ZRdb KZFP & Repeats
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Human_ZNF25

  • Protein
    Zinc finger protein 25
  • Length
    456
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P17030
  • NCBI_ID
    219749
Sequence:
MNKFQGPVTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWILEVEFPHRGFPEDLWSIHDLEARYQESQAGNSRNGELTKHQKTHTTEKACECKECGKFFCQKSALIVHQHTHSKGKSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYECKECKKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQKPHLTEHQKTHTGEKPFECTECGKFFYVKAYLMVHQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYECKECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTFYYKSDLTKHQRKHTGEKPYECTECGKSFAVNSVLRLHQRTHTGEKPYACKECGKSFSQKSHFIIHQRKHTGEKPYECQECGETFIQKSQLTAHQKTHTKKRNAEK
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 118..140
3 C2h2 146..168
4 C2h2 174..196
5 C2h2 202..224
6 C2h2 230..252
7 C2h2 258..280
8 C2h2 286..308
9 C2h2 314..336
10 C2h2 342..364
11 C2h2 370..392
12 C2h2 398..420
13 C2h2 426..448
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR8 5 **** 43.0 Weakly correlated
2 LTR10A 4 **** 28.9 Weakly correlated
3 L1P3 3 *** 74.0 Weakly correlated
4 AluJb 2 n.s 74.0 Weakly correlated
5 LTR10F 2 **** 28.9 Weakly correlated
6 AluJo 1 n.s 74.0 Weakly correlated
7 AluY 1 n.s 74.0 Weakly correlated
8 FRAM 1 ** 74.0 Weakly correlated
9 L1P4 1 * 74.0 Weakly correlated
10 L1PA2 1 n.s 15.2 Weakly correlated
11 L2b 1 n.s 99.0 Highly correlated
12 LTR13 1 *** 19.6 Weakly correlated
13 LTR33 1 * 99.0 Highly correlated
14 MIRb 1 n.s 99.0 Highly correlated
15 MLT1K 1 * 99.0 Highly correlated
16 THE1D 1 * 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP