ZRdb KZFP & Repeats
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Human_ZNF250

  • Protein
    Zinc finger protein 250
  • Length
    560
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P15622
  • NCBI_ID
    58500
Sequence:
MAAARLLPVPAGPQPLSFQAKLTFEDVAVLLSQDEWDRLCPAQRGLYRNVMMETYGNVVSLGLPGSKPDIISQLERGEDPWVLDRKGAKKSQGLWSDYSDNLKYDHTTACTQQDSLSCPWECETKGESQNTDLSPKPLISEQTVILGKTPLGRIDQENNETKQSFCLSPNSVDHREVQVLSQSMPLTPHQAVPSGERPYMCVECGKCFGRSSHLLQHQRIHTGEKPYVCSVCGKAFSQSSVLSKHRRIHTGEKPYECNECGKAFRVSSDLAQHHKIHTGEKPHECLECRKAFTQLSHLIQHQRIHTGERPYVCPLCGKAFNHSTVLRSHQRVHTGEKPHRCNECGKTFSVKRTLLQHQRIHTGEKPYTCSECGKAFSDRSVLIQHHNVHTGEKPYECSECGKTFSHRSTLMNHERIHTEEKPYACYECGKAFVQHSHLIQHQRVHTGEKPYVCGECGHAFSARRSLIQHERIHTGEKPFQCTECGKAFSLKATLIVHLRTHTGEKPYECNSCGKAFSQYSVLIQHQRIHTGEKPYECGECGRAFNQHGHLIQHQKVHRKL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 22..93
2 C2h2 199..221
3 C2h2 227..249
4 C2h2 255..277
5 C2h2 283..305
6 C2h2 311..333
7 C2h2 339..361
8 C2h2 367..389
9 C2h2 395..417
10 C2h2 423..445
11 C2h2 451..473
12 C2h2 479..501
13 C2h2 507..529
14 C2h2 535..557
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function identical protein binding
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Molecular Function sequence-specific double-stranded DNA binding
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MA3 42 **** 74.0 Weakly correlated
2 L1M4 41 **** 99.0 Highly correlated
3 L1M2 39 **** 99.0 Highly correlated
4 L1M3 39 **** 99.0 Highly correlated
5 L1MA9 36 **** 99.0 Highly correlated
6 L1MB3 32 **** 99.0 Highly correlated
7 L1MA4 25 **** 87.0 Weakly correlated
8 L1MA7 23 **** 87.0 Weakly correlated
9 L1MA8 23 **** 87.0 Weakly correlated
10 L1PREC2 23 **** 43.0 Weakly correlated
11 L1MB2 22 **** 99.0 Highly correlated
12 L1MA5 19 **** 87.0 Weakly correlated
13 L1MB4 18 **** 99.0 Highly correlated
14 L1PB1 18 *** 74.0 Weakly correlated
15 L1MA6 17 **** 87.0 Weakly correlated
16 L1MB1 17 **** 99.0 Highly correlated
17 L1MB5 17 **** 99.0 Highly correlated
18 L1MA2 16 **** 74.0 Weakly correlated
19 L1PA15 15 **** 74.0 Weakly correlated
20 L1M1 13 ** 74.0 Weakly correlated
21 L1PA16 13 ** 74.0 Weakly correlated
22 L1MB7 11 * 99.0 Highly correlated
23 L1M5 10 n.s 99.0 Highly correlated
24 L1MA4A 10 *** 87.0 Weakly correlated
25 L1MA5A 9 **** 87.0 Weakly correlated
26 L1PA13 9 * 74.0 Weakly correlated
27 L1PA7 9 n.s 74.0 Weakly correlated
28 L2c 9 n.s 99.0 Highly correlated
29 L2a 8 n.s 99.0 Highly correlated
30 MIRb 8 n.s 99.0 Highly correlated
31 L1PA10 7 n.s 74.0 Weakly correlated
32 L2b 7 n.s 99.0 Highly correlated
33 AluY 6 n.s 74.0 Weakly correlated
34 L1M4c 6 *** 99.0 Highly correlated
35 L1PA17 6 ** 74.0 Weakly correlated
36 L1PB 6 **** 74.0 Weakly correlated
37 L2 6 n.s 99.0 Highly correlated
38 AluSz 5 n.s 74.0 Weakly correlated
39 L1MB8 5 n.s 99.0 Highly correlated
40 L1P4 5 *** 74.0 Weakly correlated
41 L1PA5 5 n.s 19.6 Weakly correlated
42 L1PA8 5 n.s 74.0 Weakly correlated
43 LTR10A 5 **** 28.9 Weakly correlated
44 MIRc 5 n.s 99.0 Highly correlated
45 AluJb 4 n.s 74.0 Weakly correlated
46 AluJo 4 n.s 74.0 Weakly correlated
47 AluSc8 4 n.s 74.0 Weakly correlated
48 L1MA1 4 n.s 74.0 Weakly correlated
49 L1ME1 4 n.s 99.0 Highly correlated
50 L1P3 4 * 74.0 Weakly correlated
51 L1PA11 4 n.s 74.0 Weakly correlated
52 MIR 4 n.s 99.0 Highly correlated
53 L1M3e 3 *** 99.0 Highly correlated
54 L1PA14 3 n.s 74.0 Weakly correlated
55 L3 3 n.s 99.0 Highly correlated
56 AluSx 2 n.s 74.0 Weakly correlated
57 AluSx1 2 n.s 74.0 Weakly correlated
58 AluSz6 2 n.s 74.0 Weakly correlated
59 AluYj4 2 ** 0.0 Weakly correlated
60 FLAM_A 2 n.s 74.0 Weakly correlated
61 FRAM 2 * 74.0 Weakly correlated
62 L1MA10 2 n.s 99.0 Highly correlated
63 L1MC1 2 n.s 99.0 Highly correlated
64 L1MC4 2 n.s 99.0 Highly correlated
65 L1ME3Cz 2 n.s 99.0 Highly correlated
66 L1ME4b 2 n.s 99.0 Highly correlated
67 L1MEg 2 n.s 99.0 Highly correlated
68 L1P1 2 n.s 19.6 Weakly correlated
69 L1PA3 2 n.s 19.6 Weakly correlated
70 L1PA4 2 n.s 19.6 Weakly correlated
71 L1PB3 2 n.s 74.0 Weakly correlated
72 L1PBa 2 n.s 74.0 Weakly correlated
73 MER61A 2 *** 43.0 Weakly correlated
74 MIR1_Amn 2 * 319.0 Weakly correlated
75 MLT1B 2 n.s 99.0 Highly correlated
76 MLT1L 2 n.s 99.0 Highly correlated
77 THE1D 2 n.s 43.0 Weakly correlated
78 AluJr 1 n.s 74.0 Weakly correlated
79 AluSc 1 n.s 74.0 Weakly correlated
80 AluSg7 1 n.s 74.0 Weakly correlated
81 AluSp 1 n.s 74.0 Weakly correlated
82 AluSq2 1 n.s 74.0 Weakly correlated
83 AluSx3 1 n.s 74.0 Weakly correlated
84 AmnSINE1 1 * 319.0 Weakly correlated
85 ERVL-B4-int 1 n.s 99.0 Highly correlated
86 FLAM_C 1 n.s 74.0 Weakly correlated
87 HAL1ME 1 n.s 99.0 Highly correlated
88 L1M2a 1 * 87.0 Weakly correlated
89 L1M2c 1 * 87.0 Weakly correlated
90 L1M3d 1 * 99.0 Highly correlated
91 L1M3de 1 * 99.0 Highly correlated
92 L1M4a2 1 n.s 99.0 Highly correlated
93 L1M7 1 n.s 99.0 Highly correlated
94 L1MC 1 n.s 99.0 Highly correlated
95 L1MCc 1 n.s 99.0 Highly correlated
96 L1ME3A 1 n.s 99.0 Highly correlated
97 L1ME3G 1 n.s 99.0 Highly correlated
98 L1ME4a 1 n.s 99.0 Highly correlated
99 L1MEc 1 n.s 99.0 Highly correlated
100 L1MEi 1 n.s 99.0 Highly correlated
101 L1PA12 1 n.s 74.0 Weakly correlated
102 L1PA15-16 1 n.s 74.0 Weakly correlated
103 L1PB2 1 n.s 74.0 Weakly correlated
104 L1PB4 1 n.s 99.0 Highly correlated
105 LTR41B 1 * 99.0 Highly correlated
106 LTR78 1 n.s 99.0 Highly correlated
107 LTR7C 1 ** 28.9 Weakly correlated
108 LTR91 1 *** 99.0 Highly correlated
109 MER4A1 1 n.s 74.0 Weakly correlated
110 MER4B-int 1 n.s 99.0 Highly correlated
111 MER4E 1 * 74.0 Weakly correlated
112 MER66B 1 * 43.0 Weakly correlated
113 MER66D 1 *** 43.0 Weakly correlated
114 MLT1A0 1 n.s 99.0 Highly correlated
115 MLT1C 1 n.s 94.0 Weakly correlated
116 MLT1E3 1 n.s 99.0 Highly correlated
117 MLT1F1 1 n.s 99.0 Highly correlated
118 MSTA 1 n.s 43.0 Weakly correlated
119 MamRep605 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MA3 40 **** 74.0 Weakly correlated
2 L1M2 39 **** 99.0 Highly correlated
3 L1M3 39 **** 99.0 Highly correlated
4 L1M4 38 **** 99.0 Highly correlated
5 L1MA9 33 **** 99.0 Highly correlated
6 L1MB3 30 **** 99.0 Highly correlated
7 L1MA4 25 **** 87.0 Weakly correlated
8 L1MA8 23 **** 87.0 Weakly correlated
9 L1MA7 21 **** 87.0 Weakly correlated
10 L1PREC2 21 **** 43.0 Weakly correlated
11 L1MB2 19 **** 99.0 Highly correlated
12 L1MB4 18 **** 99.0 Highly correlated
13 L1PB1 18 *** 74.0 Weakly correlated
14 L1MA5 18 **** 87.0 Weakly correlated
15 L1MA6 17 **** 87.0 Weakly correlated
16 L1MA2 17 **** 74.0 Weakly correlated
17 L1MB1 16 **** 99.0 Highly correlated
18 L1MB5 15 **** 99.0 Highly correlated
19 L1PA15 15 **** 74.0 Weakly correlated
20 L1PA16 13 ** 74.0 Weakly correlated
21 L1M1 12 ** 74.0 Weakly correlated
22 L1MA4A 11 **** 87.0 Weakly correlated
23 L1MB7 10 n.s 99.0 Highly correlated
24 L1MA5A 9 **** 87.0 Weakly correlated
25 L1PA13 9 * 74.0 Weakly correlated
26 L1PA7 8 n.s 74.0 Weakly correlated
27 L1M5 7 n.s 99.0 Highly correlated
28 L1PA10 7 n.s 74.0 Weakly correlated
29 L1PB 6 **** 74.0 Weakly correlated
30 L1PA17 6 ** 74.0 Weakly correlated
31 L1PA5 5 n.s 19.6 Weakly correlated
32 L1P4 5 *** 74.0 Weakly correlated
33 L1M4c 5 ** 99.0 Highly correlated
34 L1PA8 5 n.s 74.0 Weakly correlated
35 L1MA1 4 n.s 74.0 Weakly correlated
36 L1P3 4 * 74.0 Weakly correlated
37 L1PA11 4 n.s 74.0 Weakly correlated
38 L1PA14 4 * 74.0 Weakly correlated
39 L1MB8 3 n.s 99.0 Highly correlated
40 L1PBa 2 n.s 74.0 Weakly correlated
41 L1P1 2 n.s 19.6 Weakly correlated
42 L1PB3 2 n.s 74.0 Weakly correlated
43 L1PA4 2 n.s 19.6 Weakly correlated
44 L1PA3 2 n.s 19.6 Weakly correlated
45 L1ME1 2 n.s 99.0 Highly correlated
46 L1MA10 2 n.s 99.0 Highly correlated
47 L1ME3Cz 2 n.s 99.0 Highly correlated
48 AluJo 1 n.s 74.0 Weakly correlated
49 L1MC1 1 n.s 99.0 Highly correlated
50 L1ME4b 1 n.s 99.0 Highly correlated
51 L1ME4a 1 n.s 99.0 Highly correlated
52 L1ME3G 1 n.s 99.0 Highly correlated
53 L1M3e 1 * 99.0 Highly correlated
54 L1M2a 1 * 87.0 Weakly correlated
55 L1M2c 1 * 87.0 Weakly correlated
56 L1M3de 1 * 99.0 Highly correlated
57 FLAM_A 1 n.s 74.0 Weakly correlated
58 L1PA12 1 n.s 74.0 Weakly correlated
59 L1PB4 1 n.s 99.0 Highly correlated
60 AluSc8 1 n.s 74.0 Weakly correlated
61 AluSz 1 n.s 74.0 Weakly correlated
62 L1PA15-16 1 n.s 74.0 Weakly correlated
63 L1MC 1 n.s 99.0 Highly correlated
64 MIRc 1 n.s 99.0 Highly correlated
65 MLT1F1 1 n.s 99.0 Highly correlated
66 L1M7 1 n.s 99.0 Highly correlated
67 L1PB2 1 n.s 74.0 Weakly correlated
68 L1MEg 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1M3 99.0 Highly correlated
2 L1M5 99.0 Highly correlated
3 L1MA4A 87.0 Weakly correlated
4 L1PB 74.0 Weakly correlated