ZRdb KZFP & Repeats
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Human_ZNF33B

  • Protein
    Zinc finger protein 33B
  • Length
    778
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q06732
  • NCBI_ID
    7582
Sequence:
MNKVDQKFQGSVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCAHKPEVIFRLEQGEEPWRLEEEFPSQSFPEVWTADHLKERSQENQSKHLWEVVFINNEMLTKEQGNVIGIPFNMDVSSFPSRKMFCQYDSRGMSFNTVSELVISKINYLGKKSDEFNACGKLLLNIKHDETHTREKNEVLKNRNTLSHRENTLQHEKIQTLDHNFEYSICQETLLEKAVFNTRKRENAEENNCDYNEFGRTFCDSSSLLFHQIPPSKDSHYEFSDCEKFLCVKSTLSKHDGVPVKHYDCGESGNNFRRKLCLSQLQKGDKGEKHFECNECGKAFWEKSHLTRHQRVHTGEKHFQCNQCGKTFWEKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNACGKTFYQKSDLTKHQRTHTGQKPYECYECGKSFCMNSHLTVHQRTHTGEKPFECLECGKSFCQKSHLTQHQRTHIGDKPYECNACGKTFYHKSVLTRHQIIHTGLKPYECYECGKTFCLKSDLTIHQRTHTGEKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKTFCQKSQLTQHQRIHIGEKPYECNECGKAFCHKSALIVHQRTHTQEKPYKCNECGKSFCVKSGLILHERKHTGEKPYECNECGKSFSHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSDLAKHQRSHTGEKPYECNTCRKTFSQKSNLIVHQRTHIGEKPYE
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 12..83
2 C2h2 329..351
3 C2h2 357..379
4 C2h2 385..407
5 C2h2 413..435
6 C2h2 441..463
7 C2h2 469..491
8 C2h2 497..519
9 C2h2 525..547
10 C2h2 553..575
11 C2h2 581..603
12 C2h2 609..631
13 C2h2 637..659
14 C2h2 665..687
15 C2h2 693..715
16 C2h2 721..743
17 C2h2 749..771
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR33A 43 **** 99.0 Highly correlated
2 LTR50 12 **** 99.0 Highly correlated
3 LTR67B 9 **** 99.0 Highly correlated
4 LTR33B 6 **** 99.0 Highly correlated
5 MIR 6 n.s 99.0 Highly correlated
6 LTR10A 4 **** 28.9 Weakly correlated
7 AluY 4 n.s 74.0 Weakly correlated
8 AluJb 2 n.s 74.0 Weakly correlated
9 L2c 2 n.s 99.0 Highly correlated
10 L2a 2 n.s 99.0 Highly correlated
11 MLT1C 2 n.s 94.0 Weakly correlated
12 FRAM 2 *** 74.0 Weakly correlated
13 MER41-int 1 * 74.0 Weakly correlated
14 MER50B 1 *** 43.0 Weakly correlated
15 MER34B-int 1 *** 99.0 Highly correlated
16 LTR78 1 * 99.0 Highly correlated
17 LTR33A_ 1 ** 99.0 Highly correlated
18 LTR23 1 *** 74.0 Weakly correlated
19 MER50 1 * 43.0 Weakly correlated
20 MER50-int 1 ** 43.0 Weakly correlated
21 LFSINE_Vert 1 *** 319.0 Weakly correlated
22 MER83B-int 1 *** 99.0 Highly correlated
23 MIRc 1 n.s 99.0 Highly correlated
24 MLT1E2-int 1 **** 99.0 Highly correlated
25 MLT1E3 1 ** 99.0 Highly correlated
26 MLT1F1 1 ** 99.0 Highly correlated
27 MLT1J 1 n.s 99.0 Highly correlated
28 MLT1L 1 * 99.0 Highly correlated
29 MLT1N2 1 ** 99.0 Highly correlated
30 MSTD 1 * 74.0 Weakly correlated
31 MamGypLTR3 1 *** 99.0 Highly correlated
32 THE1B 1 n.s 43.0 Weakly correlated
33 L1M1 1 n.s 74.0 Weakly correlated
34 AluJo 1 n.s 74.0 Weakly correlated
35 AluJr 1 n.s 74.0 Weakly correlated
36 AluJr4 1 n.s 74.0 Weakly correlated
37 AluSc5 1 * 74.0 Weakly correlated
38 AluSg4 1 * 74.0 Weakly correlated
39 AluSg7 1 * 74.0 Weakly correlated
40 AluSq10 1 ** 74.0 Weakly correlated
41 AluSx 1 n.s 74.0 Weakly correlated
42 AluSx1 1 n.s 74.0 Weakly correlated
43 AluYh9 1 **** 15.2 Weakly correlated
44 AluYm1 1 * 19.6 Weakly correlated
45 HAL1 1 n.s 99.0 Highly correlated
46 LTR1A2 1 ** 43.0 Weakly correlated
47 L1MB4 1 n.s 99.0 Highly correlated
48 L1MB7 1 n.s 99.0 Highly correlated
49 L1MC5a 1 n.s 99.0 Highly correlated
50 L1ME4b 1 n.s 99.0 Highly correlated
51 L1MEg 1 n.s 99.0 Highly correlated
52 L1P1 1 n.s 19.6 Weakly correlated
53 L1PA2 1 n.s 15.2 Weakly correlated
54 L1PA5 1 n.s 19.6 Weakly correlated
55 L1PA6 1 n.s 28.9 Weakly correlated
56 L1PA7 1 n.s 74.0 Weakly correlated
57 LTR13 1 ** 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR33A 38 **** 99.0 Highly correlated
2 LTR67B 8 **** 99.0 Highly correlated
3 LTR50 7 **** 99.0 Highly correlated
4 LTR33B 5 **** 99.0 Highly correlated
5 MIR 3 n.s 99.0 Highly correlated
6 L2a 2 n.s 99.0 Highly correlated
7 L2c 1 n.s 99.0 Highly correlated
8 AluJb 1 n.s 74.0 Weakly correlated
9 L1MB7 1 n.s 99.0 Highly correlated
10 L1PA7 1 n.s 74.0 Weakly correlated
11 LTR33A_ 1 ** 99.0 Highly correlated
12 L1MEg 1 n.s 99.0 Highly correlated
13 MER41-int 1 * 74.0 Weakly correlated
14 MER50 1 * 43.0 Weakly correlated
15 AluYh9 1 **** 15.2 Weakly correlated
16 MER83B-int 1 *** 99.0 Highly correlated
17 MLT1E2-int 1 **** 99.0 Highly correlated
18 HAL1 1 n.s 99.0 Highly correlated
19 MER50B 1 *** 43.0 Weakly correlated
20 MER34B-int 1 *** 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LTR33A 99.0 Highly correlated
2 LTR50 99.0 Highly correlated
3 LTR67B 99.0 Highly correlated