ZRdb KZFP & Repeats
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Human_ZNF37A

  • Protein
    Zinc finger protein 37A
  • Length
    561
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P17032
  • NCBI_ID
    7587
Sequence:
MITSQGSVSFRDVTVGFTQEEWQHLDPAQRTLYRDVMLENYSHLVSVGYCIPKPEVILKLEKGEEPWILEEKFPSQSHLELINTSRNYSIMKFNEFNKGGKCFCDEKHEIIHSEEEPSEYNKNGNSFWLNEDLIWHQKIKNWEQSFEYNECGKAFPENSLFLVHKRGYTGQKTCKYTEHGKTCDMSFFITHQQTHPRENHYGNECGENIFEESILLEHQSVYPFSQKLNLTPIQRTHSINNIIEYNECGTFFSEKLVLHLQQRTHTGEKPYECHECGKTFTQKSAHTRHQRTHTGGKPYECHECGKTFYKNSDLIKHQRIHTGERPYGCHECGKSFSEKSTLTQHQRTHTGEKPYECHECGKTFSFKSVLTVHQKTHTGEKPYECYACGKAFLRKSDLIKHQRIHTGEKPYECNECGKSFSEKSTLTKHLRTHTGEKPYECIQCGKFFCYYSGFTEHLRRHTGEKPFGCNECGKTFRQKSALIVHQRTHIRQKPYGCNQCGKSFCVKSKLIAHHRTHTGEKPYECNVCGKSFYVKSKLTVHQRIHLGRNPINVVNEGNYSG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 dec2h2 146..168
3 dec2h2 243..265
4 C2h2 271..293
5 C2h2 299..321
6 C2h2 327..349
7 C2h2 355..377
8 C2h2 383..405
9 C2h2 411..433
10 C2h2 439..461
11 C2h2 467..489
12 C2h2 495..517
13 C2h2 523..545
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of DNA-templated transcription
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR16C 230 **** 99.0 Highly correlated
2 LTR33 6 **** 99.0 Highly correlated
3 LTR10A 4 **** 28.9 Weakly correlated
4 AluSx1 3 n.s 74.0 Weakly correlated
5 THE1B 2 n.s 43.0 Weakly correlated
6 LTR76 2 **** 74.0 Weakly correlated
7 LTR16A2 2 **** 99.0 Highly correlated
8 LTR12E 2 **** 19.6 Weakly correlated
9 MLT1C 2 n.s 94.0 Weakly correlated
10 L2 2 n.s 99.0 Highly correlated
11 MLT1F1 2 *** 99.0 Highly correlated
12 AluSp 2 n.s 74.0 Weakly correlated
13 AluSc8 2 n.s 74.0 Weakly correlated
14 AluJr 2 n.s 74.0 Weakly correlated
15 MIRb 1 n.s 99.0 Highly correlated
16 MER50 1 * 43.0 Weakly correlated
17 MER50-int 1 ** 43.0 Weakly correlated
18 MER51A 1 ** 43.0 Weakly correlated
19 MER66B 1 ** 43.0 Weakly correlated
20 LTR52 1 ** 99.0 Highly correlated
21 MER88 1 **** 99.0 Highly correlated
22 MER90 1 *** 99.0 Highly correlated
23 MIR3 1 n.s 99.0 Highly correlated
24 MLT1H2 1 * 99.0 Highly correlated
25 MIRc 1 n.s 99.0 Highly correlated
26 MSTA 1 n.s 43.0 Weakly correlated
27 MLT2F 1 ** 99.0 Highly correlated
28 MLT1B 1 n.s 99.0 Highly correlated
29 MLT2A2 1 * 74.0 Weakly correlated
30 MLT1L 1 n.s 99.0 Highly correlated
31 LTR16A 1 * 99.0 Highly correlated
32 AluJo 1 n.s 74.0 Weakly correlated
33 AluSx 1 n.s 74.0 Weakly correlated
34 AluYj4 1 ** 0.0 Weakly correlated
35 HERV3-int 1 ** 28.9 Weakly correlated
36 L1P1 1 n.s 19.6 Weakly correlated
37 L1PA13 1 n.s 74.0 Weakly correlated
38 L1PA2 1 n.s 15.2 Weakly correlated
39 L2a 1 n.s 99.0 Highly correlated
40 L2b 1 n.s 99.0 Highly correlated
41 MER41A 1 * 74.0 Weakly correlated
42 LTR16E1 1 ** 99.0 Highly correlated
43 LTR4 1 **** 28.9 Weakly correlated
44 LTR41C 1 *** 99.0 Highly correlated
45 AluJb 1 n.s 74.0 Weakly correlated
46 LTR78 1 * 99.0 Highly correlated
47 MER11A 1 ** 28.9 Weakly correlated
48 MER34A1 1 *** 99.0 Highly correlated
49 MER39B 1 ** 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR16C 222 **** 99.0 Highly correlated
2 LTR33 4 **** 99.0 Highly correlated
3 LTR16A2 2 **** 99.0 Highly correlated
4 LTR16A 1 * 99.0 Highly correlated
5 LTR78 1 * 99.0 Highly correlated
6 LTR16E1 1 ** 99.0 Highly correlated
7 L2 1 n.s 99.0 Highly correlated
8 LTR4 1 **** 28.9 Weakly correlated
9 MER90 1 *** 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP