ZRdb KZFP & Repeats
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Human_ZNF222

  • Protein
    Zinc finger protein 222
  • Length
    451
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q9UK12
  • NCBI_ID
    7673
Sequence:
MAKLYEAVTFKDVAVIFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGGKIQTEMETVPEAGTHEEFSCKQIWEQIASDLTRSQDTTISNSQLFEQDDNPSQIKARLSTVHTREKPFQGENCKQFFSDVSFFDLPQQLYSGEKSHTCDECGKSFCYISALHIHQRVHMGVKCYKCDVCGKEFSQSSRLQTHQRVHTGEKPFKCEQCGKGFRCRSALKVHCKLHMREKPYNCEKCGKAFMHNFQLQKHHRIHTGEKPFKCEICGKSFCLRSSLNRHCMVHTAEKLYKSEKYGRGFIDRLDLHKHQMIHMGQKPYNCKECGKSFKWSSYLLVHQRVHTGEKPYKCEECGKGYISKSGLDFHHRTHTGERSYNCDNCGKSFRHASSILNHKKLHCQRKPLKCEDCGKRLVCRSYCKDQQRDHSGENPSKCEDCGKRYKRRLNLDIILSLFLNDI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..85
2 C2h2 145..167
3 C2h2 173..195
4 C2h2 201..223
5 C2h2 229..251
6 C2h2 257..279
7 dec2h2 285..307
8 C2h2 313..335
9 C2h2 341..363
10 C2h2 369..391
11 dec2h2 397..419
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 28 * 74.0 Weakly correlated
2 L1PA16 25 **** 74.0 Weakly correlated
3 AluY 22 n.s 74.0 Weakly correlated
4 L1PA15-16 20 **** 74.0 Weakly correlated
5 AluSx 19 n.s 74.0 Weakly correlated
6 AluSz6 16 ** 74.0 Weakly correlated
7 AluSz 15 n.s 74.0 Weakly correlated
8 L2c 15 n.s 99.0 Weakly correlated
9 AluJo 13 n.s 74.0 Weakly correlated
10 AluSx1 12 n.s 74.0 Weakly correlated
11 MIRb 12 n.s 99.0 Weakly correlated
12 AluSq2 11 n.s 74.0 Weakly correlated
13 L1PA17 11 **** 74.0 Weakly correlated
14 LTR18A 11 **** 43.0 Highly correlated
15 AluSg 10 n.s 74.0 Weakly correlated
16 AluSp 10 n.s 74.0 Weakly correlated
17 AluSx3 9 * 74.0 Weakly correlated
18 L1PB4 9 *** 99.0 Weakly correlated
19 MIR3 9 n.s 99.0 Weakly correlated
20 HUERS-P3-int 8 **** 43.0 Highly correlated
21 L1MA4 7 * 87.0 Weakly correlated
22 L2a 7 n.s 99.0 Weakly correlated
23 MIR 7 n.s 99.0 Weakly correlated
24 MLT1H 7 *** 99.0 Weakly correlated
25 HERVIP10F-int 6 **** 28.9 Weakly correlated
26 L1M1 6 n.s 74.0 Weakly correlated
27 L1PA2 6 n.s 15.2 Weakly correlated
28 L1PA4 6 n.s 19.6 Weakly correlated
29 L2b 6 n.s 99.0 Weakly correlated
30 AluJr4 5 n.s 74.0 Weakly correlated
31 AluSc8 5 n.s 74.0 Weakly correlated
32 FLAM_C 5 * 74.0 Weakly correlated
33 L1MC4 5 n.s 99.0 Weakly correlated
34 LTR41 5 **** 99.0 Weakly correlated
35 MER52A 5 *** 74.0 Weakly correlated
36 MLT1F2 5 ** 99.0 Weakly correlated
37 AluJr 4 n.s 74.0 Weakly correlated
38 AluSc 4 n.s 74.0 Weakly correlated
39 L1MEd 4 n.s 99.0 Weakly correlated
40 L1P4a 4 **** 74.0 Weakly correlated
41 L1P4d 4 **** 74.0 Weakly correlated
42 L1PA15 4 n.s 74.0 Weakly correlated
43 L1PREC2 4 n.s 43.0 Highly correlated
44 L2 4 n.s 99.0 Weakly correlated
45 LTR10A 4 **** 28.9 Weakly correlated
46 LTR13 4 **** 19.6 Weakly correlated
47 MIRc 4 n.s 99.0 Weakly correlated
48 MLT1F 4 ** 99.0 Weakly correlated
49 THE1B 4 n.s 43.0 Highly correlated
50 AluSg7 3 n.s 74.0 Weakly correlated
51 AluSq 3 n.s 74.0 Weakly correlated
52 AmnSINE1 3 **** 319.0 Weakly correlated
53 HERVK3-int 3 *** 28.9 Weakly correlated
54 L1M3f 3 *** 87.0 Weakly correlated
55 L1MA6 3 n.s 87.0 Weakly correlated
56 L1ME4a 3 n.s 99.0 Weakly correlated
57 L1P3 3 n.s 74.0 Weakly correlated
58 L1PA3 3 n.s 19.6 Weakly correlated
59 L3 3 n.s 99.0 Weakly correlated
60 MLT1K 3 n.s 99.0 Weakly correlated
61 AluYm1 2 n.s 19.6 Weakly correlated
62 ERVL-E-int 2 n.s 99.0 Weakly correlated
63 FLAM_A 2 n.s 74.0 Weakly correlated
64 FRAM 2 * 74.0 Weakly correlated
65 HAL1 2 n.s 99.0 Weakly correlated
66 HERVE-int 2 ** 19.6 Weakly correlated
67 HERVIP10B3-int 2 ** 28.9 Weakly correlated
68 HERVL18-int 2 ** 43.0 Highly correlated
69 HERVL40-int 2 ** 99.0 Weakly correlated
70 HUERS-P3b-int 2 ** 43.0 Highly correlated
71 L1M4 2 n.s 99.0 Weakly correlated
72 L1M5 2 n.s 99.0 Weakly correlated
73 L1MA3 2 n.s 74.0 Weakly correlated
74 L1MB4 2 n.s 99.0 Weakly correlated
75 L1MC5a 2 n.s 99.0 Weakly correlated
76 L1MD2 2 n.s 99.0 Weakly correlated
77 L1MDa 2 n.s 99.0 Weakly correlated
78 L1ME3G 2 n.s 99.0 Weakly correlated
79 L1ME4b 2 n.s 99.0 Weakly correlated
80 L1MEf 2 n.s 99.0 Weakly correlated
81 L1PA13 2 n.s 74.0 Weakly correlated
82 L1PA5 2 n.s 19.6 Weakly correlated
83 LTR10F 2 *** 28.9 Weakly correlated
84 LTR13_ 2 **** 28.9 Weakly correlated
85 LTR16A1 2 ** 99.0 Weakly correlated
86 LTR28C 2 *** 43.0 Highly correlated
87 LTR50 2 ** 99.0 Weakly correlated
88 LTR52-int 2 **** 99.0 Weakly correlated
89 MER4-int 2 n.s 74.0 Weakly correlated
90 MER61-int 2 * 43.0 Highly correlated
91 MER77 2 ** 99.0 Weakly correlated
92 MLT1D 2 n.s 99.0 Weakly correlated
93 MLT1J2 2 n.s 99.0 Weakly correlated
94 THE1A-int 2 n.s 43.0 Highly correlated
95 Alu 1 * 74.0 Weakly correlated
96 AluSc5 1 n.s 74.0 Weakly correlated
97 AluSx4 1 n.s 74.0 Weakly correlated
98 AluYa5 1 n.s 15.2 Weakly correlated
99 AluYb8 1 n.s 15.2 Weakly correlated
100 AluYc 1 n.s 74.0 Weakly correlated
101 AluYc3 1 ** 74.0 Weakly correlated
102 AluYg6 1 ** 15.2 Weakly correlated
103 AluYh9 1 **** 15.2 Weakly correlated
104 AluYk11 1 ** 15.2 Weakly correlated
105 ERVL-B4-int 1 n.s 99.0 Weakly correlated
106 FAM 1 n.s 87.0 Weakly correlated
107 HERVI-int 1 ** 28.9 Weakly correlated
108 HERVIP10FH-int 1 * 28.9 Weakly correlated
109 HERVS71-int 1 * 28.9 Weakly correlated
110 L1HS 1 n.s 8.6 Weakly correlated
111 L1M2 1 n.s 99.0 Weakly correlated
112 L1M2b 1 ** 87.0 Weakly correlated
113 L1M2c 1 * 87.0 Weakly correlated
114 L1M3 1 n.s 99.0 Weakly correlated
115 L1M4a2 1 n.s 99.0 Weakly correlated
116 L1M4b 1 n.s 99.0 Weakly correlated
117 L1M6 1 n.s 99.0 Weakly correlated
118 L1MA7 1 n.s 87.0 Weakly correlated
119 L1MA8 1 n.s 87.0 Weakly correlated
120 L1MB1 1 n.s 99.0 Weakly correlated
121 L1MB3 1 n.s 99.0 Weakly correlated
122 L1MB7 1 n.s 99.0 Weakly correlated
123 L1MC1 1 n.s 99.0 Weakly correlated
124 L1MC5 1 n.s 99.0 Weakly correlated
125 L1MCa 1 n.s 99.0 Weakly correlated
126 L1ME1 1 n.s 99.0 Weakly correlated
127 L1ME3A 1 n.s 99.0 Weakly correlated
128 L1ME3D 1 n.s 99.0 Weakly correlated
129 L1ME3E 1 n.s 99.0 Weakly correlated
130 L1MEc 1 n.s 99.0 Weakly correlated
131 L1MEi 1 n.s 99.0 Weakly correlated
132 L1P1 1 n.s 19.6 Weakly correlated
133 L1P4 1 n.s 74.0 Weakly correlated
134 L1PA10 1 n.s 74.0 Weakly correlated
135 L1PA11 1 n.s 74.0 Weakly correlated
136 L1PA6 1 n.s 28.9 Weakly correlated
137 L1PA8 1 n.s 74.0 Weakly correlated
138 L1PBa 1 n.s 74.0 Weakly correlated
139 L3b 1 n.s 99.0 Weakly correlated
140 L5 1 ** 99.0 Weakly correlated
141 LTR12D 1 * 19.6 Weakly correlated
142 LTR12F 1 * 28.9 Weakly correlated
143 LTR14B 1 ** 28.9 Weakly correlated
144 LTR16C 1 n.s 99.0 Weakly correlated
145 LTR16E1 1 n.s 99.0 Weakly correlated
146 LTR1A1 1 ** 43.0 Highly correlated
147 LTR1A2 1 * 43.0 Highly correlated
148 LTR33C 1 ** 99.0 Weakly correlated
149 LTR35A 1 *** 43.0 Highly correlated
150 LTR39-int 1 *** 43.0 Highly correlated
151 LTR4 1 *** 28.9 Weakly correlated
152 LTR41B 1 * 99.0 Weakly correlated
153 LTR41C 1 ** 99.0 Weakly correlated
154 LTR43-int 1 ** 74.0 Weakly correlated
155 LTR72 1 *** 74.0 Weakly correlated
156 LTR76 1 ** 74.0 Weakly correlated
157 MER11A 1 n.s 28.9 Weakly correlated
158 MER39B 1 * 74.0 Weakly correlated
159 MER50 1 n.s 43.0 Highly correlated
160 MER50-int 1 * 43.0 Highly correlated
161 MER51C 1 *** 43.0 Highly correlated
162 MER68B 1 ** 99.0 Weakly correlated
163 MER83B 1 *** 43.0 Highly correlated
164 MER90 1 ** 99.0 Weakly correlated
165 MLT1B 1 n.s 99.0 Weakly correlated
166 MLT1E1A 1 n.s 99.0 Weakly correlated
167 MLT1E3 1 n.s 99.0 Weakly correlated
168 MLT1G 1 n.s 99.0 Weakly correlated
169 MLT1H2 1 n.s 99.0 Weakly correlated
170 MLT1J 1 n.s 99.0 Weakly correlated
171 MLT2D 1 n.s 99.0 Weakly correlated
172 MSTA 1 n.s 43.0 Highly correlated
173 MSTA-int 1 n.s 43.0 Highly correlated
174 MamGypLTR3a 1 * 99.0 Weakly correlated
175 MamGypsy2-LTR 1 ** 99.0 Weakly correlated
176 MamRTE1 1 n.s 99.0 Weakly correlated
177 PABL_B-int 1 ** 74.0 Weakly correlated
178 SVA_E 1 * 0.0 Weakly correlated
179 THE1B-int 1 n.s 43.0 Highly correlated
180 THE1C-int 1 n.s 43.0 Highly correlated
181 THE1D 1 n.s 43.0 Highly correlated
182 THE1D-int 1 n.s 28.9 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 9 n.s 74.0 Weakly correlated
2 AluSx 8 n.s 74.0 Weakly correlated
3 AluJo 5 n.s 74.0 Weakly correlated
4 AluSz6 4 n.s 74.0 Weakly correlated
5 AluSg 4 n.s 74.0 Weakly correlated
6 AluSx1 4 n.s 74.0 Weakly correlated
7 AluSz 4 n.s 74.0 Weakly correlated
8 AluSx3 3 n.s 74.0 Weakly correlated
9 AluSq2 3 n.s 74.0 Weakly correlated
10 L1MA3 2 n.s 74.0 Weakly correlated
11 AluJb 2 n.s 74.0 Weakly correlated
12 AluSp 2 n.s 74.0 Weakly correlated
13 L1MEd 2 n.s 99.0 Weakly correlated
14 HUERS-P3b-int 1 * 43.0 Highly correlated
15 AluSq 1 n.s 74.0 Weakly correlated
16 L1MB7 1 n.s 99.0 Weakly correlated
17 AluYm1 1 n.s 19.6 Weakly correlated
18 MIRb 1 n.s 99.0 Weakly correlated
19 THE1B 1 n.s 43.0 Highly correlated
20 MLT1F2 1 n.s 99.0 Weakly correlated
21 L1PA16 1 n.s 74.0 Weakly correlated
22 AluSc 1 n.s 74.0 Weakly correlated
23 HERVIP10F-int 1 * 28.9 Weakly correlated
24 AluYc 1 n.s 74.0 Weakly correlated
25 AluSc8 1 n.s 74.0 Weakly correlated
26 L2c 1 n.s 99.0 Weakly correlated
27 MLT1F 1 n.s 99.0 Weakly correlated
28 L1PA17 1 n.s 74.0 Weakly correlated
29 L1M1 1 n.s 74.0 Weakly correlated
30 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 ALUSX 74.0 Weakly correlated
2 ALUY 74.0 Weakly correlated