ZRdb KZFP & Repeats
...

Human_ZNF354B

  • Protein
    Zinc finger protein 354B
  • Length
    612
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q96LW1
  • NCBI_ID
    117608
Sequence:
MAAGQREARPQVSLTFEDVAVLFTWDEWRKLAPSQRNLYRDVMLENYRNLVSLGLSFTKPKVISLLQQGEDPWEVEKDSSGVSSLGCKSTPKMTKSTQTQDSFQEQIRKRLKRDEPWNFISERSCIYEEKLKKQQDKNENLQIISVAHTKILTVDRSHKNVEFGQNFYLKSVFIKQQRFAKEKTPSKCEIQRNSFKQNSNLLNQSKIKTAEKRYKCSTCEKAFIHNSSLRKHQKNHTGEKLFKCKECLKAFSQSSALIQHQRTHTGEKPYICKECGKAFSHSASLCKHLRTHTVEKCYRCKECGKSFSRRSGLFIHQKIHAQENPHKYNPGRKASSYSTSLSGSQKIHLRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECDKTFRCNSSLSNHQRIHTGEKPYRCLECGMSFGQSAALIQHQRIHTGEKPFKCNTCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDSLKADLHV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 14..85
2 C2h2 214..236
3 C2h2 242..264
4 C2h2 270..292
5 C2h2 298..320
6 C2h2 354..376
7 C2h2 382..404
8 C2h2 410..432
9 C2h2 438..460
10 C2h2 466..488
11 C2h2 494..516
12 C2h2 522..544
13 C2h2 550..572
14 C2h2 578..600
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function chromatin binding
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 4 **** 74.0 Weakly correlated
2 LTR10A 3 **** 28.9 Weakly correlated
3 AluSx1 2 n.s 74.0 Weakly correlated
4 MIRb 2 n.s 99.0 Highly correlated
5 L1PA5 2 n.s 19.6 Weakly correlated
6 L1PA4 2 n.s 19.6 Weakly correlated
7 L1ME1 2 n.s 99.0 Highly correlated
8 L1M4b 2 ** 99.0 Highly correlated
9 L1M4 2 * 99.0 Highly correlated
10 AluSc8 1 n.s 74.0 Weakly correlated
11 L1M4a2 1 ** 99.0 Highly correlated
12 MIR 1 n.s 99.0 Highly correlated
13 MER50 1 ** 43.0 Weakly correlated
14 MER39B 1 *** 74.0 Weakly correlated
15 LTR49 1 *** 74.0 Weakly correlated
16 LTR13 1 *** 19.6 Weakly correlated
17 AluSx4 1 * 74.0 Weakly correlated
18 L3 1 n.s 99.0 Highly correlated
19 FLAM_C 1 * 74.0 Weakly correlated
20 L1M1 1 n.s 74.0 Weakly correlated
21 L1PA2 1 n.s 15.2 Weakly correlated
22 L1P4 1 ** 74.0 Weakly correlated
23 L1P1 1 * 19.6 Weakly correlated
24 L1MEd 1 n.s 99.0 Highly correlated
25 L1MEc 1 n.s 99.0 Highly correlated
26 L1ME3Cz 1 * 99.0 Highly correlated
27 L1ME3B 1 * 99.0 Highly correlated
28 L1ME3 1 * 99.0 Highly correlated
29 L1ME2 1 n.s 99.0 Highly correlated
30 L1M4a1 1 ** 99.0 Highly correlated
31 L1MB4 1 * 99.0 Highly correlated
32 L1MA9 1 n.s 99.0 Highly correlated
33 L1MA4 1 n.s 87.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 2 ** 74.0 Weakly correlated
2 L1MB4 1 * 99.0 Highly correlated
3 L1M4a1 1 ** 99.0 Highly correlated
4 L1ME2 1 n.s 99.0 Highly correlated
5 L1ME3 1 * 99.0 Highly correlated
6 L1M4b 1 * 99.0 Highly correlated
7 L1MEd 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP