ZRdb KZFP & Repeats
...

Human_ZNF324B

  • Protein
    Zinc finger protein 324B
  • Length
    544
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q6AW86
  • NCBI_ID
    388569
Sequence:
MTFEDVAVYFSQEEWGLLDTAQRALYRHVMLENFTLVTSLGLSTSRPRVVIQLERGEEPWVPSGKDMTLARNTYGRLNSGSWSLTEDRDVSGEWPRAFPDTPPGMTTSVFPVADACHSVKSLQRQPGASPSQERKPTGVSVIYWERLLLGSRSDQASISLRLTSPLRPPKSSRPREKTFTEYRVPGRQPRTPERQKPCAQEVPGRAFGNASDLKAASGGRDRRMGAAWQEPHRLLGGQEPSTWDELGEALHAGEKSFECRACSKVFVKSSDLLKHLRTHTGERPYECTQCGKAFSQTSHLTQHQRIHSGETPYACPVCGKAFRHSSSLVRHQRIHTAEKSFRCSECGKAFSHGSNLSQHRKIHAGGRPYACAQCGRRFCRNSHLIQHERTHTGEKPFVCALCGAAFSQGSSLFLHQRVHTGEKPFACAQCGRSFSRSSNLTQHQLLHTGERPFRCVDCGKGFAKGAVLLSHRRIHTGEKPFVCTQCGRAFRERPALLHHQRIHTTEKTNAAAPDCTPGPGFLQGHHRKVRRGGKPSPVLKPAKV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 1..72
2 C2h2 257..279
3 C2h2 285..307
4 C2h2 313..335
5 C2h2 341..363
6 C2h2 369..391
7 C2h2 397..419
8 C2h2 425..447
9 C2h2 453..475
10 C2h2 481..503
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR10A 4 **** 28.9 Weakly correlated
2 L1PA2 2 n.s 15.2 Weakly correlated
3 AluJb 2 n.s 74.0 Weakly correlated
4 L1P3 2 ** 74.0 Weakly correlated
5 L1P1 1 * 19.6 Weakly correlated
6 MER39B 1 *** 74.0 Weakly correlated
7 LTR13 1 *** 19.6 Weakly correlated
8 L2a 1 n.s 99.0 Highly correlated
9 L1PA5 1 n.s 19.6 Weakly correlated
10 L1P4 1 * 74.0 Weakly correlated
11 HAL1 1 n.s 99.0 Highly correlated
12 FRAM 1 ** 74.0 Weakly correlated
13 AluYh9 1 **** 15.2 Weakly correlated
14 AluY 1 n.s 74.0 Weakly correlated
15 AluSx 1 n.s 74.0 Weakly correlated
16 AluSg7 1 * 74.0 Weakly correlated
17 AluJr4 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP