Human_ZNF304
-
ProteinZinc finger protein 304
-
Length659
-
OrganismHomo sapiens (Human)
-
Time of emergence99.0 Mya
-
Time of Changing in binding specificity99.0 Mya
-
Uniprot_ID
-
NCBI_ID
Sequence:
MAAAVLMDRVQSCVTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTAESGLFQKAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRGLCRRRFSFSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSSGLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDYDGQMLFSCGDEGKAFLDTFTLLDSQMTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKFHTGKRHYTCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNKCGKAFSRKDTLVQHQRFHTGERPYECSECGKFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRKDTLVQHQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQHKKVHTGARPYECSECGKFFSRNSGLILHQRVHTGEKPYVCSECGKAYSRSSHLVRHQKAHTGERAHECNSFGGPLAASLKLV
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 14..88 | |
| 2 | C2h2 | 89..111 | |
| 3 | C2h2 | 115..139 | |
| 4 | C2h2 | 251..273 | |
| 5 | C2h2 | 279..301 | |
| 6 | C2h2 | 307..329 | |
| 7 | C2h2 | 335..357 | |
| 8 | C2h2 | 363..385 | |
| 9 | C2h2 | 391..413 | |
| 10 | C2h2 | 419..441 | |
| 11 | C2h2 | 447..469 | |
| 12 | C2h2 | 475..497 | |
| 13 | C2h2 | 503..525 | |
| 14 | C2h2 | 531..553 | |
| 15 | C2h2 | 559..581 | |
| 16 | C2h2 | 587..609 | |
| 17 | C2h2 | 615..637 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleus | |
| 2 | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| 3 | Molecular Function | metal ion binding | |
| 4 | Molecular Function | promoter-specific chromatin binding | |
| 5 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| 6 | Biological Process | angiogenesis | |
| 7 | Biological Process | chromatin organization | |
| 8 | Biological Process | integrin-mediated signaling pathway | |
| 9 | Biological Process | negative regulation of anoikis | |
| 10 | Biological Process | negative regulation of chromatin binding | |
| 11 | Biological Process | positive regulation of angiogenesis | |
| 12 | Biological Process | positive regulation of cell migration | |
| 13 | Biological Process | positive regulation of DNA methylation-dependent heterochromatin assembly | |
| 14 | Biological Process | positive regulation of epithelial cell proliferation | |
| 15 | Biological Process | positive regulation of histone H3-K27 trimethylation | |
| 16 | Biological Process | positive regulation of histone H3-K9 trimethylation | |
| 17 | Biological Process | positive regulation of transcription by RNA polymerase II | |
| 18 | Biological Process | Ras protein signal transduction | |
| 19 | Biological Process | regulation of transcription by RNA polymerase II |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MLT1F2 | 416 | **** | 99.0 | Highly correlated | |
| 2 | MLT1F | 256 | **** | 99.0 | Highly correlated | |
| 3 | MLT1F1 | 195 | **** | 99.0 | Highly correlated | |
| 4 | MLT1E1A | 125 | **** | 99.0 | Highly correlated | |
| 5 | MLT1E1 | 32 | **** | 99.0 | Highly correlated | |
| 6 | L2a | 16 | n.s | 99.0 | Highly correlated | |
| 7 | AluSz | 15 | n.s | 74.0 | Weakly correlated | |
| 8 | AluJb | 12 | n.s | 74.0 | Weakly correlated | |
| 9 | MIRb | 12 | n.s | 99.0 | Highly correlated | |
| 10 | L2c | 11 | n.s | 99.0 | Highly correlated | |
| 11 | AluSx1 | 10 | n.s | 74.0 | Weakly correlated | |
| 12 | MLT1E2 | 10 | **** | 99.0 | Highly correlated | |
| 13 | MLT1H1 | 10 | **** | 99.0 | Highly correlated | |
| 14 | AluSx | 9 | n.s | 74.0 | Weakly correlated | |
| 15 | AluJo | 8 | n.s | 74.0 | Weakly correlated | |
| 16 | AluJr | 8 | n.s | 74.0 | Weakly correlated | |
| 17 | AluSz6 | 8 | n.s | 74.0 | Weakly correlated | |
| 18 | MLT1H | 8 | *** | 99.0 | Highly correlated | |
| 19 | MIRc | 7 | n.s | 99.0 | Highly correlated | |
| 20 | L2 | 6 | n.s | 99.0 | Highly correlated | |
| 21 | MLT1E | 6 | **** | 99.0 | Highly correlated | |
| 22 | AluSp | 5 | n.s | 74.0 | Weakly correlated | |
| 23 | L1PA5 | 5 | n.s | 19.6 | Weakly correlated | |
| 24 | MIR | 5 | n.s | 99.0 | Highly correlated | |
| 25 | MIR3 | 5 | n.s | 99.0 | Highly correlated | |
| 26 | MLT1E3 | 5 | **** | 99.0 | Highly correlated | |
| 27 | MLT1H2 | 5 | **** | 99.0 | Highly correlated | |
| 28 | AluSc | 4 | n.s | 74.0 | Weakly correlated | |
| 29 | AluSg7 | 4 | * | 74.0 | Weakly correlated | |
| 30 | AluSq2 | 4 | n.s | 74.0 | Weakly correlated | |
| 31 | AluY | 4 | n.s | 74.0 | Weakly correlated | |
| 32 | FRAM | 4 | ** | 74.0 | Weakly correlated | |
| 33 | L1M5 | 4 | n.s | 99.0 | Highly correlated | |
| 34 | L1ME4c | 4 | * | 99.0 | Highly correlated | |
| 35 | L1P3 | 4 | * | 74.0 | Weakly correlated | |
| 36 | L1PA2 | 4 | n.s | 15.2 | Weakly correlated | |
| 37 | L2b | 4 | n.s | 99.0 | Highly correlated | |
| 38 | LTR8A | 4 | *** | 43.0 | Weakly correlated | |
| 39 | MLT1G3 | 4 | *** | 99.0 | Highly correlated | |
| 40 | AluSc8 | 3 | n.s | 74.0 | Weakly correlated | |
| 41 | AluSx3 | 3 | n.s | 74.0 | Weakly correlated | |
| 42 | L1PA3 | 3 | n.s | 19.6 | Weakly correlated | |
| 43 | LTR10A | 3 | **** | 28.9 | Weakly correlated | |
| 44 | MLT1G1 | 3 | ** | 99.0 | Highly correlated | |
| 45 | MSTA | 3 | n.s | 43.0 | Weakly correlated | |
| 46 | AluJr4 | 2 | n.s | 74.0 | Weakly correlated | |
| 47 | AluSg | 2 | n.s | 74.0 | Weakly correlated | |
| 48 | AluSx4 | 2 | n.s | 74.0 | Weakly correlated | |
| 49 | L1M1 | 2 | n.s | 74.0 | Weakly correlated | |
| 50 | L1M4 | 2 | n.s | 99.0 | Highly correlated | |
| 51 | L1ME4a | 2 | n.s | 99.0 | Highly correlated | |
| 52 | L1ME4b | 2 | n.s | 99.0 | Highly correlated | |
| 53 | L1PA4 | 2 | n.s | 19.6 | Weakly correlated | |
| 54 | MIR1_Amn | 2 | * | 319.0 | Weakly correlated | |
| 55 | MLT1G | 2 | * | 99.0 | Highly correlated | |
| 56 | MSTD | 2 | n.s | 74.0 | Weakly correlated | |
| 57 | AluSc5 | 1 | n.s | 74.0 | Weakly correlated | |
| 58 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 59 | AluYh3 | 1 | n.s | 15.2 | Weakly correlated | |
| 60 | AluYh9 | 1 | **** | 15.2 | Weakly correlated | |
| 61 | AluYj4 | 1 | n.s | 0.0 | Weakly correlated | |
| 62 | AluYm1 | 1 | n.s | 19.6 | Weakly correlated | |
| 63 | CR1-3_Croc | 1 | ** | 319.0 | Weakly correlated | |
| 64 | ERVL-E-int | 1 | n.s | 99.0 | Highly correlated | |
| 65 | FAM | 1 | n.s | 87.0 | Weakly correlated | |
| 66 | FLAM_C | 1 | n.s | 74.0 | Weakly correlated | |
| 67 | L1M2 | 1 | n.s | 99.0 | Highly correlated | |
| 68 | L1M4a1 | 1 | n.s | 99.0 | Highly correlated | |
| 69 | L1M4b | 1 | n.s | 99.0 | Highly correlated | |
| 70 | L1MA7 | 1 | n.s | 87.0 | Weakly correlated | |
| 71 | L1MA8 | 1 | n.s | 87.0 | Weakly correlated | |
| 72 | L1MA9 | 1 | n.s | 99.0 | Highly correlated | |
| 73 | L1MB3 | 1 | n.s | 99.0 | Highly correlated | |
| 74 | L1MB7 | 1 | n.s | 99.0 | Highly correlated | |
| 75 | L1MB8 | 1 | n.s | 99.0 | Highly correlated | |
| 76 | L1MC5a | 1 | n.s | 99.0 | Highly correlated | |
| 77 | L1ME1 | 1 | n.s | 99.0 | Highly correlated | |
| 78 | L1ME2 | 1 | n.s | 99.0 | Highly correlated | |
| 79 | L1ME3B | 1 | n.s | 99.0 | Highly correlated | |
| 80 | L1MEh | 1 | n.s | 99.0 | Highly correlated | |
| 81 | L1P1 | 1 | n.s | 19.6 | Weakly correlated | |
| 82 | L1P4 | 1 | n.s | 74.0 | Weakly correlated | |
| 83 | L1PA13 | 1 | n.s | 74.0 | Weakly correlated | |
| 84 | L1PA15-16 | 1 | n.s | 74.0 | Weakly correlated | |
| 85 | L1PB4 | 1 | n.s | 99.0 | Highly correlated | |
| 86 | L3 | 1 | n.s | 99.0 | Highly correlated | |
| 87 | L4_A_Mam | 1 | n.s | 99.0 | Highly correlated | |
| 88 | LTR10F | 1 | ** | 28.9 | Weakly correlated | |
| 89 | LTR12C | 1 | n.s | 19.6 | Weakly correlated | |
| 90 | LTR12D | 1 | * | 19.6 | Weakly correlated | |
| 91 | LTR13 | 1 | * | 19.6 | Weakly correlated | |
| 92 | LTR16A1 | 1 | n.s | 99.0 | Highly correlated | |
| 93 | LTR16A2 | 1 | * | 99.0 | Highly correlated | |
| 94 | LTR26 | 1 | * | 74.0 | Weakly correlated | |
| 95 | LTR27D | 1 | ** | 43.0 | Weakly correlated | |
| 96 | LTR44 | 1 | ** | 74.0 | Weakly correlated | |
| 97 | LTR50 | 1 | n.s | 99.0 | Highly correlated | |
| 98 | LTR79 | 1 | n.s | 99.0 | Highly correlated | |
| 99 | LTR8 | 1 | n.s | 43.0 | Weakly correlated | |
| 100 | LTR8B | 1 | n.s | 43.0 | Weakly correlated | |
| 101 | MER21B | 1 | n.s | 99.0 | Highly correlated | |
| 102 | MER21C | 1 | n.s | 99.0 | Highly correlated | |
| 103 | MER39 | 1 | n.s | 74.0 | Weakly correlated | |
| 104 | MER39B | 1 | * | 74.0 | Weakly correlated | |
| 105 | MER4D1 | 1 | n.s | 74.0 | Weakly correlated | |
| 106 | MER50 | 1 | n.s | 43.0 | Weakly correlated | |
| 107 | MER52C | 1 | * | 74.0 | Weakly correlated | |
| 108 | MER61C | 1 | ** | 43.0 | Weakly correlated | |
| 109 | MER65A | 1 | * | 74.0 | Weakly correlated | |
| 110 | MER67C | 1 | n.s | 99.0 | Highly correlated | |
| 111 | MER67D | 1 | * | 99.0 | Highly correlated | |
| 112 | MER73 | 1 | ** | 87.0 | Weakly correlated | |
| 113 | MLT1A | 1 | n.s | 99.0 | Highly correlated | |
| 114 | MLT1A0 | 1 | n.s | 99.0 | Highly correlated | |
| 115 | MLT1B | 1 | n.s | 99.0 | Highly correlated | |
| 116 | MLT1C | 1 | n.s | 94.0 | Weakly correlated | |
| 117 | MLT1D-int | 1 | * | 99.0 | Highly correlated | |
| 118 | MLT1F-int | 1 | ** | 99.0 | Highly correlated | |
| 119 | MLT1J | 1 | n.s | 99.0 | Highly correlated | |
| 120 | MLT1K | 1 | n.s | 99.0 | Highly correlated | |
| 121 | MLT2A1 | 1 | n.s | 74.0 | Weakly correlated | |
| 122 | MLT2B4 | 1 | n.s | 99.0 | Highly correlated | |
| 123 | MSTB | 1 | n.s | 43.0 | Weakly correlated | |
| 124 | MamRTE1 | 1 | n.s | 99.0 | Highly correlated | |
| 125 | SVA_A | 1 | * | 19.6 | Weakly correlated | |
| 126 | SVA_D | 1 | n.s | 15.2 | Weakly correlated | |
| 127 | THE1B | 1 | n.s | 43.0 | Weakly correlated | |
| 128 | THE1C | 1 | n.s | 43.0 | Weakly correlated | |
| 129 | THE1D | 1 | n.s | 43.0 | Weakly correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MLT1F2 | 374 | **** | 99.0 | Highly correlated | |
| 2 | MLT1F | 251 | **** | 99.0 | Highly correlated | |
| 3 | MLT1F1 | 186 | **** | 99.0 | Highly correlated | |
| 4 | MLT1E1A | 106 | **** | 99.0 | Highly correlated | |
| 5 | MLT1E1 | 28 | **** | 99.0 | Highly correlated | |
| 6 | MLT1E2 | 10 | **** | 99.0 | Highly correlated | |
| 7 | MLT1H1 | 10 | **** | 99.0 | Highly correlated | |
| 8 | MLT1H | 8 | *** | 99.0 | Highly correlated | |
| 9 | MLT1E | 6 | **** | 99.0 | Highly correlated | |
| 10 | MLT1E3 | 5 | **** | 99.0 | Highly correlated | |
| 11 | MLT1H2 | 4 | *** | 99.0 | Highly correlated | |
| 12 | MLT1G3 | 4 | *** | 99.0 | Highly correlated | |
| 13 | MLT1G1 | 3 | ** | 99.0 | Highly correlated | |
| 14 | MLT1G | 2 | * | 99.0 | Highly correlated | |
| 15 | MIRc | 2 | n.s | 99.0 | Highly correlated | |
| 16 | LTR8A | 2 | * | 43.0 | Weakly correlated | |
| 17 | AluSq2 | 1 | n.s | 74.0 | Weakly correlated | |
| 18 | MLT1C | 1 | n.s | 94.0 | Weakly correlated | |
| 19 | AluY | 1 | n.s | 74.0 | Weakly correlated | |
| 20 | AluSx1 | 1 | n.s | 74.0 | Weakly correlated | |
| 21 | AluJr | 1 | n.s | 74.0 | Weakly correlated | |
| 22 | MSTA | 1 | n.s | 43.0 | Weakly correlated | |
| 23 | L2b | 1 | n.s | 99.0 | Highly correlated | |
| 24 | MLT2B4 | 1 | n.s | 99.0 | Highly correlated | |
| 25 | L2a | 1 | n.s | 99.0 | Highly correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP |
|---|