ZRdb KZFP & Repeats
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Human_ZNF34

  • Protein
    Zinc finger protein 34
  • Length
    560
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q8IZ26
  • NCBI_ID
    80778
Sequence:
MLLLLSDQLLLTALRKPNPQAMAALFLSAPPQAEVTFEDVAVYLSREEWGRLGPAQRGLYRDVMLETYGNLVSLGVGPAGPKPGVISQLERGDEPWVLDVQGTSGKEHLRVNSPALGTRTEYKELTSQETFGEEDPQGSEPVEACDHISKSEGSLEKLVEQRGPRAVTLTNGESSRESGGNLRLLSRPVPDQRPHKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVKEDQKIPTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPYKCDECGKAFSQSCEFINHRRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSAYSSLIYHQRIHTGEKPYKCNDCGKAFSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIHTGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQSTHLIQHQRIHTGEKPYKCSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIHTGEKPYKCSECGKAFRHSSNMCQHQRIHLREDFSM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 35..108
2 C2h2 195..217
3 C2h2 251..273
4 C2h2 279..301
5 C2h2 307..329
6 C2h2 335..357
7 C2h2 363..385
8 C2h2 391..413
9 C2h2 419..441
10 C2h2 447..469
11 C2h2 475..497
12 C2h2 503..525
13 C2h2 531..553
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component cytosol
2 Cellular Component nucleoplasm
3 Cellular Component nucleus
4 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HAL1 4 ** 99.0 Highly correlated
2 HAL1ME 4 **** 99.0 Highly correlated
3 MIRb 4 n.s 99.0 Highly correlated
4 L1M6 4 **** 99.0 Highly correlated
5 LTR10A 3 **** 28.9 Weakly correlated
6 MLT1H 2 ** 99.0 Highly correlated
7 L2 2 n.s 99.0 Highly correlated
8 MER50 2 *** 43.0 Weakly correlated
9 L1MEi 2 ** 99.0 Highly correlated
10 L1MEh 2 *** 99.0 Highly correlated
11 MIR3 2 n.s 99.0 Highly correlated
12 L1MC1 2 n.s 99.0 Highly correlated
13 LTR76 2 **** 74.0 Weakly correlated
14 MLT1H2 2 *** 99.0 Highly correlated
15 HERV3-int 2 **** 28.9 Weakly correlated
16 AluSx1 2 n.s 74.0 Weakly correlated
17 MLT1J2 2 *** 99.0 Highly correlated
18 AluSc8 2 * 74.0 Weakly correlated
19 LTR4 2 **** 28.9 Weakly correlated
20 AluJb 2 n.s 74.0 Weakly correlated
21 LTR50 1 ** 99.0 Highly correlated
22 LTR55 1 *** 99.0 Highly correlated
23 LTR81A 1 *** 99.0 Highly correlated
24 LTR88a 1 *** 99.0 Highly correlated
25 LTR88b 1 *** 99.0 Highly correlated
26 MER11A 1 ** 28.9 Weakly correlated
27 MSTB1-int 1 *** 74.0 Weakly correlated
28 MER31A 1 ** 87.0 Weakly correlated
29 MER41-int 1 * 74.0 Weakly correlated
30 MER50-int 1 ** 43.0 Weakly correlated
31 MER61B 1 *** 43.0 Weakly correlated
32 MER65C 1 *** 74.0 Weakly correlated
33 MIR 1 n.s 99.0 Highly correlated
34 MIR1_Amn 1 * 319.0 Weakly correlated
35 MIRc 1 n.s 99.0 Highly correlated
36 MLT1I 1 * 99.0 Highly correlated
37 MLT1K 1 n.s 99.0 Highly correlated
38 MLT1L 1 * 99.0 Highly correlated
39 L1MEc 1 n.s 99.0 Highly correlated
40 AluJr4 1 n.s 74.0 Weakly correlated
41 AluSc 1 n.s 74.0 Weakly correlated
42 AluSc5 1 * 74.0 Weakly correlated
43 AluSx 1 n.s 74.0 Weakly correlated
44 AluYj4 1 ** 0.0 Weakly correlated
45 L1M3e 1 ** 99.0 Highly correlated
46 L1MA3 1 n.s 74.0 Weakly correlated
47 L1MA8 1 n.s 87.0 Weakly correlated
48 L1MB7 1 n.s 99.0 Highly correlated
49 L1MC3 1 n.s 99.0 Highly correlated
50 L1MD3 1 * 99.0 Highly correlated
51 L1ME4b 1 n.s 99.0 Highly correlated
52 LTR41 1 ** 99.0 Highly correlated
53 L1MEd 1 n.s 99.0 Highly correlated
54 L1MEf 1 n.s 99.0 Highly correlated
55 L1MEj 1 ** 99.0 Highly correlated
56 L1PA2 1 n.s 15.2 Weakly correlated
57 L1PA4 1 n.s 19.6 Weakly correlated
58 L2a 1 n.s 99.0 Highly correlated
59 L2b 1 n.s 99.0 Highly correlated
60 L2c 1 n.s 99.0 Highly correlated
61 LTR24C 1 *** 74.0 Weakly correlated
62 LTR25-int 1 ** 43.0 Weakly correlated
63 LTR2C 1 **** 19.6 Weakly correlated
64 LTR40a 1 ** 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M6 4 **** 99.0 Highly correlated
2 HAL1ME 4 **** 99.0 Highly correlated
3 HAL1 2 n.s 99.0 Highly correlated
4 L1MC1 2 n.s 99.0 Highly correlated
5 MLT1H2 2 *** 99.0 Highly correlated
6 L1MEi 2 ** 99.0 Highly correlated
7 MSTB1-int 1 *** 74.0 Weakly correlated
8 AluSx1 1 n.s 74.0 Weakly correlated
9 MER31A 1 ** 87.0 Weakly correlated
10 L1MA3 1 n.s 74.0 Weakly correlated
11 MLT1J2 1 * 99.0 Highly correlated
12 MER50 1 ** 43.0 Weakly correlated
13 LTR50 1 ** 99.0 Highly correlated
14 L1MD3 1 * 99.0 Highly correlated
15 MLT1H 1 * 99.0 Highly correlated
16 MER61B 1 *** 43.0 Weakly correlated
17 LTR88a 1 *** 99.0 Highly correlated
18 LTR41 1 ** 99.0 Highly correlated
19 MLT1I 1 * 99.0 Highly correlated
20 L1MEj 1 ** 99.0 Highly correlated
21 MIRb 1 n.s 99.0 Highly correlated
22 L1MEf 1 n.s 99.0 Highly correlated
23 L2 1 n.s 99.0 Highly correlated
24 L1MEh 1 ** 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP