ZRdb KZFP & Repeats
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Human_ZNF354A

  • Protein
    Zinc finger protein 354A
  • Length
    605
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    O60765
  • NCBI_ID
    6940
Sequence:
MAAGQREARPQVSLTFEDVAVLFTRDEWRKLAPSQRNLYRDVMLENYRNLVSLGLPFTKPKVISLLQQGEDPWEVEKDGSGVSSLGSKSSHKTTKSTQTQDSSFQGLILKRSNRNVPWDLKLEKPYIYEGRLEKKQDKKGSFQIVSATHKKIPTIERSHKNTELSQNFSPKSVLIRQQILPREKTPPKCEIQGNSLKQNSQLLNQPKITADKRYKCSLCEKTFINTSSLRKHEKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYICKECGKAFTLSTSLYKHLRTHTVEKSYRCKECGKSFSRRSGLFIHQKIHAEENPCKYNPGRKASSCSTSLSGCQRIHSRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYRCEECGISFGQSSALIQHRRIHTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKLFNHRSSLTNHYKIHIEEDP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..85
2 C2h2 214..236
3 C2h2 242..264
4 C2h2 270..292
5 C2h2 298..320
6 C2h2 354..376
7 C2h2 382..404
8 C2h2 410..432
9 C2h2 438..460
10 C2h2 464..488
11 C2h2 494..516
12 C2h2 522..544
13 C2h2 550..572
14 C2h2 578..600
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component cytosol
2 Cellular Component nucleolus
3 Cellular Component nucleoplasm
4 Cellular Component nucleus
5 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
6 Molecular Function metal ion binding
7 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
8 Biological Process regulation of transcription by RNA polymerase II
9 Biological Process sensory perception of sound
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEc 186 **** 99.0 Highly correlated
2 L1MEf 107 **** 99.0 Highly correlated
3 L1MDa 78 **** 99.0 Highly correlated
4 L1ME1 52 **** 99.0 Highly correlated
5 L1M4 47 **** 99.0 Highly correlated
6 L1MEd 47 **** 99.0 Highly correlated
7 L1MD1 34 **** 99.0 Highly correlated
8 L1MB7 31 **** 99.0 Highly correlated
9 AluSx 27 n.s 74.0 Weakly correlated
10 L1MEg 27 **** 99.0 Highly correlated
11 AluJb 24 n.s 74.0 Weakly correlated
12 L1PA4 24 *** 19.6 Weakly correlated
13 AluSx1 22 n.s 74.0 Weakly correlated
14 AluJr 21 * 74.0 Weakly correlated
15 L1PA5 21 *** 19.6 Weakly correlated
16 L1MD2 19 **** 99.0 Highly correlated
17 AluJo 18 * 74.0 Weakly correlated
18 L1M4a1 17 **** 99.0 Highly correlated
19 L1MA2 17 **** 74.0 Weakly correlated
20 L1ME2 17 **** 99.0 Highly correlated
21 L1MEi 17 **** 99.0 Highly correlated
22 AluY 16 n.s 74.0 Weakly correlated
23 L1M1 16 **** 74.0 Weakly correlated
24 AluSz 15 n.s 74.0 Weakly correlated
25 L1M4c 14 **** 99.0 Highly correlated
26 L1PA7 14 n.s 74.0 Weakly correlated
27 L1M4a2 13 **** 99.0 Highly correlated
28 L1MB3 13 *** 99.0 Highly correlated
29 AluSz6 12 n.s 74.0 Weakly correlated
30 L1MEh 12 **** 99.0 Highly correlated
31 L2c 12 n.s 99.0 Highly correlated
32 L1M5 11 n.s 99.0 Highly correlated
33 L1MB8 11 ** 99.0 Highly correlated
34 AluSp 10 n.s 74.0 Weakly correlated
35 L1MA3 10 * 74.0 Weakly correlated
36 L1PA2 10 * 15.2 Weakly correlated
37 L2a 10 n.s 99.0 Highly correlated
38 L1MA4 9 ** 87.0 Weakly correlated
39 L1MA9 9 * 99.0 Highly correlated
40 L1ME2z 9 **** 99.0 Highly correlated
41 L1ME3B 9 **** 99.0 Highly correlated
42 MIRb 8 n.s 99.0 Highly correlated
43 AluSq2 7 n.s 74.0 Weakly correlated
44 L1MB1 7 ** 99.0 Highly correlated
45 L1MD 7 *** 99.0 Highly correlated
46 L1MD3 7 **** 99.0 Highly correlated
47 L1P3 7 *** 74.0 Weakly correlated
48 L1PA3 7 n.s 19.6 Weakly correlated
49 L1PBa 7 *** 74.0 Weakly correlated
50 AluSc8 6 n.s 74.0 Weakly correlated
51 AluSx3 6 n.s 74.0 Weakly correlated
52 L1MA1 6 * 74.0 Weakly correlated
53 L1ME3 6 ** 99.0 Highly correlated
54 L1ME3A 6 n.s 99.0 Highly correlated
55 L1P2 6 *** 28.9 Weakly correlated
56 L1PA6 6 n.s 28.9 Weakly correlated
57 L1PA8 6 n.s 74.0 Weakly correlated
58 AluSc 5 n.s 74.0 Weakly correlated
59 FLAM_C 5 * 74.0 Weakly correlated
60 L1M4b 5 ** 99.0 Highly correlated
61 L1MB4 5 * 99.0 Highly correlated
62 L1MB5 5 * 99.0 Highly correlated
63 L1MCc 5 *** 99.0 Highly correlated
64 L1ME3F 5 *** 99.0 Highly correlated
65 L1MEj 5 **** 99.0 Highly correlated
66 L1PB1 5 n.s 74.0 Weakly correlated
67 MER21C 5 ** 99.0 Highly correlated
68 MIR 5 n.s 99.0 Highly correlated
69 AluJr4 4 n.s 74.0 Weakly correlated
70 AluSg 4 n.s 74.0 Weakly correlated
71 HAL1 4 n.s 99.0 Highly correlated
72 L1MA7 4 n.s 87.0 Weakly correlated
73 L1MC1 4 n.s 99.0 Highly correlated
74 L1MC4 4 n.s 99.0 Highly correlated
75 L1MCa 4 n.s 99.0 Highly correlated
76 L1ME3Cz 4 n.s 99.0 Highly correlated
77 L1ME3G 4 n.s 99.0 Highly correlated
78 L2 4 n.s 99.0 Highly correlated
79 L2b 4 n.s 99.0 Highly correlated
80 AluSg7 3 n.s 74.0 Weakly correlated
81 AluYh3 3 *** 15.2 Weakly correlated
82 AluYj4 3 ** 0.0 Weakly correlated
83 FLAM_A 3 * 74.0 Weakly correlated
84 L1M3 3 n.s 99.0 Highly correlated
85 L1MA6 3 n.s 87.0 Weakly correlated
86 L1MA8 3 n.s 87.0 Weakly correlated
87 L1MB2 3 n.s 99.0 Highly correlated
88 L1MC3 3 n.s 99.0 Highly correlated
89 L1MC5a 3 n.s 99.0 Highly correlated
90 L1ME3D 3 * 99.0 Highly correlated
91 L1P1 3 n.s 19.6 Weakly correlated
92 L1P4 3 * 74.0 Weakly correlated
93 L1PA10 3 n.s 74.0 Weakly correlated
94 L1PA16 3 n.s 74.0 Weakly correlated
95 L1PREC2 3 n.s 43.0 Weakly correlated
96 LTR10A 3 **** 28.9 Weakly correlated
97 MLT1B 3 n.s 99.0 Highly correlated
98 Alu 2 *** 74.0 Weakly correlated
99 AluYm1 2 n.s 19.6 Weakly correlated
100 FRAM 2 * 74.0 Weakly correlated
101 HERVIP10F-int 2 ** 28.9 Weakly correlated
102 HERVK-int 2 ** 28.9 Weakly correlated
103 L1M2 2 n.s 99.0 Highly correlated
104 L1M3c 2 ** 99.0 Highly correlated
105 L1M3f 2 ** 87.0 Weakly correlated
106 L1M6 2 n.s 99.0 Highly correlated
107 L1MC 2 n.s 99.0 Highly correlated
108 L1MCb 2 * 99.0 Highly correlated
109 L1ME4a 2 n.s 99.0 Highly correlated
110 L1ME4b 2 n.s 99.0 Highly correlated
111 L1MEb 2 ** 99.0 Highly correlated
112 L1PA15 2 n.s 74.0 Weakly correlated
113 L3 2 n.s 99.0 Highly correlated
114 LTR13 2 ** 19.6 Weakly correlated
115 LTR19B 2 **** 43.0 Weakly correlated
116 MER41E 2 **** 74.0 Weakly correlated
117 MER50 2 * 43.0 Weakly correlated
118 MER50-int 2 ** 43.0 Weakly correlated
119 MLT1F 2 n.s 99.0 Highly correlated
120 MLT1F1 2 * 99.0 Highly correlated
121 AluSq 1 n.s 74.0 Weakly correlated
122 AluSx4 1 n.s 74.0 Weakly correlated
123 AluYa5 1 n.s 15.2 Weakly correlated
124 AluYd8 1 *** 15.2 Weakly correlated
125 AluYe5 1 * 74.0 Weakly correlated
126 AluYf1 1 n.s 19.6 Weakly correlated
127 AluYh3a3 1 ** 15.2 Weakly correlated
128 AluYh9 1 **** 15.2 Weakly correlated
129 HERVI-int 1 ** 28.9 Weakly correlated
130 L1M7 1 n.s 99.0 Highly correlated
131 L1MA10 1 n.s 99.0 Highly correlated
132 L1MA4A 1 n.s 87.0 Weakly correlated
133 L1MA5A 1 n.s 87.0 Weakly correlated
134 L1MC2 1 n.s 99.0 Highly correlated
135 L1MC4a 1 n.s 99.0 Highly correlated
136 L1MDb 1 * 99.0 Highly correlated
137 L1ME3C 1 n.s 99.0 Highly correlated
138 L1ME3E 1 n.s 99.0 Highly correlated
139 L1PA13 1 n.s 74.0 Weakly correlated
140 L1PA14 1 n.s 74.0 Weakly correlated
141 L1PA17 1 n.s 74.0 Weakly correlated
142 L1PA8A 1 n.s 74.0 Weakly correlated
143 L1PB4 1 n.s 99.0 Highly correlated
144 L1PBa1 1 n.s 74.0 Weakly correlated
145 LTR16 1 n.s 99.0 Highly correlated
146 LTR16B 1 ** 99.0 Highly correlated
147 LTR41 1 * 99.0 Highly correlated
148 LTR41B 1 * 99.0 Highly correlated
149 LTR49 1 * 74.0 Weakly correlated
150 LTR49-int 1 n.s 74.0 Weakly correlated
151 LTR54 1 * 74.0 Weakly correlated
152 LTR55 1 ** 99.0 Highly correlated
153 LTR79 1 n.s 99.0 Highly correlated
154 LTR8 1 n.s 43.0 Weakly correlated
155 LTR9B 1 * 43.0 Weakly correlated
156 MER4-int 1 n.s 74.0 Weakly correlated
157 MER92B 1 * 99.0 Highly correlated
158 MIR3 1 n.s 99.0 Highly correlated
159 MIRc 1 n.s 99.0 Highly correlated
160 MLT1D 1 n.s 99.0 Highly correlated
161 MLT1F2 1 n.s 99.0 Highly correlated
162 MLT1G 1 n.s 99.0 Highly correlated
163 MLT1J1 1 n.s 99.0 Highly correlated
164 MLT1L 1 n.s 99.0 Highly correlated
165 MLT1O 1 n.s 99.0 Highly correlated
166 MLT2F 1 n.s 99.0 Highly correlated
167 MSTB 1 n.s 43.0 Weakly correlated
168 MamRTE1 1 n.s 99.0 Highly correlated
169 MamSINE1 1 n.s 99.0 Highly correlated
170 SVA_C 1 * 15.2 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEc 132 **** 99.0 Highly correlated
2 L1MEf 68 **** 99.0 Highly correlated
3 L1MDa 49 **** 99.0 Highly correlated
4 L1ME1 37 **** 99.0 Highly correlated
5 L1M4 30 **** 99.0 Highly correlated
6 L1MEd 28 **** 99.0 Highly correlated
7 L1MD1 24 **** 99.0 Highly correlated
8 L1MB7 23 **** 99.0 Highly correlated
9 L1MEg 18 **** 99.0 Highly correlated
10 L1PA4 15 n.s 19.6 Weakly correlated
11 L1MA2 14 **** 74.0 Weakly correlated
12 L1ME2 14 **** 99.0 Highly correlated
13 L1PA7 12 n.s 74.0 Weakly correlated
14 L1M1 12 ** 74.0 Weakly correlated
15 L1PA5 11 n.s 19.6 Weakly correlated
16 L1MEi 11 **** 99.0 Highly correlated
17 L1MD2 10 *** 99.0 Highly correlated
18 L1MB8 10 ** 99.0 Highly correlated
19 L1M4a2 10 **** 99.0 Highly correlated
20 L1M4a1 10 **** 99.0 Highly correlated
21 L1M4c 9 **** 99.0 Highly correlated
22 L1MA3 9 * 74.0 Weakly correlated
23 L1MB3 9 * 99.0 Highly correlated
24 L1ME2z 7 *** 99.0 Highly correlated
25 L1MEh 7 **** 99.0 Highly correlated
26 L1MA4 7 n.s 87.0 Weakly correlated
27 L1PA3 5 n.s 19.6 Weakly correlated
28 L1MB1 5 * 99.0 Highly correlated
29 L1P2 5 ** 28.9 Weakly correlated
30 L1PA2 5 n.s 15.2 Weakly correlated
31 L1PBa 5 ** 74.0 Weakly correlated
32 L1ME3B 5 * 99.0 Highly correlated
33 L1MA1 5 * 74.0 Weakly correlated
34 L1PA8 4 n.s 74.0 Weakly correlated
35 L1MD3 4 ** 99.0 Highly correlated
36 L1PA6 4 n.s 28.9 Weakly correlated
37 L1P3 4 * 74.0 Weakly correlated
38 L1ME3F 4 ** 99.0 Highly correlated
39 L1MA9 4 n.s 99.0 Highly correlated
40 L1ME3A 4 n.s 99.0 Highly correlated
41 L1MEj 3 ** 99.0 Highly correlated
42 L1M5 3 n.s 99.0 Highly correlated
43 L1ME3 3 n.s 99.0 Highly correlated
44 L1MB5 3 n.s 99.0 Highly correlated
45 L1MCc 3 * 99.0 Highly correlated
46 L1MB4 3 n.s 99.0 Highly correlated
47 L1MC1 3 n.s 99.0 Highly correlated
48 L1PB1 3 n.s 74.0 Weakly correlated
49 L2a 3 n.s 99.0 Highly correlated
50 L1PA16 3 n.s 74.0 Weakly correlated
51 L1MA7 3 n.s 87.0 Weakly correlated
52 L1M2 2 n.s 99.0 Highly correlated
53 L1M3c 2 ** 99.0 Highly correlated
54 L1PREC2 2 n.s 43.0 Weakly correlated
55 L1ME3Cz 2 n.s 99.0 Highly correlated
56 L1MCa 2 n.s 99.0 Highly correlated
57 L1PA10 2 n.s 74.0 Weakly correlated
58 L1M4b 2 n.s 99.0 Highly correlated
59 L1MD 2 n.s 99.0 Highly correlated
60 L1ME3G 2 n.s 99.0 Highly correlated
61 L1M6 2 n.s 99.0 Highly correlated
62 L1P1 1 n.s 19.6 Weakly correlated
63 L2b 1 n.s 99.0 Highly correlated
64 L1MB2 1 n.s 99.0 Highly correlated
65 L1MDb 1 * 99.0 Highly correlated
66 L1MC2 1 n.s 99.0 Highly correlated
67 L1MA8 1 n.s 87.0 Weakly correlated
68 L1MA6 1 n.s 87.0 Weakly correlated
69 L1MEb 1 n.s 99.0 Highly correlated
70 L1PA14 1 n.s 74.0 Weakly correlated
71 L1MC5a 1 n.s 99.0 Highly correlated
72 L1ME3E 1 n.s 99.0 Highly correlated
73 L1MC4 1 n.s 99.0 Highly correlated
74 MLT1O 1 n.s 99.0 Highly correlated
75 L1M3f 1 n.s 87.0 Weakly correlated
76 L1ME3D 1 n.s 99.0 Highly correlated
77 L1M7 1 n.s 99.0 Highly correlated
78 MER41E 1 ** 74.0 Weakly correlated
79 L1MC3 1 n.s 99.0 Highly correlated
80 MIRb 1 n.s 99.0 Highly correlated
81 MER50-int 1 * 43.0 Weakly correlated
82 L3 1 n.s 99.0 Highly correlated
83 L1MA10 1 n.s 99.0 Highly correlated
84 L1MC 1 n.s 99.0 Highly correlated
85 L1MCb 1 n.s 99.0 Highly correlated
86 L2c 1 n.s 99.0 Highly correlated
87 L1P4 1 n.s 74.0 Weakly correlated
88 L1MA5A 1 n.s 87.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP