ZRdb KZFP & Repeats
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Human_ZNF225

  • Protein
    Zinc finger protein 225
  • Length
    706
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q9UK10
  • NCBI_ID
    7768
Sequence:
MTTLKEAVTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLSVGHQSLHRDTFHFLKEEKFWMMETATQREGNLGGKIQMEMETVSESGTHEGLFSHQTWEQISSDLTRFQDSMVNSFQFSKQDDMPCQVDAGLSIIHVRQKPSEGRTCKKSFSDVSVLDLHQQLQSREKSHTCDECGKSFCYSSALRIHQRVHMGEKLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKCEQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFIHDSQLQEHQRIHTGEKPFKCDICCKSFRSRANLNRHSMVHMREKPFRCDTCGKSFGLKSALNSHRMVHTGEKRYKCEECGKRFIYRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVRVHSGETTFKCEECGKGFYTNSQRYSHQRAHSGEKPYRCEECGKGYKRRLDLDFHQRVHRGEKPYNCKECGKSFGWASCLLNHQRIHSGEKPFKCEECGKRFTQNSQLYTHRRVHSGEKPFKCEECGKRFTQNSQLYSHRRVHTGVKPYKCEECGKGFNSKFNLDMHQRVHTGERPYNCKECGKSFSRASSILNHKRLHGDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFRWASTHLTHQRLHSREKLLQCEDCGKSIVHSSCLKDQQRDQSGEKTSKCEDCGKRYKRRLNLDTLLSLFLNDT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..78
2 C2h2 176..198
3 C2h2 204..226
4 C2h2 232..254
5 C2h2 260..282
6 C2h2 288..310
7 C2h2 316..338
8 C2h2 344..366
9 C2h2 372..394
10 C2h2 400..422
11 C2h2 428..450
12 C2h2 456..478
13 C2h2 484..506
14 C2h2 512..534
15 C2h2 540..562
16 C2h2 568..590
17 C2h2 596..618
18 C2h2 624..646
19 dec2h2 652..674
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M3f 32 **** 87.0 Moderately correlated
2 L1MA4 19 **** 87.0 Moderately correlated
3 AluSp 11 *** 74.0 Highly correlated
4 AluJb 10 n.s 74.0 Highly correlated
5 AluSx 8 n.s 74.0 Highly correlated
6 AluSc8 5 ** 74.0 Highly correlated
7 HAL1 5 ** 99.0 Weakly correlated
8 L1M4 5 * 99.0 Weakly correlated
9 AluSq2 4 n.s 74.0 Highly correlated
10 AluSx1 4 n.s 74.0 Highly correlated
11 L1PA5 4 n.s 19.6 Weakly correlated
12 AluJr 3 n.s 74.0 Highly correlated
13 AluSz6 3 n.s 74.0 Highly correlated
14 AluY 3 n.s 74.0 Highly correlated
15 L1M2 3 * 99.0 Weakly correlated
16 L1MEc 3 n.s 99.0 Weakly correlated
17 L1P3 3 ** 74.0 Highly correlated
18 LTR10A 3 **** 28.9 Weakly correlated
19 MER50 3 *** 43.0 Weakly correlated
20 MIRb 3 n.s 99.0 Weakly correlated
21 AluSg 2 n.s 74.0 Highly correlated
22 AluSg4 2 * 74.0 Highly correlated
23 AluSz 2 n.s 74.0 Highly correlated
24 FRAM 2 ** 74.0 Highly correlated
25 L1M5 2 n.s 99.0 Weakly correlated
26 L1MB4 2 * 99.0 Weakly correlated
27 L1MB5 2 n.s 99.0 Weakly correlated
28 L1MD3 2 ** 99.0 Weakly correlated
29 L1ME1 2 n.s 99.0 Weakly correlated
30 L1MEi 2 ** 99.0 Weakly correlated
31 L1P1 2 * 19.6 Weakly correlated
32 L1P4 2 ** 74.0 Highly correlated
33 L1PA10 2 n.s 74.0 Highly correlated
34 L1PA15-16 2 ** 74.0 Highly correlated
35 L1PA2 2 n.s 15.2 Weakly correlated
36 L1PA4 2 n.s 19.6 Weakly correlated
37 L1PB3 2 * 74.0 Highly correlated
38 L2 2 n.s 99.0 Weakly correlated
39 L2c 2 n.s 99.0 Weakly correlated
40 MER4-int 2 ** 74.0 Highly correlated
41 MER61-int 2 ** 43.0 Weakly correlated
42 MIR 2 n.s 99.0 Weakly correlated
43 MIRc 2 n.s 99.0 Weakly correlated
44 MLT1A 2 * 99.0 Weakly correlated
45 Alu 1 ** 74.0 Highly correlated
46 AluJo 1 n.s 74.0 Highly correlated
47 AluJr4 1 n.s 74.0 Highly correlated
48 AluSc 1 n.s 74.0 Highly correlated
49 AluSx3 1 n.s 74.0 Highly correlated
50 AluYb8 1 * 15.2 Weakly correlated
51 AluYm1 1 * 19.6 Weakly correlated
52 CR1-L3A_Croc 1 **** 319.0 Weakly correlated
53 FAM 1 ** 87.0 Moderately correlated
54 FLAM_A 1 n.s 74.0 Highly correlated
55 FLAM_C 1 n.s 74.0 Highly correlated
56 HAL1ME 1 n.s 99.0 Weakly correlated
57 L1M1 1 n.s 74.0 Highly correlated
58 L1M3 1 n.s 99.0 Weakly correlated
59 L1M3c 1 ** 99.0 Weakly correlated
60 L1M4a2 1 * 99.0 Weakly correlated
61 L1M4b 1 n.s 99.0 Weakly correlated
62 L1MA2 1 n.s 74.0 Highly correlated
63 L1MA4A 1 n.s 87.0 Moderately correlated
64 L1MA5A 1 n.s 87.0 Moderately correlated
65 L1MA7 1 n.s 87.0 Moderately correlated
66 L1MA8 1 n.s 87.0 Moderately correlated
67 L1MB7 1 n.s 99.0 Weakly correlated
68 L1MC2 1 n.s 99.0 Weakly correlated
69 L1MC3 1 n.s 99.0 Weakly correlated
70 L1MC4 1 n.s 99.0 Weakly correlated
71 L1MC4a 1 n.s 99.0 Weakly correlated
72 L1MC5a 1 n.s 99.0 Weakly correlated
73 L1MCa 1 n.s 99.0 Weakly correlated
74 L1MCc 1 * 99.0 Weakly correlated
75 L1MD 1 n.s 99.0 Weakly correlated
76 L1MD1 1 n.s 99.0 Weakly correlated
77 L1ME2 1 n.s 99.0 Weakly correlated
78 L1ME3Cz 1 n.s 99.0 Weakly correlated
79 L1ME3E 1 * 99.0 Weakly correlated
80 L1ME4b 1 n.s 99.0 Weakly correlated
81 L1MEf 1 n.s 99.0 Weakly correlated
82 L1PA13 1 n.s 74.0 Highly correlated
83 L1PA15 1 n.s 74.0 Highly correlated
84 L1PA16 1 n.s 74.0 Highly correlated
85 L1PA17 1 n.s 74.0 Highly correlated
86 L1PB4 1 n.s 99.0 Weakly correlated
87 L1PBa 1 n.s 74.0 Highly correlated
88 L2b 1 n.s 99.0 Weakly correlated
89 LTR13 1 ** 19.6 Weakly correlated
90 LTR83 1 *** 99.0 Weakly correlated
91 MER39B 1 ** 74.0 Highly correlated
92 MER4A1_ 1 *** 74.0 Highly correlated
93 MER50-int 1 ** 43.0 Weakly correlated
94 MER57-int 1 * 87.0 Moderately correlated
95 MER61C 1 *** 43.0 Weakly correlated
96 MLT1E2 1 * 99.0 Weakly correlated
97 MLT1F 1 * 99.0 Weakly correlated
98 MLT1F1 1 * 99.0 Weakly correlated
99 MLT1G3 1 * 99.0 Weakly correlated
100 MLT1H2-int 1 *** 99.0 Weakly correlated
101 THE1A 1 * 43.0 Weakly correlated
102 THE1B 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M3f 18 **** 87.0 Moderately correlated
2 L1MA4 13 **** 87.0 Moderately correlated
3 AluSp 8 ** 74.0 Highly correlated
4 AluJb 5 n.s 74.0 Highly correlated
5 HAL1 3 n.s 99.0 Weakly correlated
6 AluSx1 3 n.s 74.0 Highly correlated
7 AluSz6 3 n.s 74.0 Highly correlated
8 L1M4 3 n.s 99.0 Weakly correlated
9 AluSg 2 n.s 74.0 Highly correlated
10 L1ME1 2 n.s 99.0 Weakly correlated
11 AluSq2 2 n.s 74.0 Highly correlated
12 L1MEi 2 ** 99.0 Weakly correlated
13 AluSx 2 n.s 74.0 Highly correlated
14 AluY 2 n.s 74.0 Highly correlated
15 AluJr 2 n.s 74.0 Highly correlated
16 MER4-int 2 ** 74.0 Highly correlated
17 L1M2 2 n.s 99.0 Weakly correlated
18 L1PA10 2 n.s 74.0 Highly correlated
19 THE1B 1 n.s 43.0 Weakly correlated
20 L1ME3Cz 1 n.s 99.0 Weakly correlated
21 L1MEf 1 n.s 99.0 Weakly correlated
22 AluSc 1 n.s 74.0 Highly correlated
23 L1PA16 1 n.s 74.0 Highly correlated
24 L1PBa 1 n.s 74.0 Highly correlated
25 L1MCa 1 n.s 99.0 Weakly correlated
26 L1MA5A 1 n.s 87.0 Moderately correlated
27 FAM 1 ** 87.0 Moderately correlated
28 L1ME2 1 n.s 99.0 Weakly correlated
29 MIR 1 n.s 99.0 Weakly correlated
30 MLT1H2-int 1 *** 99.0 Weakly correlated
31 AluSc8 1 n.s 74.0 Highly correlated
32 AluSx3 1 n.s 74.0 Highly correlated
33 L1MB4 1 n.s 99.0 Weakly correlated
34 MER57-int 1 * 87.0 Moderately correlated
35 MLT1E2 1 * 99.0 Weakly correlated
36 L1MB7 1 n.s 99.0 Weakly correlated
37 AluSz 1 n.s 74.0 Highly correlated
38 L1MC4a 1 n.s 99.0 Weakly correlated
39 L1MD 1 n.s 99.0 Weakly correlated
40 L1MD3 1 n.s 99.0 Weakly correlated
41 L2 1 n.s 99.0 Weakly correlated
42 L1M5 1 n.s 99.0 Weakly correlated
43 L1MA7 1 n.s 87.0 Moderately correlated
44 L1ME3E 1 * 99.0 Weakly correlated
45 MIRb 1 n.s 99.0 Weakly correlated
46 L1MA4A 1 n.s 87.0 Moderately correlated
47 L1MB5 1 n.s 99.0 Weakly correlated
48 L1MA2 1 n.s 74.0 Highly correlated
49 L1PA13 1 n.s 74.0 Highly correlated
50 L1PA17 1 n.s 74.0 Highly correlated
51 L1PB3 1 n.s 74.0 Highly correlated
52 LTR83 1 *** 99.0 Weakly correlated
53 FLAM_C 1 n.s 74.0 Highly correlated
54 L1M4a2 1 * 99.0 Weakly correlated
55 L1MA8 1 n.s 87.0 Moderately correlated
56 L1PA15 1 n.s 74.0 Highly correlated
57 AluSg4 1 n.s 74.0 Highly correlated
58 HAL1ME 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP