ZRdb KZFP & Repeats
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Human_ZNF256

  • Protein
    Zinc finger protein 256
  • Length
    627
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q9Y2P7
  • NCBI_ID
    10172
Sequence:
MAAAELTAPAQGIVTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSLGGSGAGDEEAPYQQSTSPQRVSQVRIPKALPSPQKTNPCEICGPVLRQILHLVEHQGTHHGQKLYTDGACRKQLQFTAYLHQHQKQHVGQKHFRSNGGRDMFLSSCTFEVSGKPFTCKEVGKDFLVRSRFLQQQAAHTRKKSNRTKSAVAFHSVKNHYNWGECVKAFSYKHVRVQHQGDLIRERSYMCSECGKSFSTSCSLSDHLRVHTSEKPYTCGECGKSYRQSSSLITHRRIHTGVRPHQCDECGKLFNRKYDLLIHQRVHTGERPYKCSECGKSFSHSSSLITHQRIHTGMRPYECSECGKSFIHSSSLITHQRVHTGTRPYMCSECGKSFSQSCHLIKHRRLHIGEGPYECSECGKLFTYRSRFFQHQRVHTGVRSHECHECGKLFSRKFDLIVHERVHTGERPYECSECGKSFTCKSYLISHWKVHTGARPYECGECGKSFTHSSTLLQHQRVHTGERPYECNECGKFFSQSSSLIRHRRSHTGERPYECSECWKSFSNHSSLVKHRRVHTGERPYECSECGKSFSQSSNLTNHQRIHSGERPYECSDCGKFFTFNSNLLKHQNVHKG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..96
2 C2h2 90..112
3 C2h2 239..261
4 C2h2 267..289
5 C2h2 295..317
6 C2h2 323..345
7 C2h2 351..373
8 C2h2 379..401
9 C2h2 407..429
10 C2h2 435..457
11 C2h2 463..485
12 C2h2 491..513
13 C2h2 519..541
14 C2h2 547..569
15 C2h2 575..597
16 C2h2 603..625
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleoplasm
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of DNA-templated transcription
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 12 **** 0.0 Weakly correlated
2 AluSc8 7 ** 74.0 Highly correlated
3 FRAM 7 **** 74.0 Highly correlated
4 L1P3 7 **** 74.0 Highly correlated
5 AluYm1 4 *** 19.6 Weakly correlated
6 AluYa8 4 **** 15.2 Weakly correlated
7 MER21B 3 ** 99.0 Weakly correlated
8 L1PA5 3 n.s 19.6 Weakly correlated
9 AluJo 3 n.s 74.0 Highly correlated
10 AluY 2 n.s 74.0 Highly correlated
11 L1PA2 2 n.s 15.2 Weakly correlated
12 AluJb 2 n.s 74.0 Highly correlated
13 AluSp 2 n.s 74.0 Highly correlated
14 HUERS-P3b-int 2 *** 43.0 Weakly correlated
15 L1PA10 1 n.s 74.0 Highly correlated
16 L1PA4 1 n.s 19.6 Weakly correlated
17 SVA_C 1 * 15.2 Weakly correlated
18 L2 1 n.s 99.0 Weakly correlated
19 L2b 1 n.s 99.0 Weakly correlated
20 LTR13 1 * 19.6 Weakly correlated
21 MLT-int 1 ** 99.0 Weakly correlated
22 MLT1L 1 n.s 99.0 Weakly correlated
23 L1P4 1 n.s 74.0 Highly correlated
24 L1MEg 1 n.s 99.0 Weakly correlated
25 L1MC4 1 n.s 99.0 Weakly correlated
26 L1M4 1 n.s 99.0 Weakly correlated
27 L1HS 1 n.s 8.6 Weakly correlated
28 AluYi6 1 *** 15.2 Weakly correlated
29 AluYb8 1 n.s 15.2 Weakly correlated
30 AluYa5 1 n.s 15.2 Weakly correlated
31 AluSz 1 n.s 74.0 Highly correlated
32 AluSx3 1 n.s 74.0 Highly correlated
33 AluSq 1 n.s 74.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSp 1 n.s 74.0 Highly correlated
2 AluJo 1 n.s 74.0 Highly correlated
3 L1PA5 1 n.s 19.6 Weakly correlated
4 AluSz 1 n.s 74.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP