ZRdb KZFP & Repeats
...

Human_ZNF230

  • Protein
    Zinc finger protein 230
  • Length
    474
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q9UIE0
  • NCBI_ID
    7773
Sequence:
MTTFKEAVTFKDVAVFFTEEELGLLDPAQRKLYQDVMLENFTNLLSVGHQPFHPFHFLREEKFWMMETATQREGNSGGKTIAEAGPHEDCPCQQIWEQTASDLTQSQDSIINNSHFFEQGDVPSQVEAGLSIIHTGQKPSQNGKCKQSFSDVAIFDPPQQFHSGEKSHTCNECGKSFCYISALRIHQRVHLREKLSKCDMRGKEFSQSSCLQTRERVHTGEKPFKCEQCGKGFRCRAILQVHCKLHTGEKPYICEKCGRAFIHDFQLQKHQIIHTGEKPFKCEICGKSFCLRSSLNRHCMVHTAEKLYKSEECGKGFTDSLDLHKHQIIHTGQKPYNCKECGKSFRWSSYLLIHQRIHSGEKPYRCEECGKGYISKSGLNLHQRVHTGERPYNCKECGKSFSRASSILNHKKLHCRKKPFKCEDCGKRLVHRSFCKDQQGDHNGENSSKCEDCGKRYKRRLNLDIILSLFLNDM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 8..76
2 C2h2 168..190
3 C2h2 196..218
4 C2h2 224..246
5 C2h2 252..274
6 C2h2 280..302
7 C2h2 308..330
8 C2h2 336..358
9 C2h2 364..386
10 C2h2 392..414
11 C2h2 420..442
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA17 40 **** 74.0 Weakly correlated
2 AluY 33 n.s 74.0 Weakly correlated
3 L1PA16 27 *** 74.0 Weakly correlated
4 AluJb 26 n.s 74.0 Weakly correlated
5 LTR13 23 **** 19.6 Weakly correlated
6 LTR41 19 **** 99.0 Weakly correlated
7 L2a 18 n.s 99.0 Weakly correlated
8 L1M1 17 * 74.0 Weakly correlated
9 AluSx 16 n.s 74.0 Weakly correlated
10 L1PA15-16 16 **** 74.0 Weakly correlated
11 L2c 16 n.s 99.0 Weakly correlated
12 AluSz 15 n.s 74.0 Weakly correlated
13 AluSx1 14 n.s 74.0 Weakly correlated
14 L1M3f 14 **** 87.0 Weakly correlated
15 L1MA4 14 * 87.0 Weakly correlated
16 MIR 14 n.s 99.0 Weakly correlated
17 MIRb 14 n.s 99.0 Weakly correlated
18 MIRc 14 n.s 99.0 Weakly correlated
19 AluJr 13 n.s 74.0 Weakly correlated
20 AluSz6 13 n.s 74.0 Weakly correlated
21 THE1C-int 13 **** 43.0 Moderately correlated
22 AluJo 11 n.s 74.0 Weakly correlated
23 L1PA7 11 n.s 74.0 Weakly correlated
24 MIR3 11 n.s 99.0 Weakly correlated
25 THE1B-int 11 * 43.0 Moderately correlated
26 AluSc8 10 n.s 74.0 Weakly correlated
27 L1MEc 10 n.s 99.0 Weakly correlated
28 L1P4a 10 **** 74.0 Weakly correlated
29 AluSg 9 n.s 74.0 Weakly correlated
30 L1ME1 9 n.s 99.0 Weakly correlated
31 L1MEf 9 n.s 99.0 Weakly correlated
32 THE1D-int 9 *** 28.9 Highly correlated
33 AluSq2 8 n.s 74.0 Weakly correlated
34 AluYj4 8 **** 0.0 Weakly correlated
35 HUERS-P3-int 8 **** 43.0 Moderately correlated
36 L1P3 8 ** 74.0 Weakly correlated
37 L1PA15 8 n.s 74.0 Weakly correlated
38 L1MB8 7 n.s 99.0 Weakly correlated
39 L1PB4 7 n.s 99.0 Weakly correlated
40 L2 7 n.s 99.0 Weakly correlated
41 L2b 7 n.s 99.0 Weakly correlated
42 AluSp 6 n.s 74.0 Weakly correlated
43 L1M4 6 n.s 99.0 Weakly correlated
44 L1M4b 6 * 99.0 Weakly correlated
45 L1MB5 6 n.s 99.0 Weakly correlated
46 L1MEg 6 n.s 99.0 Weakly correlated
47 L1PREC2 6 n.s 43.0 Moderately correlated
48 LTR50 6 **** 99.0 Weakly correlated
49 LTR8 6 ** 43.0 Moderately correlated
50 MER83 6 **** 43.0 Moderately correlated
51 SVA_F 6 **** 0.0 Weakly correlated
52 AluSx3 5 n.s 74.0 Weakly correlated
53 HERVL40-int 5 **** 99.0 Weakly correlated
54 L1MD2 5 n.s 99.0 Weakly correlated
55 MSTA-int 5 n.s 43.0 Moderately correlated
56 MamRTE1 5 ** 99.0 Weakly correlated
57 AluSc 4 n.s 74.0 Weakly correlated
58 FLAM_C 4 n.s 74.0 Weakly correlated
59 HERVIP10F-int 4 *** 28.9 Highly correlated
60 L1MC4 4 n.s 99.0 Weakly correlated
61 L1MC5a 4 n.s 99.0 Weakly correlated
62 L1MDa 4 n.s 99.0 Weakly correlated
63 L1P4d 4 **** 74.0 Weakly correlated
64 L1PA4 4 n.s 19.6 Weakly correlated
65 LTR10A 4 **** 28.9 Highly correlated
66 LTR41B 4 **** 99.0 Weakly correlated
67 MER50 4 * 43.0 Moderately correlated
68 MLT1K 4 n.s 99.0 Weakly correlated
69 THE1B 4 n.s 43.0 Moderately correlated
70 AluSg4 3 n.s 74.0 Weakly correlated
71 HUERS-P3b-int 3 ** 43.0 Moderately correlated
72 L1M2 3 n.s 99.0 Weakly correlated
73 L1M3e 3 ** 99.0 Weakly correlated
74 L1MA3 3 n.s 74.0 Weakly correlated
75 L1MB7 3 n.s 99.0 Weakly correlated
76 L1MC4a 3 n.s 99.0 Weakly correlated
77 L1PA3 3 n.s 19.6 Weakly correlated
78 L1PA5 3 n.s 19.6 Weakly correlated
79 LOR1-int 3 * 74.0 Weakly correlated
80 LTR1A2 3 ** 43.0 Moderately correlated
81 LTR71B 3 **** 43.0 Moderately correlated
82 MER21B 3 n.s 99.0 Weakly correlated
83 MER61-int 3 * 43.0 Moderately correlated
84 MER61A 3 *** 43.0 Moderately correlated
85 AluJr4 2 n.s 74.0 Weakly correlated
86 AluSq 2 n.s 74.0 Weakly correlated
87 AluYa5 2 n.s 15.2 Weakly correlated
88 AluYb8 2 n.s 15.2 Weakly correlated
89 AluYf1 2 * 19.6 Weakly correlated
90 FRAM 2 n.s 74.0 Weakly correlated
91 HAL1 2 n.s 99.0 Weakly correlated
92 L1HS 2 n.s 8.6 Weakly correlated
93 L1M2a 2 * 87.0 Weakly correlated
94 L1MA4A 2 n.s 87.0 Weakly correlated
95 L1MA9 2 n.s 99.0 Weakly correlated
96 L1ME2 2 n.s 99.0 Weakly correlated
97 L1ME3A 2 n.s 99.0 Weakly correlated
98 L1ME3D 2 n.s 99.0 Weakly correlated
99 L1MEd 2 n.s 99.0 Weakly correlated
100 L1P2 2 n.s 28.9 Highly correlated
101 L1P4 2 n.s 74.0 Weakly correlated
102 L1PA10 2 n.s 74.0 Weakly correlated
103 L1PA14 2 n.s 74.0 Weakly correlated
104 L1PA2 2 n.s 15.2 Weakly correlated
105 L3 2 n.s 99.0 Weakly correlated
106 LTR12E 2 *** 19.6 Weakly correlated
107 LTR41C 2 ** 99.0 Weakly correlated
108 LTR55 2 *** 99.0 Weakly correlated
109 LTR5_Hs 2 * 0.0 Weakly correlated
110 LTR78 2 n.s 99.0 Weakly correlated
111 MER21C 2 n.s 99.0 Weakly correlated
112 MER4-int 2 n.s 74.0 Weakly correlated
113 MLT1A0 2 n.s 99.0 Weakly correlated
114 MLT1E3 2 n.s 99.0 Weakly correlated
115 MLT1F 2 n.s 99.0 Weakly correlated
116 MLT1H 2 n.s 99.0 Weakly correlated
117 MLT1J 2 n.s 99.0 Weakly correlated
118 MLT2F 2 * 99.0 Weakly correlated
119 Plat_L3 2 * 99.0 Weakly correlated
120 SVA_D 2 n.s 15.2 Weakly correlated
121 THE1A-int 2 n.s 43.0 Moderately correlated
122 Alu 1 * 74.0 Weakly correlated
123 AluSg7 1 n.s 74.0 Weakly correlated
124 AluSq10 1 n.s 74.0 Weakly correlated
125 AluSq4 1 n.s 74.0 Weakly correlated
126 AluSx4 1 n.s 74.0 Weakly correlated
127 AluYe5 1 n.s 74.0 Weakly correlated
128 AluYe6 1 ** 74.0 Weakly correlated
129 AluYh3a3 1 ** 15.2 Weakly correlated
130 AluYh9 1 *** 15.2 Weakly correlated
131 AluYk4 1 n.s 15.2 Weakly correlated
132 AmnSINE1 1 * 319.0 Weakly correlated
133 ERV24B_Prim-int 1 * 74.0 Weakly correlated
134 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
135 FLAM_A 1 n.s 74.0 Weakly correlated
136 HAL1ME 1 n.s 99.0 Weakly correlated
137 HERV17-int 1 n.s 28.9 Highly correlated
138 HERVE_a-int 1 n.s 28.9 Highly correlated
139 HERVK-int 1 n.s 28.9 Highly correlated
140 HERVL18-int 1 n.s 43.0 Moderately correlated
141 L1M3 1 n.s 99.0 Weakly correlated
142 L1M4a1 1 n.s 99.0 Weakly correlated
143 L1M4a2 1 n.s 99.0 Weakly correlated
144 L1M5 1 n.s 99.0 Weakly correlated
145 L1MA1 1 n.s 74.0 Weakly correlated
146 L1MA2 1 n.s 74.0 Weakly correlated
147 L1MA5 1 n.s 87.0 Weakly correlated
148 L1MA5A 1 n.s 87.0 Weakly correlated
149 L1MA6 1 n.s 87.0 Weakly correlated
150 L1MA7 1 n.s 87.0 Weakly correlated
151 L1MA8 1 n.s 87.0 Weakly correlated
152 L1MB1 1 n.s 99.0 Weakly correlated
153 L1MB3 1 n.s 99.0 Weakly correlated
154 L1MB4 1 n.s 99.0 Weakly correlated
155 L1MC 1 n.s 99.0 Weakly correlated
156 L1MC3 1 n.s 99.0 Weakly correlated
157 L1MC5 1 n.s 99.0 Weakly correlated
158 L1MCc 1 n.s 99.0 Weakly correlated
159 L1MDb 1 n.s 99.0 Weakly correlated
160 L1ME3B 1 n.s 99.0 Weakly correlated
161 L1ME3Cz 1 n.s 99.0 Weakly correlated
162 L1ME3F 1 n.s 99.0 Weakly correlated
163 L1ME4b 1 n.s 99.0 Weakly correlated
164 L1ME4c 1 n.s 99.0 Weakly correlated
165 L1MEh 1 n.s 99.0 Weakly correlated
166 L1MEi 1 n.s 99.0 Weakly correlated
167 L1P1 1 n.s 19.6 Weakly correlated
168 L1P5 1 ** 74.0 Weakly correlated
169 L1PA11 1 n.s 74.0 Weakly correlated
170 L1PA13 1 n.s 74.0 Weakly correlated
171 L1PA6 1 n.s 28.9 Highly correlated
172 L1PB1 1 n.s 74.0 Weakly correlated
173 L1PB2 1 n.s 74.0 Weakly correlated
174 L3b 1 n.s 99.0 Weakly correlated
175 LTR103b_Mam 1 ** 99.0 Weakly correlated
176 LTR10B1 1 ** 28.9 Highly correlated
177 LTR12C 1 n.s 19.6 Weakly correlated
178 LTR16D2 1 ** 99.0 Weakly correlated
179 LTR18A 1 ** 43.0 Moderately correlated
180 LTR1A1 1 * 43.0 Moderately correlated
181 LTR24 1 ** 74.0 Weakly correlated
182 LTR26E 1 ** 74.0 Weakly correlated
183 LTR27E 1 * 43.0 Moderately correlated
184 LTR3B 1 *** 28.9 Highly correlated
185 LTR43 1 * 74.0 Weakly correlated
186 LTR47A2 1 ** 74.0 Weakly correlated
187 LTR76 1 ** 74.0 Weakly correlated
188 LTR82B 1 n.s 99.0 Weakly correlated
189 LTR88b 1 * 99.0 Weakly correlated
190 LTR8B 1 n.s 43.0 Moderately correlated
191 LTR91 1 ** 99.0 Weakly correlated
192 MER11A 1 n.s 28.9 Highly correlated
193 MER21-int 1 n.s 99.0 Weakly correlated
194 MER34 1 n.s 87.0 Weakly correlated
195 MER41C 1 * 74.0 Weakly correlated
196 MER51A 1 n.s 43.0 Moderately correlated
197 MER57A1 1 n.s 43.0 Moderately correlated
198 MER61D 1 ** 43.0 Moderately correlated
199 MER61E 1 * 43.0 Moderately correlated
200 MER65C 1 * 74.0 Weakly correlated
201 MER66-int 1 n.s 43.0 Moderately correlated
202 MER66A 1 ** 43.0 Moderately correlated
203 MER67C 1 n.s 99.0 Weakly correlated
204 MLT1A1 1 n.s 87.0 Weakly correlated
205 MLT1A1-int 1 n.s 87.0 Weakly correlated
206 MLT1B-int 1 * 99.0 Weakly correlated
207 MLT1C 1 n.s 94.0 Weakly correlated
208 MLT1D 1 n.s 99.0 Weakly correlated
209 MLT1G 1 n.s 99.0 Weakly correlated
210 MLT1G3-int 1 ** 99.0 Weakly correlated
211 MLT1I 1 n.s 99.0 Weakly correlated
212 MLT1J2 1 n.s 99.0 Weakly correlated
213 MLT1J2-int 1 * 99.0 Weakly correlated
214 MLT1L 1 n.s 99.0 Weakly correlated
215 MLT2A2 1 n.s 74.0 Weakly correlated
216 MSTA 1 n.s 43.0 Moderately correlated
217 MSTB1 1 n.s 74.0 Weakly correlated
218 MamGypLTR3a 1 n.s 99.0 Weakly correlated
219 MamGypsy2-LTR 1 ** 99.0 Weakly correlated
220 MamRep1527 1 n.s 99.0 Weakly correlated
221 SVA_A 1 n.s 19.6 Weakly correlated
222 SVA_E 1 n.s 0.0 Weakly correlated
223 THE1-int 1 ** 43.0 Moderately correlated
224 THE1D 1 n.s 43.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA17 4 n.s 74.0 Weakly correlated
2 L1PA7 3 n.s 74.0 Weakly correlated
3 L1P4a 3 ** 74.0 Weakly correlated
4 L1PA16 2 n.s 74.0 Weakly correlated
5 LTR5_Hs 1 n.s 0.0 Weakly correlated
6 L3b 1 n.s 99.0 Weakly correlated
7 L2a 1 n.s 99.0 Weakly correlated
8 L1ME2 1 n.s 99.0 Weakly correlated
9 L1MB8 1 n.s 99.0 Weakly correlated
10 L1M4 1 n.s 99.0 Weakly correlated
11 L2 1 n.s 99.0 Weakly correlated
12 L1PA15 1 n.s 74.0 Weakly correlated
13 L1M2a 1 n.s 87.0 Weakly correlated
14 MIRc 1 n.s 99.0 Weakly correlated
15 MER50 1 n.s 43.0 Moderately correlated
16 LTR41B 1 * 99.0 Weakly correlated
17 HUERS-P3b-int 1 n.s 43.0 Moderately correlated
18 MLT1G 1 n.s 99.0 Weakly correlated
19 AluJr 1 n.s 74.0 Weakly correlated
20 L1ME1 1 n.s 99.0 Weakly correlated
21 AluJb 1 n.s 74.0 Weakly correlated
22 LOR1-int 1 n.s 74.0 Weakly correlated
23 L1MEc 1 n.s 99.0 Weakly correlated
24 L1M1 1 n.s 74.0 Weakly correlated
25 L1PA15-16 1 n.s 74.0 Weakly correlated
26 L1P4d 1 * 74.0 Weakly correlated
27 LTR26E 1 ** 74.0 Weakly correlated
28 L1MEf 1 n.s 99.0 Weakly correlated
29 L1MB7 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP