ZRdb KZFP & Repeats
...

Human_ZNF354C

  • Protein
    Zinc finger protein 354C
  • Length
    554
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q86Y25
  • NCBI_ID
    30832
Sequence:
MAVDLLSAQEPVTFRDVAVFFSQDEWLHLDSAQRALYREVMLENYSSLVSLGIPFSMPKLIHQLQQGEDPCMVEREVPSDTRLGFKTWLETEALPHRQDIFIEETSQGMVKKESIKDGHWDINFEEAVEFESEIEEEQEKKPLRQMIDSHEKTISEDGNHTSLELGKSLFTNTALVTQQSVPIERIPNMYYTFGKDFKQNFDLMKCFQIYPGGKPHICNECGKSFKQNLHLIEHQRIHTGEKPYKCNECEKTFSHRSSLLSHQRIHTGEKPYKCNECEKAFSNSSTLIKHLRVHTGEKPYRCRECGKAFSQCSTLTVHQRIHTGEKLYKCGECEKAFNCRAKLHRHQRIHTGEKPYKCSECGKGYSQFTSLAEHQRFHTGEQLYTCLECGRTFTRIVTLIEHQRIHTGQKPYQCNECEKAFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKVHTKEKLYKWKEYGKPFICSSSLTQYQRFFKGDKAYEV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 12..83
2 C2h2 216..238
3 C2h2 244..266
4 C2h2 272..294
5 C2h2 300..322
6 C2h2 328..350
7 C2h2 356..378
8 C2h2 384..406
9 C2h2 412..434
10 C2h2 440..462
11 C2h2 468..490
12 C2h2 496..518
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleoplasm
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSx 41 n.s 74.0 Weakly correlated
2 AluSx1 31 n.s 74.0 Weakly correlated
3 AluJb 28 n.s 74.0 Weakly correlated
4 LTR8 23 **** 43.0 Weakly correlated
5 AluSz 19 n.s 74.0 Weakly correlated
6 AluY 19 n.s 74.0 Weakly correlated
7 L2a 19 n.s 99.0 Highly correlated
8 L2c 19 n.s 99.0 Highly correlated
9 L2b 17 n.s 99.0 Highly correlated
10 L1MC4 15 n.s 99.0 Highly correlated
11 AluSg 14 n.s 74.0 Weakly correlated
12 AluSq2 14 n.s 74.0 Weakly correlated
13 MIRb 14 n.s 99.0 Highly correlated
14 MIR 13 n.s 99.0 Highly correlated
15 PRIMA4-int 13 **** 74.0 Weakly correlated
16 AluJo 12 n.s 74.0 Weakly correlated
17 AluSx3 12 n.s 74.0 Weakly correlated
18 AluYj4 10 **** 0.0 Weakly correlated
19 HERVIP10FH-int 9 **** 28.9 Weakly correlated
20 HAL1 8 n.s 99.0 Highly correlated
21 LTR10A 8 **** 28.9 Weakly correlated
22 L2 7 n.s 99.0 Highly correlated
23 AluJr 6 n.s 74.0 Weakly correlated
24 AluSc8 6 n.s 74.0 Weakly correlated
25 AluSp 6 n.s 74.0 Weakly correlated
26 L1ME2z 6 * 99.0 Highly correlated
27 LTR10F 6 **** 28.9 Weakly correlated
28 MER4-int 6 ** 74.0 Weakly correlated
29 MIR3 6 n.s 99.0 Highly correlated
30 AluSc 5 n.s 74.0 Weakly correlated
31 AluSq 5 n.s 74.0 Weakly correlated
32 AluSz6 5 n.s 74.0 Weakly correlated
33 HERV17-int 5 *** 28.9 Weakly correlated
34 L1ME1 5 n.s 99.0 Highly correlated
35 MIRc 5 n.s 99.0 Highly correlated
36 MLT1B 5 n.s 99.0 Highly correlated
37 L1MA8 4 n.s 87.0 Weakly correlated
38 L1MD2 4 n.s 99.0 Highly correlated
39 L1MEd 4 n.s 99.0 Highly correlated
40 L1P1 4 n.s 19.6 Weakly correlated
41 L1PA2 4 n.s 15.2 Weakly correlated
42 L1PA4 4 n.s 19.6 Weakly correlated
43 L1PA5 4 n.s 19.6 Weakly correlated
44 L1M1 3 n.s 74.0 Weakly correlated
45 L1PA3 3 n.s 19.6 Weakly correlated
46 MSTD 3 n.s 74.0 Weakly correlated
47 AluSg7 2 n.s 74.0 Weakly correlated
48 AluYa5 2 n.s 15.2 Weakly correlated
49 AluYa8 2 **** 15.2 Weakly correlated
50 AluYm1 2 n.s 19.6 Weakly correlated
51 HERVH48-int 2 ** 28.9 Weakly correlated
52 L1M3 2 n.s 99.0 Highly correlated
53 L1M4 2 n.s 99.0 Highly correlated
54 L1M4c 2 n.s 99.0 Highly correlated
55 L1MA9 2 n.s 99.0 Highly correlated
56 L1MB1 2 n.s 99.0 Highly correlated
57 L1MB2 2 n.s 99.0 Highly correlated
58 L1MB8 2 n.s 99.0 Highly correlated
59 L1ME3G 2 n.s 99.0 Highly correlated
60 L1ME4b 2 n.s 99.0 Highly correlated
61 L1PA16 2 n.s 74.0 Weakly correlated
62 L1PB4 2 n.s 99.0 Highly correlated
63 LTR13 2 * 19.6 Weakly correlated
64 MER39B 2 * 74.0 Weakly correlated
65 MER50 2 n.s 43.0 Weakly correlated
66 MLT2C2 2 ** 99.0 Highly correlated
67 MSTB1 2 n.s 74.0 Weakly correlated
68 Alu 1 * 74.0 Weakly correlated
69 AluSg4 1 n.s 74.0 Weakly correlated
70 AluSq4 1 n.s 74.0 Weakly correlated
71 AluSx4 1 n.s 74.0 Weakly correlated
72 AluYe5 1 n.s 74.0 Weakly correlated
73 AluYf1 1 n.s 19.6 Weakly correlated
74 AluYh9 1 *** 15.2 Weakly correlated
75 HAL1b 1 n.s 99.0 Highly correlated
76 HERV35I-int 1 n.s 43.0 Weakly correlated
77 HERV9N-int 1 n.s 19.6 Weakly correlated
78 HERVFH21-int 1 * 28.9 Weakly correlated
79 L1HS 1 n.s 8.6 Weakly correlated
80 L1M5 1 n.s 99.0 Highly correlated
81 L1M7 1 n.s 99.0 Highly correlated
82 L1MA4 1 n.s 87.0 Weakly correlated
83 L1MB3 1 n.s 99.0 Highly correlated
84 L1MB4 1 n.s 99.0 Highly correlated
85 L1MB5 1 n.s 99.0 Highly correlated
86 L1MB7 1 n.s 99.0 Highly correlated
87 L1MC 1 n.s 99.0 Highly correlated
88 L1ME3A 1 n.s 99.0 Highly correlated
89 L1ME3B 1 n.s 99.0 Highly correlated
90 L1ME4a 1 n.s 99.0 Highly correlated
91 L1MEc 1 n.s 99.0 Highly correlated
92 L1MEg 1 n.s 99.0 Highly correlated
93 L1MEg2 1 * 99.0 Highly correlated
94 L1P4 1 n.s 74.0 Weakly correlated
95 L1P4a 1 n.s 74.0 Weakly correlated
96 L1PA13 1 n.s 74.0 Weakly correlated
97 L1PB 1 n.s 74.0 Weakly correlated
98 L1PB1 1 n.s 74.0 Weakly correlated
99 L3 1 n.s 99.0 Highly correlated
100 L5 1 * 99.0 Highly correlated
101 LOR1-int 1 n.s 74.0 Weakly correlated
102 LTR13_ 1 ** 28.9 Weakly correlated
103 LTR16A1 1 n.s 99.0 Highly correlated
104 LTR26 1 * 74.0 Weakly correlated
105 LTR41B 1 * 99.0 Highly correlated
106 LTR67B 1 n.s 99.0 Highly correlated
107 LTR84a 1 * 99.0 Highly correlated
108 MER101-int 1 n.s 74.0 Weakly correlated
109 MER110 1 * 99.0 Highly correlated
110 MER4A 1 n.s 74.0 Weakly correlated
111 MER50-int 1 n.s 43.0 Weakly correlated
112 MER51-int 1 n.s 43.0 Weakly correlated
113 MER66B 1 n.s 43.0 Weakly correlated
114 MER67C 1 n.s 99.0 Highly correlated
115 MIR1_Amn 1 n.s 319.0 Weakly correlated
116 MLT1C 1 n.s 94.0 Weakly correlated
117 MLT1F1 1 n.s 99.0 Highly correlated
118 MLT1F2 1 n.s 99.0 Highly correlated
119 MLT1G 1 n.s 99.0 Highly correlated
120 MLT1J1-int 1 * 99.0 Highly correlated
121 MLT1J2 1 n.s 99.0 Highly correlated
122 MLT2B2 1 n.s 99.0 Highly correlated
123 MLT2B4 1 n.s 99.0 Highly correlated
124 MLT2D 1 n.s 99.0 Highly correlated
125 MSTC 1 n.s 74.0 Weakly correlated
126 MamRTE1 1 n.s 99.0 Highly correlated
127 MamRep1151 1 n.s 99.0 Highly correlated
128 THE1C 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 PRIMA4-int 8 **** 74.0 Weakly correlated
2 HERVIP10FH-int 7 **** 28.9 Weakly correlated
3 MER4-int 5 * 74.0 Weakly correlated
4 L1ME2z 4 n.s 99.0 Highly correlated
5 L2a 3 n.s 99.0 Highly correlated
6 L2c 3 n.s 99.0 Highly correlated
7 MLT1B 3 n.s 99.0 Highly correlated
8 AluYj4 2 n.s 0.0 Weakly correlated
9 AluSx 2 n.s 74.0 Weakly correlated
10 L2b 2 n.s 99.0 Highly correlated
11 L1MD2 2 n.s 99.0 Highly correlated
12 MIRc 2 n.s 99.0 Highly correlated
13 MLT2C2 2 ** 99.0 Highly correlated
14 AluSx1 2 n.s 74.0 Weakly correlated
15 HERV35I-int 1 n.s 43.0 Weakly correlated
16 L2 1 n.s 99.0 Highly correlated
17 LTR84a 1 * 99.0 Highly correlated
18 MSTB1 1 n.s 74.0 Weakly correlated
19 L1MEd 1 n.s 99.0 Highly correlated
20 MIRb 1 n.s 99.0 Highly correlated
21 AluSc8 1 n.s 74.0 Weakly correlated
22 AluSc 1 n.s 74.0 Weakly correlated
23 L1ME3G 1 n.s 99.0 Highly correlated
24 HAL1 1 n.s 99.0 Highly correlated
25 MLT2B4 1 n.s 99.0 Highly correlated
26 AluJb 1 n.s 74.0 Weakly correlated
27 L1MC4 1 n.s 99.0 Highly correlated
28 MSTC 1 n.s 74.0 Weakly correlated
29 L1ME4b 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 HERVIP10FH-INT 28.9 Weakly correlated