ZRdb KZFP & Repeats
...

Human_ZNF3

  • Protein
    Zinc finger protein 3
  • Length
    446
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    160.0 Mya
  • Time of Changing in binding specificity
    160.0 Mya
  • Uniprot_ID
    P17036
  • NCBI_ID
    7551
Sequence:
METQADLVSQEPQALLDSALPSKVPAFSDKDSLGDEMLAAALLKAKSQELVTFEDVAVYFIRKEWKRLEPAQRDLYRDVMLENYGNVFSLDRETRTENDQEISEDTRSHGVLLGRFQKDISQGLKFKEAYEREVSLKRPLGNSPGERLNRKMPDFGQVTVEEKLTPRGERSEKYNDFGNSFTVNSNLISHQRLPVGDRPHKCDECSKSFNRTSDLIQHQRIHTGEKPYECNECGKAFSQSSHLIQHQRIHTGEKPYECSDCGKTFSCSSALILHRRIHTGEKPYECNECGKTFSWSSTLTHHQRIHTGEKPYACNECGKAFSRSSTLIHHQRIHTGEKPYECNECGKAFSQSSHLYQHQRIHTGEKPYECMECGGKFTYSSGLIQHQRIHTGENPYECSECGKAFRYSSALVRHQRIHTGEKPLNGIGMSKSSLRVTTELNIREST
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 51..123
2 C2h2 200..222
3 C2h2 228..250
4 C2h2 256..278
5 C2h2 284..306
6 C2h2 312..334
7 C2h2 340..362
8 C2h2 368..390
9 C2h2 396..418
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA binding
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
5 Molecular Function identical protein binding
6 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
7 Molecular Function zinc ion binding
8 Biological Process cell differentiation
9 Biological Process leukocyte activation
10 Biological Process negative regulation of transcription by RNA polymerase II
11 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2a 15 *** 99.0 Weakly correlated
2 L2b 9 *** 99.0 Weakly correlated
3 LTR8 6 **** 43.0 Weakly correlated
4 MIRc 4 * 99.0 Weakly correlated
5 MIRb 4 n.s 99.0 Weakly correlated
6 MIR 4 n.s 99.0 Weakly correlated
7 MLT2D 3 **** 99.0 Weakly correlated
8 MIR3 3 * 99.0 Weakly correlated
9 LTR10A 3 **** 28.9 Weakly correlated
10 L2c 3 n.s 99.0 Weakly correlated
11 L2 2 n.s 99.0 Weakly correlated
12 LTR50 2 *** 99.0 Weakly correlated
13 AluJb 1 n.s 74.0 Weakly correlated
14 L1P1 1 n.s 19.6 Weakly correlated
15 MLT2C1 1 ** 99.0 Weakly correlated
16 AluJo 1 n.s 74.0 Weakly correlated
17 AluJr 1 n.s 74.0 Weakly correlated
18 AluSg 1 n.s 74.0 Weakly correlated
19 AluSx1 1 n.s 74.0 Weakly correlated
20 MER39B 1 ** 74.0 Weakly correlated
21 AluY 1 n.s 74.0 Weakly correlated
22 LTR13 1 ** 19.6 Weakly correlated
23 FLAM_C 1 n.s 74.0 Weakly correlated
24 HAL1 1 n.s 99.0 Weakly correlated
25 L1MA8 1 n.s 87.0 Weakly correlated
26 L1MEf 1 n.s 99.0 Weakly correlated
27 L1PA5 1 n.s 19.6 Weakly correlated
28 L1PA2 1 n.s 15.2 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJo 1 n.s 74.0 Weakly correlated
2 L2a 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP