Human_ZNF224
-
ProteinZinc finger protein 224
-
Length707
-
OrganismHomo sapiens (Human)
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Time of emergence69.0 Mya
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Time of Changing in binding specificity69.0 Mya
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Uniprot_ID
-
NCBI_ID
Sequence:
MTTFKEAMTFKDVAVVFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQAFHRDTFHFLREEKIWMMKTAIQREGNSGDKIQTEMETVSEAGTHQEWSFQQIWEKIASDLTRSQDLMINSSQFSKEGDFPCQTEAGLSVIHTRQKSSQGNGYKPSFSDVSHFDFHQQLHSGEKSHTCDECGKNFCYISALRIHQRVHMGEKCYKCDVCGKEFSQSSHLQTHQRVHTGEKPFKCVECGKGFSRRSALNVHHKLHTGEKPYNCEECGKAFIHDSQLQEHQRIHTGEKPFKCDICGKSFCGRSRLNRHSMVHTAEKPFRCDTCDKSFRQRSALNSHRMIHTGEKPYKCEECGKGFICRRDLYTHHMVHTGEKPYNCKECGKSFRWASCLLKHQRVHSGEKPFKCEECGKGFYTNSQCYSHQRSHSGEKPYKCVECGKGYKRRLDLDFHQRVHTGEKLYNCKECGKSFSRAPCLLKHERLHSGEKPFQCEECGKRFTQNSHLHSHQRVHTGEKPYKCEKCGKGYNSKFNLDMHQKVHTGERPYNCKECGKSFGWASCLLKHQRLHSGEKPFKCEECGKRFTQNSQLHSHQRVHTGEKPYKCDECGKGFSWSSTRLTHQRRHSRETPLKCEQHGKNIVQNSFSKVQEKVHSVEKPYKCEDCGKGYNRRLNLDMHQRVHMGEKTWKCRECDMCFSQASSLRLHQNVHVGEKP
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 8..78 | |
| 2 | C2h2 | 176..198 | |
| 3 | C2h2 | 204..226 | |
| 4 | C2h2 | 232..254 | |
| 5 | C2h2 | 260..282 | |
| 6 | C2h2 | 288..310 | |
| 7 | C2h2 | 316..338 | |
| 8 | C2h2 | 344..366 | |
| 9 | C2h2 | 372..394 | |
| 10 | C2h2 | 400..422 | |
| 11 | C2h2 | 428..450 | |
| 12 | C2h2 | 456..478 | |
| 13 | C2h2 | 484..506 | |
| 14 | C2h2 | 512..534 | |
| 15 | dec2h2 | 540..562 | |
| 16 | C2h2 | 568..590 | |
| 17 | C2h2 | 596..618 | |
| 18 | C2h2 | 652..674 | |
| 19 | C2h2 | 680..702 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nuclear membrane | |
| 2 | Cellular Component | nucleoplasm | |
| 3 | Cellular Component | nucleus | |
| 4 | Cellular Component | transcription repressor complex | |
| 5 | Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
| 6 | Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
| 7 | Molecular Function | metal ion binding | |
| 8 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| 9 | Molecular Function | sequence-specific DNA binding | |
| 10 | Biological Process | negative regulation of DNA-templated transcription | |
| 11 | Biological Process | negative regulation of transcription by RNA polymerase II | |
| 12 | Biological Process | regulation of transcription by RNA polymerase II |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MER70A | 135 | **** | 87.0 | Weakly correlated | |
| 2 | MER70B | 89 | **** | 87.0 | Weakly correlated | |
| 3 | AluJb | 66 | **** | 74.0 | Moderately correlated | |
| 4 | MER50 | 44 | **** | 43.0 | Weakly correlated | |
| 5 | AluJo | 35 | **** | 74.0 | Moderately correlated | |
| 6 | MER50-int | 27 | **** | 43.0 | Weakly correlated | |
| 7 | MIRb | 21 | n.s | 99.0 | Weakly correlated | |
| 8 | MIR | 20 | n.s | 99.0 | Weakly correlated | |
| 9 | AluJr | 17 | n.s | 74.0 | Moderately correlated | |
| 10 | AluSx1 | 16 | n.s | 74.0 | Moderately correlated | |
| 11 | L2a | 15 | n.s | 99.0 | Weakly correlated | |
| 12 | L1PA13 | 12 | ** | 74.0 | Moderately correlated | |
| 13 | MIR3 | 12 | * | 99.0 | Weakly correlated | |
| 14 | AluSz | 10 | n.s | 74.0 | Moderately correlated | |
| 15 | FLAM_C | 10 | **** | 74.0 | Moderately correlated | |
| 16 | L2c | 9 | n.s | 99.0 | Weakly correlated | |
| 17 | LTR10A | 9 | **** | 28.9 | Weakly correlated | |
| 18 | LTR12C | 9 | *** | 19.6 | Weakly correlated | |
| 19 | MER52A | 9 | **** | 74.0 | Moderately correlated | |
| 20 | AluSx | 8 | n.s | 74.0 | Moderately correlated | |
| 21 | AluSz6 | 8 | n.s | 74.0 | Moderately correlated | |
| 22 | MIRc | 8 | n.s | 99.0 | Weakly correlated | |
| 23 | AluJr4 | 7 | * | 74.0 | Moderately correlated | |
| 24 | L1M2 | 7 | n.s | 99.0 | Weakly correlated | |
| 25 | L1M4b | 7 | *** | 99.0 | Weakly correlated | |
| 26 | L1ME1 | 7 | n.s | 99.0 | Weakly correlated | |
| 27 | L2 | 7 | n.s | 99.0 | Weakly correlated | |
| 28 | L2b | 7 | n.s | 99.0 | Weakly correlated | |
| 29 | MLT1D | 7 | n.s | 99.0 | Weakly correlated | |
| 30 | MSTB1 | 7 | **** | 74.0 | Moderately correlated | |
| 31 | AluY | 6 | n.s | 74.0 | Moderately correlated | |
| 32 | L1ME4a | 6 | n.s | 99.0 | Weakly correlated | |
| 33 | L1M5 | 5 | n.s | 99.0 | Weakly correlated | |
| 34 | L1MA8 | 5 | n.s | 87.0 | Weakly correlated | |
| 35 | L1MC4a | 5 | n.s | 99.0 | Weakly correlated | |
| 36 | L1PB1 | 5 | n.s | 74.0 | Moderately correlated | |
| 37 | ERVL-B4-int | 4 | n.s | 99.0 | Weakly correlated | |
| 38 | FLAM_A | 4 | * | 74.0 | Moderately correlated | |
| 39 | Harlequin-int | 4 | *** | 74.0 | Moderately correlated | |
| 40 | L1MA4 | 4 | n.s | 87.0 | Weakly correlated | |
| 41 | L1MB7 | 4 | n.s | 99.0 | Weakly correlated | |
| 42 | L1ME4b | 4 | n.s | 99.0 | Weakly correlated | |
| 43 | LTR13 | 4 | **** | 19.6 | Weakly correlated | |
| 44 | MLT1I | 4 | * | 99.0 | Weakly correlated | |
| 45 | AluSp | 3 | n.s | 74.0 | Moderately correlated | |
| 46 | AluSq2 | 3 | n.s | 74.0 | Moderately correlated | |
| 47 | AluYj4 | 3 | ** | 0.0 | Weakly correlated | |
| 48 | FRAM | 3 | * | 74.0 | Moderately correlated | |
| 49 | L1M4 | 3 | n.s | 99.0 | Weakly correlated | |
| 50 | L1MB4 | 3 | n.s | 99.0 | Weakly correlated | |
| 51 | L1MEc | 3 | n.s | 99.0 | Weakly correlated | |
| 52 | L1MEg | 3 | n.s | 99.0 | Weakly correlated | |
| 53 | L1PA15 | 3 | n.s | 74.0 | Moderately correlated | |
| 54 | L1PA2 | 3 | n.s | 15.2 | Weakly correlated | |
| 55 | L1PA5 | 3 | n.s | 19.6 | Weakly correlated | |
| 56 | L3 | 3 | n.s | 99.0 | Weakly correlated | |
| 57 | LTR13A | 3 | **** | 28.9 | Weakly correlated | |
| 58 | MIR1_Amn | 3 | * | 319.0 | Weakly correlated | |
| 59 | AluSc8 | 2 | n.s | 74.0 | Moderately correlated | |
| 60 | ERV3-16A3_I-int | 2 | n.s | 99.0 | Weakly correlated | |
| 61 | HERVIP10FH-int | 2 | ** | 28.9 | Weakly correlated | |
| 62 | L1M3e | 2 | ** | 99.0 | Weakly correlated | |
| 63 | L1MA6 | 2 | n.s | 87.0 | Weakly correlated | |
| 64 | L1MB3 | 2 | n.s | 99.0 | Weakly correlated | |
| 65 | L1MB5 | 2 | n.s | 99.0 | Weakly correlated | |
| 66 | L1MB8 | 2 | n.s | 99.0 | Weakly correlated | |
| 67 | L1MC4 | 2 | n.s | 99.0 | Weakly correlated | |
| 68 | L1MC5 | 2 | n.s | 99.0 | Weakly correlated | |
| 69 | L1MD | 2 | n.s | 99.0 | Weakly correlated | |
| 70 | L1ME3 | 2 | n.s | 99.0 | Weakly correlated | |
| 71 | L1ME4c | 2 | n.s | 99.0 | Weakly correlated | |
| 72 | L1MEi | 2 | n.s | 99.0 | Weakly correlated | |
| 73 | L1P1 | 2 | n.s | 19.6 | Weakly correlated | |
| 74 | L1PA16 | 2 | n.s | 74.0 | Moderately correlated | |
| 75 | L1PA6 | 2 | n.s | 28.9 | Weakly correlated | |
| 76 | L1PA7 | 2 | n.s | 74.0 | Moderately correlated | |
| 77 | L1PB4 | 2 | n.s | 99.0 | Weakly correlated | |
| 78 | L4_B_Mam | 2 | * | 99.0 | Weakly correlated | |
| 79 | LTR16A2 | 2 | ** | 99.0 | Weakly correlated | |
| 80 | LTR16B2 | 2 | ** | 99.0 | Weakly correlated | |
| 81 | LTR16E1 | 2 | * | 99.0 | Weakly correlated | |
| 82 | LTR18A | 2 | **** | 43.0 | Weakly correlated | |
| 83 | LTR1E | 2 | *** | 43.0 | Weakly correlated | |
| 84 | LTR25-int | 2 | * | 43.0 | Weakly correlated | |
| 85 | LTR27E | 2 | *** | 43.0 | Weakly correlated | |
| 86 | LTR50 | 2 | * | 99.0 | Weakly correlated | |
| 87 | LTR78B | 2 | * | 99.0 | Weakly correlated | |
| 88 | MER21A | 2 | * | 74.0 | Moderately correlated | |
| 89 | MER21C | 2 | n.s | 99.0 | Weakly correlated | |
| 90 | MER34B-int | 2 | *** | 99.0 | Weakly correlated | |
| 91 | MER41B | 2 | n.s | 74.0 | Moderately correlated | |
| 92 | MER41D | 2 | *** | 74.0 | Moderately correlated | |
| 93 | MER4E | 2 | ** | 74.0 | Moderately correlated | |
| 94 | MER52C | 2 | ** | 74.0 | Moderately correlated | |
| 95 | MER52D | 2 | * | 74.0 | Moderately correlated | |
| 96 | MLT1J | 2 | n.s | 99.0 | Weakly correlated | |
| 97 | MLT1J1 | 2 | * | 99.0 | Weakly correlated | |
| 98 | MLT1L | 2 | n.s | 99.0 | Weakly correlated | |
| 99 | MSTA1 | 2 | *** | 74.0 | Moderately correlated | |
| 100 | MamGypLTR1d | 2 | *** | 99.0 | Weakly correlated | |
| 101 | Plat_L3 | 2 | ** | 99.0 | Weakly correlated | |
| 102 | AluSc | 1 | n.s | 74.0 | Moderately correlated | |
| 103 | AluSg | 1 | n.s | 74.0 | Moderately correlated | |
| 104 | AluSq | 1 | n.s | 74.0 | Moderately correlated | |
| 105 | AluSx3 | 1 | n.s | 74.0 | Moderately correlated | |
| 106 | AluYe5 | 1 | * | 74.0 | Moderately correlated | |
| 107 | AluYh9 | 1 | **** | 15.2 | Weakly correlated | |
| 108 | AmnSINE1 | 1 | * | 319.0 | Weakly correlated | |
| 109 | ERVL-int | 1 | n.s | 99.0 | Weakly correlated | |
| 110 | FAM | 1 | n.s | 87.0 | Weakly correlated | |
| 111 | HAL1 | 1 | n.s | 99.0 | Weakly correlated | |
| 112 | HAL1b | 1 | n.s | 99.0 | Weakly correlated | |
| 113 | HERV16-int | 1 | n.s | 99.0 | Weakly correlated | |
| 114 | L1M1 | 1 | n.s | 74.0 | Moderately correlated | |
| 115 | L1M2b | 1 | ** | 87.0 | Weakly correlated | |
| 116 | L1M3 | 1 | n.s | 99.0 | Weakly correlated | |
| 117 | L1M3b | 1 | * | 99.0 | Weakly correlated | |
| 118 | L1M6 | 1 | n.s | 99.0 | Weakly correlated | |
| 119 | L1M6B | 1 | ** | 99.0 | Weakly correlated | |
| 120 | L1M7 | 1 | n.s | 99.0 | Weakly correlated | |
| 121 | L1MA3 | 1 | n.s | 74.0 | Moderately correlated | |
| 122 | L1MA4A | 1 | n.s | 87.0 | Weakly correlated | |
| 123 | L1MA5 | 1 | n.s | 87.0 | Weakly correlated | |
| 124 | L1MA5A | 1 | n.s | 87.0 | Weakly correlated | |
| 125 | L1MB1 | 1 | n.s | 99.0 | Weakly correlated | |
| 126 | L1MD3 | 1 | n.s | 99.0 | Weakly correlated | |
| 127 | L1MDa | 1 | n.s | 99.0 | Weakly correlated | |
| 128 | L1ME3A | 1 | n.s | 99.0 | Weakly correlated | |
| 129 | L1ME3E | 1 | n.s | 99.0 | Weakly correlated | |
| 130 | L1ME3G | 1 | n.s | 99.0 | Weakly correlated | |
| 131 | L1MEd | 1 | n.s | 99.0 | Weakly correlated | |
| 132 | L1MEf | 1 | n.s | 99.0 | Weakly correlated | |
| 133 | L1P4 | 1 | n.s | 74.0 | Moderately correlated | |
| 134 | L1P4b | 1 | ** | 74.0 | Moderately correlated | |
| 135 | L1PA10 | 1 | n.s | 74.0 | Moderately correlated | |
| 136 | L1PA3 | 1 | n.s | 19.6 | Weakly correlated | |
| 137 | L1PA4 | 1 | n.s | 19.6 | Weakly correlated | |
| 138 | L1PA8 | 1 | n.s | 74.0 | Moderately correlated | |
| 139 | LFSINE_Vert | 1 | * | 319.0 | Weakly correlated | |
| 140 | LOR1b | 1 | * | 74.0 | Moderately correlated | |
| 141 | LTR1 | 1 | ** | 43.0 | Weakly correlated | |
| 142 | LTR12E | 1 | ** | 19.6 | Weakly correlated | |
| 143 | LTR13_ | 1 | *** | 28.9 | Weakly correlated | |
| 144 | LTR16D | 1 | * | 99.0 | Weakly correlated | |
| 145 | LTR18B | 1 | ** | 43.0 | Weakly correlated | |
| 146 | LTR1D | 1 | * | 43.0 | Weakly correlated | |
| 147 | LTR24B | 1 | ** | 74.0 | Moderately correlated | |
| 148 | LTR28B | 1 | ** | 43.0 | Weakly correlated | |
| 149 | LTR28C | 1 | * | 43.0 | Weakly correlated | |
| 150 | LTR4 | 1 | *** | 28.9 | Weakly correlated | |
| 151 | LTR41B | 1 | * | 99.0 | Weakly correlated | |
| 152 | LTR41C | 1 | * | 99.0 | Weakly correlated | |
| 153 | LTR48B | 1 | * | 74.0 | Moderately correlated | |
| 154 | LTR53-int | 1 | * | 99.0 | Weakly correlated | |
| 155 | LTR76 | 1 | ** | 74.0 | Moderately correlated | |
| 156 | LTR8 | 1 | n.s | 43.0 | Weakly correlated | |
| 157 | LTR85c | 1 | * | 99.0 | Weakly correlated | |
| 158 | MER11A | 1 | n.s | 28.9 | Weakly correlated | |
| 159 | MER41-int | 1 | n.s | 74.0 | Moderately correlated | |
| 160 | MER4A | 1 | * | 74.0 | Moderately correlated | |
| 161 | MER4CL34 | 1 | * | 43.0 | Weakly correlated | |
| 162 | MER52-int | 1 | n.s | 99.0 | Weakly correlated | |
| 163 | MER54A | 1 | * | 87.0 | Weakly correlated | |
| 164 | MER54B | 1 | ** | 87.0 | Weakly correlated | |
| 165 | MER57-int | 1 | n.s | 87.0 | Weakly correlated | |
| 166 | MER65D | 1 | ** | 87.0 | Weakly correlated | |
| 167 | MLT1A0 | 1 | n.s | 99.0 | Weakly correlated | |
| 168 | MLT1C | 1 | n.s | 94.0 | Weakly correlated | |
| 169 | MLT1E2 | 1 | n.s | 99.0 | Weakly correlated | |
| 170 | MLT1F1 | 1 | n.s | 99.0 | Weakly correlated | |
| 171 | MLT1F2 | 1 | n.s | 99.0 | Weakly correlated | |
| 172 | MLT1J-int | 1 | * | 99.0 | Weakly correlated | |
| 173 | MLT1J2 | 1 | n.s | 99.0 | Weakly correlated | |
| 174 | MLT1K | 1 | n.s | 99.0 | Weakly correlated | |
| 175 | MLT1M | 1 | * | 99.0 | Weakly correlated | |
| 176 | MSTA | 1 | n.s | 43.0 | Weakly correlated | |
| 177 | MSTD-int | 1 | n.s | 74.0 | Moderately correlated | |
| 178 | MamRTE1 | 1 | n.s | 99.0 | Weakly correlated | |
| 179 | THE1B | 1 | n.s | 43.0 | Weakly correlated | |
| 180 | THE1B-int | 1 | n.s | 43.0 | Weakly correlated | |
| 181 | THE1D | 1 | n.s | 43.0 | Weakly correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MER70A | 3 | **** | 87.0 | Weakly correlated | |
| 2 | MER70B | 3 | *** | 87.0 | Weakly correlated | |
| 3 | L1M2 | 2 | n.s | 99.0 | Weakly correlated | |
| 4 | AluSz6 | 2 | n.s | 74.0 | Moderately correlated | |
| 5 | MER50 | 2 | n.s | 43.0 | Weakly correlated | |
| 6 | MIR3 | 1 | n.s | 99.0 | Weakly correlated | |
| 7 | AluYh9 | 1 | **** | 15.2 | Weakly correlated | |
| 8 | MLT1D | 1 | n.s | 99.0 | Weakly correlated | |
| 9 | L1M4 | 1 | n.s | 99.0 | Weakly correlated | |
| 10 | AluSx1 | 1 | n.s | 74.0 | Moderately correlated | |
| 11 | L1PA15 | 1 | n.s | 74.0 | Moderately correlated | |
| 12 | Plat_L3 | 1 | n.s | 99.0 | Weakly correlated | |
| 13 | MLT1J2 | 1 | n.s | 99.0 | Weakly correlated | |
| 14 | MIRb | 1 | n.s | 99.0 | Weakly correlated | |
| 15 | MER41B | 1 | n.s | 74.0 | Moderately correlated | |
| 16 | L1MB7 | 1 | n.s | 99.0 | Weakly correlated | |
| 17 | L1MB4 | 1 | n.s | 99.0 | Weakly correlated | |
| 18 | AluJr | 1 | n.s | 74.0 | Moderately correlated | |
| 19 | MLT1C | 1 | n.s | 94.0 | Weakly correlated | |
| 20 | AluJb | 1 | n.s | 74.0 | Moderately correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP |
|---|