ZRdb KZFP & Repeats
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Human_ZNF337

  • Protein
    Zinc finger protein 337
  • Length
    751
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
  • NCBI_ID
Sequence:
MGPQGARRQAFLAFGDVTVDFTQKEWRLLSPAQRALYREVTLENYSHLVSLGILHSKPELIRRLEQGEVPWGEERRRRPGPCAGIYAEHVLRPKNLGLAHQRQQQLQFSDQSFQSDTAEGQEKEKSTKPMAFSSPPLRHAVSSRRRNSVVEIESSQGQRENPTEIDKVLKGIENSRWGAFKCAERGQDFSRKMMVIIHKKAHSRQKLFTCRECHQGFRDESALLLHQNTHTGEKSYVCSVCGRGFSLKANLLRHQRTHSGEKPFLCKVCGRGYTSKSYLTVHERTHTGEKPYECQECGRRFNDKSSYNKHLKAHSGEKPFVCKECGRGYTNKSYFVVHKRIHSGEKPYRCQECGRGFSNKSHLITHQRTHSGEKPFACRQCKQSFSVKGSLLRHQRTHSGEKPFVCKDCERSFSQKSTLVYHQRTHSGEKPFVCRECGQGFIQKSTLVKHQITHSEEKPFVCKDCGRGFIQKSTFTLHQRTHSEEKPYGCRECGRRFRDKSSYNKHLRAHLGEKRFFCRDCGRGFTLKPNLTIHQRTHSGEKPFMCKQCEKSFSLKANLLRHQWTHSGERPFNCKDCGRGFILKSTLLFHQKTHSGEKPFICSECGQGFIWKSNLVKHQLAHSGKQPFVCKECGRGFNWKGNLLTHQRTHSGEKPFVCNVCGQGFSWKRSLTRHHWRIHSKEKPFVCQECKRGYTSKSDLTVHERIHTGERPYECQECGRKFSNKSYYSKHLKRHLREKRFCTGSVGEASS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 12..83
2 dec2h2 180..202
3 C2h2 208..230
4 C2h2 236..258
5 C2h2 264..286
6 C2h2 292..314
7 C2h2 320..342
8 C2h2 348..370
9 C2h2 376..398
10 C2h2 404..426
11 C2h2 432..454
12 C2h2 460..482
13 C2h2 488..510
14 C2h2 516..538
15 C2h2 544..566
16 C2h2 572..594
17 C2h2 600..622
18 C2h2 628..650
19 C2h2 656..679
20 C2h2 685..707
21 C2h2 713..735
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M2 67 **** 99.0 Weakly correlated
2 L1PA15-16 51 **** 74.0 Weakly correlated
3 L1PA16 50 **** 74.0 Weakly correlated
4 L1PB4 30 **** 99.0 Weakly correlated
5 L1PA17 28 **** 74.0 Weakly correlated
6 L1M4c 27 **** 99.0 Weakly correlated
7 L1PA10 27 **** 74.0 Weakly correlated
8 L2a 27 n.s 99.0 Weakly correlated
9 L1MA4A 23 **** 87.0 Weakly correlated
10 L1PB3 20 **** 74.0 Weakly correlated
11 AluJb 17 n.s 74.0 Weakly correlated
12 L1M4 16 **** 99.0 Weakly correlated
13 L1MB3 16 **** 99.0 Weakly correlated
14 L1P4a 15 **** 74.0 Weakly correlated
15 L2c 15 n.s 99.0 Weakly correlated
16 L1MA5 14 **** 87.0 Weakly correlated
17 L1PA11 14 **** 74.0 Weakly correlated
18 L1MCa 13 **** 99.0 Weakly correlated
19 MIRb 13 n.s 99.0 Weakly correlated
20 L2 12 n.s 99.0 Weakly correlated
21 AluSz 11 n.s 74.0 Weakly correlated
22 L1MA6 10 **** 87.0 Weakly correlated
23 L1MA9 10 ** 99.0 Weakly correlated
24 MIR 10 n.s 99.0 Weakly correlated
25 AluJo 9 n.s 74.0 Weakly correlated
26 AluSp 9 n.s 74.0 Weakly correlated
27 L1PA13 9 * 74.0 Weakly correlated
28 L2b 9 n.s 99.0 Weakly correlated
29 MIRc 9 n.s 99.0 Weakly correlated
30 AluSq2 8 n.s 74.0 Weakly correlated
31 AluSx 8 n.s 74.0 Weakly correlated
32 L1M1 8 n.s 74.0 Weakly correlated
33 L1MA4 7 * 87.0 Weakly correlated
34 LTR8 7 **** 43.0 Highly correlated
35 MIR3 7 n.s 99.0 Weakly correlated
36 AluSx1 6 n.s 74.0 Weakly correlated
37 AluY 6 n.s 74.0 Weakly correlated
38 L1MA7 6 * 87.0 Weakly correlated
39 L1P3 6 ** 74.0 Weakly correlated
40 L1PA14 6 ** 74.0 Weakly correlated
41 L1PA2 6 n.s 15.2 Weakly correlated
42 L1PA5 6 n.s 19.6 Weakly correlated
43 L3 6 n.s 99.0 Weakly correlated
44 HAL1 5 n.s 99.0 Weakly correlated
45 L1M2a 5 **** 87.0 Weakly correlated
46 L1MB2 5 * 99.0 Weakly correlated
47 L1MB7 5 n.s 99.0 Weakly correlated
48 L1MC1 5 n.s 99.0 Weakly correlated
49 L1MC4 5 n.s 99.0 Weakly correlated
50 L1PA15 5 n.s 74.0 Weakly correlated
51 L1PA3 5 n.s 19.6 Weakly correlated
52 L1PBa 5 ** 74.0 Weakly correlated
53 MSTA 5 n.s 43.0 Highly correlated
54 AluSq 4 n.s 74.0 Weakly correlated
55 AluSx3 4 n.s 74.0 Weakly correlated
56 L1M5 4 n.s 99.0 Weakly correlated
57 L1MB1 4 * 99.0 Weakly correlated
58 L1PBb 4 **** 74.0 Weakly correlated
59 L1PREC2 4 n.s 43.0 Highly correlated
60 LTR10A 4 **** 28.9 Weakly correlated
61 MER50 4 *** 43.0 Highly correlated
62 MLT1J 4 n.s 99.0 Weakly correlated
63 MLT1K 4 n.s 99.0 Weakly correlated
64 AluSc8 3 n.s 74.0 Weakly correlated
65 L1M2a1 3 **** 79.0 Weakly correlated
66 L1M2c 3 **** 87.0 Weakly correlated
67 L1M3b 3 *** 99.0 Weakly correlated
68 L1M3de 3 **** 99.0 Weakly correlated
69 L1MA10 3 * 99.0 Weakly correlated
70 L1MA3 3 n.s 74.0 Weakly correlated
71 L1MA5A 3 * 87.0 Weakly correlated
72 L1MA8 3 n.s 87.0 Weakly correlated
73 L1MB8 3 n.s 99.0 Weakly correlated
74 L1MDa 3 n.s 99.0 Weakly correlated
75 L1ME4b 3 n.s 99.0 Weakly correlated
76 L1PA7 3 n.s 74.0 Weakly correlated
77 L1PA8 3 n.s 74.0 Weakly correlated
78 LOR1-int 3 *** 74.0 Weakly correlated
79 LTR16A 3 ** 99.0 Weakly correlated
80 AluJr 2 n.s 74.0 Weakly correlated
81 AluSc 2 n.s 74.0 Weakly correlated
82 AluSg 2 n.s 74.0 Weakly correlated
83 L1M4b 2 n.s 99.0 Weakly correlated
84 L1MA1 2 n.s 74.0 Weakly correlated
85 L1MB4 2 n.s 99.0 Weakly correlated
86 L1MB5 2 n.s 99.0 Weakly correlated
87 L1MC2 2 n.s 99.0 Weakly correlated
88 L1MC3 2 n.s 99.0 Weakly correlated
89 L1ME1 2 n.s 99.0 Weakly correlated
90 L1ME4a 2 n.s 99.0 Weakly correlated
91 L1MEf 2 n.s 99.0 Weakly correlated
92 L1MEi 2 n.s 99.0 Weakly correlated
93 L1P4 2 n.s 74.0 Weakly correlated
94 L1PA4 2 n.s 19.6 Weakly correlated
95 L1PA6 2 n.s 28.9 Weakly correlated
96 L3b 2 n.s 99.0 Weakly correlated
97 LTR1A2 2 ** 43.0 Highly correlated
98 LTR43B 2 **** 74.0 Weakly correlated
99 LTR78 2 * 99.0 Weakly correlated
100 MER52A 2 n.s 74.0 Weakly correlated
101 MER66C 2 *** 43.0 Highly correlated
102 MLT1A0 2 n.s 99.0 Weakly correlated
103 MLT1A1 2 n.s 87.0 Weakly correlated
104 MLT1C 2 n.s 94.0 Weakly correlated
105 MLT1F2 2 n.s 99.0 Weakly correlated
106 MLT1H2 2 * 99.0 Weakly correlated
107 MLT1J2 2 n.s 99.0 Weakly correlated
108 THE1C 2 n.s 43.0 Highly correlated
109 THE1D 2 n.s 43.0 Highly correlated
110 AluJr4 1 n.s 74.0 Weakly correlated
111 AluSc5 1 n.s 74.0 Weakly correlated
112 AluSg7 1 n.s 74.0 Weakly correlated
113 AluSq10 1 * 74.0 Weakly correlated
114 AluSz6 1 n.s 74.0 Weakly correlated
115 AluYa5 1 n.s 15.2 Weakly correlated
116 AluYh9 1 **** 15.2 Weakly correlated
117 AluYm1 1 n.s 19.6 Weakly correlated
118 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
119 HAL1M8 1 n.s 99.0 Weakly correlated
120 HERVE_a-int 1 * 28.9 Weakly correlated
121 HERVL74-int 1 ** 99.0 Weakly correlated
122 HUERS-P1-int 1 * 43.0 Highly correlated
123 L1M3a 1 * 99.0 Weakly correlated
124 L1M3c 1 * 99.0 Weakly correlated
125 L1M3d 1 * 99.0 Weakly correlated
126 L1M4a1 1 n.s 99.0 Weakly correlated
127 L1M8 1 n.s 99.0 Weakly correlated
128 L1MA2 1 n.s 74.0 Weakly correlated
129 L1MC4a 1 n.s 99.0 Weakly correlated
130 L1MC5a 1 n.s 99.0 Weakly correlated
131 L1MD 1 n.s 99.0 Weakly correlated
132 L1MD3 1 n.s 99.0 Weakly correlated
133 L1MDb 1 * 99.0 Weakly correlated
134 L1ME3B 1 n.s 99.0 Weakly correlated
135 L1ME3Cz 1 n.s 99.0 Weakly correlated
136 L1ME3G 1 n.s 99.0 Weakly correlated
137 L1MEb 1 n.s 99.0 Weakly correlated
138 L1MEd 1 n.s 99.0 Weakly correlated
139 L1MEg 1 n.s 99.0 Weakly correlated
140 L1P1 1 n.s 19.6 Weakly correlated
141 L1P4d 1 ** 74.0 Weakly correlated
142 L1PB1 1 n.s 74.0 Weakly correlated
143 L1PB2 1 n.s 74.0 Weakly correlated
144 L4_A_Mam 1 n.s 99.0 Weakly correlated
145 LFSINE_Vert 1 * 319.0 Weakly correlated
146 LTR13 1 * 19.6 Weakly correlated
147 LTR16 1 n.s 99.0 Weakly correlated
148 LTR16B1 1 * 99.0 Weakly correlated
149 LTR16C 1 n.s 99.0 Weakly correlated
150 LTR16E1 1 n.s 99.0 Weakly correlated
151 LTR1F1 1 ** 43.0 Highly correlated
152 LTR21A 1 *** 28.9 Weakly correlated
153 LTR27E 1 ** 43.0 Highly correlated
154 LTR33C 1 ** 99.0 Weakly correlated
155 LTR41B 1 * 99.0 Weakly correlated
156 LTR48 1 * 74.0 Weakly correlated
157 LTR49-int 1 n.s 74.0 Weakly correlated
158 LTR50 1 n.s 99.0 Weakly correlated
159 LTR62 1 ** 74.0 Weakly correlated
160 LTR7 1 n.s 19.6 Weakly correlated
161 LTR71A 1 *** 43.0 Highly correlated
162 LTR71B 1 ** 43.0 Highly correlated
163 LTR76 1 ** 74.0 Weakly correlated
164 LTR85b 1 ** 99.0 Weakly correlated
165 LTR91 1 *** 99.0 Weakly correlated
166 MER101B 1 *** 87.0 Weakly correlated
167 MER11C 1 n.s 19.6 Weakly correlated
168 MER21A 1 n.s 74.0 Weakly correlated
169 MER39B 1 * 74.0 Weakly correlated
170 MER4-int 1 n.s 74.0 Weakly correlated
171 MER41B 1 n.s 74.0 Weakly correlated
172 MER49 1 * 43.0 Highly correlated
173 MER50-int 1 * 43.0 Highly correlated
174 MER50B 1 * 43.0 Highly correlated
175 MER52C 1 * 74.0 Weakly correlated
176 MER54A 1 * 87.0 Weakly correlated
177 MER54B 1 ** 87.0 Weakly correlated
178 MER61B 1 ** 43.0 Highly correlated
179 MER68 1 * 99.0 Weakly correlated
180 MER74A 1 * 99.0 Weakly correlated
181 MER89 1 * 99.0 Weakly correlated
182 MER90a 1 * 99.0 Weakly correlated
183 MLT1D 1 n.s 99.0 Weakly correlated
184 MLT1E2 1 n.s 99.0 Weakly correlated
185 MLT1F 1 n.s 99.0 Weakly correlated
186 MLT1F1 1 n.s 99.0 Weakly correlated
187 MLT1G 1 n.s 99.0 Weakly correlated
188 MLT1G1 1 n.s 99.0 Weakly correlated
189 MLT1H 1 n.s 99.0 Weakly correlated
190 MLT2B1 1 n.s 99.0 Weakly correlated
191 MLT2B4 1 n.s 99.0 Weakly correlated
192 MSTB 1 n.s 43.0 Highly correlated
193 MSTB1 1 n.s 74.0 Weakly correlated
194 MSTB2 1 * 74.0 Weakly correlated
195 MSTD 1 n.s 74.0 Weakly correlated
196 MamGypLTR3 1 ** 99.0 Weakly correlated
197 MamGypLTR3a 1 * 99.0 Weakly correlated
198 MamRTE1 1 n.s 99.0 Weakly correlated
199 MamRep605 1 n.s 99.0 Weakly correlated
200 THE1A 1 n.s 43.0 Highly correlated
201 THE1B 1 n.s 43.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M2 65 **** 99.0 Weakly correlated
2 L1PA15-16 51 **** 74.0 Weakly correlated
3 L1PA16 46 **** 74.0 Weakly correlated
4 L1PB4 29 **** 99.0 Weakly correlated
5 L1PA10 27 **** 74.0 Weakly correlated
6 L1PA17 25 **** 74.0 Weakly correlated
7 L1M4c 25 **** 99.0 Weakly correlated
8 L1MA4A 21 **** 87.0 Weakly correlated
9 L1PB3 20 **** 74.0 Weakly correlated
10 L1PA11 15 **** 74.0 Weakly correlated
11 L1P4a 14 **** 74.0 Weakly correlated
12 L1MCa 11 **** 99.0 Weakly correlated
13 L1MA5 11 **** 87.0 Weakly correlated
14 L1M4 10 * 99.0 Weakly correlated
15 L1MA6 9 **** 87.0 Weakly correlated
16 L1MB3 9 * 99.0 Weakly correlated
17 L1PA13 8 * 74.0 Weakly correlated
18 L1M1 7 n.s 74.0 Weakly correlated
19 L1MA9 6 n.s 99.0 Weakly correlated
20 L1PBa 6 *** 74.0 Weakly correlated
21 L1MA7 5 * 87.0 Weakly correlated
22 L1MA4 5 n.s 87.0 Weakly correlated
23 L1PA3 5 n.s 19.6 Weakly correlated
24 L1MB2 5 * 99.0 Weakly correlated
25 L2a 4 n.s 99.0 Weakly correlated
26 L1PA15 4 n.s 74.0 Weakly correlated
27 L2c 4 n.s 99.0 Weakly correlated
28 L1PA14 4 * 74.0 Weakly correlated
29 L1M2a 4 **** 87.0 Weakly correlated
30 L1PBb 4 **** 74.0 Weakly correlated
31 L1MA8 3 n.s 87.0 Weakly correlated
32 L1MDa 3 n.s 99.0 Weakly correlated
33 LOR1-int 3 *** 74.0 Weakly correlated
34 L1M3b 3 *** 99.0 Weakly correlated
35 L1MB1 3 n.s 99.0 Weakly correlated
36 L1PA8 3 n.s 74.0 Weakly correlated
37 L1M2c 3 **** 87.0 Weakly correlated
38 L1M3de 3 **** 99.0 Weakly correlated
39 L1MA3 3 n.s 74.0 Weakly correlated
40 L1M2a1 3 **** 79.0 Weakly correlated
41 L1PREC2 3 n.s 43.0 Highly correlated
42 L1MC1 3 n.s 99.0 Weakly correlated
43 L1MB7 3 n.s 99.0 Weakly correlated
44 L1MA10 2 n.s 99.0 Weakly correlated
45 L2 2 n.s 99.0 Weakly correlated
46 L1PA7 2 n.s 74.0 Weakly correlated
47 MER66C 2 *** 43.0 Highly correlated
48 L1ME1 2 n.s 99.0 Weakly correlated
49 L1M4b 2 n.s 99.0 Weakly correlated
50 L1MB5 2 n.s 99.0 Weakly correlated
51 L1MC2 2 n.s 99.0 Weakly correlated
52 L1MB4 2 n.s 99.0 Weakly correlated
53 L1PA5 2 n.s 19.6 Weakly correlated
54 L1PA2 2 n.s 15.2 Weakly correlated
55 L1PA4 2 n.s 19.6 Weakly correlated
56 MER52A 1 n.s 74.0 Weakly correlated
57 AluJo 1 n.s 74.0 Weakly correlated
58 L1MA1 1 n.s 74.0 Weakly correlated
59 HAL1 1 n.s 99.0 Weakly correlated
60 L3 1 n.s 99.0 Weakly correlated
61 L2b 1 n.s 99.0 Weakly correlated
62 L1MB8 1 n.s 99.0 Weakly correlated
63 L1MC3 1 n.s 99.0 Weakly correlated
64 L1MC4a 1 n.s 99.0 Weakly correlated
65 L1ME4a 1 n.s 99.0 Weakly correlated
66 MLT1J 1 n.s 99.0 Weakly correlated
67 L1P3 1 n.s 74.0 Weakly correlated
68 MLT1A0 1 n.s 99.0 Weakly correlated
69 L1ME3G 1 n.s 99.0 Weakly correlated
70 L1P4d 1 ** 74.0 Weakly correlated
71 L1PB2 1 n.s 74.0 Weakly correlated
72 MLT1K 1 n.s 99.0 Weakly correlated
73 AluSq2 1 n.s 74.0 Weakly correlated
74 AluSz 1 n.s 74.0 Weakly correlated
75 L1M3d 1 * 99.0 Weakly correlated
76 L1MEf 1 n.s 99.0 Weakly correlated
77 L1P1 1 n.s 19.6 Weakly correlated
78 MLT1J2 1 n.s 99.0 Weakly correlated
79 LTR16C 1 n.s 99.0 Weakly correlated
80 L1PA6 1 n.s 28.9 Weakly correlated
81 L1M3c 1 * 99.0 Weakly correlated
82 MIRb 1 n.s 99.0 Weakly correlated
83 MLT1A1 1 n.s 87.0 Weakly correlated
84 L1ME3Cz 1 n.s 99.0 Weakly correlated
85 L1MEg 1 n.s 99.0 Weakly correlated
86 LTR27E 1 ** 43.0 Highly correlated
87 MLT1H2 1 n.s 99.0 Weakly correlated
88 MLT2B4 1 n.s 99.0 Weakly correlated
89 L1M3a 1 * 99.0 Weakly correlated
90 L1ME4b 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1M1 74.0 Weakly correlated
2 L1M2 99.0 Weakly correlated
3 L1M4 99.0 Weakly correlated
4 L1M4C 99.0 Weakly correlated
5 L1MCA 99.0 Weakly correlated
6 L1P4A 74.0 Weakly correlated
7 L1PA15-16 74.0 Weakly correlated
8 L1PBA 74.0 Weakly correlated