ZRdb KZFP & Repeats
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Human_ZNF235

  • Protein
    Zinc finger protein 235
  • Length
    738
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q14590
  • NCBI_ID
    9310
Sequence:
MTKFQEAVTFKDVAVAFTEEELGLLDSAQRKLYRDVMLENFRNLVSVGHQSFKPDMISQLEREEKLWMKELQTQRGKHSGDRNQNEMATLHKAGLRCFSLGELSCWQIKRHIASKLARSQDSMINIEGKSSQFPKHHDSPCQVGAGESIQASVDDNCLVNHIGDHSSIIENQEFPTGKVPNSWSKIYLNETQNYQRSCKQTQMKNKLCIFAPYVDIFSCISHHHDDNIVHKRDKVHSNSDCGKDTLKVSPLTQRSIHTGQKTYQGNECEEAFNDSSSLELHKQVHLGKKSPACSTHEKDTSYSSGIPVQQSVRTGKKRYWCHECGKGFSQSSNLQTHQRVHTGEKPYTCHECGKSFNQSSHLYAHLPIHTGEKPYRCDSCGKGFSRSTDLNIHCRVHTGEKPYKCEVCGKGFTQRSHLQAHERIHTGEKPYKCGDCGKRFSCSSNLHTHQRVHTEEKPYKCDECGKCFSLSFNLHSHQRVHTGEKPYKCEECGKGFSSASSFQSHQRVHTGEKPFRCNVCGKGFSQSSYFQAHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFKCDACQKRFSQASHLQAHQRVHTGEKPYKCDTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDVCCKGFSQRSHLIYHQRVHTGGNL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 dec2h2 263..285
3 C2h2 319..341
4 C2h2 347..369
5 C2h2 375..397
6 C2h2 403..425
7 C2h2 431..453
8 C2h2 459..481
9 C2h2 487..509
10 C2h2 515..537
11 C2h2 543..565
12 C2h2 571..593
13 C2h2 599..621
14 C2h2 627..649
15 C2h2 655..677
16 C2h2 683..705
17 C2h2 711..733
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSx 3 n.s 74.0 Weakly correlated
2 LTR10A 3 **** 28.9 Weakly correlated
3 L1PA5 2 n.s 19.6 Weakly correlated
4 L1MEc 2 n.s 99.0 Highly correlated
5 L1MCc 1 ** 99.0 Highly correlated
6 MIR 1 n.s 99.0 Highly correlated
7 MER39B 1 *** 74.0 Weakly correlated
8 LTR13 1 *** 19.6 Weakly correlated
9 L1PA2 1 n.s 15.2 Weakly correlated
10 L1P1 1 * 19.6 Weakly correlated
11 L1MEd 1 n.s 99.0 Highly correlated
12 L1MEb 1 ** 99.0 Highly correlated
13 L1ME2 1 n.s 99.0 Highly correlated
14 AluJb 1 n.s 74.0 Weakly correlated
15 L1MB7 1 n.s 99.0 Highly correlated
16 L1M4a2 1 ** 99.0 Highly correlated
17 L1M4 1 n.s 99.0 Highly correlated
18 L1M3c 1 ** 99.0 Highly correlated
19 HAL1 1 n.s 99.0 Highly correlated
20 FRAM 1 ** 74.0 Weakly correlated
21 FLAM_C 1 * 74.0 Weakly correlated
22 AluYm1 1 ** 19.6 Weakly correlated
23 AluY 1 n.s 74.0 Weakly correlated
24 AluSg 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP