ZRdb KZFP & Repeats
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Human_ZNF311

  • Protein
    Zinc finger protein 311
  • Length
    666
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q5JNZ3
  • NCBI_ID
    282890
Sequence:
MQEVVLLDESSGPPSQLLWTRQDTQLPQESALLPAPYPAFTKDGSQGNLPQADITLMSQAQESVTFEDVAVNFTNREWQCLTYAQRHLYKDVMLENYGNMVSLGFPFPKPPLISHLEREVDPCVQDPQDRESLSCSYPVSADKMWPENEKASSQQEIFENGEAYWMKFNSLLKVDSRDPKVREVCVQDVKLENQWETSIREKLREEKEGSEEVTCKKGKNQKVLSKNLNPNSKHSQCNKVLIAQKLHECARCGKNFSWHSDLILHEQIHSGEKPHVCNECGKAFKTRNQLSMHRIIHTGEKPFNCTQCGKAFNSRSALCRHKKTHSGEKPHECRDCGKAFKTRNRLCMHQLIHTGEKPYKCNCCGKAFQFKHSLTIHGRIHTGEKPYECEECGKAFSGSSDLTKHIRIHTGERPYECSKCGRAFSRSSDLSKHKRIHTREKHYGCPQCGKDFSIKAELTKHRRIHTEEKRYRCEECGKAFRHNCKRRAHEREHTGEKPYQCRDCGKTFQDKHCLTIHQRIHTGEKPYKCLECGKAFSGKSNLTNHRRIHTGEKPHKCEVCGMAFHHSSVLRQHKRIHTGEKPYTCSECGTSFRQGSALIGHKRVHTGEKPYECEECGKAFRVSSNLTGHKKRKHQVWSTHELDGSRKSLSPVTVSQTSVVSILTSA
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 64..135
2 C2h2 247..269
3 C2h2 275..297
4 C2h2 303..325
5 C2h2 331..353
6 C2h2 359..381
7 C2h2 387..409
8 C2h2 415..437
9 C2h2 443..465
10 C2h2 471..493
11 C2h2 499..521
12 C2h2 527..549
13 C2h2 555..577
14 C2h2 583..605
15 C2h2 611..634
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR10A 3 **** 28.9 Weakly correlated
2 L1PA2 2 n.s 15.2 Weakly correlated
3 L2c 2 n.s 99.0 Highly correlated
4 L1PA5 2 n.s 19.6 Weakly correlated
5 L1PA4 1 n.s 19.6 Weakly correlated
6 SVA_D 1 * 15.2 Weakly correlated
7 MIRb 1 n.s 99.0 Highly correlated
8 MER50 1 ** 43.0 Weakly correlated
9 MER39B 1 ** 74.0 Weakly correlated
10 LTR13 1 ** 19.6 Weakly correlated
11 LTR12C 1 n.s 19.6 Weakly correlated
12 AluSx 1 n.s 74.0 Weakly correlated
13 L1P1 1 n.s 19.6 Weakly correlated
14 L1M4 1 n.s 99.0 Highly correlated
15 AluYm1 1 * 19.6 Weakly correlated
16 AluYh9 1 **** 15.2 Weakly correlated
17 AluYa5 1 * 15.2 Weakly correlated
18 AluY 1 n.s 74.0 Weakly correlated
19 AluSx1 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA5 1 n.s 19.6 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP