ZRdb KZFP & Repeats
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Human_ZNF283

  • Protein
    Zinc finger protein 283
  • Length
    679
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q8N7M2
  • NCBI_ID
    284349
Sequence:
MESRSVAQAGVQWCDLGSLQAPPPGFTLFSCLSLLSSWDYSSGFSGFCASPIEESHGALISSCNSRTMTDGLVTFRDVAIDFSQEEWECLDPAQRDLYVDVMLENYSNLVSLDLESKTYETKKIFSENDIFEINFSQWEMKDKSKTLGLEASIFRNNWKCKSIFEGLKGHQEGYFSQMIISYEKIPSYRKSKSLTPHQRIHNTEKSYVCKECGKACSHGSKLVQHERTHTAEKHFECKECGKNYLSAYQLNVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGVKSYKCKECGKAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGYQLTQHQKIHTGKKPYECKICGKAFCWGYQLTRHQIFHTGEKPYECKECGKAFNCGSSLIQHERIHTGEKPYECKECGKAFSRGYHLSQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHTGEKSHECKECGKTFCSGYQLTRHQVFHTGEKPYECKECGKAFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLVKHERVHTNEKSYECKDCGKAFGSGYQLSVHQRFHTGEKLYQRKEFGKTFTCGSKLVHERTHSNDKPYKYNECGEAFLWTTYSNEKIDTDETL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 73..152
2 C2h2 205..227
3 C2h2 233..255
4 C2h2 261..283
5 C2h2 289..311
6 C2h2 317..339
7 C2h2 345..367
8 C2h2 373..395
9 C2h2 401..423
10 C2h2 429..451
11 C2h2 457..479
12 C2h2 485..507
13 C2h2 513..535
14 C2h2 541..563
15 C2h2 569..591
16 C2h2 597..619
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1H 179 **** 99.0 Highly correlated
2 MLT1H2 29 **** 99.0 Highly correlated
3 L2a 22 ** 99.0 Highly correlated
4 MIRb 18 ** 99.0 Highly correlated
5 THE1B 14 **** 43.0 Weakly correlated
6 L2c 12 * 99.0 Highly correlated
7 AluSx1 10 n.s 74.0 Weakly correlated
8 MIR 9 n.s 99.0 Highly correlated
9 MSTA 9 **** 43.0 Weakly correlated
10 AluY 8 n.s 74.0 Weakly correlated
11 MIR3 8 ** 99.0 Highly correlated
12 AluJr 7 n.s 74.0 Weakly correlated
13 THE1C 7 **** 43.0 Weakly correlated
14 AluJb 6 n.s 74.0 Weakly correlated
15 AluSz 6 n.s 74.0 Weakly correlated
16 THE1A 6 **** 43.0 Weakly correlated
17 THE1D 6 *** 43.0 Weakly correlated
18 AluSz6 5 n.s 74.0 Weakly correlated
19 L2b 5 n.s 99.0 Highly correlated
20 AluSx 4 n.s 74.0 Weakly correlated
21 L1M5 4 n.s 99.0 Highly correlated
22 LTR10A 4 **** 28.9 Weakly correlated
23 MLT1I 4 *** 99.0 Highly correlated
24 FLAM_C 3 * 74.0 Weakly correlated
25 L1M6 3 ** 99.0 Highly correlated
26 L1MC4 3 n.s 99.0 Highly correlated
27 L1PA15 3 n.s 74.0 Weakly correlated
28 L2 3 n.s 99.0 Highly correlated
29 AluSc 2 n.s 74.0 Weakly correlated
30 AluSc8 2 n.s 74.0 Weakly correlated
31 AluSg 2 n.s 74.0 Weakly correlated
32 AluSq2 2 n.s 74.0 Weakly correlated
33 ERVL-E-int 2 n.s 99.0 Highly correlated
34 HAL1 2 n.s 99.0 Highly correlated
35 HAL1b 2 ** 99.0 Highly correlated
36 L1MB3 2 n.s 99.0 Highly correlated
37 L1MD3 2 * 99.0 Highly correlated
38 L1ME3F 2 ** 99.0 Highly correlated
39 L1ME4b 2 n.s 99.0 Highly correlated
40 L1MEf 2 n.s 99.0 Highly correlated
41 MER50 2 ** 43.0 Weakly correlated
42 MIRc 2 n.s 99.0 Highly correlated
43 MLT1C 2 n.s 94.0 Weakly correlated
44 MLT1D 2 n.s 99.0 Highly correlated
45 MLT1L 2 * 99.0 Highly correlated
46 THE1B-int 2 n.s 43.0 Weakly correlated
47 AluJo 1 n.s 74.0 Weakly correlated
48 AluSg4 1 n.s 74.0 Weakly correlated
49 AluSp 1 n.s 74.0 Weakly correlated
50 AluSq10 1 ** 74.0 Weakly correlated
51 AluSx3 1 n.s 74.0 Weakly correlated
52 FLAM_A 1 n.s 74.0 Weakly correlated
53 HAL1M8 1 * 99.0 Highly correlated
54 HUERS-P3-int 1 * 43.0 Weakly correlated
55 L1M4b 1 n.s 99.0 Highly correlated
56 L1MA7 1 n.s 87.0 Weakly correlated
57 L1MA8 1 n.s 87.0 Weakly correlated
58 L1MB2 1 n.s 99.0 Highly correlated
59 L1MC3 1 n.s 99.0 Highly correlated
60 L1MDa 1 n.s 99.0 Highly correlated
61 L1ME3 1 n.s 99.0 Highly correlated
62 L1ME3A 1 n.s 99.0 Highly correlated
63 L1ME3B 1 n.s 99.0 Highly correlated
64 L1ME3E 1 n.s 99.0 Highly correlated
65 L1ME4a 1 n.s 99.0 Highly correlated
66 L1ME5 1 * 99.0 Highly correlated
67 L1MEc 1 n.s 99.0 Highly correlated
68 L1PA2 1 n.s 15.2 Weakly correlated
69 L1PA5 1 n.s 19.6 Weakly correlated
70 L1PB1 1 n.s 74.0 Weakly correlated
71 L4_A_Mam 1 n.s 99.0 Highly correlated
72 L4_B_Mam 1 * 99.0 Highly correlated
73 LFSINE_Vert 1 ** 319.0 Weakly correlated
74 LTR16 1 * 99.0 Highly correlated
75 LTR1B1 1 *** 43.0 Weakly correlated
76 LTR2752 1 ** 43.0 Weakly correlated
77 LTR33 1 n.s 99.0 Highly correlated
78 LTR41 1 ** 99.0 Highly correlated
79 LTR48 1 ** 74.0 Weakly correlated
80 LTR67B 1 * 99.0 Highly correlated
81 LTR85a 1 ** 99.0 Highly correlated
82 LTR9 1 ** 43.0 Weakly correlated
83 MER39 1 * 74.0 Weakly correlated
84 MER68 1 * 99.0 Highly correlated
85 MER68B 1 *** 99.0 Highly correlated
86 MER70A 1 ** 87.0 Weakly correlated
87 MER74A 1 * 99.0 Highly correlated
88 MIR1_Amn 1 * 319.0 Weakly correlated
89 MLT1A 1 n.s 99.0 Highly correlated
90 MLT1A0 1 n.s 99.0 Highly correlated
91 MLT1A1 1 n.s 87.0 Weakly correlated
92 MLT1B 1 n.s 99.0 Highly correlated
93 MLT1E2 1 n.s 99.0 Highly correlated
94 MLT1H-int 1 ** 99.0 Highly correlated
95 MLT1H1 1 * 99.0 Highly correlated
96 MLT1J 1 n.s 99.0 Highly correlated
97 MLT2B2 1 * 99.0 Highly correlated
98 MSTA-int 1 n.s 43.0 Weakly correlated
99 MamRTE1 1 n.s 99.0 Highly correlated
100 Plat_L3 1 ** 99.0 Highly correlated
101 THE1C-int 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1H 164 **** 99.0 Highly correlated
2 MLT1H2 20 **** 99.0 Highly correlated
3 THE1B 12 **** 43.0 Weakly correlated
4 MSTA 8 **** 43.0 Weakly correlated
5 THE1C 7 **** 43.0 Weakly correlated
6 L2a 6 n.s 99.0 Highly correlated
7 THE1D 6 *** 43.0 Weakly correlated
8 THE1A 6 **** 43.0 Weakly correlated
9 AluSx1 3 n.s 74.0 Weakly correlated
10 AluJr 3 n.s 74.0 Weakly correlated
11 AluSz 3 n.s 74.0 Weakly correlated
12 L2c 3 n.s 99.0 Highly correlated
13 MIRb 3 n.s 99.0 Highly correlated
14 AluSz6 3 n.s 74.0 Weakly correlated
15 HAL1 2 n.s 99.0 Highly correlated
16 L2b 2 n.s 99.0 Highly correlated
17 MLT1C 2 n.s 94.0 Weakly correlated
18 L1PA15 2 n.s 74.0 Weakly correlated
19 MLT1I 2 * 99.0 Highly correlated
20 AluSg 2 n.s 74.0 Weakly correlated
21 LTR48 1 ** 74.0 Weakly correlated
22 AluSq2 1 n.s 74.0 Weakly correlated
23 MER74A 1 * 99.0 Highly correlated
24 LTR9 1 ** 43.0 Weakly correlated
25 L1MA4A 1 n.s 87.0 Weakly correlated
26 L1MA8 1 n.s 87.0 Weakly correlated
27 LTR16 1 * 99.0 Highly correlated
28 LTR1B1 1 *** 43.0 Weakly correlated
29 LTR2752 1 ** 43.0 Weakly correlated
30 AluY 1 n.s 74.0 Weakly correlated
31 ERVL-E-int 1 n.s 99.0 Highly correlated
32 MIRc 1 n.s 99.0 Highly correlated
33 FLAM_C 1 n.s 74.0 Weakly correlated
34 L1MC3 1 n.s 99.0 Highly correlated
35 MamRTE1 1 n.s 99.0 Highly correlated
36 THE1B-int 1 n.s 43.0 Weakly correlated
37 AluJb 1 n.s 74.0 Weakly correlated
38 L4_A_Mam 1 n.s 99.0 Highly correlated
39 MER50 1 * 43.0 Weakly correlated
40 AluSc8 1 n.s 74.0 Weakly correlated
41 HUERS-P3-int 1 * 43.0 Weakly correlated
42 MLT1A0 1 n.s 99.0 Highly correlated
43 Plat_L3 1 ** 99.0 Highly correlated
44 THE1C-int 1 n.s 43.0 Weakly correlated
45 LTR41 1 ** 99.0 Highly correlated
46 L2 1 n.s 99.0 Highly correlated
47 MSTA-int 1 n.s 43.0 Weakly correlated
48 AluSx 1 n.s 74.0 Weakly correlated
49 L1ME4b 1 n.s 99.0 Highly correlated
50 MLT1A1 1 n.s 87.0 Weakly correlated
51 MLT1E2 1 n.s 99.0 Highly correlated
52 AluJo 1 n.s 74.0 Weakly correlated
53 L1M5 1 n.s 99.0 Highly correlated
54 L1MC4 1 n.s 99.0 Highly correlated
55 LTR33 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 THE1B 43.0 Weakly correlated