Weakly correlated
131 LTR16A1 2 * 99.0 Highly correlated
132 LTR16B2 2 ** 99.0 Highly correlated
133 LTR16C 2 n.s 99.0 Highly correlated
134 LTR1A2 2 ** 43.0 Weakly correlated
135 LTR33 2 n.s 99.0 Highly correlated
136 LTR36 2 *** 74.0 Weakly correlated
137 LTR67B 2 * 99.0 Highly correlated
138 LTR78 2 n.s 99.0 Highly correlated
139 LTR8B 2 * 43.0 Weakly correlated
140 MER11C 2 * 19.6 Weakly correlated
141 MER4-int 2 n.s 74.0 Weakly correlated
142 MER50-int 2 ** 43.0 Weakly correlated
143 MER52A 2 n.s 74.0 Weakly correlated
144 MER89-int 2 ** 99.0 Highly correlated
145 MIR1_Amn 2 n.s 319.0 Weakly correlated
146 MLT1A 2 n.s 99.0 Highly correlated
147 MLT1D 2 n.s 99.0 Highly correlated
148 MLT1E2 2 n.s 99.0 Highly correlated
149 MLT1F 2 n.s 99.0 Highly correlated
150 MLT1H 2 n.s 99.0 Highly correlated
151 MLT1J2 2 n.s 99.0 Highly correlated
152 MLT2B2 2 * 99.0 Highly correlated
153 MLT2F 2 * 99.0 Highly correlated
154 MSTB-int 2 * 43.0 Weakly correlated
155 THE1A-int 2 n.s 43.0 Weakly correlated
156 THE1D-int 2 n.s 28.9 Weakly correlated
157 Alu 1 * 74.0 Weakly correlated
158 AluSq 1 n.s 74.0 Weakly correlated
159 AluYa5 1 n.s 15.2 Weakly correlated
160 AluYc 1 n.s 74.0 Weakly correlated
161 AluYg6 1 ** 15.2 Weakly correlated
162 AluYj4 1 n.s 0.0 Weakly correlated
163 ERVL-E-int 1 n.s 99.0 Highly correlated
164 HERV9N-int 1 * 19.6 Weakly correlated
165 HERVH-int 1 n.s 28.9 Weakly correlated
166 HUERS-P3-int 1 n.s 43.0 Weakly correlated
167 L1M3b 1 * 99.0 Highly correlated
168 L1M3c 1 n.s 99.0 Highly correlated
169 L1M4a2 1 n.s 99.0 Highly correlated
170 L1MA5A 1 n.s 87.0 Weakly correlated
171 L1MC 1 n.s 99.0 Highly correlated
172 L1MD 1 n.s 99.0 Highly correlated
173 L1MDb 1 n.s 99.0 Highly correlated
174 L1ME2 1 n.s 99.0 Highly correlated
175 L1ME2z 1 n.s 99.0 Highly correlated
176 L1ME3G 1 n.s 99.0 Highly correlated
177 L1MEb 1 n.s 99.0 Highly correlated
178 L1P1 1 n.s 19.6 Weakly correlated
179 L1PA12 1 n.s 74.0 Weakly correlated
180 L1PA13 1 n.s 74.0 Weakly correlated
181 L1PA2 1 n.s 15.2 Weakly correlated
182 L1PA5 1 n.s 19.6 Weakly correlated
183 L1PA8 1 n.s 74.0 Weakly correlated
184 L3b 1 n.s 99.0 Highly correlated
185 L4_C_Mam 1 n.s 99.0 Highly correlated
186 LOR1a 1 * 74.0 Weakly correlated
187 LTR101_Mam 1 * 99.0 Highly correlated
188 LTR104_Mam 1 * 99.0 Highly correlated
189 LTR106_Mam 1 ** 99.0 Highly correlated
190 LTR10B 1 *** 28.9 Weakly correlated
191 LTR16 1 n.s 99.0 Highly correlated
192 LTR16A 1 n.s 99.0 Highly correlated
193 LTR16B1 1 * 99.0 Highly correlated
194 LTR16D2 1 ** 99.0 Highly correlated
195 LTR16E2 1 n.s 99.0 Highly correlated
196 LTR18A 1 ** 43.0 Weakly correlated
197 LTR26C 1 ** 0.0 Weakly correlated
198 LTR37A 1 * 99.0 Highly correlated
199 LTR40a 1 n.s 99.0 Highly correlated
200 LTR40c 1 * 99.0 Highly correlated
201 LTR41 1 * 99.0 Highly correlated
202 LTR42 1 ** 74.0 Weakly correlated
203 LTR79 1 n.s 99.0 Highly correlated
204 LTR82A 1 * 99.0 Highly correlated
205 LTR85b 1 * 99.0 Highly correlated
206 LTR9A1 1 * 43.0 Weakly correlated
207 MER11B 1 * 19.6 Weakly correlated
208 MER21A 1 n.s 74.0 Weakly correlated
209 MER31A 1 * 87.0 Weakly correlated
210 MER39B 1 n.s 74.0 Weakly correlated
211 MER4A1 1 n.s 74.0 Weakly correlated
212 MER4B 1 n.s 74.0 Weakly correlated
213 MER50 1 n.s 43.0 Weakly correlated
214 MER52-int 1 n.s 99.0 Highly correlated
215 MER52C 1 * 74.0 Weakly correlated
216 MER54A 1 * 87.0 Weakly correlated
217 MER57A1 1 * 43.0 Weakly correlated
218 MER61A 1 * 43.0 Weakly correlated
219 MER61B 1 ** 43.0 Weakly correlated
220 MER67C 1 n.s 99.0 Highly correlated
221 MER68 1 n.s 99.0 Highly correlated
222 MER83 1 ** 43.0 Weakly correlated
223 MLT1A1 1 n.s 87.0 Weakly correlated
224 MLT1H1 1 n.s 99.0 Highly correlated
225 MLT1H2 1 n.s 99.0 Highly correlated
226 MLT1H2-int 1 ** 99.0 Highly correlated
227 MLT1J-int 1 * 99.0 Highly correlated
228 MLT1M 1 * 99.0 Highly correlated
229 MLT2A2 1 n.s 74.0 Weakly correlated
230 MLT2B4 1 n.s 99.0 Highly correlated
231 MLT2D 1 n.s 99.0 Highly correlated
232 MSTA-int 1 n.s 43.0 Weakly correlated
233 MSTA1 1 ** 74.0 Weakly correlated
234 MSTB 1 n.s 43.0 Weakly correlated
235 MSTB1 1 n.s 74.0 Weakly correlated
236 MSTB2 1 n.s 74.0 Weakly correlated
237 MamGypsy2-I 1 n.s 99.0 Highly correlated
238 MamSINE1 1 n.s 99.0 Highly correlated
239 Plat_L3 1 n.s 99.0 Highly correlated
240 THE1B 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEd 169 **** 99.0 Highly correlated
2 L1MEg 15 **** 99.0 Highly correlated
3 L2c 6 n.s 99.0 Highly correlated
4 THE1D 5 n.s 43.0 Weakly correlated
5 L2a 5 n.s 99.0 Highly correlated
6 L1ME3A 4 n.s 99.0 Highly correlated
7 L1ME3Cz 4 n.s 99.0 Highly correlated
8 MLT1J 4 n.s 99.0 Highly correlated
9 MSTA 4 n.s 43.0 Weakly correlated
10 MIRb 4 n.s 99.0 Highly correlated
11 MIR 3 n.s 99.0 Highly correlated
12 L1ME3D 3 * 99.0 Highly correlated
13 L1MC4 3 n.s 99.0 Highly correlated
14 L1ME3B 3 n.s 99.0 Highly correlated
15 L2b 3 n.s 99.0 Highly correlated
16 L1ME1 3 n.s 99.0 Highly correlated
17 L1MC5 2 n.s 99.0 Highly correlated
18 L1MB7 2 n.s 99.0 Highly correlated
19 MIRc 2 n.s 99.0 Highly correlated
20 L1ME3C 2 n.s 99.0 Highly correlated
21 L1ME3F 2 n.s 99.0 Highly correlated
22 L1PA4 2 n.s 19.6 Weakly correlated
23 THE1B-int 2 n.s 43.0 Weakly correlated
24 MER11A 2 * 28.9 Weakly correlated
25 L1M1 2 n.s 74.0 Weakly correlated
26 L1MB3 2 n.s 99.0 Highly correlated
27 MLT1L 2 n.s 99.0 Highly correlated
28 MER89 2 ** 99.0 Highly correlated
29 L1ME5 2 * 99.0 Highly correlated
30 L1MC5a 2 n.s 99.0 Highly correlated
31 L1MB5 2 n.s 99.0 Highly correlated
32 L1M4c 1 n.s 99.0 Highly correlated
33 MLT1G1 1 n.s 99.0 Highly correlated
34 L1M4b 1 n.s 99.0 Highly correlated
35 L1M3 1 n.s 99.0 Highly correlated
36 HERVI-int 1 ** 28.9 Weakly correlated
37 AluJb 1 n.s 74.0 Weakly correlated
38 Plat_L3 1 n.s 99.0 Highly correlated
39 MSTB-int 1 n.s 43.0 Weakly correlated
40 MSTA1 1 ** 74.0 Weakly correlated
41 MLT1N2 1 n.s 99.0 Highly correlated
42 MLT1K 1 n.s 99.0 Highly correlated
43 MLT1H 1 n.s 99.0 Highly correlated
44 MLT1E2 1 n.s 99.0 Highly correlated
45 MER4B 1 n.s 74.0 Weakly correlated
46 MER90a 1 * 99.0 Highly correlated
47 LTR106_Mam 1 ** 99.0 Highly correlated
48 MLT1H2 1 n.s 99.0 Highly correlated
49 AluJr 1 n.s 74.0 Weakly correlated
50 ERV3-16A3_I-int 1 n.s 99.0 Highly correlated
51 ERVL-E-int 1 n.s 99.0 Highly correlated
52 L1MA9 1 n.s 99.0 Highly correlated
53 L1P1 1 n.s 19.6 Weakly correlated
54 L1PBa 1 n.s 74.0 Weakly correlated
55 LTR16D2 1 ** 99.0 Highly correlated
56 L1PB3 1 n.s 74.0 Weakly correlated
57 HERV9N-int 1 * 19.6 Weakly correlated
58 THE1A-int 1 n.s 43.0 Weakly correlated
59 THE1C 1 n.s 43.0 Weakly correlated
60 L1MA2 1 n.s 74.0 Weakly correlated
61 LTR78 1 n.s 99.0 Highly correlated
62 L1MEi 1 n.s 99.0 Highly correlated
63 L1MA1 1 n.s 74.0 Weakly correlated
64 L1MB1 1 n.s 99.0 Highly correlated
65 L1MD2 1 n.s 99.0 Highly correlated
66 L1MDb 1 n.s 99.0 Highly correlated
67 MER68 1 n.s 99.0 Highly correlated
68 MLT1B 1 n.s 99.0 Highly correlated
69 MLT1J2 1 n.s 99.0 Highly correlated
70 L1MA6 1 n.s 87.0 Weakly correlated
71 L1MB2 1 n.s 99.0 Highly correlated
72 L1MC 1 n.s 99.0 Highly correlated
73 L1ME4b 1 n.s 99.0 Highly correlated
74 LTR79 1 n.s 99.0 Highly correlated
75 L1M8 1 n.s 99.0 Highly correlated
76 LOR1a 1 * 74.0 Weakly correlated
77 HERVH-int 1 n.s 28.9 Weakly correlated
78 MamRTE1 1 n.s 99.0 Highly correlated
79 LTR81A 1 * 99.0 Highly correlated
80 LTR12C 1 n.s 19.6 Weakly correlated
81 L1ME4a 1 n.s 99.0 Highly correlated
82 L1ME3 1 n.s 99.0 Highly correlated
83 HERVIP10FH-int 1 * 28.9 Weakly correlated
84 L1ME3E 1 n.s 99.0 Highly correlated
85 THE1B 1 n.s 43.0 Weakly correlated
86 L1PB1 1 n.s 74.0 Weakly correlated
87 MLT1A0 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1MED 99.0 Highly correlated
2 L1MEG 99.0 Highly correlated