ZRdb KZFP & Repeats
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Human_ZNF398

  • Protein
    Zinc finger protein 398
  • Length
    642
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    160.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q8TD17
  • NCBI_ID
    57541
Sequence:
MAEAAPAPTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEGKWAVLGTLLQEYGLLQRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLISMDYAINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEEPGISTSDILSWIKQEEEPQVGAPPESKESDVYKSTYADEELVIKAEGLARSSLCPEVPVPFSSPPAAAKDAFSDVAFKSQQSTSMTPFGRPATDLPEASEGQVTFTQLGSYPLPPPVGEQVFSCHHCGKNLSQDMLLTHQCSHATEHPLPCAQCPKHFTPQADLSSTSQDHASETPPTCPHCARTFTHPSRLTYHLRVHNSTERPFPCPDCPKRFADQARLTSHRRAHASERPFRCAQCGRSFSLKISLLLHQRGHAQERPFSCPQCGIDFNGHSALIRHQMIHTGERPYPCTDCSKSFMRKEHLLNHRRLHTGERPFSCPHCGKSFIRKHHLMKHQRIHTGERPYPCSYCGRSFRYKQTLKDHLRSGHNGGCGGDSDPSGQPPNPPGPLITGLETSGLGVNTEGLETNQWYGEGSGGGVL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 143..214
2 C2h2 343..364
3 dec2h2 370..392
4 C2h2 398..420
5 C2h2 427..449
6 C2h2 455..477
7 C2h2 483..505
8 C2h2 511..533
9 C2h2 539..561
10 C2h2 567..590
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process positive regulation of DNA-templated transcription
8 Biological Process regulation of DNA-templated transcription
9 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA5 5 n.s 19.6 Weakly correlated
2 LTR10A 3 **** 28.9 Weakly correlated
3 L2b 3 n.s 99.0 Highly correlated
4 HAL1 2 n.s 99.0 Highly correlated
5 AluSx 2 n.s 74.0 Weakly correlated
6 L1PA2 1 n.s 15.2 Weakly correlated
7 MLT1F1 1 * 99.0 Highly correlated
8 MIR 1 n.s 99.0 Highly correlated
9 MER39B 1 ** 74.0 Weakly correlated
10 L2c 1 n.s 99.0 Highly correlated
11 L2 1 n.s 99.0 Highly correlated
12 L1P1 1 n.s 19.6 Weakly correlated
13 L1ME4b 1 n.s 99.0 Highly correlated
14 L1MDa 1 n.s 99.0 Highly correlated
15 L1MA9 1 n.s 99.0 Highly correlated
16 L1M4 1 n.s 99.0 Highly correlated
17 AluYh9 1 **** 15.2 Weakly correlated
18 AluSz 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MA9 1 n.s 99.0 Highly correlated
2 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP