ZRdb KZFP & Repeats
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Human_ZNF343

  • Protein
    Zinc finger protein 343
  • Length
    599
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q6P1L6
  • NCBI_ID
    79175
Sequence:
MMLPYPSALGDQYWEEILLPKNGENVETMKKLTQNHKAKGLPSNDTDCPQKKEGKAQIVVPVTFRDVTVIFTEAEWKRLSPEQRNLYKEVMLENYRNLLSLAEPKPEIYTCSSCLLAFSCQQFLSQHVLQIFLGLCAENHFHPGNSSPGHWKQQGQQYSHVSCWFENAEGQERGGGSKPWSARTEERETSRAFPSPLQRQSASPRKGNMVVETEPSSAQRPNPVQLDKGLKELETLRFGAINCREYEPDHNLESNFITNPRTLLGKKPYICSDCGRSFKDRSTLIRHHRIHSMEKPYVCSECGRGFSQKSNLSRHQRTHSEEKPYLCRECGQSFRSKSILNRHQWTHSEEKPYVCSECGRGFSEKSSFIRHQRTHSGEKPYVCLECGRSFCDKSTLRKHQRIHSGEKPYVCRECGRGFSQNSDLIKHQRTHLDEKPYVCRECGRGFCDKSTLIIHERTHSGEKPYVCGECGRGFSRKSLLLVHQRTHSGEKHYVCRECRRGFSQKSNLIRHQRTHSNEKPYICRECGRGFCDKSTLIVHERTHSGEKPYVCSECGRGFSRKSLLLVHQRTHSGEKHYVCRECGRGFSHKSNLIRHQRTH
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 62..139
2 C2h2 269..291
3 C2h2 297..319
4 C2h2 325..347
5 C2h2 353..375
6 C2h2 381..403
7 C2h2 409..431
8 C2h2 437..459
9 C2h2 465..487
10 C2h2 493..515
11 C2h2 521..543
12 C2h2 549..571
13 C2h2 577..599
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Molecular Function sequence-specific double-stranded DNA binding
7 Biological Process negative regulation of transcription by RNA polymerase II
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 32 n.s 74.0 Highly correlated
2 LTR50 31 **** 99.0 Weakly correlated
3 L2c 23 n.s 99.0 Weakly correlated
4 L1PA2 22 * 15.2 Weakly correlated
5 MIRb 20 n.s 99.0 Weakly correlated
6 L2a 19 n.s 99.0 Weakly correlated
7 L2b 18 n.s 99.0 Weakly correlated
8 L2 15 n.s 99.0 Weakly correlated
9 MIRc 15 n.s 99.0 Weakly correlated
10 AluSx1 13 n.s 74.0 Highly correlated
11 MIR 13 n.s 99.0 Weakly correlated
12 AluSz 12 n.s 74.0 Highly correlated
13 MIR3 12 n.s 99.0 Weakly correlated
14 AluJo 8 n.s 74.0 Highly correlated
15 L1PA3 8 n.s 19.6 Weakly correlated
16 AluJr 7 n.s 74.0 Highly correlated
17 AluSx 7 n.s 74.0 Highly correlated
18 AluY 7 n.s 74.0 Highly correlated
19 LTR12C 7 n.s 19.6 Weakly correlated
20 MSTA 7 n.s 43.0 Weakly correlated
21 AluSz6 6 n.s 74.0 Highly correlated
22 MIR1_Amn 6 ** 319.0 Weakly correlated
23 AluSp 5 n.s 74.0 Highly correlated
24 AluSx3 5 n.s 74.0 Highly correlated
25 L1M4b 5 n.s 99.0 Weakly correlated
26 L1PA5 5 n.s 19.6 Weakly correlated
27 LTR41 5 **** 99.0 Weakly correlated
28 AluSg 4 n.s 74.0 Highly correlated
29 FLAM_A 4 n.s 74.0 Highly correlated
30 L1PA4 4 n.s 19.6 Weakly correlated
31 L3 4 n.s 99.0 Weakly correlated
32 LTR16A 4 * 99.0 Weakly correlated
33 LTR16A1 4 ** 99.0 Weakly correlated
34 MSTB 4 n.s 43.0 Weakly correlated
35 THE1C 4 n.s 43.0 Weakly correlated
36 THE1D 4 n.s 43.0 Weakly correlated
37 AluSc 3 n.s 74.0 Highly correlated
38 AluSq 3 n.s 74.0 Highly correlated
39 FLAM_C 3 n.s 74.0 Highly correlated
40 HAL1 3 n.s 99.0 Weakly correlated
41 L1P3 3 n.s 74.0 Highly correlated
42 LTR10A 3 **** 28.9 Weakly correlated
43 LTR1A2 3 * 43.0 Weakly correlated
44 MLT1C 3 n.s 94.0 Weakly correlated
45 MLT1G 3 * 99.0 Weakly correlated
46 MLT1J 3 n.s 99.0 Weakly correlated
47 AluSc8 2 n.s 74.0 Highly correlated
48 AluSg7 2 n.s 74.0 Highly correlated
49 AluSq2 2 n.s 74.0 Highly correlated
50 AluYa5 2 n.s 15.2 Weakly correlated
51 AluYb8 2 n.s 15.2 Weakly correlated
52 AluYm1 2 n.s 19.6 Weakly correlated
53 AmnSINE1 2 ** 319.0 Weakly correlated
54 FRAM 2 n.s 74.0 Highly correlated
55 L1HS 2 n.s 8.6 Weakly correlated
56 L1MA9 2 n.s 99.0 Weakly correlated
57 L1MB7 2 n.s 99.0 Weakly correlated
58 L1MC4 2 n.s 99.0 Weakly correlated
59 L1MD1 2 n.s 99.0 Weakly correlated
60 L1ME4b 2 n.s 99.0 Weakly correlated
61 L1MEf 2 n.s 99.0 Weakly correlated
62 L1P1 2 n.s 19.6 Weakly correlated
63 L1P2 2 n.s 28.9 Weakly correlated
64 L1PBa 2 n.s 74.0 Highly correlated
65 L3b 2 n.s 99.0 Weakly correlated
66 LTR12D 2 * 19.6 Weakly correlated
67 LTR16B1 2 * 99.0 Weakly correlated
68 LTR1D1 2 ** 43.0 Weakly correlated
69 LTR22A 2 *** 43.0 Weakly correlated
70 LTR33B 2 * 99.0 Weakly correlated
71 LTR78 2 n.s 99.0 Weakly correlated
72 MER21C 2 n.s 99.0 Weakly correlated
73 MER4C 2 ** 74.0 Highly correlated
74 MER50 2 n.s 43.0 Weakly correlated
75 MER52D 2 n.s 74.0 Highly correlated
76 MLT1A0 2 n.s 99.0 Weakly correlated
77 MLT1E2 2 n.s 99.0 Weakly correlated
78 MLT1H 2 n.s 99.0 Weakly correlated
79 MLT1K 2 n.s 99.0 Weakly correlated
80 MLT1L 2 n.s 99.0 Weakly correlated
81 MamRTE1 2 n.s 99.0 Weakly correlated
82 AluJr4 1 n.s 74.0 Highly correlated
83 AluSc5 1 n.s 74.0 Highly correlated
84 AluSx4 1 n.s 74.0 Highly correlated
85 AluYg6 1 * 15.2 Weakly correlated
86 AluYk2 1 n.s 19.6 Weakly correlated
87 ERVL-B4-int 1 n.s 99.0 Weakly correlated
88 ERVL-E-int 1 n.s 99.0 Weakly correlated
89 HERVFH21-int 1 * 28.9 Weakly correlated
90 L1M3 1 n.s 99.0 Weakly correlated
91 L1M4 1 n.s 99.0 Weakly correlated
92 L1M4c 1 n.s 99.0 Weakly correlated
93 L1MB3 1 n.s 99.0 Weakly correlated
94 L1MB5 1 n.s 99.0 Weakly correlated
95 L1MC3 1 n.s 99.0 Weakly correlated
96 L1MC5 1 n.s 99.0 Weakly correlated
97 L1MC5a 1 n.s 99.0 Weakly correlated
98 L1MDa 1 n.s 99.0 Weakly correlated
99 L1MDb 1 n.s 99.0 Weakly correlated
100 L1ME3 1 n.s 99.0 Weakly correlated
101 L1ME3A 1 n.s 99.0 Weakly correlated
102 L1ME3Cz 1 n.s 99.0 Weakly correlated
103 L1ME3G 1 n.s 99.0 Weakly correlated
104 L1ME4c 1 n.s 99.0 Weakly correlated
105 L1MEc 1 n.s 99.0 Weakly correlated
106 L1MEg 1 n.s 99.0 Weakly correlated
107 L1P4 1 n.s 74.0 Highly correlated
108 L1PA6 1 n.s 28.9 Weakly correlated
109 L1PA7 1 n.s 74.0 Highly correlated
110 L1PB1 1 n.s 74.0 Highly correlated
111 L1PB2 1 n.s 74.0 Highly correlated
112 L1PB4 1 n.s 99.0 Weakly correlated
113 LTR103_Mam 1 * 99.0 Weakly correlated
114 LTR104_Mam 1 n.s 99.0 Weakly correlated
115 LTR12 1 n.s 28.9 Weakly correlated
116 LTR12E 1 * 19.6 Weakly correlated
117 LTR13 1 n.s 19.6 Weakly correlated
118 LTR16B2 1 n.s 99.0 Weakly correlated
119 LTR16C 1 n.s 99.0 Weakly correlated
120 LTR16E1 1 n.s 99.0 Weakly correlated
121 LTR19C 1 ** 43.0 Weakly correlated
122 LTR21A 1 ** 28.9 Weakly correlated
123 LTR33 1 n.s 99.0 Weakly correlated
124 LTR35 1 ** 43.0 Weakly correlated
125 LTR3B_ 1 ** 28.9 Weakly correlated
126 LTR41B 1 n.s 99.0 Weakly correlated
127 LTR45 1 ** 99.0 Weakly correlated
128 LTR75 1 * 99.0 Weakly correlated
129 LTR81 1 ** 99.0 Weakly correlated
130 LTR81A 1 * 99.0 Weakly correlated
131 MER11C 1 n.s 19.6 Weakly correlated
132 MER21B 1 n.s 99.0 Weakly correlated
133 MER39B 1 n.s 74.0 Highly correlated
134 MER41A 1 n.s 74.0 Highly correlated
135 MER41D 1 * 74.0 Highly correlated
136 MER50-int 1 n.s 43.0 Weakly correlated
137 MER52A 1 n.s 74.0 Highly correlated
138 MER52C 1 n.s 74.0 Highly correlated
139 MER57B1 1 n.s 43.0 Weakly correlated
140 MER57C2 1 * 87.0 Moderately correlated
141 MER61A 1 n.s 43.0 Weakly correlated
142 MER65D 1 * 87.0 Moderately correlated
143 MER67A 1 * 99.0 Weakly correlated
144 MER68 1 n.s 99.0 Weakly correlated
145 MER72B 1 ** 43.0 Weakly correlated
146 MER90 1 n.s 99.0 Weakly correlated
147 MLT1A1 1 n.s 87.0 Moderately correlated
148 MLT1D 1 n.s 99.0 Weakly correlated
149 MLT1F2 1 n.s 99.0 Weakly correlated
150 MLT1G-int 1 ** 99.0 Weakly correlated
151 MLT1G3 1 n.s 99.0 Weakly correlated
152 MLT1H2 1 n.s 99.0 Weakly correlated
153 MLT1I 1 n.s 99.0 Weakly correlated
154 MLT1M 1 n.s 99.0 Weakly correlated
155 MSTB1 1 n.s 74.0 Highly correlated
156 MSTB2 1 n.s 74.0 Highly correlated
157 MSTC 1 n.s 74.0 Highly correlated
158 MSTD 1 n.s 74.0 Highly correlated
159 MamGypLTR1c 1 n.s 99.0 Weakly correlated
160 MamGypLTR3 1 * 99.0 Weakly correlated
161 MamGypLTR3a 1 n.s 99.0 Weakly correlated
162 MamGypsy2-LTR 1 * 99.0 Weakly correlated
163 SVA_C 1 n.s 15.2 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA2 12 n.s 15.2 Weakly correlated
2 LTR50 12 **** 99.0 Weakly correlated
3 AluJb 6 n.s 74.0 Highly correlated
4 L2a 5 n.s 99.0 Weakly correlated
5 L2c 5 n.s 99.0 Weakly correlated
6 L2 5 n.s 99.0 Weakly correlated
7 MSTA 5 n.s 43.0 Weakly correlated
8 L1PA3 5 n.s 19.6 Weakly correlated
9 AluSx1 4 n.s 74.0 Highly correlated
10 MIRb 4 n.s 99.0 Weakly correlated
11 THE1D 4 n.s 43.0 Weakly correlated
12 L1PA4 3 n.s 19.6 Weakly correlated
13 LTR41 3 ** 99.0 Weakly correlated
14 LTR12C 3 n.s 19.6 Weakly correlated
15 MLT1G 3 * 99.0 Weakly correlated
16 L2b 2 n.s 99.0 Weakly correlated
17 L1P2 2 n.s 28.9 Weakly correlated
18 LTR22A 2 *** 43.0 Weakly correlated
19 MIR 2 n.s 99.0 Weakly correlated
20 L1HS 2 n.s 8.6 Weakly correlated
21 AluSz6 2 n.s 74.0 Highly correlated
22 AluSq2 2 n.s 74.0 Highly correlated
23 LTR78 2 n.s 99.0 Weakly correlated
24 AluSz 2 n.s 74.0 Highly correlated
25 AluJo 2 n.s 74.0 Highly correlated
26 MSTB 2 n.s 43.0 Weakly correlated
27 THE1C 2 n.s 43.0 Weakly correlated
28 MLT1H 2 n.s 99.0 Weakly correlated
29 LTR33B 2 * 99.0 Weakly correlated
30 AluSc5 1 n.s 74.0 Highly correlated
31 MamGypsy2-LTR 1 * 99.0 Weakly correlated
32 AluSp 1 n.s 74.0 Highly correlated
33 FLAM_A 1 n.s 74.0 Highly correlated
34 LTR12D 1 n.s 19.6 Weakly correlated
35 MIR1_Amn 1 n.s 319.0 Weakly correlated
36 MSTB2 1 n.s 74.0 Highly correlated
37 L1PA5 1 n.s 19.6 Weakly correlated
38 AluYb8 1 n.s 15.2 Weakly correlated
39 L1MD1 1 n.s 99.0 Weakly correlated
40 L1ME3A 1 n.s 99.0 Weakly correlated
41 MER52D 1 n.s 74.0 Highly correlated
42 MLT1E2 1 n.s 99.0 Weakly correlated
43 MLT1G3 1 n.s 99.0 Weakly correlated
44 MSTD 1 n.s 74.0 Highly correlated
45 L1PB1 1 n.s 74.0 Highly correlated
46 MER21C 1 n.s 99.0 Weakly correlated
47 MLT1D 1 n.s 99.0 Weakly correlated
48 MLT1M 1 n.s 99.0 Weakly correlated
49 MER21B 1 n.s 99.0 Weakly correlated
50 MLT1J 1 n.s 99.0 Weakly correlated
51 HAL1 1 n.s 99.0 Weakly correlated
52 L1MB3 1 n.s 99.0 Weakly correlated
53 MamRTE1 1 n.s 99.0 Weakly correlated
54 AluY 1 n.s 74.0 Highly correlated
55 FLAM_C 1 n.s 74.0 Highly correlated
56 L1MEg 1 n.s 99.0 Weakly correlated
57 AluSx3 1 n.s 74.0 Highly correlated
58 AluSc 1 n.s 74.0 Highly correlated
59 L1M4b 1 n.s 99.0 Weakly correlated
60 L1MC3 1 n.s 99.0 Weakly correlated
61 L1MC5 1 n.s 99.0 Weakly correlated
62 L1MEf 1 n.s 99.0 Weakly correlated
63 L1P1 1 n.s 19.6 Weakly correlated
64 LTR1A2 1 n.s 43.0 Weakly correlated
65 LTR1D1 1 * 43.0 Weakly correlated
66 MER90 1 n.s 99.0 Weakly correlated
67 MIRc 1 n.s 99.0 Weakly correlated
68 MLT1L 1 n.s 99.0 Weakly correlated
69 AluJr 1 n.s 74.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 ALUJB 74.0 Highly correlated
2 L1PA2 15.2 Weakly correlated
3 LTR50 99.0 Weakly correlated