ZRdb KZFP & Repeats
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Human_ZNF234

  • Protein
    Zinc finger protein 234
  • Length
    700
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q14588
  • NCBI_ID
    10780
Sequence:
MTTFKEGLTFKDVAVVFTEEELGLLDPVQRNLYQDVMLENFRNLLSVGHHPFKHDVFLLEKEKKLDIMKTATQRKGKSADKIQSEVETVPEAGRHEELYWGQIWKQIASDLIKYEDSMISISRFPRQGDLSCQVRAGLYTTHTGQKFYQCDEYKKSFTDVFNFDLHQQLHSGEKSHTCDECGKSFCYISALHIHQRVHMGEKCYKCDVCGKEFSQSSHLQTHQRVHTVEKPFKCVECGKGFSRRSTLTVHCKLHSGEKPYNCEECGRAFIHASHLQEHQRIHTGEKPFKCDTCGKNFRRRSALNNHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKPYKCEECGKCFIQPSQFQAHRRIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKCNECGKSFRMKIHYQVHLVVHTGEKPYKCEVCGKAFRQSSYLKIHLKAHSVQKPFKCEECGQGFNQSSRLQIHQLIHTGEKPYKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVFSQASHLLTHQRVHSGEKPFKCEECGKSFSRSAHLQAHQKVHTGEKPYKCGECGKGFKWSLNLDMHQRVHTGEKPYTCGECGKHFSQASSLQLHQSVHTGEKPYKCDVCGKVFSRSSQLQYHRRVHTGEKPYKCEICGKRFSWRSNLVSHHKIHAAGTFYENDENSKNIRELSEGGSSTR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..90
2 dec2h2 148..170
3 C2h2 176..198
4 C2h2 204..226
5 C2h2 232..254
6 C2h2 260..282
7 C2h2 288..310
8 C2h2 316..338
9 C2h2 344..366
10 C2h2 372..394
11 C2h2 400..422
12 C2h2 428..450
13 C2h2 456..478
14 C2h2 484..506
15 C2h2 512..534
16 C2h2 540..562
17 C2h2 568..590
18 C2h2 596..618
19 C2h2 624..646
20 C2h2 652..674
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 18 n.s 74.0 Weakly correlated
2 LTR8 14 **** 43.0 Weakly correlated
3 SVA_F 13 **** 0.0 Weakly correlated
4 L1P3 10 **** 74.0 Weakly correlated
5 AluSc8 9 * 74.0 Weakly correlated
6 AluYj4 9 **** 0.0 Weakly correlated
7 L1MB8 8 n.s 99.0 Highly correlated
8 SVA_D 8 **** 15.2 Weakly correlated
9 SVA_E 7 **** 0.0 Weakly correlated
10 AluSx1 6 n.s 74.0 Weakly correlated
11 L2c 6 n.s 99.0 Highly correlated
12 AluSx 6 n.s 74.0 Weakly correlated
13 AluY 4 n.s 74.0 Weakly correlated
14 L1PA5 4 n.s 19.6 Weakly correlated
15 MER52A 4 * 74.0 Weakly correlated
16 AluSp 4 n.s 74.0 Weakly correlated
17 LTR8B 4 *** 43.0 Weakly correlated
18 LTR10A 4 **** 28.9 Weakly correlated
19 FRAM 3 * 74.0 Weakly correlated
20 L1MC1 3 n.s 99.0 Highly correlated
21 L1MB2 3 n.s 99.0 Highly correlated
22 L1MA9 3 n.s 99.0 Highly correlated
23 AluJr 3 n.s 74.0 Weakly correlated
24 AluSz6 3 n.s 74.0 Weakly correlated
25 ERV3-16A3_I-int 3 n.s 99.0 Highly correlated
26 MER21B 3 * 99.0 Highly correlated
27 MIRc 2 n.s 99.0 Highly correlated
28 L2b 2 n.s 99.0 Highly correlated
29 L1P4 2 n.s 74.0 Weakly correlated
30 L1PA14 2 n.s 74.0 Weakly correlated
31 L1PA2 2 n.s 15.2 Weakly correlated
32 L2a 2 n.s 99.0 Highly correlated
33 MLT1D-int 2 ** 99.0 Highly correlated
34 L1MC4 2 n.s 99.0 Highly correlated
35 MLT1E3 2 * 99.0 Highly correlated
36 LTR10F 2 *** 28.9 Weakly correlated
37 L1M4 2 n.s 99.0 Highly correlated
38 L1M3 2 n.s 99.0 Highly correlated
39 LTR28C 2 *** 43.0 Weakly correlated
40 MLT2A1 2 n.s 74.0 Weakly correlated
41 AluYa8 2 **** 15.2 Weakly correlated
42 AluSz 2 n.s 74.0 Weakly correlated
43 AluSg4 2 n.s 74.0 Weakly correlated
44 AluSc 2 n.s 74.0 Weakly correlated
45 THE1B-int 1 n.s 43.0 Weakly correlated
46 LTR16A 1 n.s 99.0 Highly correlated
47 MER52D 1 n.s 74.0 Weakly correlated
48 MER57B1 1 * 43.0 Weakly correlated
49 MIRb 1 n.s 99.0 Highly correlated
50 MLT1C-int 1 * 94.0 Weakly correlated
51 MLT1K 1 n.s 99.0 Highly correlated
52 MLT1L 1 n.s 99.0 Highly correlated
53 MSTA 1 n.s 43.0 Weakly correlated
54 L1ME1 1 n.s 99.0 Highly correlated
55 AluJo 1 n.s 74.0 Weakly correlated
56 AluSq 1 n.s 74.0 Weakly correlated
57 AluYh9 1 **** 15.2 Weakly correlated
58 AluYm1 1 n.s 19.6 Weakly correlated
59 ERVL-int 1 n.s 99.0 Highly correlated
60 HAL1 1 n.s 99.0 Highly correlated
61 L1M2 1 n.s 99.0 Highly correlated
62 L1MB7 1 n.s 99.0 Highly correlated
63 L1MC3 1 n.s 99.0 Highly correlated
64 L1MD 1 n.s 99.0 Highly correlated
65 LTR13 1 * 19.6 Weakly correlated
66 L1P1 1 n.s 19.6 Weakly correlated
67 L1PA10 1 n.s 74.0 Weakly correlated
68 L1PA3 1 n.s 19.6 Weakly correlated
69 L1PA4 1 n.s 19.6 Weakly correlated
70 L1PB1 1 n.s 74.0 Weakly correlated
71 L2 1 n.s 99.0 Highly correlated
72 LTR105_Mam 1 ** 99.0 Highly correlated
73 LTR10B1 1 ** 28.9 Weakly correlated
74 LTR12C 1 n.s 19.6 Weakly correlated
75 LTR12D 1 * 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 3 n.s 74.0 Weakly correlated
2 AluSp 2 n.s 74.0 Weakly correlated
3 AluSq 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP