ZRdb KZFP & Repeats
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Human_ZNF223

  • Protein
    Zinc finger protein 223
  • Length
    482
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q9UK11
  • NCBI_ID
    7766
Sequence:
MTMSKEAVTFKDVAVVFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQPFHRDTFHFLREEKFWMMDIATQREGNSGGKIQPEMKTFPEAGPHEGWSCQQIWEEIASDLTRPQDSTIKSSQFFEQGDAHSQVEEGLSIMHTGQKPSNCGKCKQSFSDMSIFDLPQQIRSAEKSHSCDECGKSFCYISALHIHQRVHLGEKLFKCDVCGKEFSQSLHLQTHQRVHTGEKPFKCEQCGRGFRCRSALTVHCKLHMGEKHYNCEACGRAFIHDFQLQKHQRIHTGEKPFKCEICSVSFRLRSSLNRHCVVHTGKKPNSTGEYGKGFIRRLDLCKHQTIHTGEKPYNCKECGKSFRRSSYLLIHQRVHTGEKPYKCDKCGKSYITKSGLDLHHRAHTGERPYNCDDCGKSFRQASSILNHKRLHCRKKPFKCEDCGKKLVYRSYRKDQQKNHSGENPSKCEDCGKRYKRRLNLDIILSLFLNDT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..78
2 C2h2 176..198
3 C2h2 204..226
4 C2h2 232..254
5 C2h2 260..282
6 C2h2 288..310
7 dec2h2 316..338
8 C2h2 344..366
9 C2h2 372..394
10 C2h2 400..422
11 dec2h2 428..450
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA binding
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA16 19 **** 74.0 Weakly correlated
2 L1PA15 7 *** 74.0 Weakly correlated
3 L1PREC2 6 *** 43.0 Highly correlated
4 AluJb 5 n.s 74.0 Weakly correlated
5 L1P4a 5 **** 74.0 Weakly correlated
6 L1P3 5 **** 74.0 Weakly correlated
7 L1PA5 4 n.s 19.6 Weakly correlated
8 L1PA2 4 n.s 15.2 Weakly correlated
9 LTR10A 4 **** 28.9 Weakly correlated
10 AluYj4 3 **** 0.0 Weakly correlated
11 L2c 2 n.s 99.0 Weakly correlated
12 L1PA4 2 n.s 19.6 Weakly correlated
13 L1PB4 2 n.s 99.0 Weakly correlated
14 L1P4 2 ** 74.0 Weakly correlated
15 L1P1 2 * 19.6 Weakly correlated
16 LTR10F 2 **** 28.9 Weakly correlated
17 MIRb 2 n.s 99.0 Weakly correlated
18 L1MB8 2 n.s 99.0 Weakly correlated
19 MIR 1 n.s 99.0 Weakly correlated
20 MLT1F1 1 * 99.0 Weakly correlated
21 MLT1B 1 n.s 99.0 Weakly correlated
22 L1PA7 1 n.s 74.0 Weakly correlated
23 MLT1A 1 n.s 99.0 Weakly correlated
24 L1PB1 1 n.s 74.0 Weakly correlated
25 MIRc 1 n.s 99.0 Weakly correlated
26 MIR3 1 n.s 99.0 Weakly correlated
27 MER50 1 * 43.0 Highly correlated
28 MER39B 1 ** 74.0 Weakly correlated
29 LTR13_ 1 **** 28.9 Weakly correlated
30 LTR13 1 ** 19.6 Weakly correlated
31 L2a 1 n.s 99.0 Weakly correlated
32 L2b 1 n.s 99.0 Weakly correlated
33 L1PA15-16 1 * 74.0 Weakly correlated
34 L1M4b 1 n.s 99.0 Weakly correlated
35 AluJo 1 n.s 74.0 Weakly correlated
36 AluSg 1 n.s 74.0 Weakly correlated
37 AluSp 1 n.s 74.0 Weakly correlated
38 AluY 1 n.s 74.0 Weakly correlated
39 AluYh9 1 **** 15.2 Weakly correlated
40 AluYm1 1 * 19.6 Weakly correlated
41 AmnSINE1 1 ** 319.0 Weakly correlated
42 HAL1 1 n.s 99.0 Weakly correlated
43 L1M4 1 n.s 99.0 Weakly correlated
44 L1PA3 1 n.s 19.6 Weakly correlated
45 L1MA4 1 n.s 87.0 Weakly correlated
46 L1MA8 1 n.s 87.0 Weakly correlated
47 L1MA9 1 n.s 99.0 Weakly correlated
48 L1MC5 1 n.s 99.0 Weakly correlated
49 L1ME4b 1 n.s 99.0 Weakly correlated
50 L1MEc 1 n.s 99.0 Weakly correlated
51 L1P4d 1 *** 74.0 Weakly correlated
52 L1PA13 1 n.s 74.0 Weakly correlated
53 L1PA17 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA16 1 n.s 74.0 Weakly correlated
2 MIRb 1 n.s 99.0 Weakly correlated
3 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP