ZRdb KZFP & Repeats
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Human_ZNF268

  • Protein
    Zinc finger protein 268
  • Length
    947
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q14587
  • NCBI_ID
    10795
Sequence:
MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELCMVQAQVPNQTCPNTVWKIDDLMDWHQENKDKLGSTAKSFECTTFGKLCLLSTKYLSRQKPHKCGTHGKSLKYIDFTSDYARNNPNGFQVHGKSFFHSKHEQTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVHQQTHAEEKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHTGENPYECCECGKVFSRKDQLVSHQKTHSGQKPYVCNECGKAFGLKSQLIIHERIHTGEKPYECNECQKAFNTKSNLMVHQRTHTGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFKSQLIIHQRIHTGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTHTGEKPFECSECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKGVHTGVKPYGCSQCAKTFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTGEKPHECRECGKSFSFNSQLIVHQRIHTGENPYECSECGKAFNRKDQLISHQRTHAGEKPYGCSECGKAFSSKSYLIIHMRTHSGEKPYECNECGKAFIWKSLLIVHERTHAGVNPYKCSQCEKSFSGKLRLLVHQRMHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKTFSQKSILSAHQRTHTGEKPCKCTECGKAFCWKSQLIMHQRTHVDDKH
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 81..152
2 C2h2 276..298
3 C2h2 304..326
4 C2h2 332..354
5 C2h2 360..382
6 C2h2 388..410
7 C2h2 416..438
8 C2h2 444..466
9 C2h2 472..494
10 C2h2 500..522
11 C2h2 528..550
12 C2h2 556..578
13 C2h2 584..606
14 C2h2 612..634
15 C2h2 640..662
16 C2h2 668..690
17 C2h2 696..718
18 C2h2 724..746
19 C2h2 752..774
20 C2h2 780..802
21 C2h2 808..830
22 C2h2 836..858
23 C2h2 864..886
24 C2h2 892..914
25 C2h2 920..942
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component cytoplasm
2 Cellular Component cytosol
3 Cellular Component nucleus
4 Molecular Function DNA binding
5 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
6 Molecular Function DNA-binding transcription factor activity
7 Molecular Function metal ion binding
8 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
9 Biological Process cell differentiation
10 Biological Process cellular response to tumor necrosis factor
11 Biological Process negative regulation of apoptotic process
12 Biological Process negative regulation of cell population proliferation
13 Biological Process negative regulation of transcription by RNA polymerase II
14 Biological Process positive regulation of apoptotic process
15 Biological Process positive regulation of cell differentiation
16 Biological Process positive regulation of cell migration
17 Biological Process positive regulation of cell population proliferation
18 Biological Process positive regulation of NIK/NF-kappaB signaling
19 Biological Process positive regulation of protein catabolic process
20 Biological Process positive regulation of protein homodimerization activity
21 Biological Process positive regulation of protein phosphorylation
22 Biological Process positive regulation of transcription by RNA polymerase II
23 Biological Process regulation of cell cycle
24 Biological Process regulation of DNA-templated transcription
25 Biological Process regulation of mitotic cell cycle
26 Biological Process regulation of protein heterodimerization activity
27 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 9 **** 74.0 Weakly correlated
2 AluY 4 n.s 74.0 Weakly correlated
3 MER21B 4 **** 99.0 Moderately correlated
4 LTR10A 4 **** 28.9 Weakly correlated
5 LTR10F 3 **** 28.9 Weakly correlated
6 AluYj4 2 *** 0.0 Weakly correlated
7 SVA_E 1 ** 0.0 Weakly correlated
8 AluJb 1 n.s 74.0 Weakly correlated
9 MLT1L 1 n.s 99.0 Moderately correlated
10 LTR76 1 *** 74.0 Weakly correlated
11 LTR10B1 1 *** 28.9 Weakly correlated
12 L2c 1 n.s 99.0 Moderately correlated
13 L2a 1 n.s 99.0 Moderately correlated
14 L1PA2 1 n.s 15.2 Weakly correlated
15 L1PA10 1 n.s 74.0 Weakly correlated
16 L1P4 1 n.s 74.0 Weakly correlated
17 L1MC4 1 n.s 99.0 Moderately correlated
18 L1MB8 1 n.s 99.0 Moderately correlated
19 L1M3 1 n.s 99.0 Moderately correlated
20 L1HS 1 n.s 8.6 Weakly correlated
21 Harlequin-int 1 * 74.0 Weakly correlated
22 HERV17-int 1 * 28.9 Weakly correlated
23 FRAM 1 * 74.0 Weakly correlated
24 AluYa5 1 * 15.2 Weakly correlated
25 AluSc8 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSc8 1 n.s 74.0 Weakly correlated
2 AluY 1 n.s 74.0 Weakly correlated
3 L1PA10 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP