ZRdb KZFP & Repeats
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Human_ZNF30

  • Protein
    Zinc finger protein 30
  • Length
    623
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    P17039
  • NCBI_ID
    90075
Sequence:
MAHKYVGLQYHGSVTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSMGHSRSKPHVIALLEQWKEPEVTVRKDGRRWCTDLQLEDDTIGCKEMPTSENCPSFALHQKISRQKPRECQEYGKTLCQDSKPVQHERIHSSEKPNRCKECGKNFSNGHQLTIHQRLHVGEKPYKYEKCGKAFISGSAFVKHGRIHTGEKPLKCKQCGKTISGSYQLTVHKSIHTGKKPYECGECGKAFLVYGKLTRHQSTHTGEKPFGCEECGKAFSTFSYLVQHQRIHTSEKPYECKECGKAFSTSSPLAKHQRIHTGEKPYECKECGKSFTVYGQLTRHQSIHTGEKPFECKECGKAFRLSSFLHAHQRIHAEIKPYGCKECGRTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPYECKECGKAFISRHQLTVHQRVHTGEKPYECKECGKAFRVHVHLTQHRKIHTDVKPYECKECGKTFSRASYLVQHSRIHTGKKPYECKECGKAFSSGSYLVQHQRIHTGEKPYECNKCGKAFTVYGQLIGHQSVHTGEKPFECKECGKAFRLNSFLTEHQRVHTGEKPFKCKKCGKTFRYSSALKVHLRKHMSVIP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 14..85
2 dec2h2 120..142
3 C2h2 148..170
4 dec2h2 176..198
5 C2h2 204..226
6 C2h2 232..254
7 C2h2 260..282
8 C2h2 288..310
9 C2h2 316..338
10 C2h2 344..366
11 C2h2 372..394
12 C2h2 400..422
13 C2h2 428..450
14 C2h2 456..478
15 C2h2 484..506
16 C2h2 512..534
17 C2h2 540..562
18 C2h2 568..590
19 C2h2 596..618
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1E2 379 **** 99.0 Moderately correlated
2 MLT1E3 164 **** 99.0 Moderately correlated
3 MLT1E1A 140 **** 99.0 Moderately correlated
4 AluJb 35 n.s 74.0 Weakly correlated
5 MLT1F2 32 **** 99.0 Moderately correlated
6 MIRb 31 n.s 99.0 Moderately correlated
7 MLT1E 30 **** 99.0 Moderately correlated
8 MLT1E1 28 **** 99.0 Moderately correlated
9 L2c 26 n.s 99.0 Moderately correlated
10 L2b 24 n.s 99.0 Moderately correlated
11 AluJr 22 n.s 74.0 Weakly correlated
12 L2a 21 n.s 99.0 Moderately correlated
13 MIRc 20 n.s 99.0 Moderately correlated
14 LTR76 17 **** 74.0 Weakly correlated
15 MIR 15 n.s 99.0 Moderately correlated
16 LTR10A 14 **** 28.9 Weakly correlated
17 AluSz 12 n.s 74.0 Weakly correlated
18 L2 11 n.s 99.0 Moderately correlated
19 AluSx 10 n.s 74.0 Weakly correlated
20 MIR3 10 n.s 99.0 Moderately correlated
21 LTR18A 9 **** 43.0 Weakly correlated
22 MLT1F 9 **** 99.0 Moderately correlated
23 AluJo 8 n.s 74.0 Weakly correlated
24 AluSc8 8 n.s 74.0 Weakly correlated
25 L3 8 n.s 99.0 Moderately correlated
26 MamRTE1 8 **** 99.0 Moderately correlated
27 AluSp 7 n.s 74.0 Weakly correlated
28 L1M5 7 n.s 99.0 Moderately correlated
29 L1MEg 7 n.s 99.0 Moderately correlated
30 MLT1C 7 n.s 94.0 Highly correlated
31 L1MC4 6 n.s 99.0 Moderately correlated
32 L1MD3 6 ** 99.0 Moderately correlated
33 LTR12C 6 n.s 19.6 Weakly correlated
34 LTR4 6 **** 28.9 Weakly correlated
35 AluJr4 5 n.s 74.0 Weakly correlated
36 AluSx3 5 n.s 74.0 Weakly correlated
37 AluSz6 5 n.s 74.0 Weakly correlated
38 HERV3-int 5 **** 28.9 Weakly correlated
39 L1M1 5 n.s 74.0 Weakly correlated
40 L1MA3 5 n.s 74.0 Weakly correlated
41 L1MB3 5 n.s 99.0 Moderately correlated
42 L1MC 5 n.s 99.0 Moderately correlated
43 L1ME1 5 n.s 99.0 Moderately correlated
44 L1PA13 5 n.s 74.0 Weakly correlated
45 LTR18B 5 **** 43.0 Weakly correlated
46 LTR8 5 * 43.0 Weakly correlated
47 THE1B 5 n.s 43.0 Weakly correlated
48 AluSq2 4 n.s 74.0 Weakly correlated
49 AluSx1 4 n.s 74.0 Weakly correlated
50 FLAM_A 4 n.s 74.0 Weakly correlated
51 FLAM_C 4 n.s 74.0 Weakly correlated
52 HAL1ME 4 n.s 99.0 Moderately correlated
53 HERVL-int 4 n.s 74.0 Weakly correlated
54 L1M2 4 n.s 99.0 Moderately correlated
55 L1P2 4 n.s 28.9 Weakly correlated
56 L1PA5 4 n.s 19.6 Weakly correlated
57 L1PA7 4 n.s 74.0 Weakly correlated
58 L3b 4 * 99.0 Moderately correlated
59 LTR41B 4 **** 99.0 Moderately correlated
60 LTR8B 4 ** 43.0 Weakly correlated
61 MIR1_Amn 4 * 319.0 Weakly correlated
62 MLT1D 4 n.s 99.0 Moderately correlated
63 AluSg7 3 n.s 74.0 Weakly correlated
64 AluYj4 3 * 0.0 Weakly correlated
65 CR1_Mam 3 *** 99.0 Moderately correlated
66 FAM 3 ** 87.0 Weakly correlated
67 HERV4_I-int 3 *** 43.0 Weakly correlated
68 HERVIP10FH-int 3 ** 28.9 Weakly correlated
69 HERVL18-int 3 ** 43.0 Weakly correlated
70 L1M3a 3 *** 99.0 Moderately correlated
71 L1M3e 3 ** 99.0 Moderately correlated
72 L1M4 3 n.s 99.0 Moderately correlated
73 L1M4b 3 n.s 99.0 Moderately correlated
74 L1MB4 3 n.s 99.0 Moderately correlated
75 L1MB7 3 n.s 99.0 Moderately correlated
76 L1ME3G 3 n.s 99.0 Moderately correlated
77 L1MEc 3 n.s 99.0 Moderately correlated
78 L1PA2 3 n.s 15.2 Weakly correlated
79 L1PREC2 3 n.s 43.0 Weakly correlated
80 L2-3_Crp 3 ** 431.0 Weakly correlated
81 LTR103_Mam 3 **** 99.0 Moderately correlated
82 LTR10D 3 **** 28.9 Weakly correlated
83 LTR25-int 3 ** 43.0 Weakly correlated
84 LTR39-int 3 **** 43.0 Weakly correlated
85 MER57-int 3 * 87.0 Weakly correlated
86 MER57A-int 3 * 43.0 Weakly correlated
87 MLT1A 3 n.s 99.0 Moderately correlated
88 MLT1A0 3 n.s 99.0 Moderately correlated
89 MLT1F1 3 * 99.0 Moderately correlated
90 MLT1J2 3 n.s 99.0 Moderately correlated
91 MLT2B3 3 n.s 99.0 Moderately correlated
92 AluY 2 n.s 74.0 Weakly correlated
93 AluYa5 2 n.s 15.2 Weakly correlated
94 AluYc 2 n.s 74.0 Weakly correlated
95 AluYm1 2 n.s 19.6 Weakly correlated
96 FRAM 2 n.s 74.0 Weakly correlated
97 L1M2a 2 * 87.0 Weakly correlated
98 L1M3f 2 * 87.0 Weakly correlated
99 L1MA5 2 n.s 87.0 Weakly correlated
100 L1MB8 2 n.s 99.0 Moderately correlated
101 L1MC1 2 n.s 99.0 Moderately correlated
102 L1MC2 2 n.s 99.0 Moderately correlated
103 L1MC5 2 n.s 99.0 Moderately correlated
104 L1MCc 2 n.s 99.0 Moderately correlated
105 L1MD 2 n.s 99.0 Moderately correlated
106 L1ME3A 2 n.s 99.0 Moderately correlated
107 L1ME3C 2 n.s 99.0 Moderately correlated
108 L1ME3Cz 2 n.s 99.0 Moderately correlated
109 L1ME3D 2 n.s 99.0 Moderately correlated
110 L1ME4a 2 n.s 99.0 Moderately correlated
111 LTR101_Mam 2 ** 99.0 Moderately correlated
112 LTR12E 2 *** 19.6 Weakly correlated
113 LTR13 2 * 19.6 Weakly correlated
114 LTR19A 2 *** 43.0 Weakly correlated
115 LTR33 2 n.s 99.0 Moderately correlated
116 MER11A 2 n.s 28.9 Weakly correlated
117 MER31-int 2 * 99.0 Moderately correlated
118 MER4B-int 2 n.s 99.0 Moderately correlated
119 MER50-int 2 * 43.0 Weakly correlated
120 MLT1G 2 n.s 99.0 Moderately correlated
121 MLT1G3-int 2 *** 99.0 Moderately correlated
122 MLT1K 2 n.s 99.0 Moderately correlated
123 MLT1L 2 n.s 99.0 Moderately correlated
124 MSTA 2 n.s 43.0 Weakly correlated
125 MSTB1 2 n.s 74.0 Weakly correlated
126 MSTD 2 n.s 74.0 Weakly correlated
127 MamGypLTR1d 2 *** 99.0 Moderately correlated
128 MamSINE1 2 * 99.0 Moderately correlated
129 SVA_A 2 * 19.6 Weakly correlated
130 SVA_D 2 n.s 15.2 Weakly correlated
131 SVA_E 2 ** 0.0 Weakly correlated
132 SVA_F 2 n.s 0.0 Weakly correlated
133 AluSc 1 n.s 74.0 Weakly correlated
134 AluYh9 1 *** 15.2 Weakly correlated
135 AmnSINE1 1 * 319.0 Weakly correlated
136 ERVL-B4-int 1 n.s 99.0 Moderately correlated
137 HAL1b 1 n.s 99.0 Moderately correlated
138 HERVH48-int 1 * 28.9 Weakly correlated
139 HERVL40-int 1 n.s 99.0 Moderately correlated
140 HUERS-P3-int 1 n.s 43.0 Weakly correlated
141 HUERS-P3b-int 1 n.s 43.0 Weakly correlated
142 L1M3 1 n.s 99.0 Moderately correlated
143 L1M4a2 1 n.s 99.0 Moderately correlated
144 L1MA4 1 n.s 87.0 Weakly correlated
145 L1MA6 1 n.s 87.0 Weakly correlated
146 L1MA9 1 n.s 99.0 Moderately correlated
147 L1MC3 1 n.s 99.0 Moderately correlated
148 L1MC5a 1 n.s 99.0 Moderately correlated
149 L1MD2 1 n.s 99.0 Moderately correlated
150 L1ME2 1 n.s 99.0 Moderately correlated
151 L1ME3 1 n.s 99.0 Moderately correlated
152 L1ME4c 1 n.s 99.0 Moderately correlated
153 L1MEd 1 n.s 99.0 Moderately correlated
154 L1P1 1 n.s 19.6 Weakly correlated
155 L1PA10 1 n.s 74.0 Weakly correlated
156 L1PA3 1 n.s 19.6 Weakly correlated
157 L1PB1 1 n.s 74.0 Weakly correlated
158 L1PBb 1 n.s 74.0 Weakly correlated
159 L4_A_Mam 1 n.s 99.0 Moderately correlated
160 LTR16D 1 * 99.0 Moderately correlated
161 LTR27D 1 ** 43.0 Weakly correlated
162 LTR38A1 1 ** 74.0 Weakly correlated
163 LTR41 1 n.s 99.0 Moderately correlated
164 LTR49-int 1 n.s 74.0 Weakly correlated
165 LTR50 1 n.s 99.0 Moderately correlated
166 LTR57 1 ** 74.0 Weakly correlated
167 LTR64 1 ** 74.0 Weakly correlated
168 LTR79 1 n.s 99.0 Moderately correlated
169 LTR81A 1 * 99.0 Moderately correlated
170 LTR83 1 * 99.0 Moderately correlated
171 LTR88c 1 * 99.0 Moderately correlated
172 MER101-int 1 n.s 74.0 Weakly correlated
173 MER39B 1 n.s 74.0 Weakly correlated
174 MER4CL34 1 n.s 43.0 Weakly correlated
175 MER50 1 n.s 43.0 Weakly correlated
176 MER57F 1 ** 74.0 Weakly correlated
177 MER65D 1 * 87.0 Weakly correlated
178 MER66A 1 ** 43.0 Weakly correlated
179 MER68-int 1 * 99.0 Moderately correlated
180 MER72 1 n.s 43.0 Weakly correlated
181 MER74A 1 n.s 99.0 Moderately correlated
182 MER77 1 n.s 99.0 Moderately correlated
183 MLT1G1 1 n.s 99.0 Moderately correlated
184 MLT1G3 1 n.s 99.0 Moderately correlated
185 MLT1H1 1 n.s 99.0 Moderately correlated
186 MLT1J1 1 n.s 99.0 Moderately correlated
187 MamGypLTR3 1 * 99.0 Moderately correlated
188 MamGypLTR3a 1 * 99.0 Moderately correlated
189 MamGypsy2-I 1 n.s 99.0 Moderately correlated
190 MamGypsy2-LTR 1 ** 99.0 Moderately correlated
191 MamRep1527 1 n.s 99.0 Moderately correlated
192 PRIMA4-int 1 * 74.0 Weakly correlated
193 PrimLTR79 1 *** 74.0 Weakly correlated
194 THE1D-int 1 n.s 28.9 Weakly correlated
195 X6B_LINE 1 ** 99.0 Moderately correlated
196 X7A_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1E2 145 **** 99.0 Moderately correlated
2 MLT1E3 67 **** 99.0 Moderately correlated
3 MLT1E1A 54 **** 99.0 Moderately correlated
4 MLT1F2 15 **** 99.0 Moderately correlated
5 MLT1E1 14 **** 99.0 Moderately correlated
6 MLT1E 12 **** 99.0 Moderately correlated
7 AluJb 7 n.s 74.0 Weakly correlated
8 AluJr 4 n.s 74.0 Weakly correlated
9 LTR76 3 **** 74.0 Weakly correlated
10 MIRb 3 n.s 99.0 Moderately correlated
11 L2a 3 n.s 99.0 Moderately correlated
12 L1PA13 2 n.s 74.0 Weakly correlated
13 MIRc 2 n.s 99.0 Moderately correlated
14 MLT1D 2 n.s 99.0 Moderately correlated
15 MLT1F 2 n.s 99.0 Moderately correlated
16 LTR103_Mam 2 *** 99.0 Moderately correlated
17 L1MD3 2 n.s 99.0 Moderately correlated
18 MLT1F1 1 n.s 99.0 Moderately correlated
19 LTR18A 1 ** 43.0 Weakly correlated
20 L2b 1 n.s 99.0 Moderately correlated
21 L1ME3A 1 n.s 99.0 Moderately correlated
22 ERVL-B4-int 1 n.s 99.0 Moderately correlated
23 LTR18B 1 * 43.0 Weakly correlated
24 MamGypLTR1d 1 * 99.0 Moderately correlated
25 L1ME3D 1 n.s 99.0 Moderately correlated
26 L1ME4a 1 n.s 99.0 Moderately correlated
27 MLT1A0 1 n.s 99.0 Moderately correlated
28 MER4CL34 1 n.s 43.0 Weakly correlated
29 L4_A_Mam 1 n.s 99.0 Moderately correlated
30 L1P2 1 n.s 28.9 Weakly correlated
31 L1PA5 1 n.s 19.6 Weakly correlated
32 L1PREC2 1 n.s 43.0 Weakly correlated
33 L2c 1 n.s 99.0 Moderately correlated
34 MLT1C 1 n.s 94.0 Highly correlated
35 FLAM_A 1 n.s 74.0 Weakly correlated
36 L1M1 1 n.s 74.0 Weakly correlated
37 L1M4 1 n.s 99.0 Moderately correlated
38 L2 1 n.s 99.0 Moderately correlated
39 MIR1_Amn 1 n.s 319.0 Weakly correlated
40 L1ME1 1 n.s 99.0 Moderately correlated
41 L1MEc 1 n.s 99.0 Moderately correlated
42 MIR 1 n.s 99.0 Moderately correlated
43 L3 1 n.s 99.0 Moderately correlated
44 AluSc8 1 n.s 74.0 Weakly correlated
45 L1M2a 1 n.s 87.0 Weakly correlated
46 AmnSINE1 1 * 319.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP