ZRdb KZFP & Repeats
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Human_ZNF227

  • Protein
    Zinc finger protein 227
  • Length
    799
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q86WZ6
  • NCBI_ID
    7770
Sequence:
MPSQNYDLPQKKQEKMTKFQEAVTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGHLPFQPDMVSQLEAEEKLWMMETETQRSSKHQNKMETLQKFALKYLSNQELSCWQIWKQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKKSPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCHESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTYHQKVHTGKKL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 23..94
2 C2h2 250..272
3 C2h2 269..291
4 C2h2 324..346
5 C2h2 352..374
6 C2h2 380..402
7 C2h2 408..430
8 C2h2 436..458
9 C2h2 464..486
10 C2h2 492..514
11 C2h2 520..542
12 C2h2 548..570
13 C2h2 576..598
14 C2h2 604..626
15 C2h2 632..654
16 C2h2 660..682
17 C2h2 688..710
18 C2h2 716..738
19 C2h2 744..766
20 C2h2 772..794
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER21B 4 **** 99.0 Highly correlated
2 LTR10A 4 **** 28.9 Weakly correlated
3 AluY 3 n.s 74.0 Weakly correlated
4 L1PA10 3 * 74.0 Weakly correlated
5 AluSx1 2 n.s 74.0 Weakly correlated
6 L1M4 2 n.s 99.0 Highly correlated
7 AluJb 2 n.s 74.0 Weakly correlated
8 L1MB8 1 n.s 99.0 Highly correlated
9 SVA_D 1 * 15.2 Weakly correlated
10 MLT2A1 1 ** 74.0 Weakly correlated
11 L1PB1 1 n.s 74.0 Weakly correlated
12 L1P4 1 * 74.0 Weakly correlated
13 L1MC1 1 n.s 99.0 Highly correlated
14 L1MA9 1 n.s 99.0 Highly correlated
15 AluSz6 1 n.s 74.0 Weakly correlated
16 AluSz 1 n.s 74.0 Weakly correlated
17 AluSx 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP