ZRdb KZFP & Repeats
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Human_ZNF333

  • Protein
    Zinc finger protein 333
  • Length
    665
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q96JL9
  • NCBI_ID
    84449
Sequence:
MESVTFEDVAVEFIQEWALLDSARRSLCKYRMLDQCRTLASRGTPPCKPSCVSQLGQRAEPKATERGILRATGVAWESQLKPEELPSMQDLLEEASSRDMQMGPGLFLRMQLVPSIEERETPLTREDRPALQEPPWSLGCTGLKAAMQIQRVVIPVPTLGHRNPWVARDSAVPARDPAWLQEDKVEEEAMAPGLPTACSQEPVTFADVAVVFTPEEWVFLDSTQRSLYRDVMLENYRNLASVADQLCKPNALSYLEERGEQWTTDRGVLSDTCAEPQCQPQEAIPSQDTFTEILSIDVKGEQPQPGEKLYKYNELEKPFNSIEPLFQYQRIHAGEASCECQEIRNSFFQSAHLIVPEKIRSGDKSYACNKCEKSFRYSSDLIRHEKTHTAEKCFDCQECGQAFKYSSNLRRHMRTHTGEKPFECSQCGKTFTRNFNLILHQRNHTGEKPYECKDCGKAFNQPSSLRSHVRTHTGEKPFECSQCGKAFREHSSLKTHLRTHTREKPYECNQCGKPFRTSTHLNVHKRIHTGEKLYECATCGQVLSRLSTLKSHMRTHTGEKPYVCQECGRAFSEPSSLRKHARTHSGKKPYACQECGRAFGQSSHLIVHVRTHSAGRPYQCNQCEKAFRHSSSLTVHKRTHVGRETIRNGSLPLSMSHPYCGPLAN
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..74
2 C2h2 366..388
3 C2h2 394..416
4 C2h2 422..444
5 C2h2 450..472
6 C2h2 478..500
7 C2h2 506..528
8 C2h2 534..556
9 C2h2 562..584
10 C2h2 590..612
11 C2h2 618..640
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1J2 130 **** 99.0 Highly correlated
2 MLT1J1 53 **** 99.0 Highly correlated
3 MLT1H 34 **** 99.0 Highly correlated
4 MLT1I 33 **** 99.0 Highly correlated
5 L2a 16 n.s 99.0 Highly correlated
6 MLT1J 16 **** 99.0 Highly correlated
7 L2c 11 n.s 99.0 Highly correlated
8 AluJb 9 n.s 74.0 Weakly correlated
9 L2 9 n.s 99.0 Highly correlated
10 MIR 7 n.s 99.0 Highly correlated
11 L2b 6 n.s 99.0 Highly correlated
12 MIR3 6 n.s 99.0 Highly correlated
13 MIRb 6 n.s 99.0 Highly correlated
14 AluJr 5 n.s 74.0 Weakly correlated
15 AluSx 5 n.s 74.0 Weakly correlated
16 AluSx1 5 n.s 74.0 Weakly correlated
17 LTR12C 5 * 19.6 Weakly correlated
18 LTR13_ 5 **** 28.9 Weakly correlated
19 MIRc 5 n.s 99.0 Highly correlated
20 MLT1H2 5 **** 99.0 Highly correlated
21 AluSq2 4 n.s 74.0 Weakly correlated
22 AluY 4 n.s 74.0 Weakly correlated
23 LTR10A 4 **** 28.9 Weakly correlated
24 MLT1B 4 n.s 99.0 Highly correlated
25 MLT1G 4 *** 99.0 Highly correlated
26 AluSc8 3 n.s 74.0 Weakly correlated
27 AluSp 3 n.s 74.0 Weakly correlated
28 AluSx3 3 n.s 74.0 Weakly correlated
29 AluSz 3 n.s 74.0 Weakly correlated
30 AluYj4 3 *** 0.0 Weakly correlated
31 LTR13 3 *** 19.6 Weakly correlated
32 MLT1H1 3 ** 99.0 Highly correlated
33 MLT1K 3 n.s 99.0 Highly correlated
34 AluJo 2 n.s 74.0 Weakly correlated
35 AluSg 2 n.s 74.0 Weakly correlated
36 FLAM_C 2 n.s 74.0 Weakly correlated
37 FRAM 2 * 74.0 Weakly correlated
38 HAL1 2 n.s 99.0 Highly correlated
39 L1MB5 2 n.s 99.0 Highly correlated
40 L1MB7 2 n.s 99.0 Highly correlated
41 L1MD2 2 n.s 99.0 Highly correlated
42 L1ME2z 2 n.s 99.0 Highly correlated
43 L1PA5 2 n.s 19.6 Weakly correlated
44 L3 2 n.s 99.0 Highly correlated
45 L4_A_Mam 2 n.s 99.0 Highly correlated
46 LTR10F 2 *** 28.9 Weakly correlated
47 LTR8B 2 ** 43.0 Weakly correlated
48 MER66C 2 *** 43.0 Weakly correlated
49 MIR1_Amn 2 * 319.0 Weakly correlated
50 MamSINE1 2 ** 99.0 Highly correlated
51 AluSc 1 n.s 74.0 Weakly correlated
52 AluSq 1 n.s 74.0 Weakly correlated
53 AluSx4 1 n.s 74.0 Weakly correlated
54 AluSz6 1 n.s 74.0 Weakly correlated
55 AluYa5 1 n.s 15.2 Weakly correlated
56 AluYg6 1 ** 15.2 Weakly correlated
57 AluYh9 1 **** 15.2 Weakly correlated
58 AluYm1 1 n.s 19.6 Weakly correlated
59 HERVIP10F-int 1 * 28.9 Weakly correlated
60 L1M5 1 n.s 99.0 Highly correlated
61 L1MA4 1 n.s 87.0 Weakly correlated
62 L1MA9 1 n.s 99.0 Highly correlated
63 L1MC1 1 n.s 99.0 Highly correlated
64 L1MC2 1 n.s 99.0 Highly correlated
65 L1MC4 1 n.s 99.0 Highly correlated
66 L1MC5a 1 n.s 99.0 Highly correlated
67 L1MCa 1 n.s 99.0 Highly correlated
68 L1ME3 1 n.s 99.0 Highly correlated
69 L1ME3D 1 n.s 99.0 Highly correlated
70 L1ME4a 1 n.s 99.0 Highly correlated
71 L1MEd 1 n.s 99.0 Highly correlated
72 L1MEf 1 n.s 99.0 Highly correlated
73 L1PA12 1 n.s 74.0 Weakly correlated
74 L1PA8 1 n.s 74.0 Weakly correlated
75 LTR104_Mam 1 * 99.0 Highly correlated
76 LTR12E 1 ** 19.6 Weakly correlated
77 LTR16 1 n.s 99.0 Highly correlated
78 LTR16B1 1 * 99.0 Highly correlated
79 LTR25-int 1 * 43.0 Weakly correlated
80 LTR27E 1 ** 43.0 Weakly correlated
81 LTR33 1 n.s 99.0 Highly correlated
82 LTR41 1 * 99.0 Highly correlated
83 LTR41B 1 ** 99.0 Highly correlated
84 LTR78 1 n.s 99.0 Highly correlated
85 LTR8 1 n.s 43.0 Weakly correlated
86 LTR8A 1 n.s 43.0 Weakly correlated
87 MER11B 1 * 19.6 Weakly correlated
88 MER21-int 1 * 99.0 Highly correlated
89 MER31B 1 * 99.0 Highly correlated
90 MER39B 1 * 74.0 Weakly correlated
91 MER4B-int 1 n.s 99.0 Highly correlated
92 MER50 1 n.s 43.0 Weakly correlated
93 MER52A 1 n.s 74.0 Weakly correlated
94 MER52C 1 * 74.0 Weakly correlated
95 MER61B 1 ** 43.0 Weakly correlated
96 MER61E 1 ** 43.0 Weakly correlated
97 MLT1A 1 n.s 99.0 Highly correlated
98 MLT1F 1 n.s 99.0 Highly correlated
99 MLT1F1 1 n.s 99.0 Highly correlated
100 MLT1G3 1 n.s 99.0 Highly correlated
101 MamRTE1 1 n.s 99.0 Highly correlated
102 THE1A 1 n.s 43.0 Weakly correlated
103 THE1B 1 n.s 43.0 Weakly correlated
104 X6A_LINE 1 ** 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1J2 123 **** 99.0 Highly correlated
2 MLT1J1 45 **** 99.0 Highly correlated
3 MLT1I 30 **** 99.0 Highly correlated
4 MLT1H 28 **** 99.0 Highly correlated
5 MLT1J 13 **** 99.0 Highly correlated
6 MLT1B 3 n.s 99.0 Highly correlated
7 L3 2 n.s 99.0 Highly correlated
8 MLT1H2 2 * 99.0 Highly correlated
9 L2c 2 n.s 99.0 Highly correlated
10 LTR12C 2 n.s 19.6 Weakly correlated
11 MLT1F 1 n.s 99.0 Highly correlated
12 L1MB5 1 n.s 99.0 Highly correlated
13 L1PA5 1 n.s 19.6 Weakly correlated
14 AluJb 1 n.s 74.0 Weakly correlated
15 MamSINE1 1 n.s 99.0 Highly correlated
16 MLT1H1 1 n.s 99.0 Highly correlated
17 L2b 1 n.s 99.0 Highly correlated
18 L2a 1 n.s 99.0 Highly correlated
19 L1MC1 1 n.s 99.0 Highly correlated
20 MLT1F1 1 n.s 99.0 Highly correlated
21 AluSz 1 n.s 74.0 Weakly correlated
22 MLT1A 1 n.s 99.0 Highly correlated
23 MIRb 1 n.s 99.0 Highly correlated
24 L1ME2z 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP