ZRdb KZFP & Repeats
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Human_ZNF253

  • Protein
    Zinc finger protein 253
  • Length
    499
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    19.6 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    O75346
  • NCBI_ID
    56242
Sequence:
MGPLQFRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFLGIVVSKPDLVTCLEQGKKPLTMERHEMIAKPPVMSSHFAQDLWPENIQNSFQIGMLRRYEECRHDNLQLKKGCKSVGEHKVHKGGYNGLNQCLTTTQKEIFQCDKYGKVFHKFSNSNTYKTRHTGINLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRCEECGKAFNQSANLTTHKRIHTGEKPYRCEECGKAFKQSSNLTTHKKIHTGEKPYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGKAFKHPSHVTTHKKIHTRGKPYNCEECGKSFKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECGKAFNHSTTLFSHEKIHTGEKPYKCDECGKTFTWPSILSKHKRTHTGEKPYKCEECGKSFTASSTLTTHKRIHTGEKPYKCEECGKAFNWSSDLNKHKKIHIERKPYIVKNVTDLLNVPPLLISIR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 C2h2 172..194
3 C2h2 200..222
4 C2h2 228..250
5 C2h2 256..278
6 C2h2 284..306
7 C2h2 312..334
8 C2h2 340..362
9 C2h2 368..390
10 C2h2 396..418
11 C2h2 424..446
12 C2h2 452..474
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process negative regulation of DNA-templated transcription
6 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR22C0 58 **** 28.9 Moderately correlated
2 LTR22E 37 **** 28.9 Moderately correlated
3 LTR22B1 33 **** 28.9 Moderately correlated
4 LTR22B 28 **** 28.9 Moderately correlated
5 SVA_F 25 **** 0.0 Weakly correlated
6 LTR22C2 20 **** 28.9 Moderately correlated
7 AluJb 16 n.s 74.0 Weakly correlated
8 SVA_D 15 **** 15.2 Weakly correlated
9 LTR22C 14 **** 28.9 Moderately correlated
10 LTR8 12 **** 43.0 Weakly correlated
11 L1P3 11 **** 74.0 Weakly correlated
12 SVA_E 11 **** 0.0 Weakly correlated
13 AluSc8 8 ** 74.0 Weakly correlated
14 AluYj4 8 **** 0.0 Weakly correlated
15 AluY 7 n.s 74.0 Weakly correlated
16 FRAM 6 **** 74.0 Weakly correlated
17 L1MEd 5 n.s 99.0 Weakly correlated
18 L1MEi 5 *** 99.0 Weakly correlated
19 L2c 5 n.s 99.0 Weakly correlated
20 AluSz6 4 n.s 74.0 Weakly correlated
21 L1M4 4 n.s 99.0 Weakly correlated
22 L1MC4 4 n.s 99.0 Weakly correlated
23 LTR10A 4 **** 28.9 Moderately correlated
24 AluJo 3 n.s 74.0 Weakly correlated
25 AluSx1 3 n.s 74.0 Weakly correlated
26 AluYm1 3 ** 19.6 Highly correlated
27 HERVK22-int 3 *** 43.0 Weakly correlated
28 L1M2a 3 *** 87.0 Weakly correlated
29 L1M2c 3 **** 87.0 Weakly correlated
30 L1M4a2 3 ** 99.0 Weakly correlated
31 L1MA4A 3 n.s 87.0 Weakly correlated
32 L1MB7 3 n.s 99.0 Weakly correlated
33 L1MEc 3 n.s 99.0 Weakly correlated
34 L1PA2 3 n.s 15.2 Weakly correlated
35 L2 3 n.s 99.0 Weakly correlated
36 LTR10F 3 **** 28.9 Moderately correlated
37 LTR13 3 *** 19.6 Highly correlated
38 MER21B 3 ** 99.0 Weakly correlated
39 MIRb 3 n.s 99.0 Weakly correlated
40 AluJr 2 n.s 74.0 Weakly correlated
41 AluSg 2 n.s 74.0 Weakly correlated
42 AluSp 2 n.s 74.0 Weakly correlated
43 AluSq 2 n.s 74.0 Weakly correlated
44 AluSx 2 n.s 74.0 Weakly correlated
45 AluSz 2 n.s 74.0 Weakly correlated
46 AluYa8 2 **** 15.2 Weakly correlated
47 ERV3-16A3_I-int 2 n.s 99.0 Weakly correlated
48 HAL1M8 2 * 99.0 Weakly correlated
49 L1M2 2 n.s 99.0 Weakly correlated
50 L1M3 2 n.s 99.0 Weakly correlated
51 L1MA5 2 n.s 87.0 Weakly correlated
52 L1MA9 2 n.s 99.0 Weakly correlated
53 L1MC5 2 n.s 99.0 Weakly correlated
54 L1ME3A 2 n.s 99.0 Weakly correlated
55 L1MEg 2 n.s 99.0 Weakly correlated
56 L1PA11 2 n.s 74.0 Weakly correlated
57 L1PA5 2 n.s 19.6 Highly correlated
58 L1PB4 2 n.s 99.0 Weakly correlated
59 L1PBa 2 n.s 74.0 Weakly correlated
60 L1PREC2 2 n.s 43.0 Weakly correlated
61 L2a 2 n.s 99.0 Weakly correlated
62 AluJr4 1 n.s 74.0 Weakly correlated
63 AluSq2 1 n.s 74.0 Weakly correlated
64 AluYb8 1 n.s 15.2 Weakly correlated
65 AluYh9 1 **** 15.2 Weakly correlated
66 AluYi6 1 ** 15.2 Weakly correlated
67 ERVL-E-int 1 n.s 99.0 Weakly correlated
68 HAL1 1 n.s 99.0 Weakly correlated
69 HERV17-int 1 n.s 28.9 Moderately correlated
70 L1HS 1 n.s 8.6 Weakly correlated
71 L1M1 1 n.s 74.0 Weakly correlated
72 L1M3f 1 * 87.0 Weakly correlated
73 L1M4a1 1 n.s 99.0 Weakly correlated
74 L1M4b 1 n.s 99.0 Weakly correlated
75 L1M7 1 n.s 99.0 Weakly correlated
76 L1M8 1 n.s 99.0 Weakly correlated
77 L1MA4 1 n.s 87.0 Weakly correlated
78 L1MA8 1 n.s 87.0 Weakly correlated
79 L1MB8 1 n.s 99.0 Weakly correlated
80 L1MCb 1 n.s 99.0 Weakly correlated
81 L1MCc 1 n.s 99.0 Weakly correlated
82 L1MDb 1 * 99.0 Weakly correlated
83 L1MEf 1 n.s 99.0 Weakly correlated
84 L1P1 1 n.s 19.6 Highly correlated
85 L1P4 1 n.s 74.0 Weakly correlated
86 L1PA13 1 n.s 74.0 Weakly correlated
87 L1PA14 1 n.s 74.0 Weakly correlated
88 L1PA15 1 n.s 74.0 Weakly correlated
89 L1PA15-16 1 n.s 74.0 Weakly correlated
90 L1PA16 1 n.s 74.0 Weakly correlated
91 L1PA17 1 n.s 74.0 Weakly correlated
92 L1PA7 1 n.s 74.0 Weakly correlated
93 L1PA8A 1 n.s 74.0 Weakly correlated
94 L1PB1 1 n.s 74.0 Weakly correlated
95 L2b 1 n.s 99.0 Weakly correlated
96 LTR10B1 1 *** 28.9 Moderately correlated
97 LTR10E 1 ** 28.9 Moderately correlated
98 LTR12C 1 n.s 19.6 Highly correlated
99 LTR1D1 1 ** 43.0 Weakly correlated
100 LTR40a 1 n.s 99.0 Weakly correlated
101 LTR40b 1 * 99.0 Weakly correlated
102 LTR5_Hs 1 * 0.0 Weakly correlated
103 LTR8B 1 n.s 43.0 Weakly correlated
104 MER52A 1 n.s 74.0 Weakly correlated
105 MIR 1 n.s 99.0 Weakly correlated
106 MIR3 1 n.s 99.0 Weakly correlated
107 MIRc 1 n.s 99.0 Weakly correlated
108 MLT1D 1 n.s 99.0 Weakly correlated
109 MLT1I 1 n.s 99.0 Weakly correlated
110 MLT1J1-int 1 ** 99.0 Weakly correlated
111 MLT1L 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR22C0 55 **** 28.9 Moderately correlated
2 LTR22E 39 **** 28.9 Moderately correlated
3 LTR22B1 31 **** 28.9 Moderately correlated
4 LTR22B 27 **** 28.9 Moderately correlated
5 LTR22C2 18 **** 28.9 Moderately correlated
6 LTR22C 14 **** 28.9 Moderately correlated
7 FRAM 3 ** 74.0 Weakly correlated
8 AluYa8 2 **** 15.2 Weakly correlated
9 AluYj4 2 ** 0.0 Weakly correlated
10 L1MEi 1 n.s 99.0 Weakly correlated
11 MIRc 1 n.s 99.0 Weakly correlated
12 L1PB1 1 n.s 74.0 Weakly correlated
13 AluSc8 1 n.s 74.0 Weakly correlated
14 L1MA5 1 n.s 87.0 Weakly correlated
15 AluSq 1 n.s 74.0 Weakly correlated
16 L1MEf 1 n.s 99.0 Weakly correlated
17 L1PA2 1 n.s 15.2 Weakly correlated
18 HAL1M8 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP