ZRdb KZFP & Repeats
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Human_ZNF233

  • Protein
    Zinc finger protein 233
  • Length
    670
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    A6NK53
  • NCBI_ID
    353355
Sequence:
MTKFQEMVTFKDVAVVFTREELGLLDLAQRKLYQDVMLENFRNLLSVGYQPFKLDVILQLGKEDKLRMMETEIQGDGCSGHKNQNEIDTLQEVRLRFLSYEDLICWQIWEQFTSKLTSNQDLIINLQGKRSKLLKQGDSPCQVWTGESSQVSEDENYVIKLQGESSNSIKNQELPLRTTWDFWRKMYLREPQNYQSRCQQIDVKNKLCKCDHCVRQRIAHQHDDHGVHKREKAFSHNNCGKDCVKESSQHSIIQSGEQTSDENGKGLSVGSNLELHQQLHLRDKPHVNVEYGKGIGYSSGLPRHQCFHIGEKCYRNGDSGEGFSQGSHLQPHQRVSTGENLYRCQVYARSSNQNSCLPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDSAGERACKCDVYDKGFSQTSQLQAHQRGHSRDKTYKWEVSDRIFNRNSGLHQRVHTGEKPYKCEVCDKGFSKASNLQAHQRIHTGEKPYKCDVCDKNFSRNSHLQAHQRVHTGEKPYKCDTCGKDFSQISHLQAHQRVHKGEKPYKCETCGKGFSQSSHLQDHQQVHTGENPYKCDVCGKGFSWSSHLQAHQRVHTGEKPYKCEECRKGFIWNSYLHVHQRIHTGEKPYKCGMCGKSFSQTSHLQAHQRVHTGEKPYKCFVCGKGFSKSSLSSDSSESP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 dec2h2 258..280
3 dec2h2 311..336
4 dec2h2 342..364
5 dec2h2 370..392
6 dec2h2 398..420
7 C2h2 452..474
8 C2h2 480..502
9 C2h2 508..530
10 C2h2 536..558
11 C2h2 564..586
12 C2h2 592..614
13 C2h2 620..642
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 12 **** 74.0 Weakly correlated
2 LTR8 10 **** 43.0 Weakly correlated
3 AluSc8 7 ** 74.0 Weakly correlated
4 AluJb 4 n.s 74.0 Weakly correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 MER21B 3 ** 99.0 Highly correlated
7 L1PA2 3 n.s 15.2 Weakly correlated
8 AluYj4 3 *** 0.0 Weakly correlated
9 L1MB8 3 n.s 99.0 Highly correlated
10 AluJo 2 n.s 74.0 Weakly correlated
11 L2c 2 n.s 99.0 Highly correlated
12 L1P4 2 * 74.0 Weakly correlated
13 L1MC4 2 n.s 99.0 Highly correlated
14 FRAM 2 * 74.0 Weakly correlated
15 AluY 2 n.s 74.0 Weakly correlated
16 L1PA5 1 n.s 19.6 Weakly correlated
17 SVA_F 1 * 0.0 Weakly correlated
18 MLT1L 1 n.s 99.0 Highly correlated
19 MIRc 1 n.s 99.0 Highly correlated
20 MER52A 1 n.s 74.0 Weakly correlated
21 AluSg4 1 n.s 74.0 Weakly correlated
22 AluSp 1 n.s 74.0 Weakly correlated
23 LTR13 1 * 19.6 Weakly correlated
24 LTR10B1 1 *** 28.9 Weakly correlated
25 AluSx 1 n.s 74.0 Weakly correlated
26 AluSx1 1 n.s 74.0 Weakly correlated
27 L1MA9 1 n.s 99.0 Highly correlated
28 L1PA4 1 n.s 19.6 Weakly correlated
29 L1PA3 1 n.s 19.6 Weakly correlated
30 AluSz 1 n.s 74.0 Weakly correlated
31 L1PA10 1 n.s 74.0 Weakly correlated
32 L1MEg 1 n.s 99.0 Highly correlated
33 L1M3 1 n.s 99.0 Highly correlated
34 L1M4 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA5 1 n.s 19.6 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP